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1. 发明申请

US20060198891A1 Solid formulations of liquid biologically active agents 审中-公开
标题翻译：液体生物活性剂的固体制剂
公开(公告)号：US20060198891A1
公开(公告)日：2006-09-07
申请号：US11286301
申请日：2005-11-25
申请人： Francois Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothee Garrec , Damon Smith
发明人： Francois Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothee Garrec , Damon Smith
IPC分类号： A61K9/14
摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
摘要翻译：本发明涉及包含与稳定剂紧密结合的液体生物活性剂的固体产品; 特别是可以重构为透明，稳定，稳定的纳米分散体或负载胶束的固体产物，其包含作为稳定剂的聚合物和液体，优选与水不混溶的生物活性剂。本发明进一步涉及生产上述固体产品的方法; 特别是通过有效处理包含例如作为稳定剂的聚合物如两亲性嵌段共聚物或小分子量表面活性剂的稳定溶液产生的固体产物的饼或粉末的水合产生的胶束或纳米分散体，装载有液体生物活性剂，例如丙泊酚，任选的添加剂和合适的溶剂。

2. 发明申请

US20120289606A1 Solid Formulations of Liquid Biologically Active Agents 审中-公开
标题翻译：液体生物活性剂的固体制剂
公开(公告)号：US20120289606A1
公开(公告)日：2012-11-15
申请号：US13552993
申请日：2012-07-19
申请人： François Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothée Le Garrec , Damon Smith
发明人： François Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothée Le Garrec , Damon Smith
IPC分类号： A61K31/05 , A61P23/00
摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
摘要翻译：本发明涉及包含与稳定剂紧密结合的液体生物活性剂的固体产品; 特别是可以重构为透明，稳定，稳定的纳米分散体或负载胶束的固体产物，其包含作为稳定剂的聚合物和液体，优选与水不混溶的生物活性剂。本发明进一步涉及生产上述固体产品的方法; 特别是通过有效处理包含例如作为稳定剂的聚合物如两亲性嵌段共聚物或小分子量表面活性剂的稳定溶液产生的固体产物的饼或粉末的水合产生的胶束或纳米分散体，装载有液体生物活性剂，例如丙泊酚，任选的添加剂和合适的溶剂。

3. 发明申请

US20130039864A1 Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses Thereof 审中-公开
标题翻译：包含液体生物活性剂固体制剂的非静脉内剂型及其用途
公开(公告)号：US20130039864A1
公开(公告)日：2013-02-14
申请号：US13643038
申请日：2011-04-21
申请人： Francois Ravenelle , Dorothee Le Garrec , David Lessard , Sandra Gori , Damon Smith , Miloud Rahmouni , Vinayak Sant
发明人： Francois Ravenelle , Dorothee Le Garrec , David Lessard , Sandra Gori , Damon Smith , Miloud Rahmouni , Vinayak Sant
IPC分类号： A61K47/34 , A61K9/68 , A61P25/00 , A61P1/08 , A61P23/00 , A61P25/20 , A61P25/06 , A61P25/02 , A61K31/05 , A61P25/04 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/05 , A61K9/0056 , A61K9/1075 , A61K9/1635 , A61K9/19 , A61K9/2095
摘要： The disclosure relates to a non-intravenous dosage for administration of a liquid biologically active agent. The dosage form contains a solid formulation of the liquid biologically active agent, e.g. propofol, in intimate association with at least one stabilizing agent, e.g. an amphiphilic polymer or surfactant. A liquid biologically active agent is converted to a solid product, e.g. a powder, that can be easily incorporated into a number of different non-intravenous dosage forms. Upon hydration, a nanodispersion or micelle loaded with the active agent is formed. The dosage form can provide a non-intravenous route of administration for active agents that are typically only administered intravenously. Methods, uses, kits and commercial packages related to the non-intravenous dosage form are also disclosed.
摘要翻译：本公开涉及用于施用液体生物活性剂的非静脉内剂量。剂型包含液体生物活性剂的固体制剂，例如，异丙酚，与至少一种稳定剂紧密结合，例如。两亲聚合物或表面活性剂。将液体生物活性剂转化为固体产物，例如一种粉末，其可以容易地并入许多不同的非静脉内剂型中。在水合时，形成负载有活性剂的纳米分散体或胶束。剂型可以为通常仅静脉内施用的活性剂提供非静脉内给药途径。还公开了与非静脉内剂型相关的方法，用途，试剂盒和商业包装。

