专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06456880B1 Implantable cardiac stimulation device for and method of monitoring progression or regression of a patient's heart condition by monitoring ventricular repolarization interval dispersion 有权
标题翻译：可植入式心脏刺激装置及监测患者心脏病状进展或回归的方法，通过监测心室复极间隔分散
公开(公告)号：US06456880B1
公开(公告)日：2002-09-24
申请号：US09712861
申请日：2000-11-14
申请人： Euljoon Park , Joseph J. Florio , Kerry Bradley , Gene A. Bornzin , Laurence S. Sloman
发明人： Euljoon Park , Joseph J. Florio , Kerry Bradley , Gene A. Bornzin , Laurence S. Sloman
IPC分类号： A61N1365
CPC分类号： A61N1/3702 , A61N1/365
摘要： An implantable cardiac stimulation device includes a system that monitors progression or regression of a patient's heart condition. The system includes a plurality of electrode configurations for sensing cardiac activity of the heart. A sensing circuit provides an electrical signal representing electrical activity of the heart from each of the sensing electrode configurations. A processor coupled to the sensing circuit determines, at spaced apart times, and over time, a ventricular repolarization interval in each of the electrical signals and a corresponding ventricular repolarization interval dispersion. A memory stores the ventricular repolarization interval dispersions for transmission by a telemetry circuit to an external receiver for analysis.
摘要翻译：可植入心脏刺激装置包括监测患者心脏状况的进展或消退的系统。该系统包括用于感测心脏的心脏活动的多个电极配置。感测电路从每个感测电极配置提供表示心脏的电活动的电信号。耦合到感测电路的处理器在间隔开的时间和时间上确定每个电信号中的心室复极间隔和对应的心室复极间隔分散。存储器存储用于通过遥测电路传输到外部接收器用于分析的心室复极间隔分散体。

2. 发明授权

US06606517B1 Methods and apparatus for preventing atrial arrhythmias by overdrive pacing and prolonging atrial refractoriness using an implantable cardiac stimulation device 有权
$Methods and apparatus for preventing atrial arrhythmias by overdrive pacing and prolonging atrial refractoriness using an implantable cardiac stimulation device$
标题翻译：使用可植入心脏刺激装置通过过度起搏预防房性心律失常和延长心房不应性的方法和装置
公开(公告)号：US06606517B1
公开(公告)日：2003-08-12
申请号：US09548293
申请日：2000-04-12
申请人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , John W. Poore , Laurence S. Sloman , Peter Boileau , Douglas T. Kurschinski
发明人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , John W. Poore , Laurence S. Sloman , Peter Boileau , Douglas T. Kurschinski
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A method and apparatus for reducing the incidence of atrial arrhythmias by using an overdrive algorithm to determine the application of overdrive stimulation pulses to a patient's heart, e.g., in the atria. In a first aspect of the invention, the apparatus first determines an overdrive pacing rate and then applies pairs of temporally spaced (staggered) pacing pulses, i.e., primary and secondary pacing pulses, at the determined overdrive pacing rate. In a further aspect of the invention, the pairs of pacing pulses are applied at the overdrive pacing rate to multiple spatially spaced electrodes, i.e., electrodes distributed among multiple sites in a patient's heart, e.g., in the atria. In accordance with a first preferred embodiment, the electrodes may be distributed within a single atrium, e.g., the right atrium, of the patient's heart. Alternatively, a first electrode may be placed in the right atrium and a second electrode may be placed in the coronary sinus or the left atrium or multiple electrodes may be placed proximate to the left atrium. Furthermore, the invention relates to techniques for controlling overdrive pacing to multiple sites in a patient's heart so as to achieve and maintain a target degree of pacing and thus suppress tachycardias.
摘要翻译：一种用于通过使用过驱动算法来确定过度驱动刺激脉冲施加到患者心脏（例如在心房）中来减少心房心律失常发生率的方法和装置。在本发明的第一方面中，装置首先确定过驱动起搏速率，然后以确定的超速起搏速率施加时间间隔（交错）的起搏脉冲，即初级和次级起搏脉冲。在本发明的另一方面，以超速起搏速率将多对起搏脉冲施加到多个空间间隔开的电极，即分布在患者心脏中的多个部位之间的电极，例如在心房中。根据第一优选实施例，电极可以分布在患者心脏的单个心房（例如右心房）内。或者，第一电极可以放置在右心房中，并且第二电极可以放置在冠状窦或左心房中，或者多个电极可以放置在靠近左心房的位置。此外，本发明涉及用于控制对患者心脏中的多个部位的超速起搏的技术，以便实现和维持目标起搏程度，从而抑制心动过速。

