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1. 发明授权

US07736643B2 Method for screening of a lipase having improved enzymatic activity using yeast surface display vector and the lipase 失效
标题翻译：使用酵母表面显示载体和脂肪酶筛选具有改善的酶活性的脂肪酶的方法
公开(公告)号：US07736643B2
公开(公告)日：2010-06-15
申请号：US10527438
申请日：2003-09-04
申请人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
发明人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
IPC分类号： A61K38/46 , C12N9/20 , C12N15/63 , C12N1/15 , C07K14/00 , C07H21/02
CPC分类号： C40B40/02 , C12N9/18 , C12N15/1037
摘要： The present invention relates to a method for screening of the lipase having improved enzymatic activity using yeast surface display vector and the mutant lipase prepared by the same, more particularly to the method comprising; 1) cloning lipase gene into surface display vector, 2) preparing mutant lipase gene library of the step 1 by mutagenic PCR, 3) transforming the mutant lipase gene library of the step 2 and surface display vector into host cell, and 4) measuring the activity of the mutant lipase displayed in the surface of the transformed host cell and selecting the mutant lipase prepared by the same. The method of the present invention can screen the lipase having improved enzymatic activity. So, it can effectively be used for the various fields, such as food and detergent industry.
摘要翻译：本发明涉及使用酵母表面显示载体筛选具有改善的酶活性的脂肪酶的方法和由其制备的突变脂肪酶，更具体地涉及包括以下的方法： 1）将脂肪酶基因克隆到表面展示载体中，2）通过诱变PCR制备步骤1的突变脂肪酶基因文库，3）将步骤2的突变体脂肪酶基因文库和表面显示载体转化到宿主细胞中，4）测量突变脂肪酶的活性显示在转化的宿主细胞的表面，并选择由其制备的突变体脂肪酶。本发明的方法可以筛选具有改善的酶活性的脂肪酶。因此，它可以有效地用于食品和洗涤剂行业等各个领域。

2. 发明申请

US20060275760A1 Method for screening of a lipase having improved enzymatic activity using yeast surface display vector and the lipase 失效
标题翻译：使用酵母表面显示载体和脂肪酶筛选具有改善的酶活性的脂肪酶的方法
公开(公告)号：US20060275760A1
公开(公告)日：2006-12-07
申请号：US10527438
申请日：2003-09-04
申请人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
发明人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
IPC分类号： C40B30/06 , C40B40/08
CPC分类号： C40B40/02 , C12N9/18 , C12N15/1037
摘要： The present invention relates to a method for screening of the lipase having improved enzymatic activity using yeast surface display vector and the mutant lipase prepared by the same, more particularly to the method comprising; 1) cloning lipase gene into surface display vector, 2) preparing mutant lipase gene library of the step 1 by mutagenic PCR, 3) transforming the mutant lipase gene library of the step 2 and surface display vector into host cell, and 4) measuring the activity of the mutant lipase displayed in the surface of the transformed host cell and selecting the mutant lipase prepared by the same. The method of the present invention can screen the lipase having improved enzymatic activity. So, it can effectively be used for the various fields, such as food and detergent industry.
摘要翻译：本发明涉及使用酵母表面显示载体筛选具有改善的酶活性的脂肪酶的方法和由其制备的突变脂肪酶，更具体地涉及包括以下的方法： 1）将脂肪酶基因克隆到表面展示载体中，2）通过诱变PCR制备步骤1的突变脂肪酶基因文库，3）将步骤2的突变体脂肪酶基因文库和表面显示载体转化到宿主细胞中，4）测量突变脂肪酶的活性显示在转化的宿主细胞的表面，并选择由其制备的突变体脂肪酶。本发明的方法可以筛选具有改善的酶活性的脂肪酶。因此，它可以有效地用于食品和洗涤剂行业等各个领域。