4. 发明申请

US20090258071A1 COMPOSITIONS AND METHODS FOR PH TARGETED DRUG DELIVERY 审中-公开
标题翻译：用于PH指定药物递送的组合物和方法
公开(公告)号：US20090258071A1
公开(公告)日：2009-10-15
申请号：US12408481
申请日：2009-03-20
申请人： David Lessard , Laibin Luo , Dorothee Le Garrec , Damon Smith
发明人： David Lessard , Laibin Luo , Dorothee Le Garrec , Damon Smith
IPC分类号： A61K9/14 , A61K47/34 , A61K31/437 , A61P35/00
CPC分类号： A61K47/34 , A61K9/19 , A61K31/4745 , C08F297/026 , C08L53/00 , C08L2666/02 , C08L2666/24
摘要： The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock copolymers, which permit the release of the pharmaceutically active agent when exposed to an environment having a particular pH. The compositions are particularly useful for the oral delivery of water insoluble pharmaceutically active agents.
摘要翻译：本发明提供了靶向的，特别是靶向靶向的药物活性剂在哺乳动物中的递送的组合物和方法。组合物包含pH敏感的二嵌段共聚物，其允许当暴露于具有特定pH的环境时药物活性剂的释放。所述组合物特别可用于口服递送水不溶性药物活性剂。

5. 发明授权

US08895066B2 Bilayer composition for the sustained release of acetaminophen and tramadol 有权
标题翻译：持续释放对乙酰氨基酚和曲马多的双层组成
公开(公告)号：US08895066B2
公开(公告)日：2014-11-25
申请号：US12252117
申请日：2008-10-15
申请人： Ali Bichara , Sonia Gervais , Dorothee Le Garrec , Patricia Ouadji , Vinayak Sant , Shiva Gosein , Vincent Lemaire , Samir Taga , Damon Smith
发明人： Ali Bichara , Sonia Gervais , Dorothee Le Garrec , Patricia Ouadji , Vinayak Sant , Shiva Gosein , Vincent Lemaire , Samir Taga , Damon Smith
IPC分类号： A61P25/04 , A61K31/167 , A61K9/70 , A61K31/137 , A61K31/00 , A61K9/20
CPC分类号： A61K9/2072 , A61K9/2077 , A61K9/2086 , A61K31/00 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： The invention relates to a bilayer composition for the delivery of acetaminophen and tramadol over at least a twelve hour period following initial administration. A single administration of the bilayer composition can provide analgesia starting in less than half an hour to about one hour after initial administration with a duration of at least twelve hours after initial administration.
摘要翻译：本发明涉及在最初给药后至少12小时内递送对乙酰氨基酚和曲马多的双层组合物。双次组合物的单次施用可以在初次给药后少于半小时至约1小时开始，并在初次给药后持续至少12小时。

6. 发明申请

US20100068268A1 STARCH-BASED MICROPARTICLES FOR THE RELEASE OF AGENTS DISPOSED THEREIN 审中-公开
标题翻译：用于释放其中的药剂的基于淀粉的微生物
公开(公告)号：US20100068268A1
公开(公告)日：2010-03-18
申请号：US12560046
申请日：2009-09-15
申请人： Miloud Rahmouni , Mohamed Nabil Khalid , Vinayak Sant , Abdelaziz Tafer , Damon Smith
发明人： Miloud Rahmouni , Mohamed Nabil Khalid , Vinayak Sant , Abdelaziz Tafer , Damon Smith
IPC分类号： A61K9/14 , A61K47/36 , A61K9/20 , A61K9/68 , A61K35/66 , A61K35/74 , A23L1/226
CPC分类号： A61K47/36 , A61K9/1652 , A61K9/19 , A61K31/138 , A61K31/522 , C08J3/12 , C08K5/053 , C08K5/09 , C08K5/103 , C08K5/36 , C08L3/04 , C08L2666/38 , C12N1/04 , C12N1/20
摘要： The invention provides starch-based microparticles with high loading capacity for the stabilization and/or controlled release of one or more agents, for example, a pharmaceutical, a taste masking agent, a flavoring agent, or a combination thereof, disposed within the microparticles, and to methods of making and using such microparticles.
摘要翻译：本发明提供了具有高负载能力的淀粉基微粒，用于稳定和/或控制放置在微粒内的一种或多种试剂，例如药物，掩味剂，调味剂或其组合，以及制造和使用这种微粒的方法。

7. 发明申请

US20090130183A1 Bilayer Composition for the Sustained Release of Acetaminophen and Tramadol 有权
标题翻译：用于持续释放对乙酰氨基酚和曲马多的双层组合物
公开(公告)号：US20090130183A1
公开(公告)日：2009-05-21
申请号：US12252117
申请日：2008-10-15
申请人： Ali Bichara , Sonia Gervais , Dorothee Le Garrec , Patricia Ouadji , Vinayak Sant , Shiva Gosein , Vincent Lemaire , Samir Taga , Damon Smith
发明人： Ali Bichara , Sonia Gervais , Dorothee Le Garrec , Patricia Ouadji , Vinayak Sant , Shiva Gosein , Vincent Lemaire , Samir Taga , Damon Smith
IPC分类号： A61K9/70 , A61K31/167 , A61P25/04
CPC分类号： A61K9/2072 , A61K9/2077 , A61K9/2086 , A61K31/00 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： The invention relates to a bilayer composition for the delivery of acetaminophen and tramadol over at least a twelve hour period following initial administration. A single administration of the bilayer composition can provide analgesia starting in less than half an hour to about one hour after initial administration with a duration of at least twelve hours after initial administration.
摘要翻译：本发明涉及在最初给药后至少12小时内递送对乙酰氨基酚和曲马多的双层组合物。双次组合物的单次施用可以在初次给药后少于半小时至约1小时开始，并在初次给药后持续至少12小时。

