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1. 发明授权

US09943401B2 Therapeutic device for pain management and vision 有权
公开(公告)号：US09943401B2
公开(公告)日：2018-04-17
申请号：US12384659
申请日：2009-04-06
申请人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
发明人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
IPC分类号： A61F2/14 , A61F9/00 , G02C7/04
CPC分类号： A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

2. 发明授权

US08939948B2 Ocular insert apparatus and methods 有权
标题翻译：眼插装置和方法
公开(公告)号：US08939948B2
公开(公告)日：2015-01-27
申请号：US13618052
申请日：2012-09-14
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
IPC分类号： A61M35/00 , A61B17/00 , A61F9/00 , A61K9/00 , A61K47/34
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

3. 发明申请

US20130144128A1 OCULAR INSERT APPARATUS AND METHODS 有权
标题翻译： OCULAR插入装置和方法
公开(公告)号：US20130144128A1
公开(公告)日：2013-06-06
申请号：US13618052
申请日：2012-09-14
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
IPC分类号： A61B17/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

4. 发明授权

US09421126B2 Anterior segment drug delivery 有权
标题翻译：前段药物递送
公开(公告)号：US09421126B2
公开(公告)日：2016-08-23
申请号：US13151001
申请日：2011-06-01
申请人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
发明人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
IPC分类号： A61F9/00 , A61M35/00 , A61K9/00 , A61K31/19 , A61K31/407 , A61K31/4178 , A61K31/5377 , A61K31/5415 , A61K31/43 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61K9/0051 , A61K31/19 , A61K31/335 , A61K31/407 , A61K31/4178 , A61K31/43 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/002
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.
摘要翻译：治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。该第一结构将治疗系统的附着维持在眼前部至少三十天。在一些实施例中，第一结构保持恒定的尺寸和形状，例如。环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上部结膜孔，以将植入物保持在泪液和/或针对眼睛的组织。

5. 发明授权

US08277830B2 Posterior segment drug delivery 有权
公开(公告)号：US08277830B2
公开(公告)日：2012-10-02
申请号：US13252998
申请日：2011-10-04
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

6. 发明授权

US08298578B2 Posterior segment drug delivery 有权
标题翻译：后段药物递送
公开(公告)号：US08298578B2
公开(公告)日：2012-10-30
申请号：US13252942
申请日：2011-10-04
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
摘要翻译：用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。

7. 发明授权

US08399006B2 Posterior segment drug delivery 有权
标题翻译：后段药物递送
公开(公告)号：US08399006B2
公开(公告)日：2013-03-19
申请号：US12696678
申请日：2010-01-29
申请人： Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译：用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

8. 发明授权

US08715712B2 Ocular insert apparatus and methods 有权
标题翻译：眼插装置和方法
公开(公告)号：US08715712B2
公开(公告)日：2014-05-06
申请号：US13688019
申请日：2012-11-28
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Jose D. Alejandro
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Jose D. Alejandro
IPC分类号： A61F2/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

9. 发明授权

US09107773B2 Conformable therapeutic shield for vision and pain 有权
公开(公告)号：US09107773B2
公开(公告)日：2015-08-18
申请号：US13555056
申请日：2012-07-20
申请人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号： A61F13/12 , A61F9/00 , A61F9/013 , A61F9/04 , A61L27/18 , G02C7/04 , A61F9/008
CPC分类号： G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

10. 发明授权

US09498385B2 Conformable therapeutic shield for vision and pain 有权
公开(公告)号：US09498385B2
公开(公告)日：2016-11-22
申请号：US13503842
申请日：2010-10-25
申请人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号： A61F13/00 , A61F13/12 , A61F9/00 , A61F9/013 , A61F9/04 , A61L27/18 , G02C7/04 , A61F9/008
CPC分类号： G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

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