3. 发明授权

US07132273B1 Cell wall anchor proteins derived from yeast, genes thereof and cell surface expression systems using the same 有权
标题翻译：衍生自酵母的细胞壁锚蛋白，其基因和使用其的细胞表面表达系统
公开(公告)号：US07132273B1
公开(公告)日：2006-11-07
申请号：US10333951
申请日：2000-07-27
申请人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
发明人： Eui-Sung Choi , Jung-Hoon Sohn , So-Young Kim
IPC分类号： C12N1/20 , C12N15/00 , C12N1/14 , C12P21/04 , C12Q1/00 , C07K1/00 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/39
摘要： The present invention provides novel cell wall anchor proteins derived from yeast, genes thereof and the genetic method for tethering polypeptide to the yeast cell wall using the same. Particularly, the present invention provides the novel GPI (glycosyl phosphatidyl inositol)-anchor protein genes, SFD1, GAS1, TIP1 and CWP1, and their proteins, PIR2 cell wall protein gene and its protein derived from Hansenula polymorpha, and the cell surface expression system using them which immobilize foreign enzymes or polypeptides on the cell wall of a microbial cell. In addition, the present invention provides the cell surface expression system using WSC1 gene and its protein derived from yeasts, including Hansenula polymorpha and Saccharomyces cerevisiae, and STA1 gene and its protein derived from Saccharomyces diastaticus. The cell surface expression system of the present invention expects an immobilization effect as biocatalysts by adhereing a desired protein to the cell surface, and provides a means of altering target protein characteristics such as binding affinity and stability by library screening.
摘要翻译：本发明提供了源自酵母的新型细胞壁锚蛋白，其基因，以及使用该酵母细胞壁将酵母细胞壁连接多肽的遗传方法。特别地，本发明提供新型GPI（糖基磷脂酰肌醇） - 锚定蛋白基因，SFD1，GAS1，TIP1和CWP1及其蛋白质，PIR2细胞壁蛋白基因及其衍生自多形汉逊酵母的蛋白质，以及细胞表面表达系统使用它们将外来酶或多肽固定在微生物细胞的细胞壁上。此外，本发明提供了使用WSC1基因及其衍生自酵母的蛋白质，包括多形汉逊酵母和酿酒酵母的细胞表面表达系统，以及来源于糖酵母的STA1基因及其蛋白质。本发明的细胞表面表达系统期望通过将期望的蛋白质粘附到细胞表面作为生物催化剂的固定效果，并且通过文库筛选提供改变靶蛋白特征如结合亲和力和稳定性的方法。

4. 发明授权

US09148148B2 Gate driving circuit and display apparatus having the same 有权
标题翻译：栅极驱动电路及其显示装置
公开(公告)号：US09148148B2
公开(公告)日：2015-09-29
申请号：US13083295
申请日：2011-04-08
申请人： Kyung-Ho Park , Si-Hyun Ahn , Dong-Hee Shin , Hyung-Jun Park , So-Young Kim , Soo-Hyun Kim
发明人： Kyung-Ho Park , Si-Hyun Ahn , Dong-Hee Shin , Hyung-Jun Park , So-Young Kim , Soo-Hyun Kim
IPC分类号： G09G3/00 , H03K19/0185 , G09G3/36
CPC分类号： H03K19/018521 , G09G3/3677 , G09G2310/0286
摘要： Provided is a gate driving circuit including cascade-connected stages that output gate signals. An n-th one of the stages (“n” is a natural number) includes a pull-up part, a pull-up controller, a first pull-down part, a second pull-down part, and a pull-down controller. The pull-up part outputs a first clock signal as an output signal of the n-th stage. The pull-up controller selectively applies first and second powers to a control electrode of the pull-up part. The first pull-down part pulls down a voltage applied to the control electrode of the pull-up part to an off voltage. The second pull-down part pulls down a voltage applied to an output electrode of the pull-up part to the off voltage. The pull-down controller selectively applies the first and second powers to control electrodes of the first and second pull-down parts.
摘要翻译：提供了一种栅极驱动电路，其包括输出栅极信号的级联连接级。第n级（“n”是自然数）包括上拉部分，上拉控制器，第一下拉部分，第二下拉部分和下拉控制器。上拉部分输出第一时钟信号作为第n级的输出信号。上拉控制器选择性地向上拉部分的控制电极施加第一和第二功率。第一下拉部分将施加到上拉部分的控制电极的电压拉低至截止电压。第二下拉部分将施加到上拉部分的输出电极的电压拉低至截止电压。下拉控制器选择性地将第一和第二功率施加到第一和第二下拉部分的控制电极。

