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1. 发明授权

US10082500B2 Device and method for detecting a target analyte 有权
公开(公告)号：US10082500B2
公开(公告)日：2018-09-25
申请号：US14626885
申请日：2015-02-19
申请人： Franz Baudenbacher , Raymond Mernaugh , John Mayo , Brad Lubbers , Robert G. Wiley
发明人： Franz Baudenbacher , Raymond Mernaugh , John Mayo , Brad Lubbers , Robert G. Wiley
IPC分类号： G01N25/20 , G01N33/543 , B01L3/00 , G01N25/48 , G01K17/00 , B01L7/00
CPC分类号： G01N33/54306 , B01L3/502784 , B01L7/52 , B01L2200/147 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0867 , B01L2300/0896 , B01L2300/1883 , G01K17/006 , G01N25/4806 , G01N33/54373
摘要： One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.

2. 发明申请

US20150160205A1 Device And Method For Detecting A Target Analyte 审中-公开
标题翻译：用于检测目标分析物的装置和方法
公开(公告)号：US20150160205A1
公开(公告)日：2015-06-11
申请号：US14626885
申请日：2015-02-19
申请人： Franz Baudenbacher , Raymond Mernaugh , John Mayo , Brad Lubbers , Robert G. Wiley
发明人： Franz Baudenbacher , Raymond Mernaugh , John Mayo , Brad Lubbers , Robert G. Wiley
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , B01L3/502784 , B01L7/52 , B01L2200/147 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0867 , B01L2300/0896 , B01L2300/1883 , G01K17/006 , G01N25/4806 , G01N33/54373
摘要： One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.
摘要翻译：本公开的一个方面涉及一种用于检测流体样品中目标分析物的存在的量热计。量热计可以包括支撑结构，与支撑结构相关联的气密密封的热解耦中心反应区，至少一个液滴传输区和检测电子。所述至少一个液滴传送区域可以与所述支撑结构相关联并且被配置为将试剂液滴与包含所述流体样品的样品液滴合并以在所述中央反应区域中形成反应液滴。检测电子设备可以与中心反应区域进行电和/或热连通并与支撑结构相关联。热量计可以被配置为在形成反应液滴时检测由目标分析物和捕获试剂之间的反应事件产生的反应热。

3. 发明授权

US09526129B2 Thermal mechanical diffusion system and method 有权
标题翻译：热机械扩散系统及方法
公开(公告)号：US09526129B2
公开(公告)日：2016-12-20
申请号：US14572223
申请日：2014-12-16
申请人： Robert G. Wiley , Brett Clark , John Lower
发明人： Robert G. Wiley , Brett Clark , John Lower
IPC分类号： G02B6/255 , H05B1/02
CPC分类号： H05B1/023 , G02B6/2551 , G02B6/2552
摘要： Provided is a thermal mechanical diffusion system and method. In accordance with the present invention, one end of a fiber under tension is vibrated while a portion of the fiber is heated. A push-pull action of one end of the fiber forces increased (or rapid) diffusion of dopants in the portion of the fiber that is in a heat zone, which receives the heat. By controlling the amplitude and frequency of the vibration, a diffusion profile of one or more fibers can be dictated with precision. Heat sources having narrower thermal profiles can enable greater precision in dictating the diffusion profile. As an example, this can be particularly useful for creating a diffusion taper within a fiber to be spliced, where the taper is a result of thermal expansion of the fiber core. Diffusion can occur much more rapidly than is typical.
摘要翻译：提供了一种热机械扩散系统和方法。根据本发明，在加热纤维的一部分的同时，在张力下的纤维的一端振动。纤维力的一端的推拉动作增加了（或快速）扩散的纤维在处于受热区域的热区中的部分中的掺杂剂。通过控制振动的振幅和频率，可以精确地规定一根或多根光纤的扩散轮廓。具有较窄热分布的热源可以实现更大的精确度来规定扩散分布。作为示例，这对于在要拼接的光纤中产生扩散锥度特别有用，其中锥度是纤维芯的热膨胀的结果。扩散可能比典型的发生得更快。

4. 发明授权

US08858096B2 Side pump fiber, method of making same, and optical devices using same 有权
标题翻译：侧泵浦纤维及其制造方法以及使用其的光学装置
公开(公告)号：US08858096B2
公开(公告)日：2014-10-14
申请号：US13365841
申请日：2012-02-03
申请人： Robert G. Wiley
发明人： Robert G. Wiley
IPC分类号： G02B6/255 , H01S3/094 , G02B6/28 , H01S3/067
CPC分类号： G02B6/255 , G02B6/02 , G02B6/25 , G02B6/2852 , H01S3/06708 , H01S3/06745 , H01S3/094007 , H01S3/094019 , H01S3/09408 , Y10T29/49826
摘要： A side pump fiber and a method of making a side pump fiber are provided. A plurality of pump fibers can be joined to a side of a signal fiber, at different locations. The method includes creating a lengthwise, tapered, concave pocket cut in a pump (or side pump) fiber, inserting the signal fiber in the pocket cut, and then coupling the side pump fiber to the center fiber at the pocket cut. Optical amplifiers and lasers, as examples, can be made using the above method and side pump fibers.
摘要翻译：提供侧泵浦纤维和制造侧泵纤维的方法。多个泵浦纤维可以在不同的位置连接到信号光纤的一侧。该方法包括创建在泵（或侧泵）纤维中切割的纵向，锥形凹槽，将信号纤维插入口袋切割中，然后将侧泵纤维连接到口袋切割的中心纤维上。作为示例，可以使用上述方法和侧泵浦光纤制造光放大器和激光器。

