专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20150168410A1 BIOMARKERS FOR COLORECTAL CANCER DIAGNOSIS AND PREDICTION 审中-公开
标题翻译：生物标志物进行彩色癌症诊断和预测
公开(公告)号：US20150168410A1
公开(公告)日：2015-06-18
申请号：US14371088
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： G01N33/574 , C07K16/38 , C12Q1/68
CPC分类号： G01N33/57419 , C07K14/8139 , C07K16/38 , C12Q1/6886 , C12Q2600/158 , G01N2333/8139
摘要： In this invention, we disclosed and documented the applications of CST4 gene, mRNA of CST4, cDNA of CST4 splices, the corresponding amplicon of CST4-specific primers, cystatin S protein coded by CST4 gene and epitope peptide of CST4 in the diagnosis and prediction of colorectal cancer, and the detection method and testing kits of the above. This invention shall be applied in the diagnosis, dynamic monitoring and progression prediction of colorectal cancer. Methods mentioned in this invention features high sensitivity and reliability, which was verified by large-scale trial.
摘要翻译：在本发明中，我们公开并记录了CST4基因的mRNA，CST4的mRNA，CST4剪接的cDNA，CST4特异性引物的相应扩增子，CST4基因编码的半胱氨酸蛋白酶抑制蛋白S蛋白和CST4的表位肽在诊断和预测中的应用结肠直肠癌，以及上述的检测方法和检测试剂盒。本发明应用于结肠直肠癌的诊断，动态监测和进展预测。本发明提出的方法具有高灵敏度和可靠性，经大规模试验验证。

2. 发明授权

US08247444B2 Anti-tumor effect of dimeric phthalide compound 有权
标题翻译：二聚苯酞化合物的抗肿瘤作用
公开(公告)号：US08247444B2
公开(公告)日：2012-08-21
申请号：US12523792
申请日：2007-01-19
申请人： Fei Chen , Tao Wang , Yifeng Wu
发明人： Fei Chen , Tao Wang , Yifeng Wu
IPC分类号： A01N43/12 , A01N43/26 , A01N43/08 , A61K31/34 , A61K31/335
CPC分类号： A61K31/365 , C07D307/88 , C07D493/08 , C07D493/10
摘要： The present invention provides for the use of a dimeric phthalide compound, the dimeric phthalide compound has broad anti-tumor activity, can directly inhibit the proliferation of tumor cells and induce cell death, but also indirectly inhibit the development of tumors by suppressing neovascularization. And further, the dimeric phthalide compound can be used alone or in combination to treat cancer, as well as in combination with chemotherapeutics to increase the efficacy of chemotherapeutics and decrease the toxicity of chemotherapeutics.
摘要翻译：本发明提供二聚苯酞化合物的用途，二苯醚膦化合物具有广泛的抗肿瘤活性，可直接抑制肿瘤细胞的增殖并诱导细胞死亡，而且通过抑制新生血管形成间接抑制肿瘤的发生。此外，二聚苯酞化合物可以单独使用或组合使用以治疗癌症，以及与化学治疗剂组合以增加化学治疗剂的功效并降低化学治疗剂的毒性。

3. 发明授权

US08445532B2 Use of phthalide derivatives 有权
标题翻译：使用苯酞衍生物
公开(公告)号：US08445532B2
公开(公告)日：2013-05-21
申请号：US12088778
申请日：2005-09-30
申请人： Fei Chen , Tao Wang
发明人： Fei Chen , Tao Wang
IPC分类号： A61K31/34
CPC分类号： A61K31/365 , A61K2300/00
摘要： Phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent are described. The phthalide derivatives can enhance the sensitivity of drug-resistance tumor cells against chemotherapy and decrease the drug-resistance of tumor cells 5-30 folder and enhance notably several chemotherapy agents-induced apoptosis of tumor cells.
摘要翻译：描述了苯酞衍生物及其用于制造抗肿瘤剂的敏化剂或反向剂的用途。苯酞衍生物可以增强抗药性肿瘤细胞对化学疗法的敏感性，降低肿瘤细胞5-30文库的耐药性，并显着增强肿瘤细胞凋亡的几种化疗药物。

