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1. 发明授权

US06975894B2 Digital topological analysis of trabecular bone MR images and prediction of osteoporosis fractures 有权
$Digital topological analysis of trabecular bone MR images and prediction of osteoporosis fractures$
标题翻译：小梁骨MR图像的数字拓扑分析和骨质疏松性骨折的预测
公开(公告)号：US06975894B2
公开(公告)日：2005-12-13
申请号：US10121470
申请日：2002-04-11
申请人： Felix W. Wehrli , Punam K. Saha , Bryon Roos Gomberg
发明人： Felix W. Wehrli , Punam K. Saha , Bryon Roos Gomberg
IPC分类号： A61B5/055 , A61B5/103 , A61B6/00 , A61B8/00 , A61B17/56 , G06T5/00 , G06T7/00 , A61B5/05
CPC分类号： A61B5/417 , A61B5/055 , A61B5/7203 , A61B5/7264 , A61B5/7275 , A61B6/505 , G06T7/11 , G06T7/62 , G06T2207/10088 , G06T2207/20044 , G06T2207/30008
摘要： The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.
摘要翻译：本发明提供了通过数字拓扑分析确定小梁骨结构和强度的方法，系统和装置，并且首次提供了在远端半径中测量的椎体畸形与多个建筑指标之间的优越关联的证明，从而允许可靠和无创检测和确定骨质疏松症的发病机制。优选实施例提供了在小梁骨的区域的三维中的成像，之后将3D图像转换成骨架表面。数字拓扑分析应用于转换图像，并且每个图像体素被识别并分类为曲线，表面或结点; 然后与小梁骨的微结构指数相关联，定量表征骨小梁骨网。本发明可应用于体内，特别是适用于人类受试者或体外。

2. 发明授权

US07769214B2 Method for measuring structural thickness from low-resolution digital images 有权
标题翻译：从低分辨率数字图像测量结构厚度的方法
公开(公告)号：US07769214B2
公开(公告)日：2010-08-03
申请号：US10728496
申请日：2003-12-05
申请人： Felix W. Wehrli , Punam K. Saha , Bryon Gomberg
发明人： Felix W. Wehrli , Punam K. Saha , Bryon Gomberg
IPC分类号： G06K9/00
CPC分类号： G06T7/62 , G06T2207/30004
摘要： Provided are fuzzy distance transform-based methods, and an algorithm therefor, for analyzing digital images defining a volumetric region of an object from a digital image comprising finding a set of points in the image to generate a fuzzy subset, and calculating the fuzzy distance transform (FDT) of the fuzzy subset. The methods deal with the extraction of object features from digital images acquired at low resolution, specifically, the measurement of structural thickness distribution along an object. Targeted applications comprise, but are not limited to, the measurement of trabecular bone thickness in magnetic resonance or computed tomography images. Also provided are systems and device for utilizing the disclosed methods and algorithm to extract the object features from the digital images.
摘要翻译：提供了基于模糊距离变换的方法及其算法，用于分析从数字图像定义对象的体积区域的数字图像，包括找到图像中的一组点以产生模糊子集，并且计算模糊距离变换（FDT）的模糊子集。该方法处理从低分辨率获取的数字图像中的对象特征的提取，特别是沿对象的结构厚度分布的测量。靶向应用包括但不限于磁共振或计算机断层摄影图像中小梁骨厚度的测量。还提供了用于利用所公开的方法和算法从数字图像中提取对象特征的系统和装置。

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