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1. 发明申请

US20090123939A1 Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications 有权
标题翻译：用于浓缩，分离和检测应用的生物增强的电活性磁性纳米颗粒
公开(公告)号：US20090123939A1
公开(公告)日：2009-05-14
申请号：US12214325
申请日：2008-06-18
申请人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
发明人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
IPC分类号： G01N33/554 , G01N33/00 , H01B1/12 , G01N33/545
CPC分类号： G01N33/5438 , C12Q1/6813 , C12Q1/689 , G01N27/745 , G01N33/54333 , G01N33/54366 , G01N33/558 , G01N33/56911 , G01N33/56916 , Y10T428/2982 , Y10T436/25 , Y10T436/255
摘要： The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody) bound to the conductive polymer of the particulate composition. Methods and kits employing the particulate composition and the BEAM nanoparticle composition also are disclosed.
摘要翻译：本发明一般涉及由与磁性纳米粒子（例如，Fe（II） - 和/或Fe（III））的磁性金属氧化物结合的导电聚合物（例如，导电聚苯胺，聚吡咯，聚噻吩）形成的颗粒组合物。颗粒组合物可以通过进一步包括与颗粒组合物的导电聚合物结合的结合对成员（例如，抗体）形成生物增强的电活性磁性（BEAM）纳米颗粒组合物。公开了使用颗粒组合物和BEAM纳米颗粒组合物的方法和试剂盒。

2. 发明授权

US08936946B2 Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications 有权
公开(公告)号：US08936946B2
公开(公告)日：2015-01-20
申请号：US12214325
申请日：2008-06-18
申请人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
发明人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
IPC分类号： G01N33/543 , G01N27/74
CPC分类号： G01N33/5438 , C12Q1/6813 , C12Q1/689 , G01N27/745 , G01N33/54333 , G01N33/54366 , G01N33/558 , G01N33/56911 , G01N33/56916 , Y10T428/2982 , Y10T436/25 , Y10T436/255
摘要： The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody) bound to the conductive polymer of the particulate composition. Methods and kits employing the particulate composition and the BEAM nanoparticle composition also are disclosed.

3. 发明申请

US20080314766A1 Electrically-active ferromagnetic particle conductimetric biosensor test kit 有权
标题翻译：电活性铁磁颗粒电导率生物传感器检测试剂盒
公开(公告)号：US20080314766A1
公开(公告)日：2008-12-25
申请号：US12214362
申请日：2008-06-18
申请人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
发明人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： G01N33/5438 , C12Q1/6813 , C12Q1/689 , G01N27/745 , G01N33/54333 , G01N33/54366 , G01N33/558 , G01N33/56911 , G01N33/56916 , Y10T428/2982 , Y10T436/25 , Y10T436/255
摘要： A membrane strip biosensor device (10, 20, 100) using a fluid mobile conductive composition of ferromagnetic particles bound to a conductive polymer bound to a capture reagent is described. The biosensor device is designed to detect analytes at low concentrations in near real-time with an electronic data collection system and can be small. The device can be used to detect pathogens, proteins, and other biological materials of interest in food, water, and environmental samples. The device can also be used for on-site diagnosis and against potential bioterrorism. Potential users include food processing plants, meat packaging facilities, fruit and vegetable packers, restaurants, food and water safety inspectors, food wholesalers and retailers, farms, homes, medical profession, import border crossing personnel, and the police force, military, space habitation and national security.
摘要翻译：描述了使用结合到与捕获试剂结合的导电聚合物结合的铁磁性颗粒的流体移动导电组合物的膜条生物传感器装置（10,20,100）。生物传感器设备旨在通过电子数据采集系统近实时地检测低浓度的分析物，并且可以很小。该装置可用于检测食品，水和环境样品中感兴趣的病原体，蛋白质和其他生物材料。该设备还可用于现场诊断和潜在的生物恐怖。潜在用户包括食品加工厂，肉类包装设备，水果和蔬菜包装机，餐饮，食品和水安全检查员，食品批发商和零售商，农场，住房，医疗专业，进口过境人员以及警察部队，军事，太空人居和国家安全。