4. 发明申请

US20150292024A1 BIOMARKERS FOR BREAST CANCER PREDICTION AND DIAGNOSIS 审中-公开
标题翻译：乳腺癌预防和诊断的生物标志物
公开(公告)号：US20150292024A1
公开(公告)日：2015-10-15
申请号：US14371083
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/8139 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2333/8139
摘要： This invention provides the applications of CST1 gene and its splice variants (sequence shown in SEQ ID No.48) and cystatin SN protein coded by CST1 gene (sequence shown in SEQ ID No.52) for the predictions and diagnoses of human breast cancers. The invention can be used for the diagnosis of breast cancer and breast cancer metastasis, for the analysis for the susceptibility for breast cancer, for the evaluation of the treatments, medicine, efficacy and prognosis for original or metastatic breast cancer patients, and for the risk assessment for breast cancer or its metastasis. The methods described in this invention are of significant sensitivity, specificity and reliability. The invention provides the capturers of CST1 gene, its splice variants and cystatin SN and their applications in manufacturing diagnostic reagents, kits and chips for breast cancers. The diagnostic reagents, kits and chips for breast cancer are included in this invention.
摘要翻译：本发明提供CST1基因及其剪接变体（SEQ ID No.48所示序列）和CST1基因编码的半胱氨酸蛋白酶抑制蛋白SN蛋白（SEQ ID No.52所示序列）用于预测和诊断人乳腺癌的应用。本发明可用于乳腺癌和乳腺癌转移的诊断，用于乳腺癌易感性分析，原发性或转移性乳腺癌患者的治疗，药物，功效和预后评估以及风险评估评估乳腺癌或其转移。本发明描述的方法具有显着的灵敏度，特异性和可靠性。本发明提供CST1基因，其剪接变体和半胱氨酸蛋白酶抑制剂SN的捕获者及其在制造用于乳腺癌的诊断试剂，试剂盒和芯片中的应用。用于乳腺癌的诊断试剂，试剂盒和芯片包括在本发明中。

5. 发明申请

US20150160221A1 BIOMARKERS FOR BREAST CANCER PREDICTIONS AND DIAGNOSES 审中-公开
标题翻译：用于乳腺癌的生物标志物预测和诊断
公开(公告)号：US20150160221A1
公开(公告)日：2015-06-11
申请号：US14371099
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N2333/8139
摘要： The applications of CST4 gene, mRNA of CST4, cDNA of the splice variants of CST4, the amplicons of the CST4 primers, cystatin S protein coded by CST4 and epitope peptide of cystatin S in the predictions and diagnoses of human breast cancers, is disclosed in this invention. It can be used for the diagnosis and real time monitoring of breast cancers and tumor prognosis predictions. This methods disclosed are verified with large-scale clinical trials, and are of significant reliability and sensitivity.
摘要翻译： CST4基因的mRNA，CST4的mRNA，CST4的剪接变体的cDNA，CST4引物的扩增子，CST4编码的半胱氨酸蛋白酶抑制剂S蛋白和半胱氨酸蛋白酶抑制剂S的表位肽在人乳腺癌的预测和诊断中的应用被公开在本发明。可用于乳腺癌的诊断和实时监测及肿瘤预后预测。通过大规模临床试验验证了该方法的可靠性和灵敏度。

6. 发明申请

US20100010081A1 ANTI-TUMOR EFFECT OF DIMERIC PHTHALIDE COMPOUND 有权
标题翻译：二元酚酞化合物的抗肿瘤作用
公开(公告)号：US20100010081A1
公开(公告)日：2010-01-14
申请号：US12523792
申请日：2007-01-19
申请人： Fei Chen , Tao Wang , Yifeng Wu
发明人： Fei Chen , Tao Wang , Yifeng Wu
IPC分类号： A61K31/343 , A61P35/00
CPC分类号： A61K31/365 , C07D307/88 , C07D493/08 , C07D493/10
摘要： The present invention provides for the use of a dimeric phthalide compound, the dimeric phthalide compound has broad anti-tumor activity, can directly inhibit the proliferation of tumor cells and induce cell death, but also indirectly inhibit the development of tumors by suppressing neovascularization. And further, the dimeric phthalide compound can be used alone or in combination to treat cancer, as well as in combination with chemotherapeutics to increase the efficacy of chemotherapeutics and decrease the toxicity of chemotherapeutics.
摘要翻译：本发明提供二聚苯酞化合物的用途，二苯醚膦化合物具有广泛的抗肿瘤活性，可直接抑制肿瘤细胞的增殖并诱导细胞死亡，而且通过抑制新生血管形成间接抑制肿瘤的发生。此外，二聚苯酞化合物可以单独使用或组合使用以治疗癌症，以及与化学治疗剂组合以增加化学治疗剂的功效并降低化学治疗剂的毒性。

7. 发明申请

US20080255061A1 Use of Phthalide Derivatives 有权
标题翻译：使用苯酞衍生物
公开(公告)号：US20080255061A1
公开(公告)日：2008-10-16
申请号：US12088778
申请日：2005-09-30
申请人： Fei Chen , Tao Wang
发明人： Fei Chen , Tao Wang
IPC分类号： A61K31/365 , A61P35/00 , A61K31/704
CPC分类号： A61K31/365 , A61K2300/00
摘要： Disclosed a class of phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent. The phthalide derivatives according to the invention can enhance the sensitivity of drug-resistance tumor cells against chemotherapy and decrease the drug-resistance of tumor cells 5-30 folder and enhance notably several chemotherapy agents-induced apoptosis of tumor cells
摘要翻译：公开了一类苯酞衍生物及其用途来制造抗肿瘤剂的敏化剂或反向剂。根据本发明的苯酞衍生物可以增强抗药性肿瘤细胞对化疗的敏感性，并降低肿瘤细胞5-30文库的耐药性，并且显着增强几种化疗剂诱导的肿瘤细胞凋亡

