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1. 发明申请

US20080286375A1 Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate 审中-公开
标题翻译：制备包含醋酸蔗糖异丁酸盐的缓释微粒的方法
公开(公告)号：US20080286375A1
公开(公告)日：2008-11-20
申请号：US12093872
申请日：2002-11-15
申请人： Eun Seong Lee , Hyeok Lee , Jung Ju Kim
发明人： Eun Seong Lee , Hyeok Lee , Jung Ju Kim
IPC分类号： A61K9/14 , A61K38/16 , A61K38/47 , A61K38/28 , A61K38/14 , A61K38/21 , A61K39/395 , A61K38/20 , A61K38/48 , A61K38/44 , A61K39/12 , A61K38/30 , A61K38/27 , A61K38/18 , A61P43/00
CPC分类号： A61K9/1647 , A61K9/19 , A61K47/14
摘要： A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method including the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate (SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.
摘要翻译：可以简单地通过包括以下步骤的方法制备能够长时间连续释放蛋白质药物而没有药物初始爆发释放的持续释放微粒：a）将蛋白质药物溶解在水溶液中以获得水相; b）将蔗糖乙酸异丁酸酯（SAIB）和可生物降解的聚合物溶于有机溶剂中以获得油相; c）将步骤a）中获得的水相加入到步骤b）中获得的油相中以形成初级乳液; 和d）将初级乳液加入到外部水性连续相中以形成二次乳液并回收在二次乳液中形成的固体产物。

2. 发明授权

US08394391B2 Drug delivery vehicle that mimics viral properties 有权
公开(公告)号：US08394391B2
公开(公告)日：2013-03-12
申请号：US11897979
申请日：2007-08-31
申请人： You Han Bae , Eun Seong Lee , Dongin Kim , Yu Seok Youn , Kyung Taek Oh
发明人： You Han Bae , Eun Seong Lee , Dongin Kim , Yu Seok Youn , Kyung Taek Oh
IPC分类号： A61K9/00
CPC分类号： A61K9/1658 , A61K9/1641 , A61K9/167
摘要： A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand.

3. 发明申请

US20120050720A1 SYSTEM FOR DIAGNOSING PATHOLOGICAL CHANGE OF LIPID IN BLOOD VESSELS USING NON-LINEAR OPTICAL MICROSCOPY 审中-公开
标题翻译：使用非线性光学显微镜诊断血液中脂质的病理变化的系统
公开(公告)号：US20120050720A1
公开(公告)日：2012-03-01
申请号：US13320014
申请日：2009-05-11
申请人： Se Hwa Kim , Jae Yong Lee , Eun Seong Lee , Dae Won Moon
发明人： Se Hwa Kim , Jae Yong Lee , Eun Seong Lee , Dae Won Moon
IPC分类号： G01J3/44
CPC分类号： G02B21/002 , G01J3/0248 , G01J3/10 , G01J3/44 , G01N21/65 , G01N2021/653 , G02B21/0088 , G02B21/16
摘要： Disclosed is a system for diagnosing the pathological change in lipids in blood vessels using coherent anti-strokes raman microscopy which can image lipids abnormally deposited on the deep intima of blood vessels and analyze the components of the imaged lipids, without labeling or destroying blood vessels, to diagnose minute pathological changes in the blood vessels, whereby the stage of progression of lipid-related diseases can be determined.
摘要翻译：公开了一种用于使用相干抗冲击拉曼显微镜诊断血管中脂质的病理变化的系统，其可以将血液中的脂质异常沉积在血管的深内膜上并分析成像的脂质的成分，而不标记或破坏血管，诊断血管的微小病理变化，由此可以确定与脂质相关的疾病进展的阶段。

4. 发明授权

US08064053B2 3-color multiplex CARS spectrometer 有权
标题翻译： 3色多重CARS光谱仪
公开(公告)号：US08064053B2
公开(公告)日：2011-11-22
申请号：US12318373
申请日：2008-12-29
申请人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
发明人： Jae Yong Lee , Eun Seong Lee , Dae Won Moon
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/0227 , G01J3/0237 , G01J3/4412
摘要： The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.
摘要翻译：本发明涉及一种三色多重CARS光谱仪。在三色多重CARS光谱仪中，通过将由宽带激光光源产生的短波长泵浦光束与由稳定的激光产生的长波长斯托克斯光束组合，实现了样品的多分子振动的拉曼共振源和另一个具有窄线宽的短波长激光束然后被单独引入以用作与激光驱动样本相互作用的探测光束，从而产生其波长分量可以被解析的CARS光谱信号。因此，三色多路CARS光谱仪解决了传统的双色多重CARS光谱的问题，其中对于高分辨率分辨率需要的CARS信号的波长分解在宽带泵浦光引起CARS频谱失真是不可能的。

