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1. 发明申请

US20090062315A1 Pharmaceutical Acceptable Composition Containing Non-Steroidal Anti-Inflammatory Drug and Local Anesthetics 有权
标题翻译：含有非甾类抗炎药物和局部麻醉剂的药物可接受的组合物
公开(公告)号：US20090062315A1
公开(公告)日：2009-03-05
申请号：US12199849
申请日：2008-08-28
申请人： Fangchen Lee , Hui-Ling Shieh , Chiung-Ju Tsai , Shin-Hong Jang
发明人： Fangchen Lee , Hui-Ling Shieh , Chiung-Ju Tsai , Shin-Hong Jang
IPC分类号： A61K31/52 , A61K31/195 , A61K31/407 , A61P31/00 , A61P31/20 , A61P31/22 , A61K31/16 , A61K31/522
CPC分类号： A61K45/06 , A61K31/16 , A61K31/195 , A61K31/407 , A61K31/52 , A61K31/522 , A61K2300/00
摘要： A pharmaceutical acceptable composition is provided. The composition comprises an effective amount of a non-steroidal anti-inflammatory drug (NSAID), a local anesthetic, and an antiviral drug.
摘要翻译：提供药物可接受的组合物。组合物包含有效量的非甾体抗炎药（NSAID），局部麻醉剂和抗病毒药物。

2. 发明授权

US07166641B2 Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same 有权
标题翻译：含有局部麻醉剂和抗炎活性的药学上可接受的盐及其制备方法
公开(公告)号：US07166641B2
公开(公告)日：2007-01-23
申请号：US10262098
申请日：2002-10-02
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi
IPC分类号： A61K31/195 , A61K31/19
CPC分类号： C07D487/04 , A61K31/167 , A61K31/196 , A61K45/06 , C07C229/42 , C07C237/04 , Y10S514/97 , A61K2300/00
摘要： The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and/or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses. These pharmaceutically acceptable salts are suitable for use in topical treatment or parenteral injection to treat patients with localized pain, including muscle pain, joint pain, pain associated with herpes infection, and wound pain (such as surgical wound, burn wound etc.).
摘要翻译：本发明提供具有局部麻醉和抗炎活性的药学上可接受的盐。优选的药学上可接受的盐是利多卡因的双氯芬酸盐。双氯芬酸是非甾体抗炎药（“NSAID”）。利多卡因是局麻药。其他NSAID（NSAID的水杨酸衍生物除外）可用于替代双氯芬酸和/或其他局部麻醉剂，可用于替代利多卡因。药学上可接受的盐是结晶化合物，它们与单独使用的NSAID或单独的局部麻醉剂明显不同，如差示扫描量热法（DSC），热重分析（TGA），高效液相色谱（HPLC）和傅里叶变换红外光谱（FTIR）分析。这些药学上可接受的盐适用于局部治疗或肠胃外注射以治疗局部疼痛的患者，包括肌肉疼痛，关节疼痛，与疱疹感染相关的疼痛和伤口疼痛（例如手术伤口，烧伤伤口等）。

3. 发明授权

US07132452B2 Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection 失效
标题翻译：具有减轻疱疹病毒感染引起的疼痛/炎症作用的局部制剂
公开(公告)号：US07132452B2
公开(公告)日：2006-11-07
申请号：US10383525
申请日：2003-03-10
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi , Wei-Liang Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yen-Ling Yi , Wei-Liang Lin
IPC分类号： A61K31/19 , A61K31/60 , A61K9/14
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/381 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/54 , Y10S514/944
摘要： The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.
摘要翻译：本发明提供含有NSAID，特别是双氯芬酸的局部制剂。局部制剂对于缓解由疱疹病毒，特别是单纯疱疹病毒（HSV）和水痘带状疱疹病毒（VZV）引起的感染相关的疼痛/炎症特别有用。双氯芬酸用另一种非甾体抗炎药（NSAID）替代，可以达到类似的缓解，其中包括但不限于依托度酸，酮咯酸，溴芬酸，二氟尼柳，布洛芬，非诺洛芬，酮洛芬，萘普生，脱芬，甲氯芬那酸，甲芬那酸，吡罗昔康，美洛昔康，吲哚美辛，舒林酸，保泰松，氧保生素和托美丁。局部制剂的特征还在于其快速释放与由疱疹病毒引起的感染相关的疼痛和/或炎症，即在将局部制剂施用于患者皮肤后不超过七（7）天内完全缓解。