5. 发明授权

US08721196B2 Multi-electrode system with vibrating electrodes 有权
标题翻译：带电极的多电极系统
公开(公告)号：US08721196B2
公开(公告)日：2014-05-13
申请号：US13185223
申请日：2011-07-18
申请人： Robert G. Wiley , Brett Clark , Jared C. Meitzler , Clyde J. Troutman
发明人： Robert G. Wiley , Brett Clark , Jared C. Meitzler , Clyde J. Troutman
IPC分类号： G02B6/255
CPC分类号： G02B6/2553 , C03B25/02 , C03B37/15 , C03C25/002 , G02B6/245 , G02B6/2551 , G02B6/2556 , G02B6/262
摘要： A multi-electrode system includes a fiber holder that holds at least one optical fiber, a plurality of electrodes arranged to generate a heated field to heat the at least one optical fiber, and a vibration mechanism that causes at least one of the electrodes from the plurality of electrodes to vibrate. The electrodes can be disposed in at least a partial vacuum. The system can be used for processing many types of fibers, such processing including, as examples, stripping, splicing, annealing, tapering, and so on. Corresponding fiber processing methods are also provided.
摘要翻译：多电极系统包括保持至少一个光纤的光纤保持器，多个电极，其布置成产生加热场以加热至少一个光纤;以及振动机构，其使至少一个电极从多个电极振动。电极可以设置在至少部分真空中。该系统可用于处理许多类型的纤维，这种处理包括例如剥离，拼接，退火，锥形化等。还提供了相应的纤维加工方法。

6. 发明申请

US20120183265A1 THERMAL MECHANICAL DIFFUSION SYSTEM AND METHOD 有权
标题翻译：热机械扩散系统与方法
公开(公告)号：US20120183265A1
公开(公告)日：2012-07-19
申请号：US13350274
申请日：2012-01-13
申请人： Robert G. Wiley , Brett Clark , John Lower
发明人： Robert G. Wiley , Brett Clark , John Lower
IPC分类号： G02B6/255
CPC分类号： H05B1/023 , G02B6/2551 , G02B6/2552
摘要： Provided is a thermal mechanical diffusion system and method. In accordance with the present invention, one end of a fiber under tension is vibrated while a portion of the fiber is heated. A push-pull action of one end of the fiber forces increased (or rapid) diffusion of dopants in the portion of the fiber that is in a heat zone, which receives the heat. By controlling the amplitude and frequency of the vibration, a diffusion profile of one or more fibers can be dictated with precision. Heat sources having narrower thermal profiles can enable greater precision in dictating the diffusion profile. As an example, this can be particularly useful for creating a diffusion taper within a fiber to be spliced, where the taper is a result of thermal expansion of the fiber core. Diffusion can occur much more rapidly than is typical.
摘要翻译：提供了一种热机械扩散系统和方法。根据本发明，在加热纤维的一部分的同时，在张力下的纤维的一端振动。纤维力一端的推拉动作增加（或快速）扩散在接收热量的热区中的纤维部分中的掺杂剂。通过控制振动的振幅和频率，可以精确地规定一根或多根光纤的扩散轮廓。具有较窄热分布的热源可以实现更大的精确度来规定扩散分布。作为示例，这对于在要拼接的光纤中产生扩散锥度特别有用，其中锥度是纤维芯的热膨胀的结果。扩散可能比典型的发生得更快。

7. 发明申请

US20110277511A1 MULTI-ELECTRODE SYSTEM WITH VIBRATING ELECTRODES 有权
标题翻译：具有振动电极的多电极系统
公开(公告)号：US20110277511A1
公开(公告)日：2011-11-17
申请号：US13185223
申请日：2011-07-18
申请人： Robert G. Wiley , Brett Clark , Jared C. Meitzler , Clyde J. Troutman
发明人： Robert G. Wiley , Brett Clark , Jared C. Meitzler , Clyde J. Troutman
IPC分类号： G02B6/255 , C03B37/12
CPC分类号： G02B6/2553 , C03B25/02 , C03B37/15 , C03C25/002 , G02B6/245 , G02B6/2551 , G02B6/2556 , G02B6/262
摘要： A multi-electrode system includes a fiber holder that holds at least one optical fiber, a plurality of electrodes arranged to generate a heated field to heat the at least one optical fiber, and a vibration mechanism that causes at least one of the electrodes from the plurality of electrodes to vibrate. The electrodes can be disposed in at least a partial vacuum. The system can be used for processing many types of fibers, such processing including, as examples, stripping, splicing, annealing, tapering, and so on. Corresponding fiber processing methods are also provided.
摘要翻译：多电极系统包括保持至少一个光纤的光纤保持器，多个电极，其布置成产生加热场以加热至少一个光纤;以及振动机构，其使至少一个电极从多个电极振动。电极可以设置在至少部分真空中。该系统可用于处理许多类型的纤维，这种处理包括例如剥离，拼接，退火，锥形化等。还提供了相应的纤维加工方法。

