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1. 发明申请

US20060135470A1 Composition and method for treatment and prevention of traumatic synovitis and damage to articular cartilage 有权
标题翻译：用于治疗和预防创伤性滑膜炎和关节软骨损伤的组合物和方法
公开(公告)号：US20060135470A1
公开(公告)日：2006-06-22
申请号：US11015137
申请日：2004-12-17
申请人： Frank Marcum
发明人： Frank Marcum
IPC分类号： A61K31/737 , A61K31/728
CPC分类号： A61K31/728 , A61K31/737
摘要： The invention provides compositions useful for the treatment and/or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial membrane, and damage to the articular cartilage of the joint. Specifically, provided are compositions specially formulated for intra-articular and/or parenteral use in the treatment and/or prevention of traumaticsynovitis and/or damage to articular cartilage. Compositions adapted specifically for post surgical joint lavage or treatment and/or prevention of inflammatory arthritis, osteoarthritis (OA) and/or degenerative joint disease (DJD) are also provided. Compositions adapted for intra-articular and/or systemic administration comprised of therapeutic amounts of: chondroitin sulfate and hyaluronan (hyaluronic acid) are provided.
摘要翻译：本发明提供了可用于治疗和/或预防关节炎（滑液）关节损伤，特别是创伤性滑膜炎，滑膜炎症和关节关节软骨损伤的组合物。具体地，提供了专门配制用于关节内和/或肠胃外使用的治疗和/或预防创伤性肌炎和/或关节软骨损伤的组合物。还提供了专门用于术后联合灌洗或治疗和/或预防炎症性关节炎，骨关节炎（OA）和/或退行性关节病（DJD））的组合物。适用于关节内和/或全身给药的组合物包括治疗量：硫酸软骨素和透明质酸（透明质酸）。

2. 发明申请

US20080004238A1 Composition and Method for Treating Connective Tissue Damage by Transmucosal Administration 有权
标题翻译：通过粘膜下给药治疗结缔组织损伤的组合物和方法
公开(公告)号：US20080004238A1
公开(公告)日：2008-01-03
申请号：US11766515
申请日：2007-06-21
申请人： Frank Marcum , John Seanor
发明人： Frank Marcum , John Seanor
IPC分类号： A61K31/728 , A61K31/737 , A61P19/04
CPC分类号： A61K31/715 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L15/225 , A61L17/10 , A61L27/26 , C08L5/08
摘要： The present invention provides a composition, and a method of use thereof for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.
摘要翻译：本发明提供一种用于治疗人和动物中结缔组织损伤的组合物及其使用方法，其包含治疗有效量的硫酸软骨素，N-乙酰基D-葡糖胺和透明质酸（透明质酸）。特别地，本发明提供了用于治疗结缔组织损伤的组合物及其使用方法，包括但不限于关节炎疾病，骨关节炎，类风湿性关节炎，狗骨肉瘤，软骨损伤，关节损伤，关节炎症，关节滑膜炎，退行性关节病（DJD），手术后DJD，创伤性损伤，骨折，肌腱损伤，韧带损伤，骨骼损伤，肌肉骨骼损伤，纤维损伤，脂肪组织损伤，血细胞损伤和血浆损伤。用于递送本发明的组合物包括用于胃肠外，口腔和经粘膜递送和用于直接手术放置在受影响组织上的组合物。

3. 发明申请

US20080003258A1 Composition and Method for Treating Rheumatoid Arthritis 审中-公开
标题翻译：治疗类风湿关节炎的组合物和方法
公开(公告)号：US20080003258A1
公开(公告)日：2008-01-03
申请号：US11766525
申请日：2007-06-21
申请人： Frank Marcum , John Seanor
发明人： Frank Marcum , John Seanor
IPC分类号： A61K9/00 , A61F2/00 , A61K31/715 , A61M5/178 , A61P43/00 , A61K9/70 , A61K35/12
CPC分类号： A61K31/715 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61K35/545 , A61K38/18 , A61L15/225 , A61L17/10 , A61L27/26 , C08L5/08 , A61K2300/00
摘要： The present invention provides a composition, and a method of use thereof, for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.
摘要翻译：本发明提供了一种用于治疗人和动物中的结缔组织损伤的组合物及其使用方法，其包含治疗有效量的硫酸软骨素，N-乙酰基D-葡糖胺和透明质酸（透明质酸）。特别地，本发明提供了用于治疗结缔组织损伤的组合物及其使用方法，包括但不限于关节炎疾病，骨关节炎，类风湿性关节炎，狗骨肉瘤，软骨损伤，关节损伤，关节炎症，关节滑膜炎，退行性关节病（DJD），手术后DJD，创伤性损伤，骨折，肌腱损伤，韧带损伤，骨骼损伤，肌肉骨骼损伤，纤维损伤，脂肪组织损伤，血细胞损伤和血浆损伤。用于递送本发明的组合物包括用于胃肠外，口腔和经粘膜递送和用于直接手术放置在受影响组织上的组合物。

