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1. 发明申请

US20060015959A1 Transgenic animals expressing transglutaminase II 审中-公开
标题翻译：表达转谷氨酰胺酶II的转基因动物
公开(公告)号：US20060015959A1
公开(公告)日：2006-01-19
申请号：US11167991
申请日：2005-06-27
申请人： Feng Bian , Rathna Iyer , Kevin Wang , Yuang Ye
发明人： Feng Bian , Rathna Iyer , Kevin Wang , Yuang Ye
IPC分类号： A01K67/027 , C07H21/04 , C12N5/06
CPC分类号： C07K14/70503 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N9/1044 , C12N15/85 , C12N2830/008 , C12N2830/85
摘要： The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a TGII (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (NFTs), composed predominantly of amyloid β peptides and hyperphosphorylated tau, respectively. While animal models for plaque formation exist, there is no animal model that recapitulates the formation of NFTs. This invention provides transgenic mice that overexpress human TGII, an activator of cdk5, resulting in tau that is hyperphosphorylated at AD-relevant epitopes. Deposition of tau is detected in the amygdala, thalamus and cortex. Increased phosphorylated neurofilament, silver-positive neurons and neuronal death are also observed in these regions. We conclude that the overexpression of TGII, an activator of cdk5, is sufficient to produce hyperphosphorylation of tau and neuronal death. The TGII transgenic mouse represents the first model for tau pathology in AD.
摘要翻译：本发明提供具有编码TGII（蛋白激酶cdk 5的激活物）多肽的转基因的转基因非人动物和转基因非人哺乳动物细胞。与阿尔茨海默氏病（AD）相关的两个神经病理学损伤分别是淀粉样蛋白斑和主要由淀粉样β肽组成的神经原纤维缠结（NFT）。虽然存在斑块形成的动物模型，但没有重现NFT形成的动物模型。本发明提供过表达人类TGII（cdk5的激活剂）的转基因小鼠，导致在AD相关表位上过度磷酸化的tau。在杏仁核，丘脑和皮质中检测到tau的沉积。在这些区域也观察到增加的磷酸化神经丝，银阳性神经元和神经元死亡。我们得出结论，cdk5的激活剂TGII的过度表达足以产生tau和神经元死亡的过度磷酸化。 TGII转基因小鼠代表AD中第一个tau病理模型。

2. 发明申请

US20130071379A1 1B20 PCSK9 ANTAGONISTS 有权
公开(公告)号：US20130071379A1
公开(公告)日：2013-03-21
申请号：US13466433
申请日：2012-05-08
申请人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
发明人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC分类号： A61K39/395 , C07K16/40 , C07K16/30 , C12P21/02 , C12N5/07
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

3. 发明授权

US08188234B2 1D05 PCSK9 antagonists 有权
标题翻译： 1D05 PCSK9拮抗剂
公开(公告)号：US08188234B2
公开(公告)日：2012-05-29
申请号：US12322867
申请日：2009-02-06
申请人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
发明人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC分类号： C07K16/00 , A61K39/395 , C12N5/07 , C12N5/16
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

4. 发明授权

US07817581B2 Methods and systems for network channel capacity planning, measuring and analyzing of WLAN networks 有权
标题翻译： WLAN网络的网络通道容量规划，测量和分析的方法和系统
公开(公告)号：US07817581B2
公开(公告)日：2010-10-19
申请号：US12077848
申请日：2008-03-20
申请人： Warren Blackwell , Kevin Wang , Chia-Chee Kuan
发明人： Warren Blackwell , Kevin Wang , Chia-Chee Kuan
IPC分类号： H04L12/28
CPC分类号： H04W24/08 , H04W84/12
摘要： An apparatus and method for network channel capacity planning, measuring, and analyzing of WLAN networks are presented. In one embodiment, the method includes importing network and node configuration of an existing physical wireless local area network (WLAN) deployment from WLAN surveying system that captures and analyzes WLAN traffic in order to define a configuration of the existing physical WLAN, simulating a virtual WLAN using the imported network and node configuration as parameters of the simulated WLAN and applying various other configurations not present in the imported network and node configuration as parameters of the simulated WLAN, and analyzing the simulated WLAN to produce throughput statistics of network and nodes of the simulated WLAN.
摘要翻译：介绍了WLAN网络的网络通道容量规划，测量和分析方法。在一个实施例中，该方法包括从WLAN测量系统导入现有物理无线局域网（WLAN）部署的网络和节点配置，其捕获和分析WLAN业务，以定义现有物理WLAN的配置，模拟虚拟WLAN 使用导入的网络和节点配置作为模拟WLAN的参数，并应用导入的网络和节点配置中不存在的各种其他配置作为模拟WLAN的参数，并分析模拟的WLAN以产生模拟的网络和节点的吞吐量统计 WLAN。