3. 发明授权

US06731985B2 Implantable cardiac stimulation system and method for automatic capture verification calibration 有权
标题翻译：植入式心脏刺激系统和自动捕获验证校准方法
公开(公告)号：US06731985B2
公开(公告)日：2004-05-04
申请号：US09981555
申请日：2001-10-16
申请人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
发明人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac stimulation device and associated method perform an automatic calibration procedure for evaluating whether automatic capture verification can be recommended. The calibration procedure calculates and displays a number of variables for use by a medical practitioner in programming automatic capture operating parameters. An average paced depolarization integral (PDI) is determined from the cardiac signals following delivery of multiple stimulation pulse below and above capture threshold such that both pure lead polarization signals and evoked response signals may be analyzed. From the paced depolarization integral data, a capture threshold, a stimulation response curve, a minimum evoked response, a maximum lead polarization, an evoked response sensitivity, an evoked response safety margin, and a polarization safety margin are determined. Based on these variables, the calibration procedure determines if automatic capture verification can be recommended. If so, the stimulation device calculates a capture detection threshold. The automatic capture verification recommendation and the estimated calibration variables are displayed.
摘要翻译：可植入心脏刺激装置和相关方法执行自动校准程序，以评估是否可以推荐自动捕获验证。校准程序计算并显示许多变量，供医生在编程自动捕获操作参数时使用。平均节奏去极化积分（PDI）是在多次刺激脉冲传递后低于和高于捕获阈值的心脏信号确定的，以便可以分析纯铅极化信号和诱发响应信号。从起搏去极化积分数据中，确定捕获阈值，刺激响应曲线，最小诱发响应，最大引线极化，诱发响应灵敏度，诱发响应安全裕度和极化安全裕度。基于这些变量，校准过程确定是否可以推荐自动捕获验证。如果是，则刺激装置计算捕获检测阈值。显示自动捕获验证建议和估计的校准变量。

4. 发明授权

US06512953B2 System and method for automatically verifying capture during multi-chamber stimulation 有权
标题翻译：在多室刺激下自动验证捕获的系统和方法
公开(公告)号：US06512953B2
公开(公告)日：2003-01-28
申请号：US09844189
申请日：2001-04-26
申请人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
发明人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
IPC分类号： A61N1365
CPC分类号： A61N1/3712 , A61N1/3627
摘要： A system and corresponding method are provided to reliably detect capture during multi-chamber stimulation, and to further monitor the progression of congestive heart failure. The system provides a method by which intracardiac electrogram (IEGM) characteristics representing single-chamber capture and bi-ventricular capture are stored in memory and displayed. The annotation of the displayed waveforms is such that events associated with loss of capture, single-chamber capture, and bi-ventricular capture are clearly marked for ready interpretation by the physician. In a first situation, a stimulation pulse is followed by a time delay window and a subsequent depolarization complex that represents intrinsic responses of the chambers that have not been captured. In a second situation, a stimulation pulse is followed almost immediately by an evoked response that represents capture of one chamber, and a subsequent depolarization complex that represents an intrinsic response of one chamber that has not been captured. In a third situation, a stimulation pulse is almost immediately followed by an evoked response that represents simultaneous capture of two chambers.
摘要翻译：提供了一种系统和相应的方法来可靠地检测多室刺激期间的捕获，并进一步监测充血性心力衰竭的进展。该系统提供了一种表示单室捕获和双心室捕获的心内电图（IEGM）特征存储在存储器中并显示的方法。显示的波形的注释使得与丢失捕获，单室捕获和双心室捕获相关联的事件被清楚地标记以供医师准备解释。在第一种情况下，刺激脉冲之后是时间延迟窗口和随后的去极化复合体，其表示未被捕获的室的内在响应。在第二种情况下，刺激脉冲几乎立即被跟随表示一个腔室的捕获的诱发反应，以及后续的去极化复合体，其表示一个未被捕获的腔室的固有响应。在第三种情况下，刺激脉冲几乎紧随其后，表示同时捕获两个腔室的诱发反应。

