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1. 发明授权

US07361683B2 Paclitaxel aqueous injection solution and methods for preparing the same 失效
标题翻译：紫杉醇注射液及其制备方法
公开(公告)号：US07361683B2
公开(公告)日：2008-04-22
申请号：US10995262
申请日：2004-11-24
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
IPC分类号： A61K31/335
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/08 , A61K47/44
摘要： The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylated castor oil, alcohol, and an injectable aqueous solution. A sufficient amount of CO2 is added to stabilize paclitaxel in the injectable pharmaceutical composition to make the injectable pharmaceutical composition to a pH about 5.0.
摘要翻译：本发明提供含有紫杉醇作为活性成分的抗癌剂的可注射药物组合物。可注射药物组合物包含有效量的紫杉醇，其溶解在聚氧乙烯化蓖麻油，醇和可注射水溶液中。加入足够量的CO 2以稳定可注射药物组合物中的紫杉醇，使可注射药物组合物的pH约为5.0。

2. 发明申请

US20060111432A1 Paclitaxel aqueous injection solution and methods for preparing the same 失效
标题翻译：紫杉醇注射液及其制备方法
公开(公告)号：US20060111432A1
公开(公告)日：2006-05-25
申请号：US10995262
申请日：2004-11-24
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
IPC分类号： A61K31/337 , A61K33/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/08 , A61K47/44
摘要： The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylated castor oil, alcohol, and an injectable aqueous solution. A sufficient amount of CO2 is added to stabilize paclitaxel in the injectable pharmaceutical composition to make the injectable pharmaceutical composition to a pH about 5.0.
摘要翻译：本发明提供含有紫杉醇作为活性成分的抗癌剂的可注射药物组合物。可注射药物组合物包含有效量的紫杉醇，其溶解在聚氧乙烯化蓖麻油，醇和可注射水溶液中。加入足够量的CO 2以稳定可注射药物组合物中的紫杉醇，使可注射药物组合物的pH约为5.0。

3. 发明授权

US07166641B2 Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same 有权
标题翻译：含有局部麻醉剂和抗炎活性的药学上可接受的盐及其制备方法
公开(公告)号：US07166641B2
公开(公告)日：2007-01-23
申请号：US10262098
申请日：2002-10-02
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi
IPC分类号： A61K31/195 , A61K31/19
CPC分类号： C07D487/04 , A61K31/167 , A61K31/196 , A61K45/06 , C07C229/42 , C07C237/04 , Y10S514/97 , A61K2300/00
摘要： The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and/or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses. These pharmaceutically acceptable salts are suitable for use in topical treatment or parenteral injection to treat patients with localized pain, including muscle pain, joint pain, pain associated with herpes infection, and wound pain (such as surgical wound, burn wound etc.).
摘要翻译：本发明提供具有局部麻醉和抗炎活性的药学上可接受的盐。优选的药学上可接受的盐是利多卡因的双氯芬酸盐。双氯芬酸是非甾体抗炎药（“NSAID”）。利多卡因是局麻药。其他NSAID（NSAID的水杨酸衍生物除外）可用于替代双氯芬酸和/或其他局部麻醉剂，可用于替代利多卡因。药学上可接受的盐是结晶化合物，它们与单独使用的NSAID或单独的局部麻醉剂明显不同，如差示扫描量热法（DSC），热重分析（TGA），高效液相色谱（HPLC）和傅里叶变换红外光谱（FTIR）分析。这些药学上可接受的盐适用于局部治疗或肠胃外注射以治疗局部疼痛的患者，包括肌肉疼痛，关节疼痛，与疱疹感染相关的疼痛和伤口疼痛（例如手术伤口，烧伤伤口等）。