5. 发明申请

US20080244379A1 DISPLAYING DETAILED INFORMATION IN THE CONTEXT OF A CONDENSED ENUMERATION OF INFORMATION 有权
标题翻译：显示信息丰富的信息的详细信息
公开(公告)号：US20080244379A1
公开(公告)日：2008-10-02
申请号：US11694020
申请日：2007-03-30
申请人： Daniela K Busse , Ramshankar Venkatasubramanian , Kevin Wang
发明人： Daniela K Busse , Ramshankar Venkatasubramanian , Kevin Wang
IPC分类号： G06F17/00 , G06F3/048
CPC分类号： G06F17/245
摘要： Systems and techniques for displaying detailed information in the context of a condensed enumeration of information. For example, in one aspect, in one aspect, a display includes a visual rendition of a table that systematically arranges condensed information in a collection of rows and columns for reference by a human user. The table includes information characterizing a collection of items. The visual rendition of the table comprises a region that renders additional detail regarding a first item in the collection. The region is disposed in the midst of the visual rendition of the table.
摘要翻译：系统和技术，用于在浓缩的信息列举的上下文中显示详细信息。例如，在一个方面，在一个方面，在一个方面，显示器包括系统地将集中的信息放置在行和列的集合中以供人类用户参考的表的视觉再现。该表包括表征项目集合的信息。该表的视觉再现包括一个区域，其呈现关于集合中的第一项的附加细节。该区域被放置在桌子的视觉再现之中。

6. 发明申请

US20070238864A1 MULTIDIMENSIONAL PROTEIN SEPARATION 审中-公开
标题翻译：多元蛋白分离
公开(公告)号：US20070238864A1
公开(公告)日：2007-10-11
申请号：US11551141
申请日：2006-10-19
申请人： Andrew Ottens , Firas Kobeissy , Nancy Denslow , Kevin Wang
发明人： Andrew Ottens , Firas Kobeissy , Nancy Denslow , Kevin Wang
IPC分类号： C07K1/16
CPC分类号： C07K1/36 , C07K1/18 , G01N33/6848
摘要： In large scale proteome applications, protein separation is paramount to observing discrete changes and quantitative evaluation must coincide with qualitative protein identification for effective differential analysis. A four dimensional (4D) platform for resolving and differentially analyzing complex biological samples is presented. The system, collectively termed CAX-PAGE/RPLC-MSMS, combines bi-phasic ion-exchange chromatography (1st dimension) and polyacrylamide gel electrophoresis (2nd dimension) for protein separation, quantification and differential band targeting leading toward subsequent capillary reverse phase liquid chromatography (3rd dimension) and data dependant tandem mass spectrometry (4th dimension) for semi-quantitative and qualitative peptide analysis.
摘要翻译：在大规模蛋白质组学应用中，蛋白质分离对于观察离散变化是至关重要的，定量评估必须与定性蛋白质鉴定一致以进行有效的差异分析。介绍了一种用于解析和差异分析复杂生物样品的四维（4D）平台。该系统统称为CAX-PAGE / RPLC-MSMS，将双相离子交换色谱（1维）尺寸和聚丙烯酰胺凝胶电泳（2“ 蛋白质分离，定量和差异带定向，导致随后的毛细管反相液相色谱（3维尺寸）和数据依赖串联质谱（第4次维度）用于半定量和定性肽分析。

7. 发明申请

US20060246489A1 Biomarkers of liver injury 有权
标题翻译：肝损伤的生物标志物
公开(公告)号：US20060246489A1
公开(公告)日：2006-11-02
申请号：US11396406
申请日：2006-03-31
申请人： Stanislav Svetlov , Ronald Hayes , Kevin Wang , Monika Oli , Andrew Ottens
发明人： Stanislav Svetlov , Ronald Hayes , Kevin Wang , Monika Oli , Andrew Ottens
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/48
CPC分类号： G01N33/573 , C12Q1/00 , G01N33/6893 , G01N2800/08 , G01N2800/085
摘要： Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.
摘要翻译：提供了用于诊断和监测肝损伤的新型，敏感和特异性标记，包括但不限于缺血性肝损伤。这包括鉴定几种精氨酸/尿素/一氧化氮循环酶，硫化酶和血影蛋白分解相关产物等。

