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1. 发明申请

US20130116206A1 QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS 审中-公开
标题翻译：用作PET成像剂的喹啉衍生物
公开(公告)号：US20130116206A1
公开(公告)日：2013-05-09
申请号：US13518000
申请日：2010-12-22
申请人： Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
发明人： Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
IPC分类号： C07D215/54 , C07H19/056 , A61K31/706 , A61K31/4706 , A61K31/4709 , C07D401/12 , A61K45/06
CPC分类号： C07D215/54 , A61K31/4706 , A61K31/4709 , A61K31/706 , A61K45/06 , C07D401/12 , C07H19/056
摘要： There is provided compounds of formula (I), wherein R1, R2, X1, X2, and X3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as positron emission tomography (PET) imaging agents, useful in the treatment of diseases in which inhibition of epidermal growth factor receptor tyrosine kinase activity or the inhibition of HER2 activity is desired and/or required, and useful in the treatment of cancer.
摘要翻译：提供式（I）化合物，其中R1，R2，X1，X2和X3具有说明书中给出的含义及其药学上可接受的盐，该化合物可用作正电子发射断层摄影（PET）成像剂，有用在治疗其中期望和/或需要抑制表皮生长因子受体酪氨酸激酶活性或抑制HER2活性的疾病，并且可用于治疗癌症。

2. 发明授权

US08963602B2 Fast pulse generator 有权
标题翻译：快速脉冲发生器
公开(公告)号：US08963602B2
公开(公告)日：2015-02-24
申请号：US11575696
申请日：2005-09-21
申请人： David Robert Bolton , Graham Smith
发明人： David Robert Bolton , Graham Smith
IPC分类号： H03K3/00 , H03B19/00
CPC分类号： H03B19/00
摘要： A pulse generator is disclosed. The pulse generator can include an ac source for providing an ac signal. A pulsed switch can be connected to an ac output of the ac source that is adapted or configured to generate a pulsed output from the ac signal and a non-linear frequency multiplier adapted or configured to shorten the pulses of the pulsed output. The pulsed switch can include a mixer.
摘要翻译：公开了一种脉冲发生器。脉冲发生器可以包括用于提供交流信号的交流电源。脉冲开关可以连接到交流电源的交流输出，适配或配置为产生来自交流信号的脉冲输出，以及适用于或配置为缩短脉冲输出脉冲的非线性倍频器。脉冲开关可以包括混合器。

3. 发明申请

US20130129447A1 Modified Fastener and Insertion Tool 审中-公开
标题翻译：修改紧固件和插入工具
公开(公告)号：US20130129447A1
公开(公告)日：2013-05-23
申请号：US13743545
申请日：2013-01-17
申请人： Eduardo Antonio Canizares, JR. , Graham Smith
发明人： Eduardo Antonio Canizares, JR. , Graham Smith
IPC分类号： F16B23/00 , B25B23/10 , B21K1/56
CPC分类号： F16B23/0007 , A61B17/8615 , A61B17/862 , A61B17/888 , A61B17/8891 , B21K1/56 , B25B15/005 , B25B23/101 , F16B23/003 , F16B23/0061 , Y10T29/49826
摘要： According to example configurations, a modified screw head includes one or more slots or grooved channels. A screwdriver device includes a tip that can be inserted into a cavity in the head of the screw to torque the modified screw into an object. The screwdriver device includes a sleeve. The sleeve slides along a shaft of the screwdriver. The sleeve includes inward protruding posts (e.g., pins, fingers, etc.). Sliding of the sleeve over the screw's head requires that inward protruding posts in the sleeve be aligned with the grooves on the sidewall of the screw's head. Subsequent to aligning and sliding the sleeve into the grooved channels of the screw's head, the user twists the sleeve to secure the screw head to the screwdriver's tip. The sleeve can be spring-loaded to pull the head of the screw toward a handle end of the screwdriver after a user releases the sleeve.
摘要翻译：根据示例性构造，改进的螺钉头包括一个或多个槽或槽形通道。螺丝刀装置包括能够插入到螺钉的头部中的空腔中的尖端，以将改进的螺钉扭转成物体。螺丝刀装置包括套筒。套筒沿螺丝刀的轴滑动。套筒包括向内突出的柱（例如，针，手指等）。将套筒滑过螺钉头部需要使套筒内的向内突出的柱与螺钉头部侧壁上的凹槽对准。在将套筒对准和滑动到螺钉头部的槽形通道中之后，用户扭转套筒以将螺钉头固定到螺丝刀的尖端。在使用者释放套筒之后，套筒可以被弹簧加载以将螺钉的头部拉向螺丝刀的手柄端。