5. 发明授权

US08526262B2 Multi-channel semiconductor integrated circuit devices for controlling direct current generators and memory systems including the same 有权
标题翻译：用于控制直流发电机和包括其的存储器系统的多通道半导体集成电路器件
公开(公告)号：US08526262B2
公开(公告)日：2013-09-03
申请号：US12878431
申请日：2010-09-09
申请人： Jang-Woo Ryu , Jung Sik Kim , So-Young Kim
发明人： Jang-Woo Ryu , Jung Sik Kim , So-Young Kim
IPC分类号： G11C5/14
CPC分类号： G11C5/147
摘要： Multi-channel semiconductor integrated circuit devices are provided including a plurality of memory devices that are independently accessible, each of the plurality of memory devices including at least one power generation unit and a control unit for controlling an operation of the at least one power generation unit, a detection unit for detecting an operation state of the plurality of memory devices, and a common control unit for commonly controlling an operation of the at least one power generation unit of the plurality of memory devices, according to the operation state of the plurality of memory devices detected by the detection unit. The control unit of each of the plurality of memory devices controls the operation of the at least one power generation unit of a corresponding one of the plurality of memory devices.
摘要翻译：提供多通道半导体集成电路装置，其包括可独立存取的多个存储器件，多个存储器件中的每一个包括至少一个发电单元和用于控制至少一个发电单元的操作的控制单元，用于检测多个存储器件的操作状态的检测单元，以及用于共同控制多个存储器件的至少一个发电单元的操作的公共控制单元，根据多个存储器件的操作状态由检测单元检测到的存储器件。多个存储装置中的每一个的控制单元控制多个存储装置中相应一个的至少一个发电单元的操作。

6. 发明申请

US20110095814A1 CIRCUIT AND METHOD FOR GENERATING INTERNAL VOLTAGE, AND SEMICONDUCTOR DEVICE HAVING THE CIRCUIT 有权
标题翻译：用于产生内部电压的电路和方法，以及具有电路的半导体器件
公开(公告)号：US20110095814A1
公开(公告)日：2011-04-28
申请号：US12845279
申请日：2010-07-28
申请人： So-Young Kim , Jung Sik Kim , Jang-Woo Ryu , Ho Cheol Lee , Jung Bae Lee
发明人： So-Young Kim , Jung Sik Kim , Jang-Woo Ryu , Ho Cheol Lee , Jung Bae Lee
IPC分类号： G05F1/10
CPC分类号： G11C5/14
摘要： An internal voltage generating method performed in a semiconductor device, the internal voltage generating method including generating a plurality of initialization signals corresponding to a plurality of external power supply voltages; detecting a transition of a lastly-generated initialization signal from among the plurality of initialization signals and generating a detection signal; and generating a first internal voltage according to the detection signal.
摘要翻译：一种在半导体器件中执行的内部电压产生方法，所述内部电压产生方法包括产生对应于多个外部电源电压的多个初始化信号; 检测来自所述多个初始化信号中的最后生成的初始化信号的转变并产生检测信号; 以及根据检测信号产生第一内部电压。

7. 发明申请

US20120271641A1 METHOD AND APPARATUS FOR EDUTAINMENT SYSTEM CAPABLE FOR INTERACTION BY INTERLOCKING OTHER DEVICES 审中-公开
标题翻译：用于通过互锁其他设备进行交互的用于消除系统的方法和装置
公开(公告)号：US20120271641A1
公开(公告)日：2012-10-25
申请号：US13452787
申请日：2012-04-20
申请人： So-Young Kim
发明人： So-Young Kim
IPC分类号： G10L11/00 , G06F3/01
CPC分类号： G09B5/06 , G10L15/26
摘要： An apparatus and method provide interactive edutainment through connection of a smart TV and other devices (e.g., a tablet PC, a smart phone, and a projector). The method includes connecting with a control device, and when at least one main story for interactivity is stored, receiving from a user a selection of the main story to be executed through the control device. The method also includes executing the selected main story, and when a control command is received from the control device, processing the control command.
摘要翻译：一种装置和方法通过智能电视和其他设备（例如，平板电脑，智能电话和投影仪）的连接来提供交互式寓教于乐。该方法包括与控制装置的连接，当存储至少一个交互性的主要故事时，从用户接收通过控制装置执行的主要故事的选择。该方法还包括执行所选择的主要故事，并且当从控制设备接收到控制命令时，处理控制命令。

8. 发明申请

US20110075501A1 Multi-Channel Semiconductor Integrated Circuit Devices for Controlling Direct Current Generators and Memory Systems Including the Same 有权
标题翻译：用于控制直流发电机和包括其的存储器系统的多通道半导体集成电路器件
公开(公告)号：US20110075501A1
公开(公告)日：2011-03-31
申请号：US12878431
申请日：2010-09-09
申请人： Jang-Woo Ryu , Jung Sik Kim , So-Young Kim
发明人： Jang-Woo Ryu , Jung Sik Kim , So-Young Kim
IPC分类号： G11C5/14
CPC分类号： G11C5/147
摘要： Multi-channel semiconductor integrated circuit devices are provided including a plurality of memory devices that are independently accessible, each of the plurality of memory devices including at least one power generation unit and a control unit for controlling an operation of the at least one power generation unit, a detection unit for detecting an operation state of the plurality of memory devices, and a common control unit for commonly controlling an operation of the at least one power generation unit of the plurality of memory devices, according to the operation state of the plurality of memory devices detected by the detection unit. The control unit of each of the plurality of memory devices controls the operation of the at least one power generation unit of a corresponding one of the plurality of memory devices.
摘要翻译：提供多通道半导体集成电路装置，其包括可独立存取的多个存储器件，多个存储器件中的每一个包括至少一个发电单元和用于控制至少一个发电单元的操作的控制单元，用于检测多个存储器件的操作状态的检测单元，以及用于共同控制多个存储器件的至少一个发电单元的操作的公共控制单元，根据多个存储器件的操作状态由检测单元检测到的存储器件。多个存储装置中的每一个的控制单元控制多个存储装置中相应一个的至少一个发电单元的操作。

