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    • 5. 发明申请
    • METHOD FOR IDENTIFYING CELL-SPECIFIC PROTEIN COMBINATION PATTERNS
    • 识别细胞特异性蛋白质组合模式的方法
    • US20090305308A1
    • 2009-12-10
    • US11909357
    • 2006-03-21
    • Walter Schubert
    • Walter Schubert
    • G01N33/53C12Q1/02C07K16/00C40B40/10
    • G01N33/6845B82Y5/00B82Y10/00B82Y30/00G01N33/5044G01N33/54366G01N33/68G01N33/6842
    • The present invention discloses a method for identifying cell-specific protein combination patterns of cell surfaces of circulating cells of the immune system of a human or animal for the identification of different stages of organ-specific chronic inflammatory diseases or tumour diseases comprising the following steps: a) providing a sample of circulating cells of the immune system of a human or animal showing an organ-specific chronic inflammatory disease or tumour disease and providing a sample of circulating cells of the same cell type of the immune system of a healthy human or animal; b) determining cell-specific protein combination patterns of the cell surfaces of said healthy and pathologically modified cells; c) comparing the resulting protein combination patterns of the cell surfaces of said healthy and pathologically modified cells and subtracting the coincident parts of the protein combination patterns of said healthy and pathologically modified cells, thereby determining a cell-specific protein combination patterns of the cell surfaces of said pathologically modified cells resulting therefrom; and d) identifying and characterizing the resulting cell-specific protein combination pattern of the cell surfaces of said pathologically modified circulating cells of the immune system in terms of molecules and its spatial arrangement within the cell as disease specific. The invention moreover relates to compositions and kits comprising antibodies and/or ligands which can be employed for the performance of the method.
    • 本发明公开了一种用于鉴定人或动物免疫系统的循环细胞的细胞表面的细胞特异性蛋白质组合模式以识别器官特异性慢性炎性疾病或肿瘤疾病的不同阶段的方法,包括以下步骤: a)提供显示器官特异性慢性炎性疾病或肿瘤疾病的人或动物的免疫系统的循环细胞样品,并提供健康人或动物免疫系统相同细胞类型的循环细胞样品 ; b)确定所述健康和病理修饰的细胞的细胞表面的细胞特异性蛋白质组合模式; c)比较所得健康和病理修饰细胞的细胞表面的所得蛋白质组合模式,并减去所述健康和病理修饰细胞的蛋白质组合模式的重合部分,由此确定细胞表面的细胞特异性蛋白质组合模式 由此产生的所述病理修饰细胞; 和d)根据分子及其在细胞内的空间排列作为疾病特异性,鉴定和表征所述免疫系统的所述病理修饰的循环细胞的细胞表面的细胞特异性蛋白质组合模式。 本发明还涉及可用于实施该方法的抗体和/或配体的组合物和试剂盒。
    • 10. 发明授权
    • Binder composition, coating compositions containing this binder
composition, production and use thereof
    • 粘合剂组合物,含有该粘合剂组合物的涂料组合物,其生产和使用
    • US5739216A
    • 1998-04-14
    • US732474
    • 1997-01-02
    • Volker DuecoffreCarmen FlosbachFriedrich HerrmannHeinz-Walter ReifferscheidtWalter Schubert
    • Volker DuecoffreCarmen FlosbachFriedrich HerrmannHeinz-Walter ReifferscheidtWalter Schubert
    • C08L63/00C08L75/04C09D5/46C09D133/06C09D163/00C09D167/00C09D167/06C09D175/04C09D175/06
    • C09D167/00C09D133/062C09D133/068C09D163/00C09D175/04C08L63/00C08L75/04Y10T428/31551
    • Binder composition, coating compositions produced therefrom and use thereof, in particular for multi-layer lacquer coatings. The binder composition contains: A) 25 to 75 wt. % of the reaction product of one or more carboxy-functionalised (meth) acrylic copolymers containing urethane groups and/or of one or more carboxy-functionalised polyesters containing urethane groups, each having an acid value of 30 to 200 mg of KOH/g, with one or more lactones, B) 25 to 75 wt. % of one or more epoxy-functionalised crosslinking agents having at least two epoxy functions per molecule with a number average molecular weight (Mn) of 200 to 10000 g/mol, C) 0 to 60 wt. % of one or more polyols having at least two hydroxyl functions per molecule, D.sub.1) 0 to 20 wt. % of one or more melamine resins, D.sub.2) 0 to 40 wt. % of one or more free or capped polyisocyanates, wherein the sum of the weight percentages of components A), B), C), D.sub.1) and D.sub.2) amounts to 100 wt. %, together with E) 0 to 10 wt. % of one or more catalysts to catalyse the reaction of carboxyl and epoxy groups, relative to the sum of weights of components A) to D.sub.2).
    • PCT No.PCT / EP95 / 01663 Sec。 371日期1997年1月2日 102(e)日期1997年1月2日PCT提交1995年5月3日PCT公布。 出版物WO95 / 30719 日期1995年11月16日粘合剂组合物,由其制备的涂料组合物及其用途,特别是多层漆涂料。 粘合剂组合物含有:A)25〜75wt。 含有氨基甲酸酯基团的一种或多种羧基官能化(甲基)丙烯酸共聚物和/或含有氨基甲酸酯基团的一种或多种羧基官能化聚酯的反应产物的百分比,其酸值为30-200mg KOH / g, 与一种或多种内酯,B)25至75wt。 %的一种或多种环氧官能化交联剂,每分子具有至少两个环氧官能团,数均分子量(Mn)为200至10000g / mol,C)0至60wt。 %的一种或多种每分子具有至少两个羟基官能团的多元醇,D1)0-20重量% %的一种或多种三聚氰胺树脂,D2)0-40重量% %的一种或多种游离或封端的多异氰酸酯,其中组分A),B),C),D1)和D2的重量百分比之和相当于100wt。 %,连同E)0〜10wt。 %的一种或多种催化剂以催化羧基和环氧基团的反应,相对于组分A)至D2的重量之和)。