4. 发明授权

US08287810B2 Electrically-active ferromagnetic particle conductimetric biosensor test kit 有权
标题翻译：电活性铁磁颗粒电导率生物传感器检测试剂盒
公开(公告)号：US08287810B2
公开(公告)日：2012-10-16
申请号：US12214362
申请日：2008-06-18
申请人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
发明人： Evangelyn C. Alocilja , Sudeshna Pal , Emma B. Setterington
IPC分类号： G01N27/00 , G01N21/75 , G01N31/22 , G01N33/52 , G01N25/18 , G01N1/00 , G01N1/18 , B01L3/00 , C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , C12Q1/6813 , C12Q1/689 , G01N27/745 , G01N33/54333 , G01N33/54366 , G01N33/558 , G01N33/56911 , G01N33/56916 , Y10T428/2982 , Y10T436/25 , Y10T436/255
摘要： A membrane strip biosensor device using a fluid mobile conductive composition of ferromagnetic particles bound to a conductive polymer bound to a capture reagent is described. The biosensor device is designed to detect analytes at low concentrations in near real-time with an electronic data collection system and can be small. The device can be used to detect pathogens, proteins, and other biological materials of interest in food, water, and environmental samples.
摘要翻译：描述了使用结合到与捕获试剂结合的导电聚合物结合的铁磁性颗粒的流体移动导电组合物的膜条生物传感器装置。生物传感器设备旨在用电子数据采集系统近实时地检测低浓度的分析物，并且可以很小。该装置可用于检测食品，水和环境样品中感兴趣的病原体，蛋白质和其他生物材料。

5. 发明申请

US20120322064A1 HYBRIDIZATION PROBES AND METHODS OF THEIR USE 审中-公开
标题翻译：混合探针及其使用方法
公开(公告)号：US20120322064A1
公开(公告)日：2012-12-20
申请号：US13477199
申请日：2012-05-22
申请人： Evangelyn C. Alocilja , Sudeshna Pal
发明人： Evangelyn C. Alocilja , Sudeshna Pal
IPC分类号： G01N27/26 , C12M1/34 , B82Y15/00
CPC分类号： C12Q1/6825 , B82Y15/00 , C12Q1/689 , C12Q2563/131 , C12Q2563/155 , C12Q2565/519
摘要： Hybridization probes for hybridizing to the same target nucleic acid are disclosed, the hybridization probes comprising an electrically-active magnetic nanoparticle-labeled detector probe and a capture probe including a conjugating moiety for immobilization. Also disclosed is a biodetection method including the steps of: providing hybridization probes for hybridizing to the same target nucleic acid, the hybridization probes comprising an electrically-active magnetic nanoparticle-labeled detector probe and a capture probe; hybridizing the target nucleic acid with each of the electrically-active magnetic nanoparticle-labeled detector probe and a capture probe in a sample including the target nucleic acid; magnetically separating the hybridized target nucleic acid from the sample; capturing the hybridized target nucleic acid on a substrate through the capture probe; and measuring the oxidation-reduction signal of the electrically-active magnetic nanoparticle-labeled detector probe.
摘要翻译：公开了用于与相同靶核酸杂交的杂交探针，杂交探针包含电活性磁性纳米颗粒标记的检测器探针和包含用于固定的缀合部分的捕获探针。还公开了一种生物检测方法，其包括以下步骤：提供与相同靶核酸杂交的杂交探针，所述杂交探针包含电活性磁性纳米颗粒标记的检测器探针和捕获探针; 将目标核酸与包含靶核酸的样品中的每个电活性磁性纳米颗粒标记的检测器探针和捕获探针杂交; 将杂交的靶核酸与样品磁分离; 通过捕获探针在基底上捕获杂交的靶核酸; 并测量电活性磁性纳米颗粒标记的检测器探针的氧化还原信号。

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