9. 发明申请

US20110304786A1 DISPLAY SUBSTRATE 审中-公开
标题翻译：显示基板
公开(公告)号：US20110304786A1
公开(公告)日：2011-12-15
申请号：US12955582
申请日：2010-11-29
申请人： Seon-Kyoon MOK , Si-Hyun Ahn , Woo-Jung Shin , Byoung-Sun Na , So-Young Kim
发明人： Seon-Kyoon MOK , Si-Hyun Ahn , Woo-Jung Shin , Byoung-Sun Na , So-Young Kim
IPC分类号： G02F1/133
CPC分类号： G02F1/136286 , G02F1/133 , G02F1/1345 , G09G3/3696
摘要： A display substrate includes a plurality of gate lines extending in a first direction and arranged in a second direction in a display area of the display substrate, an alignment film formed in the display area and in an end area adjacent to end portions of the gate lines in a peripheral area surrounding the display area, and a plurality of circuit stages formed in the end area to connect to the gate lines and a dummy stage connected to a last circuit stage of the circuit stages. Each of the circuit stages includes a gate driving circuit disposed at the higher portion the gate line corresponding to the circuit stages and a gate connecting line formed in the peripheral area between the display area and the gate driving circuit to connect each of the circuit stages with each of the gate lines.
摘要翻译：显示基板包括在显示基板的显示区域中沿第一方向延伸并沿第二方向布置的多条栅极线，形成在显示区域中的取向膜和与栅极线的端部相邻的端部区域在围绕显示区域的外围区域中，以及形成在端部区域中以连接到栅极线的多个电路级以及连接到电路级的最后电路级的虚拟级。每个电路级包括设置在对应于电路级的栅极线的较高部分处的栅极驱动电路和形成在显示区域和栅极驱动电路之间的周边区域中的栅极连接线，以将每个电路级与每个电路级连接每条门线。

10. 发明申请

US20100211137A1 ACNE THERAPEUTIC AGENT AND SEBUM SECERNENT INHIBITOR WHICH COMPRISE INDOLE-3-ALKYLCARBO XYLICACID, AND KITS FOR PHOTODYNAMIC THERAPY CONTAINING THE SAME 审中-公开
标题翻译：含有吲哚-3-甲基胆碱酯酶的ACNE治疗剂和SEBUM SECERNENT抑制剂以及含有它们的光动力疗法的工具
公开(公告)号：US20100211137A1
公开(公告)日：2010-08-19
申请号：US12452348
申请日：2008-06-28
申请人： Dong-Seok Kim , So-Young Kim , Sun-Bang Kwon
发明人： Dong-Seok Kim , So-Young Kim , Sun-Bang Kwon
IPC分类号： A61N5/06 , C07D209/12 , A61K31/403 , A61P17/10
CPC分类号： A61K41/0057 , A61K31/405 , A61K41/0038
摘要： The present invention relates to novel uses of indole-3-alkylcarboxylic acid and derivatives thereof as a photosensitizer for the treatment of acne or for the inhibition of sebum secretion. More particularly, the present invention is directed to a photosensitizer for photodynamic therapy, a photodynamic therapy kit and photodynamic therapeutic composition comprising thereof, which contain indole-3-alkylcarboxylic acid being activated by light. The light which activates indole-3-alkylcarboxylic acid of the present invention may be ultraviolet rays or visible lights, preferably blue light or green light.
摘要翻译：本发明涉及吲哚-3-烷基羧酸及其衍生物作为光敏剂用于治疗痤疮或抑制皮脂分泌的新用途。更具体地说，本发明涉及一种用于光动力疗法的光敏剂，含有吲哚-3-烷基羧酸被光活化的光动力疗法试剂盒及其光动力治疗组合物。活化本发明的吲哚-3-烷基羧酸的光可以是紫外线或可见光，优选蓝光或绿光。

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