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1. 发明授权

US06937900B1 AC/DC multi-axis accelerometer for determining patient activity and body position 有权
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06937900B1
公开(公告)日：2005-08-30
申请号：US10205188
申请日：2002-07-24
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

2. 发明授权

US06741885B1 Implantable cardiac device for managing the progression of heart disease and method 有权
标题翻译：用于管理心脏疾病进展的植入式心脏装置和方法
公开(公告)号：US06741885B1
公开(公告)日：2004-05-25
申请号：US09908179
申请日：2001-07-17
申请人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61N1/36514
摘要： An implantable cardiac device detects a progression or regression in heart disease such as congestive heart failure. An activity sensor and a respiration sensor generate raw signals indicative of the patient's activity level and respiration level. Degradation or improvement of the patient's activity and respiration over a predetermined time corresponds to an indication of the progression or regression of the heart disease. A processor coupled to the sensors is programmed to process the raw sensor signals over the predetermined time and stores the processed sensor signals in a memory having a data storage area. A telemetry circuit coupled to the memory is configured to transmit the stored sensor signals to an external monitor for subsequent display. The processor further controls pacing of the heart, adjusts pacing therapy responsive to the process signals, and process the raw respiration signals when the patient is in a number of different active states.
摘要翻译：可植入的心脏装置检测心脏病的进展或消退，例如充血性心力衰竭。活动传感器和呼吸传感器产生指示患者的活动水平和呼吸水平的原始信号。在预定时间内降低或改善患者的活动和呼吸对应于心脏病的进展或消退的指征。耦合到传感器的处理器被编程为在预定时间内处理原始传感器信号，并将经处理的传感器信号存储在具有数据存储区域的存储器中。耦合到存储器的遥测电路被配置为将存储的传感器信号发送到外部监视器用于随后的显示。处理器进一步控制心脏的起搏，响应于过程信号调整起搏治疗，并且当患者处于多个不同的活动状态时处理原始呼吸信号。

3. 发明授权

US06351672B1 System and method for modulating the pacing rate based on patient activity and position 有权
标题翻译：基于患者活动和位置调节起搏速率的系统和方法
公开(公告)号：US06351672B1
公开(公告)日：2002-02-26
申请号：US09359025
申请日：1999-07-22
申请人： Euljoon Park , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Gene A. Bornzin , Junyu Mai
IPC分类号： A61N1365
CPC分类号： A61N1/36542
摘要： A system and method are provided for compensating for the drop in blood pressure upon standing. Upon transition from prolonged sitting, lying down, or standing position, the pacemaker abruptly increasing its pacing rate upon postural transition. The pacing rate is abruptly increased to about 80-100 bpm in 20 seconds-one minute. The pacing rate then decreases slowly to another high rate in two or three minutes and then follows the metabolically indicated rate. This pacing rate is triggered whenever a patient stands after a prolonged reclined or supine/prone position as indicated by activity variance measurements.
摘要翻译：提供了一种用于补偿静置时血压下降的系统和方法。从长时间的坐姿，躺下或站姿转移时，起搏器在姿势转换时突然增加起搏速度。起搏速度在20秒内突然增加到约80-100 bpm（一分钟）。然后起搏速度在两分钟或三分钟内缓慢下降到另一个高速率，然后遵循代谢指示的速率。如果患者在经过长时间倾斜或仰卧/俯卧位置后站立时进行起搏速度，如活动方差测量所示。

4. 发明授权

US07225023B1 System and method for modulating the pacing rate based on patient activity and position 有权
标题翻译：基于患者活动和位置调节起搏速率的系统和方法
公开(公告)号：US07225023B1
公开(公告)日：2007-05-29
申请号：US10032793
申请日：2001-10-25
申请人： Euljoon Park , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Gene A. Bornzin , Junyu Mai
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A system and method are provided for compensating for the drop in blood pressure upon standing. Upon transition from prolonged sitting, lying down, or standing position, the pacemaker abruptly increasing its pacing rate upon postural transition. This pacing rate is triggered when a patient stands after a prolonged reclined or supine/prone position.
摘要翻译：提供了一种用于补偿静置时血压下降的系统和方法。从长时间的坐姿，躺下或站姿转移时，起搏器在姿势转换时突然增加起搏速度。当患者在长时间倾斜或仰卧/俯卧位后立即触发起搏速率。

5. 发明授权

US06636766B2 System and method for preventing sudden heart rate drop using implantable cardiac pacing device 有权
公开(公告)号：US06636766B2
公开(公告)日：2003-10-21
申请号：US09849723
申请日：2001-05-03
申请人： Gene A. Bornzin , Junyu Mai , Euljoon Park , Joseph J. Florio
发明人： Gene A. Bornzin , Junyu Mai , Euljoon Park , Joseph J. Florio
IPC分类号： A61N1365
CPC分类号： A61N1/362
摘要： A rate smoothing technique is applied by the pacing device to sensed and paced heart signals so as to prevent a sharp drop in heart rate, particularly for use within patients prone to vasovagal syncope. The rate smoothing technique is applied by the pacing device during the calculation of an escape interval employed by the device in determining whether to pace the heart. The rate smoothing technique has the effect of adjusting the escape interval to ensure the heart is paced for a period of time subsequent to a sharp drop in the natural heart rate of the patient permitting the heart rate to decrease gradually rather than suddenly. The rate smoothing technique however does not interfere with a sharp increase in heart rate as may be required during sudden physical exertion. System and method examples are described herein.

6. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

7. 发明授权

US06650931B1 System and method of automatically determining the onsets and ends of cardiac events and far-field signals 有权
标题翻译：自动确定心脏事件和远场信号的开始和结束的系统和方法
公开(公告)号：US06650931B1
公开(公告)日：2003-11-18
申请号：US09992740
申请日：2001-11-14
申请人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
发明人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61B5/0452 , A61B5/7257
摘要： A system and method for determining the onset and termination of cardiac events, such as the R-wave, the T-wave and the far-field signals sensed in the atria associated with the R-wave (FFR) and T-wave (FFT). The onset is defined as the time of the first sampled point of the cardiac signal whose magnitude exceeds a pre-defined threshold for the particular event. Once the onset of an event is positively determined, the cardiac signal is sampled at given intervals. The change in magnitude of these sampled points is determined. The termination of the event is identified through an algorithm that compares the difference in magnitude of these sampled points.
摘要翻译：用于确定心脏事件的发作和终止的系统和方法，例如与R波（FFR）和T波（FFT）相关联的心房中感测到的R波，T波和远场信号）。起始被定义为心脏信号的第一采样点的时间，其幅度超过特定事件的预定阈值。一旦确定了事件的开始，就以给定的间隔对心脏信号进行采样。确定这些采样点的幅度变化。通过比较这些采样点的幅度差异的算法来识别事件的终止。

8. 发明授权

US06625490B1 System and method of automatically adjusting sensing parameters based on temporal measurement of cardiac events 有权
标题翻译：基于心脏事件的时间测量自动调整感应参数的系统和方法
公开(公告)号：US06625490B1
公开(公告)日：2003-09-23
申请号：US09992739
申请日：2001-11-14
申请人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
发明人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/3704
摘要： A system and method for automatically adjusting the sensing parameters in an implantable cardiac stimulation device is described. The adjustment is based on the amplitudes and the onsets and ends of cardiac events, such as R-waves, T-waves, far-field R-waves, and/or far-field T-waves. Having determined the onset and termination of the cardiac events for a given number of cardiac cycles, particular variables that characterize these cardiac events can be averaged and stored in memory. Such variables include the peak amplitudes sampled during a cardiac event, the duration of the cardiac event, and the duration between cardiac events. Based on the averaged variables, the system automatically adjusts the sensing parameters, such as sensitivity, and blanking and refractory periods.
摘要翻译：描述了一种用于在可植入心脏刺激装置中自动调节感测参数的系统和方法。该调整基于心脏事件的振幅和开始和结束，例如R波，T波，远场R波和/或远场T波。在确定给定数量的心动周期的心脏事件的发作和终止之后，可以将表征这些心脏事件的特定变量平均并存储在存储器中。这些变量包括在心脏事件期间采集的峰值振幅，心脏事件的持续时间以及心脏事件之间的持续时间。基于平均变量，系统自动调整感应参数，如灵敏度，消隐和不应期。

9. 发明授权

US06643548B1 Implantable cardiac stimulation device for monitoring heart sounds to detect progression and regression of heart disease and method thereof 有权
标题翻译：用于监测心脏声音的植入式心脏刺激装置，以检测心脏病的进展和消退及其方法
公开(公告)号：US06643548B1
公开(公告)日：2003-11-04
申请号：US09544596
申请日：2000-04-06
申请人： Junyu Mai , Euljoon Park
发明人： Junyu Mai , Euljoon Park
IPC分类号： A61N108
CPC分类号： A61N1/3702 , A61N1/36514 , A61N1/36528
摘要： A system and method for use in an implantable cardiac device permits the monitoring of progression and regression in heart disease, such as congestive heart failure. During a monitoring period, a sensing circuit produces an electrogram signal of the patient's heart and a sound sensor produces a phonocardiogram of the patient's heart. A processor determines a predetermined characteristic of the heart sounds, such as amplitude, time intervals between selected heart sounds, and time intervals between selected heart sound and selected electrogram features for each cardiac cycle occurring during a monitoring period. The predetermined characteristics are thereafter averaged and stored in a memory for later retrieval. Relative changes in the average time intervals over time provides an indication of the progression or regression of the heart disease.
摘要翻译：用于可植入心脏装置的系统和方法允许监测心脏病的进展和消退，例如充血性心力衰竭。在监视期间，感测电路产生患者心脏的电描记图信号，并且声音传感器产生患者心脏的心电图。处理器确定心音的预定特征，例如在所选择的心音之间的振幅，时间间隔，以及在监视期间内发生的每个心动周期的所选择的心音和所选的电描记图特征之间的时间间隔。然后将预定特征平均并存储在存储器中用于稍后检索。随着时间的推移，平均时间间隔的相对变化表明心脏病发展或消退。

10. 发明授权

US09857368B2 Method and apparatus for biomolecule analysis 有权
公开(公告)号：US09857368B2
公开(公告)日：2018-01-02
申请号：US15419973
申请日：2017-01-30
申请人： Junyu Mai
发明人： Junyu Mai
IPC分类号： B01D5/00 , G01N33/543 , G01N1/40
CPC分类号： G01N33/54393 , G01N1/4077 , G01N33/525 , G01N33/542 , G01N33/54386 , G01N2001/4088
摘要： Disclosed are devices or apparatus and methods for membrane-, bead- or cell-based biomolecule analysis, where a detectable signal can be measured after affinity binding and/or enzymatic reaction occurs on the membranes, beads or cells. The apparatus or device can rapidly separate the beads or cells from the liquid solution without using centrifugation, vacuum, or magnetic force. The apparatus or device includes a sample well for receiving a sample containing cells or beads, as well as other aqueous solutions, a porous filter membrane at the bottom of the well which is capable of retaining the cells or beads on its upper surface by size exclusion, and an absorbing plug in touch with the filter membrane for removing the liquid solution. Multiple devices can be arranged in a multi-well array in a plate so that signals from multiple assays can be directly analyzed in a plate reader or an imaging instrument.

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