5. 发明授权

US08263664B2 pH-sensitive polymeric micelles for drug delivery 有权
标题翻译：用于药物递送的pH敏感聚合物胶束
公开(公告)号：US08263664B2
公开(公告)日：2012-09-11
申请号：US12487574
申请日：2009-06-18
申请人： Dongin Kim , Zhonggao Gao , Eun Seong Lee , You Han Bae
发明人： Dongin Kim , Zhonggao Gao , Eun Seong Lee , You Han Bae
IPC分类号： A61K47/00 , A61K9/00 , A01N25/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K47/551 , A61K47/6907 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
摘要翻译：含有聚（L-组氨酸 - 共 - 苯丙氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是一种pH敏感的药物载体，其在酸性微环境，但不在血液中。由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。公开了用这种药物治疗温血动物的方法。

6. 发明申请

US20100009926A1 PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY 有权
标题翻译：用于药物递送的敏感聚合物微胶囊
公开(公告)号：US20100009926A1
公开(公告)日：2010-01-14
申请号：US12487574
申请日：2009-06-18
申请人： Dongin Kim , Zhonggao Gao , Eun Seong Lee , You Han Bae
发明人： Dongin Kim , Zhonggao Gao , Eun Seong Lee , You Han Bae
IPC分类号： A61K31/704 , C08L53/00 , A61K47/32 , A61P35/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K47/551 , A61K47/6907 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
摘要翻译：含有聚（L-组氨酸 - 共 - 苯丙氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是一种pH敏感的药物载体，其在酸性微环境，但不在血液中。由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。公开了用这种药物治疗温血动物的方法。

7. 发明授权

US07582870B2 Imaging apparatus for IR four-wave mixing polarization microscopy 失效
标题翻译：红外四波混合偏光显微镜成像设备
公开(公告)号：US07582870B2
公开(公告)日：2009-09-01
申请号：US11861997
申请日：2007-09-26
申请人： Jae Yong Lee , Eun Seong Lee
发明人： Jae Yong Lee , Eun Seong Lee
IPC分类号： G01J3/00
CPC分类号： G02B21/0064 , G01J3/433 , G01N21/21 , G01N21/23 , G01N21/636
摘要： Disclosed is an imaging apparatus for IR four-wave mixing polarization microscopy. The apparatus can include pump and probe beam sources, a polarizer, a beam combiner, a scanner, an optical focusing system, a collecting optical system, a dichroic beam splitter, a polarizing beam splitter, a photodetector, a polarization differential detector, and a data analyzer. The technology can be used to obtain a molecular vibrational microscopic image using a polarization-dependent nonlinear spectroscopic signal obtained through the focusing and spatial scanning of multi-wavelength laser beams in a sample.
摘要翻译：公开了一种用于红外四波混频偏振显微镜的成像装置。该装置可以包括泵浦和探针束源，偏振器，光束组合器，扫描器，光学聚焦系统，收集光学系统，二向色分束器，偏振分束器，光电检测器，偏振微分检测器和数据分析仪。该技术可用于使用通过样品中的多波长激光束的聚焦和空间扫描获得的偏振相关非线性光谱信号来获得分子振动显微镜图像。

8. 发明授权

US07371781B2 Tumor environment-induced ligand-expressing nanocarrier system 有权
公开(公告)号：US07371781B2
公开(公告)日：2008-05-13
申请号：US10948078
申请日：2004-09-22
申请人： You Han Bae , Kun Na , Eun Seong Lee
发明人： You Han Bae , Kun Na , Eun Seong Lee
IPC分类号： A61K47/00
CPC分类号： A61K9/1075
摘要： Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

9. 发明授权

US07951846B2 pH-sensitive polymeric micelles for drug delivery 有权
标题翻译：用于药物递送的pH敏感聚合物胶束
公开(公告)号：US07951846B2
公开(公告)日：2011-05-31
申请号：US12435283
申请日：2009-05-04
申请人： You Han Bae , Kun Na , Eun Seong Lee
发明人： You Han Bae , Kun Na , Eun Seong Lee
IPC分类号： A61K47/00 , A61K9/00 , A01K25/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/704 , C07D233/64 , C07D413/06 , C08F8/30
摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
摘要翻译：含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是不在血中由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。公开了用这种药物治疗温血动物的方法。

10. 发明申请

US20100174145A1 SPECTRALLY ENCODED COHERENT ANTI-STOKES RAMAN SCATTERING ENDOSCOPE 有权
标题翻译：光谱编码相干反射拉曼散射内窥镜
公开(公告)号：US20100174145A1
公开(公告)日：2010-07-08
申请号：US12441684
申请日：2008-11-27
申请人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
发明人： Eun Seong Lee , Jae Yong Lee , Dae Won Moon
IPC分类号： A61B1/06 , G01J3/44
CPC分类号： A61B5/6852 , A61B5/0066 , G01N21/65 , G01N2021/653
摘要： Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals.
摘要翻译：公开了一种频谱编码的相干反斯托克斯拉曼散射（CARS）内窥镜，其能够空间编码具有与拉曼位移一样多的频率差异的两个光源的光谱色散，并且在待测样品的位置上重叠两个激光束被放置，从而获得CARS信号的空间分布。

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