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1. 发明授权

US5247934A Method and apparatus for diagnosing osteoporosis with MR imaging 失效
标题翻译：用MR诊断骨质疏松症的方法和装置
公开(公告)号：US5247934A
公开(公告)日：1993-09-28
申请号：US743265
申请日：1991-08-09
申请人： Felix W. Wehrli , Steven D. Kugelmass
发明人： Felix W. Wehrli , Steven D. Kugelmass
IPC分类号： G01R33/56
CPC分类号： G01R33/56
摘要： Methods are provided for detecting and diagnosing osteoporosis using high-resolution NMR imaging of trabecular bone. One such method comprises the steps of obtaining high-resolution NMR imaging data indicative of the trabecular microstructure of a mass of bone, analyzing the imaging data to determine the density of the trabeculae of the bone, comparing the density thus obtained with reference trabecular density data, and determining on the basis of the comparison whether the subject is osteoporotic or normal. To determine trabecular density, bone volume can be computed as the area fraction of those pixels that by virtue of their characteristic pixel intensity can be assigned to bone. Trabecular thickness can be computed from the relative bone area in a region of interest divided by half the perimeter length, the perimeter length being the circumference of all bone islands observed in the region of interest. Trabecular density can be expressed as the mean number of intercepts of parallel search lines perpendicular to the orientation of the trabeculae or as the ratio of mean trabecular thickness divided by the bone area within the region of interest.
摘要翻译：提供了使用骨小梁的高分辨率NMR成像检测和诊断骨质疏松症的方法。一种这样的方法包括以下步骤：获得指示骨块骨架微观结构的高分辨率NMR成像数据，分析成像数据以确定骨小梁的密度，将由此获得的密度与参考小梁密度数据进行比较，并根据比较确定受试者是骨质疏松还是正常。为了确定小梁密度，可以计算骨量，因为它们的特征像素强度可以分配给骨骼的那些像素的面积分数。小梁厚度可以从感兴趣区域的相对骨区域除以周长的一半计算，周长是在感兴趣区域中观察到的所有骨岛的圆周。小梁密度可以表示为垂直于小梁方向的平行搜索线的平均切片数，或平均小梁厚度除以感兴趣区域内的骨骼面积的比例。

2. 再颁专利

USRE33279E Method for rapid acquisition of NMR data 失效
标题翻译：快速获取NMR数据的方法
公开(公告)号：USRE33279E
公开(公告)日：1990-07-31
申请号：US315242
申请日：1989-02-27
申请人： Felix W. Wehrli
发明人： Felix W. Wehrli
IPC分类号： G01R33/561
CPC分类号： G01R33/561
摘要： A method for rapid acquisition of NMR data utilizes excitation pulses which rotate the longitudinal magnetization through an angle smaller than 90.degree. to create a relatively large transverse magnetization component. A first 180.degree. RF pulse is then applied to create a spin-echo signal, while a second 180.degree. RF pulse is used to rapidly return to equilibrium the residual longitudinal magnetization inverted by the first pulse. The combination of the excitation and the second 180.degree. pulses permits the sequence repetition time to be shortened, thereby reducing the total data collection time. The method is applicable to, for example, two- and three-dimensional embodiments of Fourier transform and multiple-angle projection reconstruction NMR imaging methods.

3. 发明授权

US06975894B2 Digital topological analysis of trabecular bone MR images and prediction of osteoporosis fractures 有权
$Digital topological analysis of trabecular bone MR images and prediction of osteoporosis fractures$
标题翻译：小梁骨MR图像的数字拓扑分析和骨质疏松性骨折的预测
公开(公告)号：US06975894B2
公开(公告)日：2005-12-13
申请号：US10121470
申请日：2002-04-11
申请人： Felix W. Wehrli , Punam K. Saha , Bryon Roos Gomberg
发明人： Felix W. Wehrli , Punam K. Saha , Bryon Roos Gomberg
IPC分类号： A61B5/055 , A61B5/103 , A61B6/00 , A61B8/00 , A61B17/56 , G06T5/00 , G06T7/00 , A61B5/05
CPC分类号： A61B5/417 , A61B5/055 , A61B5/7203 , A61B5/7264 , A61B5/7275 , A61B6/505 , G06T7/11 , G06T7/62 , G06T2207/10088 , G06T2207/20044 , G06T2207/30008
摘要： The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.
摘要翻译：本发明提供了通过数字拓扑分析确定小梁骨结构和强度的方法，系统和装置，并且首次提供了在远端半径中测量的椎体畸形与多个建筑指标之间的优越关联的证明，从而允许可靠和无创检测和确定骨质疏松症的发病机制。优选实施例提供了在小梁骨的区域的三维中的成像，之后将3D图像转换成骨架表面。数字拓扑分析应用于转换图像，并且每个图像体素被识别并分类为曲线，表面或结点; 然后与小梁骨的微结构指数相关联，定量表征骨小梁骨网。本发明可应用于体内，特别是适用于人类受试者或体外。