4. 发明授权

US08450330B2 Pharmaceutical acceptable composition containing non-steroidal anti-inflammatory drug and local anesthetics 有权
标题翻译：含有非甾体抗炎药物和局部麻醉剂的药物可接受的组合物
公开(公告)号：US08450330B2
公开(公告)日：2013-05-28
申请号：US12199849
申请日：2008-08-28
申请人： Fangchen Lee , Hui-Ling Shieh , Chiung-Ju Tsai , Shin-Hong Jang
发明人： Fangchen Lee , Hui-Ling Shieh , Chiung-Ju Tsai , Shin-Hong Jang
IPC分类号： A01N43/90 , A01N37/30 , A61K31/52 , A61K31/205
CPC分类号： A61K45/06 , A61K31/16 , A61K31/195 , A61K31/407 , A61K31/52 , A61K31/522 , A61K2300/00
摘要： A pharmaceutical acceptable composition is provided. The composition comprises an effective amount of a non-steroidal anti-inflammatory drug (NSAID), a local anesthetic, and an antiviral drug.
摘要翻译：提供药物可接受的组合物。组合物包含有效量的非甾体抗炎药（NSAID），局部麻醉剂和抗病毒药物。

5. 发明授权

US07361683B2 Paclitaxel aqueous injection solution and methods for preparing the same 失效
标题翻译：紫杉醇注射液及其制备方法
公开(公告)号：US07361683B2
公开(公告)日：2008-04-22
申请号：US10995262
申请日：2004-11-24
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
IPC分类号： A61K31/335
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/08 , A61K47/44
摘要： The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylated castor oil, alcohol, and an injectable aqueous solution. A sufficient amount of CO2 is added to stabilize paclitaxel in the injectable pharmaceutical composition to make the injectable pharmaceutical composition to a pH about 5.0.
摘要翻译：本发明提供含有紫杉醇作为活性成分的抗癌剂的可注射药物组合物。可注射药物组合物包含有效量的紫杉醇，其溶解在聚氧乙烯化蓖麻油，醇和可注射水溶液中。加入足够量的CO 2以稳定可注射药物组合物中的紫杉醇，使可注射药物组合物的pH约为5.0。

6. 发明申请

US20060111432A1 Paclitaxel aqueous injection solution and methods for preparing the same 失效
标题翻译：紫杉醇注射液及其制备方法
公开(公告)号：US20060111432A1
公开(公告)日：2006-05-25
申请号：US10995262
申请日：2004-11-24
申请人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
发明人： Fang-Yu Lee , Shan-Chiung Chen , Bin-Ken Chen , Chiung-Ju Tsai , Yuan-Ken Lin
IPC分类号： A61K31/337 , A61K33/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/08 , A61K47/44
摘要： The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an effective amount of paclitaxel, which is dissolved in polyoxyethylated castor oil, alcohol, and an injectable aqueous solution. A sufficient amount of CO2 is added to stabilize paclitaxel in the injectable pharmaceutical composition to make the injectable pharmaceutical composition to a pH about 5.0.
摘要翻译：本发明提供含有紫杉醇作为活性成分的抗癌剂的可注射药物组合物。可注射药物组合物包含有效量的紫杉醇，其溶解在聚氧乙烯化蓖麻油，醇和可注射水溶液中。加入足够量的CO 2以稳定可注射药物组合物中的紫杉醇，使可注射药物组合物的pH约为5.0。

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