4. 发明申请

US20130066371A1 BONE GRAFT PLACEMENT DEVICE 有权
标题翻译：骨格栅放置装置
公开(公告)号：US20130066371A1
公开(公告)日：2013-03-14
申请号：US13606886
申请日：2012-09-07
申请人： Jon-Paul Rogers , Timothy P. Callahan , Jeffrey Wyman , Graham Smith , Daniel B. Ellls
发明人： Jon-Paul Rogers , Timothy P. Callahan , Jeffrey Wyman , Graham Smith , Daniel B. Ellls
IPC分类号： A61B17/04
CPC分类号： A61B17/8872 , A61B17/0401 , A61B17/0485 , A61B17/0487 , A61B17/1684 , A61B17/1697 , A61B17/1778 , A61B17/82 , A61B17/864 , A61B17/8897 , A61B2017/00407 , A61B2017/0404 , A61B2017/0488 , A61B2017/0496 , A61B2017/06176 , A61F2/4081 , A61F2/4601
摘要： A surgical assembly includes a first guidewire and a second guidewire, in which each of the first guidewire and the second guidewire are configured to be received by a bone block, a first suture loop, a second suture loop, a first locking component, and a second locking component, in which the first locking component is coupled to the first suture loop and the second locking component is coupled to the second suture loop. The locking component has a hole formed therethrough, in which the hole of the locking component is configured to receive the suture, and may be tethered to a suture by knots engaging a counterbore at opposed ends of a bore defined by the hole.
摘要翻译：外科组件包括第一导丝和第二导丝，其中第一导丝和第二导丝中的每一个被构造成由骨块，第一缝线环，第二缝合线环，第一锁定部件和第二锁定部件，其中第一锁定部件联接到第一缝合线环，并且第二锁定部件联接到第二缝合线环。锁定部件具有穿过其中形成的孔，其中锁定部件的孔构造成容纳缝合线，并且可以通过在由孔限定的孔的相对端处与沉孔接合的节点结合到缝合线。

5. 发明申请

US20080047080A1 GrillClean, a barbeque grill cleaning system 审中-公开
标题翻译： GrillClean烧烤烤架清洁系统
公开(公告)号：US20080047080A1
公开(公告)日：2008-02-28
申请号：US11895165
申请日：2007-08-24
申请人： Graham Smith
发明人： Graham Smith
IPC分类号： A46B13/00
CPC分类号： A47L13/34 , A46B2200/3033 , A46B2200/3073 , A47L17/02
摘要： GrillClean is a new method of cleaning the cooking grid of an outdoor barbeque grill. Rather than the usual method of scraping the debris from the grid while it is on the cooking unit, causing the debris to fall into the unit, this device involves removing the cooking grid from the grill and immersing it in a water bath with scrub brushes and scrub pads along with spray nozzles of water, resulting in a more complete cleaning in a much shorter period of time. This is because both sides of the grid are being cleaned at the same time with brushes and scrub pads the full width of the cooking grid and at the same time the grid is being immersed in a water bath and then rinsed by a spray as it is removed.
摘要翻译： GrillClean是一种清洁户外烧烤架的烹饪网格的新方法。而不是通常的方法，当它在烹饪单元上时从栅格上刮除碎屑，导致碎屑落入该单元中，该装置包括从烤架中移除烹饪栅格并将其浸入带有刷子的水浴中，擦洗垫以及水的喷嘴，从而在更短的时间内进行更完整的清洁。这是因为网格的两面正在用刷子和擦洗垫同时清洁烹饪格栅的整个宽度，同时网格被浸入水浴中，然后用喷雾器冲洗，因为它是删除。

6. 发明申请

US20060014433A1 Electrical connector with ESD protection 有权
公开(公告)号：US20060014433A1
公开(公告)日：2006-01-19
申请号：US10891211
申请日：2004-07-14
申请人： John Consoli , Brent Rothermel , Graham Smith
发明人： John Consoli , Brent Rothermel , Graham Smith
IPC分类号： H01R13/648
CPC分类号： H01R13/6485 , H01R12/721 , H01R13/6585
摘要： An electrical connector includes a dielectric housing that holds a plurality of electrical wafers. Each of the wafers includes a first side, a second side opposite the first side, and a forward mating edge. A plurality of contact pads on the first side are recessed from the forward mating edge, and a perimeter conductive trace is closer than the contact pads to the forward mating edge.

7. 发明授权

US06986781B2 Tissue repair system 有权
公开(公告)号：US06986781B2
公开(公告)日：2006-01-17
申请号：US09986392
申请日：2001-11-08
申请人： Graham Smith
发明人： Graham Smith
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0487 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/0437 , A61B2017/0438 , A61B2017/0456 , A61B2017/0496
摘要： A bone anchor includes an anchor body configured to be retained within bone and to receive a flexible member such that the flexible member can be pulled in a first direction while, without the aid of an enlarged portion on the flexible member, subsequent movement in a second, opposite direction can be limited. The anchor body includes a restrictor configured to engage the flexible member to selectively restrict passage of the flexible member through an opening. A tissue repair system includes first and second bone anchors coupled by a flexible member. An anchor with attached flexible member is placed in bone, and the flexible member is moved through an opening in the anchor in a first direction. The anchor is configured to limit subsequent movement of the flexible member in at least a second opposite direction.