4. 发明授权

US07132452B2 Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection 失效
标题翻译：具有减轻疱疹病毒感染引起的疼痛/炎症作用的局部制剂
公开(公告)号：US07132452B2
公开(公告)日：2006-11-07
申请号：US10383525
申请日：2003-03-10
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi , Wei-Liang Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi , Wei-Liang Lin
IPC分类号： A61K31/19 , A61K31/60 , A61K9/14
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/54 , Y10S514/944
摘要： The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.
摘要翻译：本发明提供含有NSAID，特别是双氯芬酸的局部制剂。局部制剂对于缓解由疱疹病毒，特别是单纯疱疹病毒（HSV）和水痘带状疱疹病毒（VZV）引起的感染相关的疼痛/炎症特别有用。双氯芬酸用另一种非甾体抗炎药（NSAID）替代，可以达到类似的缓解，其中包括但不限于依托度酸，酮咯酸，溴芬酸，二氟尼柳，布洛芬，非诺洛芬，酮洛芬，萘普生，脱芬，甲氯芬那酸，甲芬那酸，吡罗昔康，美洛昔康，吲哚美辛，舒林酸，保泰松，氧保生素和托美丁。局部制剂的特征还在于其快速释放与由疱疹病毒引起的感染相关的疼痛和/或炎症，即在将局部制剂施用于患者皮肤后不超过七（7）天内完全缓解。

5. 发明申请

US20070148240A1 Oral formulation containing itraconazole and methods for manufacturing and using the same 审中-公开
标题翻译：含有伊曲康唑的口服制剂及其制造和使用方法
公开(公告)号：US20070148240A1
公开(公告)日：2007-06-28
申请号：US11315124
申请日：2005-12-23
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Han-Chiang Kuo
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Han-Chiang Kuo
IPC分类号： A61K9/24 , A61K31/496
CPC分类号： A61K9/209 , A61K9/2054 , A61K31/496
摘要： The present invention provides oral pharmaceutical formulation for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The oral pharmaceutical formulation contains a core and a drug coating layer. The drug coating layer contains the azole antimicrobial drug and a binder, but not containing an emulsion (such as polyoxypropylene-polyoxyethylene block copolymers, polyoxyethylene-sorbitan-fatty acid esters, sodium lauryl sulfate, or vitamin E polyethylene glycol succinate) and/or an absorbent aid (such as DL-malic acid, citric acid, ascorbic acid, and alginic acid). The oral pharmaceutical formulation can optionally contain a protective layer, such as polyethylene glycol 20,000. The present invention also provides a method for preparing and using the formulation.
摘要翻译：本发明提供了唑吡唑，沙康唑，酮康唑，氟康唑等唑类抗菌药物的口服药物制剂。口服药物制剂含有核心和药物包衣层。药物包衣层包含唑类抗微生物药物和粘合剂，但不含乳液（例如聚氧丙烯 - 聚氧乙烯嵌段共聚物，聚氧乙烯脱水山梨醇脂肪酸酯，十二烷基硫酸钠或维生素E聚乙二醇琥珀酸酯）和/或吸收助剂（如DL-苹果酸，柠檬酸，抗坏血酸和海藻酸）。口服药物制剂可任选地含有保护层，例如聚乙二醇20,000。本发明还提供了制备和使用制剂的方法。

6. 发明申请

US20090022786A1 Oral pharmaceutical dosage form and manufacturing method thereof 审中-公开
标题翻译：口服药物剂型及其制备方法
公开(公告)号：US20090022786A1
公开(公告)日：2009-01-22
申请号：US12010829
申请日：2008-01-30
申请人： Fang-Chen Lee , Bin-Ken Chen , Han-Chiang Kuo , Chi-Huang Chen
发明人： Fang-Chen Lee , Bin-Ken Chen , Han-Chiang Kuo , Chi-Huang Chen
IPC分类号： A61K9/28 , A61K9/14 , A61K31/195 , A61K9/48 , A61K31/122 , A61K31/216
CPC分类号： A61K9/1676 , A61K9/2081 , A61K9/2866 , A61K9/5078 , A61K9/5084 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/557 , A61K2300/00
摘要： The present invention provides an coated oral pharmaceutical dosage form comprising a composition of a non-steroidal anti-inflammatory drug (NSAID) as multilayered spherical granule combined with a composition of prostaglandin, and a film coating. The present invention also provides a method for manufacturing the dosage form, which comprising the steps of preparing the compositions of NSAID and prostaglandin separately, combing the compositions to form a pharmaceutical dosage form, and coating the dosage form with a film coating.
摘要翻译：本发明提供了包含与前列腺素组合物组合的多层球形颗粒的非甾体抗炎药（NSAID）和薄膜包衣的组合物的包衣口服药物剂型。本发明还提供了一种用于制备剂型的方法，其包括以下步骤：分别制备NSAID和前列腺素的组合物，将组合物组合以形成药物剂型，并用膜包衣涂覆剂型。

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