4. 发明授权

US4587489A Method for rapid acquisition of NMR data 失效
标题翻译：快速获取NMR数据的方法
公开(公告)号：US4587489A
公开(公告)日：1986-05-06
申请号：US539780
申请日：1983-10-07
申请人： Felix W. Wehrli
发明人： Felix W. Wehrli
IPC分类号： A61B10/00 , A61B5/05 , A61B5/055 , G01R33/44 , G01R33/561 , G01R33/20
CPC分类号： G01R33/561
摘要： A method for rapid acquisition of NMR data utilizes excitation pulses which rotate the longitudinal magnetization through an angle smaller than 90.degree. to create a relatively large transverse magnetization component. A first 180.degree. RF pulse is then applied to create a spin-echo signal, while a second 180.degree. RF pulse is used to rapidly return to equilibrium the residual longitudinal magnetization inverted by the first pulse. The combination of the excitation and the second 180.degree. pulses permits the sequence repetition time to be shortened, thereby reducing the total data collection time. The method is applicable to, for example, two- and three-dimensional embodiments of Fourier transform and multiple-angle projection reconstruction NMR imaging methods.
摘要翻译：用于快速获取NMR数据的方法使用激励脉冲，其使纵向磁化转动小于90°的角度以产生相对大的横向磁化分量。然后施加第一个180°RF脉冲以产生自旋回波信号，而第二个180°RF脉冲用于快速恢复由第一脉冲反转的残余纵向磁化的平衡。激发和第二180°脉冲的组合允许缩短序列重复时间，从而减少总数据采集时间。该方法适用于例如傅立叶变换和多角度投影重建NMR成像方法的二维和三维实施例。

5. 发明授权

US07769214B2 Method for measuring structural thickness from low-resolution digital images 有权
标题翻译：从低分辨率数字图像测量结构厚度的方法
公开(公告)号：US07769214B2
公开(公告)日：2010-08-03
申请号：US10728496
申请日：2003-12-05
申请人： Felix W. Wehrli , Punam K. Saha , Bryon Gomberg
发明人： Felix W. Wehrli , Punam K. Saha , Bryon Gomberg
IPC分类号： G06K9/00
CPC分类号： G06T7/62 , G06T2207/30004
摘要： Provided are fuzzy distance transform-based methods, and an algorithm therefor, for analyzing digital images defining a volumetric region of an object from a digital image comprising finding a set of points in the image to generate a fuzzy subset, and calculating the fuzzy distance transform (FDT) of the fuzzy subset. The methods deal with the extraction of object features from digital images acquired at low resolution, specifically, the measurement of structural thickness distribution along an object. Targeted applications comprise, but are not limited to, the measurement of trabecular bone thickness in magnetic resonance or computed tomography images. Also provided are systems and device for utilizing the disclosed methods and algorithm to extract the object features from the digital images.
摘要翻译：提供了基于模糊距离变换的方法及其算法，用于分析从数字图像定义对象的体积区域的数字图像，包括找到图像中的一组点以产生模糊子集，并且计算模糊距离变换（FDT）的模糊子集。该方法处理从低分辨率获取的数字图像中的对象特征的提取，特别是沿对象的结构厚度分布的测量。靶向应用包括但不限于磁共振或计算机断层摄影图像中小梁骨厚度的测量。还提供了用于利用所公开的方法和算法从数字图像中提取对象特征的系统和装置。

6. 发明授权

US07643664B2 Virtual bone biopsy (VBB) system 有权
标题翻译：虚拟骨活检（VBB）系统
公开(公告)号：US07643664B2
公开(公告)日：2010-01-05
申请号：US12352138
申请日：2009-01-12
申请人： Felix W. Wehrli , Bryon R Gomberg
发明人： Felix W. Wehrli , Bryon R Gomberg
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G01N24/08 , G01R33/48 , G01R33/56509 , G01R33/5659 , G06T7/0012 , G06T2207/10088 , G06T2207/30008
摘要： The present invention comprises a system and method for analyzing trabecular bone structure. A means for scanning the trabecular bone using a magnetic resonance image (MRI) scanner generates bone image data, which is then processed including correcting, deshading and reducing noise in the image data.
摘要翻译：本发明包括用于分析小梁骨结构的系统和方法。使用磁共振图像（MRI）扫描仪扫描小梁骨的方法产生骨图像数据，然后处理该图像数据，包括图像数据中的校正，分页和降低噪声。

7. 发明申请

US20090154786A1 Virtual Bone Biopsy (VBB) system 有权
标题翻译：虚拟骨活检（VBB）系统
公开(公告)号：US20090154786A1
公开(公告)日：2009-06-18
申请号：US12352138
申请日：2009-01-12
申请人： Felix W. Wehrli , Bryon R. Gomberg
发明人： Felix W. Wehrli , Bryon R. Gomberg
IPC分类号： G06K9/00
CPC分类号： G01N24/08 , G01R33/48 , G01R33/56509 , G01R33/5659 , G06T7/0012 , G06T2207/10088 , G06T2207/30008
摘要： The present invention comprises a system and method for analyzing trabecular bone structure. A means for scanning the trabecular bone using a magnetic resonance image (MRI) scanner generates bone image data, which is then processed including correcting, deshading and reducing noise in the image data.
摘要翻译：本发明包括用于分析小梁骨结构的系统和方法。使用磁共振图像（MRI）扫描仪扫描小梁骨的方法产生骨图像数据，然后处理该图像数据，包括图像数据中的校正，分页和降低噪声。