8. 发明授权

US5637257A Fluoro-chloro-benzene derivatives 失效
标题翻译：氟 - 氯 - 苯衍生物
公开(公告)号：US5637257A
公开(公告)日：1997-06-10
申请号：US461741
申请日：1995-06-05
申请人： David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
发明人： David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
IPC分类号： C07C17/26 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/30 , C07C19/08
CPC分类号： C07C17/263 , C07C17/2632 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C07C2101/14
摘要： Disclosed are compounds of formula I ##STR1## wherein R is C.sub.1-12 -alkyl or halogenoalkyl wherein one or two non-adjacent CH.sub.2 groups are optionally replaced by --O--,A is ##STR2## Q is a bivalent radical of formula (2), and L.sup.0, L.sup.1 and L.sup.2 are each independently H or F, with the proviso that at least one of L.sup.0, L.sup.1 and L.sup.2 present in the molecule denotes F.
摘要翻译：公开了式I的化合物其中R是C 1-12 - 烷基或卤代烷基，其中一个或两个不相邻的CH 2基团任选被-O-取代，（2）Q是二价基团式（2）和L0，L1和L2各自独立地为H或F，条件是分子中存在的L 0，L 1和L 2中的至少一个表示F.

9. 发明授权

US5620447A Surgical instrument 失效
标题翻译：手术器械
公开(公告)号：US5620447A
公开(公告)日：1997-04-15
申请号：US534743
申请日：1995-09-27
申请人： Graham Smith , Peter M. Cessarini , Steven B. Woolfson
发明人： Graham Smith , Peter M. Cessarini , Steven B. Woolfson
IPC分类号： A61B17/28 , A61B17/32
CPC分类号： A61B17/32002 , A61B2017/00309 , A61B2017/2905 , A61B2017/2927 , A61M25/0138
摘要： A surgical instrument includes a first member that has an opening in its distal region for admitting tissue and that is rotatable with respect to a base from which the first member extends to allow the rotational orientation of the opening to be selectively changed with respect to the axis of the instrument. A second member is disposed within the first member to transmit force to move a cutting implement disposed at its distal end and cause it to cut tissue that is exposed to the implement through the opening. In another aspect of the invention, a surgical instrument includes a rigid member that has a bend region that angularly offsets a distal region from a proximal region mounted to a first section of a base; a surgical device extending distally from a second section of the base coaxially with the rigid member carries a surgical tool distal of the bend region, and is flexible at least in the bend region to transmit force applied at a proximal end of the surgical device through the bend region to operate the surgical tool; the first base section is rotatable with respect to the second base section, allowing the relative rotational orientation between the surgical tool and the bend region to be changed.
摘要翻译：手术器械包括第一构件，其在其远侧区域中具有用于允许组织的开口，并且可相对于第一构件延伸的基座旋转，以允许开口的旋转取向相对于轴线有选择地改变的仪器。第二构件设置在第一构件内以传递力以移动设置在其远端处的切割工具，并使其切割通过开口暴露于工具的组织。在本发明的另一方面，一种手术器械包括刚性构件，该刚性构件具有将远侧区域与安装到基部的第一部分的近侧区域成角度地偏移的弯曲区域; 从所述基座的与所述刚性构件同轴的第二部分向远端延伸的手术装置在所述弯曲区域的远侧承载外科手术工具，并且至少在所述弯曲区域中是柔性的，以在所述手术装置的近端处施加的力通过所述手术装置弯曲区域操作手术工具; 所述第一基部相对于所述第二基部可旋转，从而允许改变所述外科手术工具和所述弯曲区域之间的相对旋转取向。

10. 发明授权

US5254698A Phenyldioxanes 失效
标题翻译：苯二恶烷
公开(公告)号：US5254698A
公开(公告)日：1993-10-19
申请号：US654607
申请日：1991-02-12
申请人： David Coates , Simon Greenfield , Graham Smith , Volker Reiffenrath , Joachim Krause , Herbert Plach
发明人： David Coates , Simon Greenfield , Graham Smith , Volker Reiffenrath , Joachim Krause , Herbert Plach
IPC分类号： G02F1/13 , C07D319/06 , C09K19/34 , C09K19/42 , C07C319/06
CPC分类号： C09K19/3402 , C07D319/06 , C09K2019/3422
摘要： Phenyldioxanes of the formula I ##STR1## wherein R.sup.1 is an alkyl or alkenyl residue each with up to 16 C atoms, wherein one or two non-adjacent CH.sub.2 groups of these residues may be replaced by --CO--O-- or --O--CO--,Q.sup.1 and Q.sup.2 are each independently ##STR2## L.sup.1 and L.sup.2 are each independently F or H, and Y is Cl, F, CN, CF.sub.3, OCF.sub.3 or OCF.sub.2 H,m and n is 0 or 1,are suitable as components of liquid crystal media.
摘要翻译： PCT No.PCT / EP90 / 02132 Sec。 371日期1991年2月12日 102（e）日期1991年2月12日PCT提交1990年12月8日PCT公布。出版物WO91 / 09026 日期：1991年6月27日。式I的苯基二恶烷其中R 1是具有至多16个C原子的烷基或链烯基，其中这些残基的一个或两个不相邻的CH 2基团可被-CO -O-或-O-CO-，Q1和Q2各自独立地为1，L 1和L 2各自独立地为F或H，Y为Cl，F，CN，CF 3，OCF 3或OCF 2 H， m和n为0或1，适合作为液晶介质的组分。

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