4. 发明申请

US20060234978A1 Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis 有权
公开(公告)号：US20060234978A1
公开(公告)日：2006-10-19
申请号：US11105163
申请日：2005-04-13
申请人： Frank Marcum
发明人： Frank Marcum
IPC分类号： A61K31/737 , A61K31/728
CPC分类号： A61K31/728 , A61K31/737 , A61K2300/00
摘要： The invention provides compositions and methods useful for the treatment and/or prevention of interstitial cystitis and/or a related urinary tract condition in man or in animals. Specifically, provided are compositions specially formulated for direct instillation into the bladder and/or parenteral use in the treatment and/or prevention of interstitial cystitis. Compositions adapted for direct instillation into the bladder and/or for systemic administration are provided comprised of therapeutic amounts of: chondroitin sulfate in combination with hyaluronan (hyaluronic acid) are provided. Compositions adapted for direct instillation into the bladder and/or for systemic administration are also provided comprised of therapeutic amounts of: chondroitin sulfate, hyaluronan (hyaluronic acid) and N-acetyl D-glucosamine.

5. 发明授权

US07546183B1 In-flight verification of instrument landing system signals 有权
标题翻译：仪表着陆系统信号的飞行验证
公开(公告)号：US07546183B1
公开(公告)日：2009-06-09
申请号：US11373230
申请日：2006-03-10
申请人： Frank Marcum
发明人： Frank Marcum
IPC分类号： G05D1/00 , G06F19/00
CPC分类号： G01S1/022 , G01S1/18 , G01S19/15
摘要： An instrument landing system (ILS) provides signals in space receivable by an aircraft in flight to identify, for example, a point in space at which to start an approach along a glide slope path to a touchdown point on a runway. Atmospheric, ground and other conditions may cause transmission anomalies, so that the ILS signals identify a point in space displaced from its intended position. Systems and methods employed in flight use GPS or other positional data to determine the current displacement of such point, as identified by received ILS signals, from its intended position consistent with ILS specifications. In addition to reception and use of ILS and GPS signals, data on geographic runway location and correct ILS signal in space parameters is used for reference purposes in determining signal in space position discrepancies, glide slope path angular discrepancies, or both. The pilot can be alerted not to rely upon the ILS when discrepancies, which can vary on a short time basis and not be discernable from the ground, are determined to exceed safe limits.
摘要翻译：仪表着陆系统（ILS）提供飞行中飞机可接收的空间中的信号，以识别例如在沿着跑道上的接地点的滑翔坡道开始进近的空间中的一个点。大气，地面等条件可能导致传输异常，使得ILS信号识别位于其预期位置的空间中的一个点。在飞行中使用的系统和方法使用GPS或其他位置数据来确定由接收的ILS信号识别的这些点的当前位移与其与ILS规范一致的预期位置。除了接收和使用ILS和GPS信号之外，空间参数中的地理跑道位置和正确的ILS信号的数据也用于确定空间位置差异信号，滑坡斜率角差异或二者的参考。当可以在短时间内变化而不能从地面上辨别出差异时，飞行员可以被警告不依赖于ILS，这些差异被确定为超过安全限制。

6. 发明申请

US20080003257A1 Composition and Method for Treating Connective Tissue Damage 有权
标题翻译：治疗结缔组织损伤的组合和方法
公开(公告)号：US20080003257A1
公开(公告)日：2008-01-03
申请号：US11766510
申请日：2007-06-21
申请人： Frank Marcum , John Seanor , Foster Northrop
发明人： Frank Marcum , John Seanor , Foster Northrop
IPC分类号： A61K9/00 , A61F2/00 , A61K31/715 , A61M5/178 , A61P43/00 , A61K9/70 , A61K35/12
CPC分类号： A61K31/737 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61K31/56 , A61K31/7008 , A61K31/715 , A61K31/728 , A61K35/12 , A61K38/18 , A61K45/06 , A61L15/20 , A61L15/225 , A61L15/28 , A61L15/44 , A61L17/10 , A61L27/26 , A61L2300/232 , A61L2300/236 , C08L5/08 , A61K2300/00
摘要： The present invention provides a composition, and a method of use thereof for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.
摘要翻译：本发明提供一种用于治疗人和动物中结缔组织损伤的组合物及其使用方法，其包含治疗有效量的硫酸软骨素，N-乙酰基D-葡糖胺和透明质酸（透明质酸）。特别地，本发明提供了用于治疗结缔组织损伤的组合物及其使用方法，包括但不限于关节炎疾病，骨关节炎，类风湿性关节炎，狗骨肉瘤，软骨损伤，关节损伤，关节炎症，关节滑膜炎，退行性关节病（DJD），手术后DJD，创伤性损伤，骨折，肌腱损伤，韧带损伤，骨骼损伤，肌肉骨骼损伤，纤维损伤，脂肪组织损伤，血细胞损伤和血浆损伤。用于递送本发明的组合物包括用于胃肠外，口腔和经粘膜递送和用于直接手术放置在受影响组织上的组合物。

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