5. 发明授权

US5991661A System and method for measuring cardiac activity 失效
标题翻译：用于测量心脏活动的系统和方法
公开(公告)号：US5991661A
公开(公告)日：1999-11-23
申请号：US954326
申请日：1997-10-17
申请人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
发明人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device, such as a pacemaker or an implantable cardioverter-defibrillator, that includes an accelerometer-based activity sensor that processes one or more signals from the activity sensor to obtain parameters that are indicative of the heartbeat of the patient. The implantable cardiac stimulation device determines when the patient is at rest and the activity sensor provides a signal that corresponds to the acceleration of the sensor due to the heartbeat of the patient. This acceleration signal is integrated over time once to provide a contractility parameter, which is indicative of the contractility of the heart and is integrated over time twice to provide a displacement parameter, which is indicative of the displacement of the heart wall during the heartbeat. This displacement parameter is thereby indicative of the volume of blood pumped by the heart. A microprocessor uses either the contractility parameter, the displacement parameter or both to modify the delivery of therapeutic stimulation pulses to the heart.
摘要翻译：可植入心脏刺激装置，例如起搏器或植入式心律转复除颤器，其包括基于加速度计的活动传感器，其处理来自活动传感器的一个或多个信号以获得指示患者心跳的参数。可植入心脏刺激装置确定患者何时休息，并且活动传感器提供对应于由于患者心跳引起的传感器的加速度的信号。该加速度信号随着时间一度被积分以提供收缩性参数，其表示心脏的收缩性并且随时间积分两次以提供位移参数，其指示在心跳期间心脏壁的位移。因此，该位移参数指示由心脏泵送的血液的体积。微处理器使用收缩性参数，位移参数或两者来修改对心脏的治疗刺激脉冲的递送。

6. 发明授权

US07085603B1 System and method for automatically verifying capture during multi-chamber stimulation 有权
公开(公告)号：US07085603B1
公开(公告)日：2006-08-01
申请号：US10353104
申请日：2003-01-27
申请人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
发明人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627
摘要： A system and corresponding method are provided to reliably detect capture during multi-chamber stimulation, and to further monitor the progression of congestive heart failure. The system provides a method by which intracardiac electrogram (IEGM) characteristics representing single-chamber capture and bi-ventricular capture are stored in memory and displayed. The annotation of the displayed waveforms is such that events associated with loss of capture, single-chamber capture, and bi-ventricular capture are clearly marked for ready interpretation by the physician. In a first situation, a stimulation pulse is followed by a time delay window and a subsequent depolarization complex that represents intrinsic responses of the chambers that have not been captured. In a second situation, a stimulation pulse is followed almost immediately by an evoked response that represents capture of one chamber, and a subsequent depolarization complex that represents an intrinsic response of one chamber that has not been captured. In a third situation, a stimulation pulse is almost immediately followed by an evoked response that represents simultaneous capture of two chambers.

7. 发明授权

US06915164B2 Automatic capture using independent channels in bi-chamber stimulation 有权
标题翻译：在双室刺激中使用独立通道自动捕获
公开(公告)号：US06915164B2
公开(公告)日：2005-07-05
申请号：US10124164
申请日：2002-04-16
申请人： Kerry Bradley , Joseph J. Florio , Gene A. Bornzin , Euljoon Park
发明人： Kerry Bradley , Joseph J. Florio , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/368 , A61N1/37
CPC分类号： A61N1/371 , A61N1/3684
摘要： A cardiac stimulation device and method deliver independent stimulation pulses to right and left cardiac chambers, based on the capture thresholds of each chamber, and confirm capture in each chamber. A threshold test is performed in one chamber while stimulating the opposite chamber at increased pulse energy and adjusted interchamber delay.
摘要翻译：基于每个室的捕获阈值，心脏刺激装置和方法将独立的刺激脉冲输送到左心室和左心室，并确认每个腔室中的捕获。在一个腔室中执行阈值测试，同时以增加的脉冲能量和调节的车间延迟刺激相反的腔室。