8. 发明申请

US20100263685A1 METHOD AND APPARATUS FOR GENERATING AN ELECTRICAL ARC 审中-公开
标题翻译：用于生成电弧的方法和装置
公开(公告)号：US20100263685A1
公开(公告)日：2010-10-21
申请号：US11755515
申请日：2007-05-30
申请人： Robert G. Wiley
发明人： Robert G. Wiley
IPC分类号： B08B6/00
CPC分类号： G02B6/245 , G02B6/25 , G02B6/2552
摘要： A method for preparing (e.g., cleaning or stripping) an optical fiber that includes reducing the gap resistance between two electrodes by injecting negative ions into the gas or gasses that are located between the electrodes. As a result, the voltage that is required to cause dielectric breakdown and initiation of the electrical arc is drastically reduced.
摘要翻译：一种用于制备（例如清洁或剥离）光纤的方法，包括通过将负离子注入到位于电极之间的气体或气体中来减小两个电极之间的间隙电阻。结果，导致电介质击穿和电弧引发所需的电压急剧降低。

9. 发明授权

US09028158B2 Multi-stage fiber processing system and method 有权
标题翻译：多级纤维加工系统及方法
公开(公告)号：US09028158B2
公开(公告)日：2015-05-12
申请号：US13354090
申请日：2012-01-19
申请人： Robert G. Wiley , Brett Clark , John Lower
发明人： Robert G. Wiley , Brett Clark , John Lower
IPC分类号： G02B6/255
CPC分类号： G02B6/2551 , G02B6/2552
摘要： A multi-stage fiber processing system comprises first and second fiber holders configured to hold respective portions of at least one fiber and a plurality of heat sources arranged between the first and second fiber holders and configured to provide a heat zone that axially extends about the at least on fiber. The first and second fiber holders can be configured to translate away from each other for tapering. The plurality of heat sources can include two 3 electrode heat sources that deliver an extended, substantially isothermic heat field axially about the fiber. All but one heat source can be turned off to splice the fiber. The two 3 electrode heat sources can generate 9 arcs to from the heat zone, wherein arcs between the two 3 electrode heat sources can be rotated about the at least one fiber.
摘要翻译：多级光纤处理系统包括第一和第二光纤保持器，第一和第二光纤保持器被配置为保持至少一个光纤的相应部分和布置在第一和第二光纤保持器之间的多个热源，并且被配置为提供围绕该至少在纤维上。第一和第二光纤保持器可被配置为相互平移以进行锥形化。多个热源可以包括两个3个电极热源，其围绕光纤轴向传递延伸的基本上等温的热场。除了一个热源之外，所有的热源都可以关闭以将光纤接合。两个3个电极热源可以从热区产生9个弧，其中两个3个电极热源之间的电弧可围绕至少一个光纤旋转。

10. 发明申请

US20120183266A1 MULTI-STAGE FIBER PROCESSING SYSTEM AND METHOD 有权
标题翻译：多级光纤加工系统及方法
公开(公告)号：US20120183266A1
公开(公告)日：2012-07-19
申请号：US13354090
申请日：2012-01-19
申请人： Robert G. Wiley , Brett Clark , John Lower
发明人： Robert G. Wiley , Brett Clark , John Lower
IPC分类号： G02B6/255
CPC分类号： G02B6/2551 , G02B6/2552
摘要： A multi-stage fiber processing system comprises first and second fiber holders configured to hold respective portions of at least one fiber and a plurality of heat sources arranged between the first and second fiber holders and configured to provide a heat zone that axially extends about the at least on fiber. The first and second fiber holders can be configured to translate away from each other for tapering. The plurality of heat sources can include two 3 electrode heat sources that deliver an extended, substantially isothermic heat field axially about the fiber. All but one heat source can be turned off to splice the fiber. The two 3 electrode heat sources can generate 9 arcs to from the heat zone, wherein arcs between the two 3 electrode heat sources can be rotated about the at least one fiber.
摘要翻译：多级光纤处理系统包括第一和第二光纤保持器，第一和第二光纤保持器被配置为保持至少一个光纤的相应部分和布置在第一和第二光纤保持器之间的多个热源，并且被配置成提供一个热区域，至少在纤维上。第一和第二光纤保持器可被配置为相互平移以进行锥形化。多个热源可以包括两个3个电极热源，其围绕光纤轴向传递延伸的基本上等温的热场。除了一个热源之外，所有的热源都可以关闭以将光纤接合。两个3个电极热源可以从热区产生9个弧，其中两个3个电极热源之间的电弧可围绕至少一个光纤旋转。

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