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1. 发明授权

US06515103B1 Conantokins 失效
标题翻译：柯南托克斯
公开(公告)号：US06515103B1
公开(公告)日：2003-02-04
申请号：US09142080
申请日：2000-05-11
申请人： Fe C. Abogadie , Lourdes J. Cruz , Baldomero M. Olivera , Craig Walker , Clark Colledge , David R. Hillyard , Elsie Jimenez , Richard T. Layer , Li-Ming Zhou , Gregory S. Shen , R. Tyler McCabe , Jean E. Rivier
发明人： Fe C. Abogadie , Lourdes J. Cruz , Baldomero M. Olivera , Craig Walker , Clark Colledge , David R. Hillyard , Elsie Jimenez , Richard T. Layer , Li-Ming Zhou , Gregory S. Shen , R. Tyler McCabe , Jean E. Rivier
IPC分类号： A61K3800
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.
摘要翻译：本发明涉及具有10-30个氨基酸，包括优选两个或更多个γ-羧基谷氨酸残基的组合蛋白肽，柯南多肽衍生物和柯南鸟肽嵌合体，统称为聚对二聚体。凝血因子可用于治疗神经和精神疾病，例如抗惊厥剂，神经保护剂或止痛剂。

2. 发明授权

US06489298B1 Contulakin-G, analogs thereof and uses thereof 有权
标题翻译： Contulakin-G，其类似物及其用途
公开(公告)号：US06489298B1
公开(公告)日：2002-12-03
申请号：US09605991
申请日：2000-06-29
申请人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
发明人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
IPC分类号： A61K3800
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
摘要翻译：本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及到前体肽。本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和神经精神药理学障碍。

3. 发明授权

US06696408B1 Contulakin-G, analogs thereof and uses therefor 有权
公开(公告)号：US06696408B1
公开(公告)日：2004-02-24
申请号：US09606247
申请日：2000-06-29
申请人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
发明人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
IPC分类号： A01N3718
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

4. 发明授权

US06344551B1 Contulakin-G, analogs thereof and uses therefor 有权
标题翻译： Contulakin-G，其类似物和用途
公开(公告)号：US06344551B1
公开(公告)日：2002-02-05
申请号：US09605990
申请日：2000-06-29
申请人： A. Grey Craig , David Griffin , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
发明人： A. Grey Craig , David Griffin , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
IPC分类号： C12N1512
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
摘要翻译：本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及到前体肽。本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和神经精神药理学障碍。

5. 发明授权

US6153738A Contryphan peptides 有权
标题翻译：对角han肽
公开(公告)号：US6153738A
公开(公告)日：2000-11-28
申请号：US466138
申请日：1999-12-21
申请人： Richard Jacobsen , Elsie Jimenez , Lourdes J. Cruz , Baldomero M. Olivera , William R. Gray , Michelle Grilley , Maren Watkins , David R. Hillyard
发明人： Richard Jacobsen , Elsie Jimenez , Lourdes J. Cruz , Baldomero M. Olivera , William R. Gray , Michelle Grilley , Maren Watkins , David R. Hillyard
IPC分类号： A61K38/00 , C07K7/06 , C07H21/04
CPC分类号： C07K7/06 , A61K38/00 , Y10S530/857
摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1 is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.
摘要翻译：本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。更具体地说，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1，Xaa2 是Pro，4-反式 - 羟基脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr。当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。当Xaa3为D-或L-Leu时，Xaa2优选为Val。羧基末端可以含有羧基或酰胺，优选酰胺。本发明进一步针对如本文所述的特异性抗原肽和前肽。本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。本发明的对策可用作抗惊厥药或神经保护剂。

6. 发明授权

US6077934A Contryphan peptides 失效
标题翻译：对角han肽
公开(公告)号：US6077934A
公开(公告)日：2000-06-20
申请号：US61026
申请日：1998-04-16
申请人： Richard Jacobsen , Elsie Jimenez , Lourdes J. Cruz , Baldomero M. Olivera , William R. Gray , Michelle Grilley , Maren Watkins , David R. Hillyard
发明人： Richard Jacobsen , Elsie Jimenez , Lourdes J. Cruz , Baldomero M. Olivera , William R. Gray , Michelle Grilley , Maren Watkins , David R. Hillyard
IPC分类号： A61K38/00 , C07K7/06 , C07K5/00
CPC分类号： C07K7/06 , A61K38/00 , Y10S530/857
摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1, is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.
摘要翻译：本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1， Xaa2是Pro，4-反 - 羟脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr 。当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。当Xaa3为D-或L-Leu时，Xaa2优选为Val。羧基末端可以含有羧基或酰胺，优选酰胺。本发明进一步针对如本文所述的特异性抗原肽和前肽。本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。本发明的对策可用作抗惊厥药或神经保护剂。

7. 发明授权

US5633347A Conotoxin peptides 失效
标题翻译：芋螺毒素肽
公开(公告)号：US5633347A
公开(公告)日：1997-05-27
申请号：US480750
申请日：1995-06-07
申请人： Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfino O. Santos
发明人： Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfino O. Santos
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435
CPC分类号： C07K14/435 , C07K14/43504 , A61K38/00 , A61K39/00 , Y10S530/857
摘要： The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the .alpha.-conotoxin peptides. The A-lineage conotoxin peptides include the .alpha.-conotoxin peptides, the .alpha.-conotoxin-like peptides and the .kappa.-conotoxin peptides, described further below. The .alpha.-conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the .alpha.3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa- Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1). The .alpha.-conotoxin-like peptides generally share a core sequence termed the .alpha.4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa- Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The .kappa.-conotoxin peptides generally have a core sequence termed the .kappa.7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa- Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3).
摘要翻译：本发明涉及A系血凝素毒素肽，其是在编码这些肽的基因的信号序列和3'非翻译区与α-毒素肽序列中具有强同源性的芋螺毒素肽。 A系血凝素毒素肽包括下文进一步描述的α-毒素肽，α-毒素样肽和κ-毒素肽。 α-毒素 - 肽通常共有“核心”序列基序。该核心序列称为α3/5核心，并表示为Cys-Cys-Xaa-Xaa-Xaa- Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys（SEQ ID NO：1）。 α-类毒素样肽通常共有称为α4/7核心的核心序列，并表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa- Xaa-Xaa-Xaa-Xaa-Xaa-Xaa -Cys（SEQ ID NO：2）。 κ-毒素肽通常具有称为κ7/2/1/3核心的核心序列，并且表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa- Xaa-Cys-Xaa-Xaa-Cys -Xaa-Cys-Xaa-Xaa-Xaa-Cys（SEQ ID NO：3）。