8. 发明授权

US06128534A Implantable cardiac stimulation device and method for varying pacing parameters to mimic circadian cycles 失效
标题翻译：可植入的心脏刺激装置和用于改变起搏参数以模拟昼夜循环的方法
公开(公告)号：US06128534A
公开(公告)日：2000-10-03
申请号：US97726
申请日：1998-06-16
申请人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley , William Gibb
发明人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley , William Gibb
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： Provided herein are methods and apparatus for automatically adjusting pacing parameters in implantable programmable stimulation devices, such as rate-responsive pacemakers and cardioverter defibrillators. The methods and apparatus provide a circadian varying pacing parameter (e.g., pacing rate, AV Delay, etc.) that very closely mimics the natural diurnal fluctuations of a patient's heart. Using physiological parameters that vary diurnally (e.g., minute ventilation and/or activity variance, etc.), a circadian-base value is derived. In the preferred embodiments, the physiological measurements are used to derive a histogram from which certain characteristic values are determined. These physiological characteristic values, along with the predetermined characteristic rates, automatically and periodically determine a transfer function from which the patient's appropriate circadian base rate is derived. Further contemplated herein are the use of more than one physiological parameter to derive a final circadian base rate, and stimulation devices employing these methods.
摘要翻译：本文提供了用于自动调节可植入可编程刺激装置（例如速率响应式起搏器和心律转复除颤器）中的起搏参数的方法和装置。所述方法和装置提供非常接近地模仿患者心脏的天然昼夜波动的昼夜节律变化起搏参数（例如，起搏速率，AV延迟等）。使用日变化的生理参数（例如，每分通气量和/或活动方差等），得出昼夜基值。在优选实施例中，使用生理测量来导出确定特定特征值的直方图。这些生理特征值连同预定的特征率自动和周期性地确定导出患者适当的昼夜基础基率的传递函数。本文进一步考虑的是使用多于一个生理参数来导出最终昼夜节律基础速率，以及采用这些方法的刺激装置。

9. 发明授权

US5800467A Cardio-synchronous impedance measurement system for an implantable stimulation device 失效
标题翻译：用于植入式刺激装置的心电同步阻抗测量系统
公开(公告)号：US5800467A
公开(公告)日：1998-09-01
申请号：US766641
申请日：1996-12-13
申请人： Euljoon Park , Kerry Bradley , Gene A. Bornzin , Joseph J. Florio
发明人： Euljoon Park , Kerry Bradley , Gene A. Bornzin , Joseph J. Florio
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36521 , A61N1/3682
摘要： In a pacing system, the pacing controller induces the leads to deliver an impedance measurement pulse to the right ventricle of the heart at at least a 15 ms interval during a window of time following detection of the R-wave or the delivery of a pacing pulse. The window of time corresponds to a period of ventricular ejection. The two or three measured impedance values are then used to determine an impedance slope that has a strong biological correlation to the contractility of the heart. The impedance slope is then used by the controller of the pacing system to adjust the delivery of pacing pulses for purposes such as maximizing contractility for a given AV delay, PV delay and pacing rate of pacing pulses.
摘要翻译：在起搏系统中，起搏控制器引导引线在检测到R波或递送起搏脉冲之后的窗口期间以至少15ms的间隔向心脏的右心室递送阻抗测量脉冲。时间窗口对应于心室射血期。然后使用两个或三个测量的阻抗值来确定与心脏的收缩力具有强烈生物相关性的阻抗斜率。因此，起搏系统的控制器使用阻抗斜率来调整起搏脉冲的传递，以便为给定的AV延迟最大化收缩性，起搏脉冲的PV延迟和起搏速率。

10. 发明授权

US06782291B1 Implantable cardiac stimulation device with automatic evoked response sensing electrode configuration selection and method 有权
标题翻译：可植入心脏刺激装置具有自动诱发响应感应电极配置选择和方法
公开(公告)号：US06782291B1
公开(公告)日：2004-08-24
申请号：US09655438
申请日：2000-09-05
申请人： Gene A. Bornzin , Joseph J. Florio , Laurence S. Sloman , Brian M. Mann , Jason A. Sholder
发明人： Gene A. Bornzin , Joseph J. Florio , Laurence S. Sloman , Brian M. Mann , Jason A. Sholder
IPC分类号： A61N1372
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/371
摘要： An implantable cardiac stimulation device applies pacing stimulation pulses to a heart and senses evoked responses to the pacing stimulation pulses. A pulse generator applies the stimulation pacing pulses to the heart in accordance with a pacing configuration. A sensor control selects an evoked response sensing electrode configuration from among a plurality of evoked response sensing electrode configurations in response to the pacing configuration. A sensor is then programmed to sense the evoked responses with the selected evoked response sensing electrode configuration. In accordance with a preferred embodiment, signal-to-noise ratios obtained with the various electrode configurations are used to select a best electrode configuration for sensing evoked responses.
摘要翻译：可植入心脏刺激装置将起搏刺激脉冲应用于心脏并感测对起搏刺激脉冲的诱发反应。脉冲发生器根据起搏配置将刺激起搏脉冲施加到心脏。传感器控制器响应于起搏配置从多个诱发响应感测电极配置中选择诱发响应感测电极配置。然后将传感器编程为用所选择的诱发响应感测电极配置感测诱发的反应。根据优选实施例，用各种电极配置获得的信噪比用于选择用于感测诱发响应的最佳电极配置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式