8. 发明授权

US10563941B2 Auto-releasing method and arrangement of detachable magazine for firearm 有权
公开(公告)号：US10563941B2
公开(公告)日：2020-02-18
申请号：US15900744
申请日：2018-02-20
申请人： Fei Chen , Rui Guo
发明人： Fei Chen , Rui Guo
IPC分类号： F41A17/38 , F41A9/59
摘要： An auto-releasing method and arrangement of a detachable magazine for a firearm is provided. The auto-releasing arrangement is able to physically remind the operator that it is the right time to replace the magazine and to continue fire without having to performing a series of magazine reloading operations to reset the firearm into the fire mode, wherein the magazine will automatically be released and removed from the magazine receiving cavity of the firearm. In other words, the operator can simply insert another loaded magazine into the magazine receiving cavity while the firearm still has at least one cartridge chambered for firing, so that the time cost on performing such operations can substantially be saved to increase the survival probability during a gunfight or the like.

9. 发明授权

US09251317B2 Network video messaging 有权
标题翻译：网络视频短信
公开(公告)号：US09251317B2
公开(公告)日：2016-02-02
申请号：US12408909
申请日：2009-03-23
申请人： Zhangwei Xu , Martin Hall , Mark McNulty , Guruprakash Rao , Xiaofeng Gao , Fei Chen , Ricardo Lopez-Barquilla , Martin Holladay
发明人： Zhangwei Xu , Martin Hall , Mark McNulty , Guruprakash Rao , Xiaofeng Gao , Fei Chen , Ricardo Lopez-Barquilla , Martin Holladay
IPC分类号： G06F21/10 , H04L29/00 , H04L12/58 , H04L29/08 , H04L29/06
CPC分类号： G06F21/10 , H04L29/00 , H04L51/08 , H04L51/10 , H04L51/24 , H04L63/08 , H04L63/126 , H04L67/06 , H04L2463/101
摘要： Embodiments related to network video messaging are disclosed. One disclosed embodiment provides a method that comprises receiving a video message from a client application of a source client; associating a navigation link with the video message; transmitting a notification message to the recipient client including the navigation link; receiving a retrieval request from the recipient client to access the video content via the navigation link; and transmitting the video content to the recipient client responsive to receiving the retrieval request by providing a persistent download of the video content from the storage server if the download condition indicates that a persistent download of the video content is permissible; and providing a transient download of the video content to the recipient client while prohibiting a persistent download of the video content if the download condition indicates that a persistent download of the video content is not permissible.
摘要翻译：公开了与网络视频消息相关的实施例。一个公开的实施例提供了一种方法，包括从源客户端的客户端应用接收视频消息; 将导航链接与视频消息相关联; 向包括导航链路的接收方客户端发送通知消息; 从所述接收方客户接收检索请求，经由所述导航链接访问所述视频内容; 以及如果所述下载条件指示所述视频内容的持续下载是允许的，则通过从所述存储服务器提供所述视频内容的持续下载来响应于接收到所述检索请求而将所述视频内容发送到所述接收者客户端; 以及如果所述下载条件指示所述视频内容的持续下载是不允许的，则向所述接收者客户端提供所述视频内容的暂时下载，同时禁止所述视频内容的持续下载。

10. 发明授权

US09216962B2 Thiazole compounds, methods for preparation and use thereof 有权
标题翻译：噻唑化合物，其制备方法和用途
公开(公告)号：US09216962B2
公开(公告)日：2015-12-22
申请号：US14116944
申请日：2012-05-07
申请人： Fajun Nan , Fei Chen , Yangming Zhang , Jia Li , Yubo Zhou , Mingbo Su , Jian Ding , Linghua Meng , Xin Xie , Shixian Wang
发明人： Fajun Nan , Fei Chen , Yangming Zhang , Jia Li , Yubo Zhou , Mingbo Su , Jian Ding , Linghua Meng , Xin Xie , Shixian Wang
IPC分类号： C07D417/00 , C07D277/56 , C07D277/58 , C07D277/60 , C07D417/14 , C07D417/04
CPC分类号： C07D277/56 , C07D277/58 , C07D277/60 , C07D417/04 , C07D417/14
摘要： The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses for treatments against tumor and multiple sclerosis as inhibitors of histone deacetylase.
摘要翻译：本发明涉及式I的噻唑化合物，其制备方法和用途。更具体地，本发明涉及天然产物大唑的新衍生物，其制备方法及其用于治疗肿瘤和多发性硬化的用途，作为组蛋白脱乙酰酶的抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式