8. 发明授权

US06369193B1 Contulakin-G, analogs thereof and uses therefor 有权
公开(公告)号：US06369193B1
公开(公告)日：2002-04-09
申请号：US09420797
申请日：1999-10-19
申请人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz
发明人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz
IPC分类号： C07K200
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

9. 发明授权

US5670622A Conotoxin peptide PIIIA 失效
标题翻译：芋螺毒肽PIIIA
公开(公告)号：US5670622A
公开(公告)日：1997-09-23
申请号：US599556
申请日：1996-02-15
申请人： Ki-Joon Shon , Doju Yoshikami , Maren Marsh , Lourdes J. Cruz , David R. Hillyard , Baldomero M. Olivera
发明人： Ki-Joon Shon , Doju Yoshikami , Maren Marsh , Lourdes J. Cruz , David R. Hillyard , Baldomero M. Olivera
IPC分类号： A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： C07K14/435 , A61K38/00 , Y10S530/855
摘要： The invention is directed to a new .mu.-conotoxin named GIIIA. .mu.-Conotoxin PIIIA consists of 22 amino residues and is found in the Eastern Pacific fish-hunting species Conus purpurascens. This conotoxin is a new Na.sup.+ channel blocker and can be used to resolve tetrodotoxin-sensitive sodium channels into three categories: 1) sensitive to .mu.-PIIIA and .mu.-conotoxin GIIIA; 2) sensitive to .mu.-PIIIA but not to .mu.-GIIIA; and 3) sensitive to neither of these two .mu.-conotoxins. In rat brain, binding competition studies between the two .mu.-conotoxins and saxitoxin suggest at least three pharmacologically distinguishable binding sites. Thus, .mu.-conotoxin PIIIA should be a key tool for distinguishing among different sodium channel subtypes.
摘要翻译：本发明涉及一种名为GIIIA的新型mu -conotoxin。 mu-毒素PIIIA由22个氨基酸残基组成，在东太平洋狩猎物种Conus purpurascens中发现。这种芋螺毒素是一种新的Na +通道阻断剂，可用于将河豚毒素敏感的钠通道分解为三类：1）对mu -PIIIA和mu -conotoxin GIIIA敏感; 2）对mu -PIIIA敏感但不对mu-GIIIA敏感; 和3）对这两种mu -conotoxins都不敏感。在大鼠脑中，两种mu-毒素和saxitoxin之间的结合竞争研究表明至少有三个药理学上可区分的结合位点。因此，mu -conotoxin PIIIA应该是区分不同钠通道亚型的关键工具。

10. 发明授权

US5595972A Conotoxin peptides 失效
标题翻译：芋螺毒素肽
公开(公告)号：US5595972A
公开(公告)日：1997-01-21
申请号：US487174
申请日：1995-06-07
申请人： Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfino D. Santos
发明人： Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfino D. Santos
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61K49/00 , A61P35/00 , C07K14/435 , A61K38/10
CPC分类号： C07K14/435 , A61K38/17 , C07K14/43504 , A61K39/00 , Y10S436/813
摘要： The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the .alpha.-conotoxin peptides. The A-lineage conotoxin peptides include the .alpha.-conotoxin peptides, the .alpha.-conotoxin-like peptides and the .kappa.-conotoxin peptides, described further below. The .alpha.-conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the .alpha.3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 1). The .alpha.-conotoxin-like peptides generally share a core sequence termed the .alpha.4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The .kappa.-conotoxin peptides generally have a core sequence termed the .kappa.7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3) .alpha.-conotoxins MII (SEQ ID NO:54) and U002 (SEQ ID NO:10) preferentially bind to neuronal nicotinic acetylcholine receptors, rather than neuromuscular receptors. These latter two conotoxins can be used to diagnose and treat small-cell lung carcinomas, which have cholinergic nicotinic receptors.
摘要翻译：本发明涉及A系血凝素毒素肽，其是在编码这些肽的基因的信号序列和3'非翻译区与α-毒素肽序列中具有强同源性的芋螺毒素肽。 A系血凝素毒素肽包括下文进一步描述的α-毒素肽，α-毒素样肽和κ-毒素肽。 α-毒素 - 肽通常共有“核心”序列基序。该核心序列称为α3/ 5核，并表示为Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys（SEQ ID NO：1）。 α-类毒素样肽通常共有称为α4/7核心的核心序列，并表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa -Cys（SEQ ID NO：2）。 κ-毒素肽通常具有称为kappa 7/2/1/3核心的核心序列，并且表示为Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys -Xaa-Cys-Xaa-Xaa-Xaa-Cys（SEQ ID NO：3）α-毒素MII（SEQ ID NO：54）和U002（SEQ ID NO：10）优先结合神经元烟碱乙酰胆碱受体，而不是神经肌肉受体。后两种芋螺毒素可用于诊断和治疗具有胆碱能烟碱受体的小细胞肺癌。

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