8. 发明授权

US06775401B2 Subvoxel processing: a method for reducing partial volume blurring 有权
标题翻译： Subvoxel处理：减少部分体积模糊的方法
公开(公告)号：US06775401B2
公开(公告)日：2004-08-10
申请号：US09820225
申请日：2001-03-28
申请人： Scott N. Hwang , Felix W. Wehrli
发明人： Scott N. Hwang , Felix W. Wehrli
IPC分类号： G06K900
CPC分类号： G06T7/0012 , G06T5/003 , G06T5/20 , G06T2200/04 , G06T2207/30008
摘要： The present invention comprises a novel method, system and device for post-processing images, such as trabecular bone images, obtained by MRI, CT, or other image technologies, to provide increasing apparent image resolution and to alleviate the effects of partial volume blurring, which otherwise precludes accurate measurement of structures in the limited-resolution regime in which image voxel size is larger than the typical structural element to be resolved. Since acquiring images at increased resolution often exacts an unacceptable signal-to-noise penalty, methods and systems to alleviate the adverse effects of partial volume blurring are instrumental for the accurate measurement of architectural parameters in applications, such as predicting the mechanical competence of trabecular bone networks. Referred to as “subvoxel processing,” the invention is applicable to volumes of interest containing material phases of two discrete signal intensities, and it has been shown to be significantly more accurate than trilinear interpolation in decreasing apparent voxel size, especially in the presence of noise.
摘要翻译：本发明包括用于后处理通过MRI，CT或其他图像技术获得的小梁骨图像的图像的新方法，系统和装置，以提供增加的视觉分辨率并减轻部分体积模糊的影响，否则排除了图像体素尺寸大于要解析的典型结构元素的有限分辨率体系中的结构的精确测量。由于以更高的分辨率获取图像通常会导致不可接受的信号噪声损失，减轻部分体积模糊的不利影响的方法和系统对于应用中的建筑参数的准确测量是有用的，例如预测小梁骨的机械能力网络。被称为“子体素处理”，本发明适用于包含两个离散信号强度的物质相位的感兴趣体积，并且已经显示出在减少表观体素尺寸方面比三线性插值显着更精确，特别是在存在噪声的情况下。

9. 发明授权

US07477770B2 Virtual bone biopsy 有权
标题翻译：虚拟骨活组织检查
公开(公告)号：US07477770B2
公开(公告)日：2009-01-13
申请号：US10497747
申请日：2002-12-05
申请人： Felix W. Wehrli , Bryon R. Gomberg
发明人： Felix W. Wehrli , Bryon R. Gomberg
IPC分类号： G06K9/00
CPC分类号： G01N24/08 , G01R33/48 , G01R33/56509 , G01R33/5659 , G06T7/0012 , G06T2207/10088 , G06T2207/30008
摘要： The present indention comprises a system and method for analyzing trabecular bone structure. A means for scanning the trabecular bone using a magnetic resonance image (MRI) scanner generates bone image data, which is then processed including correcting, deshadi4 and reducing noise in the image data.
摘要翻译：本发明包括用于分析小梁骨结构的系统和方法。使用磁共振图像（MRI）扫描仪扫描小梁骨的方法产生骨图像数据，然后处理该图像数据，包括图像数据中的校正，分页和降低噪声。

10. 发明授权

US5270651A Method and apparatus for diagnosing osteoporosis 失效
标题翻译：诊断骨质疏松症的方法和装置
公开(公告)号：US5270651A
公开(公告)日：1993-12-14
申请号：US703411
申请日：1991-05-21
申请人： Felix W. Wehrli
发明人： Felix W. Wehrli
IPC分类号： G01R33/483 , G01R33/50 , G01R33/20
CPC分类号： G01R33/50 , G01R33/483
摘要： A method for noninvasively detecting osteoporosis in human subjects by means of NMR imaging is described. In the preferred embodiment, a series of images are acquired whereby the echo time TE is incremented until a predefined number of images, each differing in echo time, has been acquired. The images are then displayed, a region of interest (ROI) is selected and mean signal amplitudes are computed (block 46). The mean signal amplitude values are then used as inputs for the curve fitting procedure that computes T2* (block 48). The final step of the process compares the computed value of T2* with a normal baseline (block 50), which permits the subject to be classified as either normal or osteoporotic (block 52).
摘要翻译：描述了通过NMR成像在人类受试者中非侵入性检测骨质疏松症的方法。在优选实施例中，获取一系列图像，从而使回波时间TE增加，直到获得每个不同回波时间的预定数量的图像。然后显示图像，选择感兴趣区域（ROI）并计算平均信号幅度（方框46）。然后将平均信号幅度值用作计算T2 *的曲线拟合过程的输入（框48）。该过程的最后一步将T2 *的计算值与正常基线（框50）进行比较，这允许受试者被归类为正常或骨质疏松（框52）。

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