8. 发明申请

US20070128275A1 Trazodone composition for once a day administration 有权
标题翻译：曲唑酮组合物，每天给药一次
公开(公告)号：US20070128275A1
公开(公告)日：2007-06-07
申请号：US11519194
申请日：2006-09-11
申请人： Sonia Gervais , Damon Smith , Miloud Rahmouni , Pauline Contamin , Rachid Ouzerourou , My Ma , Angela Ferrada , Fouzia Soulhi
发明人： Sonia Gervais , Damon Smith , Miloud Rahmouni , Pauline Contamin , Rachid Ouzerourou , My Ma , Angela Ferrada , Fouzia Soulhi
IPC分类号： A61K9/22 , A61K31/496
CPC分类号： A61K9/2072 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/28 , A61K9/2866 , A61K31/135 , A61K31/16 , A61K31/167 , A61K31/4402 , A61K31/496
摘要： The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a controlled release excipient so that, once administered orally, the trazodone or the trazodone derivative is maintained at a therapeutic plasma concentration from at least 1 hour to at least 24 hours after initial administration. After administration, the initial therapeutic action takes effect within the first hour and lasts at least about 24 hours. This therapeutic effect remains relatively and substantially stable for the remaining period of 24 hours. The formulations can be used for treating depression and/or sleeping disorders.
摘要翻译：本发明涉及曲唑酮或曲唑酮衍生物每天一次的制剂。制剂含有曲唑酮或曲唑酮衍生物和控制释放赋形剂，使得一旦口服给药，曲唑酮或曲唑酮衍生物在治疗血浆浓度后维持在初次给药后至少1小时至至少24小时。给药后，初始治疗作用在第一小时内生效，持续至少约24小时。这种治疗效果在24小时的剩余时间内保持相对且基本稳定。制剂可用于治疗抑郁症和/或睡眠障碍。

9. 发明授权

US08590694B2 Transport apparatus 有权
标题翻译：运输设备
公开(公告)号：US08590694B2
公开(公告)日：2013-11-26
申请号：US12795927
申请日：2010-06-08
申请人： Damon Smith
发明人： Damon Smith
IPC分类号： B65G17/12 , B65G17/30
CPC分类号： B65H31/3081 , B43M3/04 , B65H2301/42266 , B65H2403/724 , B65H2404/311 , B65H2404/33 , B65H2515/32 , B65H2220/02
摘要： Apparatus for transporting documents in a paper handling system, comprising: a drive train; a document transport element connected to the drive train for moving documents; and means adapted to apply a relatively high voltage element to generate a high torque when the transport element is not loaded and to reduce the voltage and thus the torque a predetermined time after the transport element engages a document to be moved.
摘要翻译：用于在纸张处理系统中运送文件的装置，包括：传动系; 文档传送元件，连接到用于移动文件的传动系; 以及适于在传送元件未被加载时施加相对较高的电压元件以产生高扭矩的装置，并且在传送元件接合要移动的文件之后的预定时间内减小电压并因此降低转矩。

10. 发明授权

US08453418B2 Document inserting apparatus 有权
标题翻译：文件插入装置
公开(公告)号：US08453418B2
公开(公告)日：2013-06-04
申请号：US12796104
申请日：2010-06-08
申请人： Damon Smith , David Dronsfield
发明人： Damon Smith , David Dronsfield
IPC分类号： B43M3/04
CPC分类号： B43M3/045
摘要： An apparatus for inserting a document into an envelope. The apparatus includes a mechanism for holding an envelope at an insert station; pivotally mounted fingers for opening the envelope; and a platform for guiding the document over the fingers and into the envelope. The platform is pivoted at an upstream end and upwardly spring biased so that the platform is depressed against the spring bias, by an amount dependent on the weight of the insert document moving over, so that a light insert document follows a path which subtends a steeper angle to the horizontal compared to a heavy insert document.
摘要翻译：一种将文件插入信封中的装置。该装置包括用于在插入台处保持封套的机构; 用于打开信封的枢转安装的手指; 以及用于将文件引导到手指上并进入信封的平台。平台在上游端枢转并且向上弹簧偏置，使得平台抵抗弹簧偏压被减小一定量，这取决于移动的插入物文件的重量，使得光插入物文档遵循一个路径，其对准较陡峭的与重型插入文档相比，与水平方向的角度相比。

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