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1. 发明申请

US20150168410A1 BIOMARKERS FOR COLORECTAL CANCER DIAGNOSIS AND PREDICTION 审中-公开
标题翻译：生物标志物进行彩色癌症诊断和预测
公开(公告)号：US20150168410A1
公开(公告)日：2015-06-18
申请号：US14371088
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： G01N33/574 , C07K16/38 , C12Q1/68
CPC分类号： G01N33/57419 , C07K14/8139 , C07K16/38 , C12Q1/6886 , C12Q2600/158 , G01N2333/8139
摘要： In this invention, we disclosed and documented the applications of CST4 gene, mRNA of CST4, cDNA of CST4 splices, the corresponding amplicon of CST4-specific primers, cystatin S protein coded by CST4 gene and epitope peptide of CST4 in the diagnosis and prediction of colorectal cancer, and the detection method and testing kits of the above. This invention shall be applied in the diagnosis, dynamic monitoring and progression prediction of colorectal cancer. Methods mentioned in this invention features high sensitivity and reliability, which was verified by large-scale trial.
摘要翻译：在本发明中，我们公开并记录了CST4基因的mRNA，CST4的mRNA，CST4剪接的cDNA，CST4特异性引物的相应扩增子，CST4基因编码的半胱氨酸蛋白酶抑制蛋白S蛋白和CST4的表位肽在诊断和预测中的应用结肠直肠癌，以及上述的检测方法和检测试剂盒。本发明应用于结肠直肠癌的诊断，动态监测和进展预测。本发明提出的方法具有高灵敏度和可靠性，经大规模试验验证。

2. 发明申请

US20150292024A1 BIOMARKERS FOR BREAST CANCER PREDICTION AND DIAGNOSIS 审中-公开
标题翻译：乳腺癌预防和诊断的生物标志物
公开(公告)号：US20150292024A1
公开(公告)日：2015-10-15
申请号：US14371083
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/8139 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2333/8139
摘要： This invention provides the applications of CST1 gene and its splice variants (sequence shown in SEQ ID No.48) and cystatin SN protein coded by CST1 gene (sequence shown in SEQ ID No.52) for the predictions and diagnoses of human breast cancers. The invention can be used for the diagnosis of breast cancer and breast cancer metastasis, for the analysis for the susceptibility for breast cancer, for the evaluation of the treatments, medicine, efficacy and prognosis for original or metastatic breast cancer patients, and for the risk assessment for breast cancer or its metastasis. The methods described in this invention are of significant sensitivity, specificity and reliability. The invention provides the capturers of CST1 gene, its splice variants and cystatin SN and their applications in manufacturing diagnostic reagents, kits and chips for breast cancers. The diagnostic reagents, kits and chips for breast cancer are included in this invention.
摘要翻译：本发明提供CST1基因及其剪接变体（SEQ ID No.48所示序列）和CST1基因编码的半胱氨酸蛋白酶抑制蛋白SN蛋白（SEQ ID No.52所示序列）用于预测和诊断人乳腺癌的应用。本发明可用于乳腺癌和乳腺癌转移的诊断，用于乳腺癌易感性分析，原发性或转移性乳腺癌患者的治疗，药物，功效和预后评估以及风险评估评估乳腺癌或其转移。本发明描述的方法具有显着的灵敏度，特异性和可靠性。本发明提供CST1基因，其剪接变体和半胱氨酸蛋白酶抑制剂SN的捕获者及其在制造用于乳腺癌的诊断试剂，试剂盒和芯片中的应用。用于乳腺癌的诊断试剂，试剂盒和芯片包括在本发明中。

3. 发明申请

US20150160221A1 BIOMARKERS FOR BREAST CANCER PREDICTIONS AND DIAGNOSES 审中-公开
标题翻译：用于乳腺癌的生物标志物预测和诊断
公开(公告)号：US20150160221A1
公开(公告)日：2015-06-11
申请号：US14371099
申请日：2012-01-09
申请人： Tao Wang , Xiangyun Qu , Fei Chen
发明人： Tao Wang , Xiangyun Qu , Fei Chen
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N2333/8139
摘要： The applications of CST4 gene, mRNA of CST4, cDNA of the splice variants of CST4, the amplicons of the CST4 primers, cystatin S protein coded by CST4 and epitope peptide of cystatin S in the predictions and diagnoses of human breast cancers, is disclosed in this invention. It can be used for the diagnosis and real time monitoring of breast cancers and tumor prognosis predictions. This methods disclosed are verified with large-scale clinical trials, and are of significant reliability and sensitivity.
摘要翻译： CST4基因的mRNA，CST4的mRNA，CST4的剪接变体的cDNA，CST4引物的扩增子，CST4编码的半胱氨酸蛋白酶抑制剂S蛋白和半胱氨酸蛋白酶抑制剂S的表位肽在人乳腺癌的预测和诊断中的应用被公开在本发明。可用于乳腺癌的诊断和实时监测及肿瘤预后预测。通过大规模临床试验验证了该方法的可靠性和灵敏度。

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