8. 发明申请

US20050118980A1 Variable rate RC calibration circuit with filter cut-off frequency programmability 审中-公开
标题翻译：具有滤波器截止频率可编程性的可变速率RC校准电路
公开(公告)号：US20050118980A1
公开(公告)日：2005-06-02
申请号：US10724415
申请日：2003-12-01
申请人： Hung-Chuan Pai , Liang Dai , Kevin Wang , Jie Huang
发明人： Hung-Chuan Pai , Liang Dai , Kevin Wang , Jie Huang
IPC分类号： H03F1/34 , H03F3/45 , H03H11/12 , H03H19/00 , H04B1/30 , H04B1/16
CPC分类号： H03H11/1291 , H03F1/34 , H03F3/45475 , H03F3/45968 , H03F3/45977 , H03F2200/78 , H03F2203/45212 , H03F2203/45424 , H03F2203/45514 , H03H19/004 , H04B1/30
摘要： Two reference signals are applied to an RC calibration circuit, which utilizes programmable resistors and switched capacitor resistors in parallel at the inputs of a differential amplifier with feedback capacitors, for the first cycle and then the two reference signals are swapped for the successive cycle. The circuit inherent DC offset is cancelled by these two successive cycles. The time duration when the difference of the differential amplifier outputs in the calibration circuit starts to reverse ramping direction and the time when the difference crosses zero is counted in terms of reference clock cycles by a binary counter. The binary count is used to select the capacitance of the capacitor arrays in an RC filter for time constant calibration. This calibration circuit provides the flexibility for various reference clock rates by adjusting the programmable resistors. By tuning the same programmable resistors, this calibration circuit in addition provides the capability to changing the cut-off frequency of an RC filter circuit to another predetermined value.
摘要翻译：两个参考信号被施加到RC校准电路，其在具有反馈电容器的差分放大器的输入端并联使用可编程电阻器和开关电容器电阻器，用于第一周期，然后两个参考信号被交换为连续循环。电路固有的直流偏移由这两个连续的周期消除。当校准电路中的差分放大器输出的差开始反向斜坡方向和差异跨越零的时间时，通过二进制计数器来计算参考时钟周期的持续时间。二进制计数用于选择RC滤波器中电容器阵列的电容进行时间常数校准。该校准电路通过调整可编程电阻器为各种参考时钟速率提供了灵活性。通过调谐相同的可编程电阻器，该校准电路另外提供了将RC滤波器电路的截止频率改变到另一个预定值的能力。

9. 发明申请

US20100038919A1 PC tray latch 审中-公开
标题翻译： PC托盘闩锁
公开(公告)号：US20100038919A1
公开(公告)日：2010-02-18
申请号：US12228332
申请日：2008-08-12
申请人： Kevin Wang
发明人： Kevin Wang
IPC分类号： E05C19/06
CPC分类号： G06F1/187 , G11B33/124 , Y10T292/09
摘要： A drive tray has a drive tray body with a retaining protrusion. A first lever arm is pivotally mounted on the drive tray body at a first lever arm first end and at a primary axis. The first lever arm has an open position and a closed position. The first lever arm also has a stopping protrusion. The first lever arm has a first lever arm length sufficient for providing a mechanical advantage to the stopping protrusion. The stopping protrusion protrudes away from a flat side of the drive tray for locking the drive tray to a case when in the first lever arm is in a closed position. The stopping protrusion retracts into a flat face of the drive tray when the first lever arm is in open position.
摘要翻译：驱动器托盘具有带有保持突起的驱动器盘体。第一杠杆臂在第一杠杆臂第一端和主轴处可枢转地安装在驱动盘体上。第一杠杆臂具有打开位置和关闭位置。第一杠杆臂还具有止动突起。第一杠杆臂具有足以为止动突起提供机械优点的第一杠杆臂长度。止动突起远离驱动盘的平坦侧突出，用于将驱动器盘锁定到第一杠杆臂处于关闭位置的情况。当第一杆臂处于打开位置时，止动突起缩回到驱动盘的平坦表面。

10. 发明申请

US20090238095A1 Methods and systems for network channel capacity planning, measuring and analyzing of WLAN networks 有权
标题翻译： WLAN网络的网络通道容量规划，测量和分析的方法和系统
公开(公告)号：US20090238095A1
公开(公告)日：2009-09-24
申请号：US12077848
申请日：2008-03-20
申请人： Warren Blackwell , Kevin Wang , Chia-Chee Kuan
发明人： Warren Blackwell , Kevin Wang , Chia-Chee Kuan
IPC分类号： H04L12/28
CPC分类号： H04W24/08 , H04W84/12
摘要： An apparatus and method for network channel capacity planning, measuring, and analyzing of WLAN networks are presented. In one embodiment, the method includes importing network and node configuration of an existing physical wireless local area network (WLAN) deployment from WLAN surveying system that captures and analyzes WLAN traffic in order to define a configuration of the existing physical WLAN, simulating a virtual WLAN using the imported network and node configuration as parameters of the simulated WLAN and applying various other configurations not present in the imported network and node configuration as parameters of the simulated WLAN, and analyzing the simulated WLAN to produce throughput statistics of network and nodes of the simulated WLAN.
摘要翻译：介绍了WLAN网络的网络通道容量规划，测量和分析方法。在一个实施例中，该方法包括从WLAN测量系统导入现有物理无线局域网（WLAN）部署的网络和节点配置，其捕获和分析WLAN业务，以定义现有物理WLAN的配置，模拟虚拟WLAN 使用导入的网络和节点配置作为模拟WLAN的参数，并应用导入的网络和节点配置中不存在的各种其他配置作为模拟WLAN的参数，并分析模拟的WLAN以产生模拟的网络和节点的吞吐量统计 WLAN。

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