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1. 发明授权

US08801652B2 Early stage peritonitis detection apparatus and methods 有权
标题翻译：早期腹膜炎检测仪及方法
公开(公告)号：US08801652B2
公开(公告)日：2014-08-12
申请号：US11880656
申请日：2007-07-23
申请人： Frank J. Landherr , Lynn E. Jensen , Jay M. Lan
发明人： Frank J. Landherr , Lynn E. Jensen , Jay M. Lan
IPC分类号： A61M1/00 , G06F19/00 , B01D61/00
CPC分类号： A61M1/28 , A61M2205/331
摘要： The invention provides, inter alia, automated medical methods and apparatus that test PD effluent in a flow path (e.g., with an APD system or CAPD setup) to detect, for example, the onset of peritonitis, based on optical characteristics of the effluent resolved at cellular scales of distance. For example, according to one aspect of the invention, an APD machine includes, in an effluent flow path, apparatus for early stage peritonitis detection comprising an illumination source and a detector. The source is arranged to illuminate peritoneal effluent in a chamber that forms part of the flow path, and the detector is arranged to detect illuminant scattered by the effluent. The detector detects that reflected or scattered illuminant at a cellular scale of resolution, e.g., on a scale such that separate cellular-sized biological (or other) components in the effluent can be distinguished from one another based on scattering events detected by the detector.
摘要翻译：本发明尤其提供了一种自动化医疗方法和装置，其基于流出物的光学特性来测定PD流出物在流动路径（例如，使用APD系统或CAPD装置）中以检测例如腹膜炎的发作，在距离的细胞尺度。例如，根据本发明的一个方面，APD机器在流出物流路中包括用于早期腹膜炎检测的装置，其包括照明源和检测器。来源设置为照射形成流路的一部分的室中的腹膜流出物，并且检测器被布置成检测由流出物散射的发光体。检测器以分辨率的细胞尺度（例如，尺度）检测反射或散射的光源，使得流出物中的分离的细胞大小的生物（或其他）组分可以基于由检测器检测到的散射事件彼此区分开。

2. 发明授权

US07837666B2 Systems and methods for delivery of peritoneal dialysis (PD) solutions 有权
标题翻译：腹膜透析（PD）解决方案的系统和方法
公开(公告)号：US07837666B2
公开(公告)日：2010-11-23
申请号：US11340403
申请日：2006-01-26
申请人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
IPC分类号： B01D11/00 , A61M37/00 , A61M5/32 , A61B19/00
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

3. 发明授权

US08328784B2 Systems and methods for delivery of peritoneal dialysis (PD) solutions 有权
标题翻译：腹膜透析（PD）解决方案的系统和方法
公开(公告)号：US08328784B2
公开(公告)日：2012-12-11
申请号：US12423627
申请日：2009-04-14
申请人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
IPC分类号： B01D11/00 , A61M37/00 , A61M5/32 , A61B19/00
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

4. 发明申请

US20090078592A1 SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS 有权
标题翻译：用于输送透析（PD）解决方案的系统和方法
公开(公告)号：US20090078592A1
公开(公告)日：2009-03-26
申请号：US12326141
申请日：2008-12-02
申请人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
IPC分类号： B65D81/24 , A61M1/00
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

5. 发明授权

US07935070B2 Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product 有权
标题翻译：含有中性pH和葡萄糖降解产物的腹膜透析（PD）溶液的葡萄糖的系统和方法
公开(公告)号：US07935070B2
公开(公告)日：2011-05-03
申请号：US11046667
申请日：2005-01-28
申请人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
IPC分类号： A61M37/00 , A61B19/00
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。

6. 发明申请

US20090264854A1 Systems and Methods for Delivery of Peritoneal Dialysis (PD) Solutions 有权
标题翻译：腹膜透析（PD）解决方案的系统和方法
公开(公告)号：US20090264854A1
公开(公告)日：2009-10-22
申请号：US12423627
申请日：2009-04-14
申请人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
IPC分类号： A61J1/14
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

7. 发明授权

US09180069B2 Systems and methods for delivery of peritoneal dialysis (PD) solutions 有权
标题翻译：腹膜透析（PD）解决方案的系统和方法
公开(公告)号：US09180069B2
公开(公告)日：2015-11-10
申请号：US13523387
申请日：2012-06-14
申请人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
IPC分类号： A61B19/00 , A61J1/10 , A61J1/20 , A61M1/28 , A61M5/14 , A61M39/22 , A61M1/16
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

8. 发明申请

US20120259275A1 SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS 有权
标题翻译：用于输送透析（PD）解决方案的系统和方法
公开(公告)号：US20120259275A1
公开(公告)日：2012-10-11
申请号：US13523387
申请日：2012-06-14
申请人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Spencer Clark , Olli Tuominen , Jay M. Lan
IPC分类号： A61M1/28
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

9. 发明授权

US08052631B2 Systems and methods for delivery of peritoneal dialysis (PD) solutions 有权
标题翻译：腹膜透析（PD）解决方案的系统和方法
公开(公告)号：US08052631B2
公开(公告)日：2011-11-08
申请号：US12326141
申请日：2008-12-02
申请人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
发明人： Lynn E. Jensen , Olli Tuominen , Jay M. Lan
IPC分类号： A61M29/00 , A61B19/00
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

10. 发明申请

US20120095392A1 SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS WITH INTEGRATED INTER-CHAMBER DIFFUSER 有权
标题翻译：用于递送具有集成的室内扩散器的透析（PD）解决方案的系统和方法
公开(公告)号：US20120095392A1
公开(公告)日：2012-04-19
申请号：US12904637
申请日：2010-10-14
申请人： Lynn E. Jensen , Venugopal R. Ghatikar , DeLoy Lindley , Melvin D. Jensen
发明人： Lynn E. Jensen , Venugopal R. Ghatikar , DeLoy Lindley , Melvin D. Jensen
IPC分类号： A61M1/28
CPC分类号： A61J1/10 , A61J1/2003 , A61J1/2013 , A61J1/2027 , A61J1/2089 , A61J1/2093 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/26 , A61M1/287
摘要： The invention provides, in some aspects, a container system for medical solutions such as peritoneal dialysis (PD) solutions. The invention particularly features a system which includes a first compartment that contains a first medical solution, e.g., a PD osmotic agent, and a second compartment that contains a second medical solution, e.g., a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. To that end, a container system can include a diffuser that is disposed in a fluid pathway between the first and second compartments, e.g., to facilitate homogeneous mixing of the first and second PD agents. That diffuser is disposed within and moves relative to a structure, such as a port that defines the fluid pathway between those compartment. Thus, for example, the diffuser can comprise a body that “floats” within that pathway-defining structure and that moves from one end to the other (and/or to from points there between), depending on a direction of solution flow through the structure.
摘要翻译：本发明在一些方面提供了一种用于医疗溶液例如腹膜透析（PD）溶液的容器系统。本发明特别地涉及一种系统，其包括含有第一药液（例如PD渗透剂）的第一隔室和含有第二药液（例如PD缓冲剂）的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。为此，容器系统可以包括设置在第一和第二隔室之间的流体通路中的扩散器，例如以促进第一和第二PD试剂的均匀混合。该扩散器设置在诸如限定这些隔室之间的流体通道的端口的结构内并且相对于结构移动。因此，例如，漫射器可以包括在该路径限定结构内“浮动”并且从一端移动到另一端（和/或从其之间的点）的主体，这取决于溶液流动的方向结构体。

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