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1. 发明授权

US06720024B2 Methods using dry powder deposition apparatuses 失效
标题翻译：使用干粉沉积设备的方法
公开(公告)号：US06720024B2
公开(公告)日：2004-04-13
申请号：US10305452
申请日：2002-11-27
申请人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati
发明人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati
IPC分类号： B05D104
CPC分类号： A61J3/00 , A61J1/035 , A61K9/70 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50
摘要： Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; and an optical detection device for quantifying the amount of grains deposited.
摘要翻译：本发明提供了一种用于在基板上沉积晶粒的干式沉积装置，包括：具有一个或多个收集区的静电卡盘，其中基板层叠在卡盘上用于加工;带电粒子输送装置，用于将带电粒子引导在收集区的位置处的基板上的静电沉积; 和用于量化沉积的颗粒量的光学检测装置。

2. 发明授权

US6063194A Dry powder deposition apparatus 失效
标题翻译：干粉沉积装置
公开(公告)号：US6063194A
公开(公告)日：2000-05-16
申请号：US095246
申请日：1998-06-10
申请人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati , Aaron W. Levine , Bogdan Brycki
发明人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati , Aaron W. Levine , Bogdan Brycki
IPC分类号： A61J1/03 , A61J3/00 , A61K9/70 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50 , B05B5/025
CPC分类号： A61J3/00 , A61K9/70 , B65B1/04 , B65B1/30 , B65B11/50 , A61J1/035 , B05B5/08
摘要： Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising:an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing;a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; andan optical detection device for quantifying the amount of grains deposited.
摘要翻译：尤其提供了用于在基板上沉积晶粒的干式沉积装置，包括：具有一个或多个收集区的静电卡盘，其中所述基板层叠在所述卡盘上用于加工; 带电粒子输送装置，用于在收集区的位置处引导带电粒子在基底上静电沉积; 以及用于量化沉积的晶粒量的光学检测装置。

3. 发明授权

US06511712B1 Methods using dry powder deposition apparatuses 失效
标题翻译：使用干粉沉积设备的方法
公开(公告)号：US06511712B1
公开(公告)日：2003-01-28
申请号：US09531639
申请日：2000-03-21
申请人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati
发明人： Eugene Samuel Poliniak , Hoi Cheong Steve Sun , Nitin Vithalbhai Desai , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , Peter Zanzucchi , David Keller , Dominic Stephen Rosati
IPC分类号： B05D104
CPC分类号： A61J3/00 , A61J1/035 , A61K9/70 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50
摘要： Provided is a method using a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; and an optical detection device for quantifying the amount of grains deposited.
摘要翻译：提供了一种使用用于在基板上沉积晶粒的干式沉积装置的方法，包括：具有一个或多个收集区的静电卡盘，其中基板层叠在卡盘上用于加工;带电粒子输送装置，用于引导带电粒子进行静电沉积在收集区的位置处的基底上; 和用于量化沉积的颗粒量的光学检测装置。

4. 发明授权

US6149774A AC waveforms biasing for bead manipulating chucks 失效
公开(公告)号：US6149774A
公开(公告)日：2000-11-21
申请号：US095425
申请日：1998-06-10
申请人： Hoi Cheong Steve Sun , Eugene Samuel Poliniak , Dominic Stephen Rosati , Bawa Singh , Nitin Vithalbhai Desai
发明人： Hoi Cheong Steve Sun , Eugene Samuel Poliniak , Dominic Stephen Rosati , Bawa Singh , Nitin Vithalbhai Desai
IPC分类号： B01J19/08 , B01J19/00 , G01N35/00 , H02N13/00
CPC分类号： H02N13/00 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , G01N2035/00574 , Y10S118/02 , Y10T279/23
摘要： AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.

5. 发明授权

US5753302A Acoustic dispenser 失效
标题翻译：声音分配器
公开(公告)号：US5753302A
公开(公告)日：1998-05-19
申请号：US661211
申请日：1996-06-10
申请人： Hoi Cheong Steve Sun , Pabitra Datta , William Yat Chung Chiang , Howard Christopher Rivenburg , Bawa Singh , Dominic S. Rosati , James Regis Matey
发明人： Hoi Cheong Steve Sun , Pabitra Datta , William Yat Chung Chiang , Howard Christopher Rivenburg , Bawa Singh , Dominic S. Rosati , James Regis Matey
IPC分类号： A61K41/00 , B05B5/047 , B05B17/06 , B05D1/06 , B05B7/00 , B05C3/05 , B05D1/12
CPC分类号： A61K41/00 , A61K41/0014 , B05B17/06 , B05B5/047 , B01J2219/00468
摘要： The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.
摘要翻译：本发明提供一种用于将物体推向基板的声学分配器，以及分配器的使用方法。声学分配器使用声振动源和用于施加声振动的膜，其中物体从膜推进到基底。声音分配器和本发明的方法可以与许多类型的物体一起使用。在一些实施方案中，物体是干粉末中的颗粒，其可以包括例如药物活性成分。在其它实施方案中，物体是珠，其优选具有约100至约300微米的平均直径。此外，声音分配器可以与多于一种类型的物体一起使用，例如两种类型的物体，例如珠粒和干粉。在一些情况下，声音分配器还包括用于基于尺寸将一种类型的物体与另一种物体分离的膜，由此在沉积之前一种类型的物体与另一种物体分离。

6. 发明授权

US5857456A Inhaler apparatus with an electronic means for enhanced release of dry powders 失效
标题翻译：具有电子装置的吸入装置，用于增强干粉的释放
公开(公告)号：US5857456A
公开(公告)日：1999-01-12
申请号：US661212
申请日：1996-06-10
申请人： Hoi Cheong Steve Sun , Bawa Singh , Howard Christopher Rivenburg , Pabitra Datta , Nitin Vithabhi Desai
发明人： Hoi Cheong Steve Sun , Bawa Singh , Howard Christopher Rivenburg , Pabitra Datta , Nitin Vithabhi Desai
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0051 , A61M15/0055 , A61M2205/0233
摘要： The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrateIn another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.
摘要翻译：本发明部分地涉及具有沉积有药剂的基底的吸入器装置，该基底被配置为电子释放药物。在优选实施例中，吸入器在其上包括导电层和介电层。在优选实施例中，吸入器还包括位于衬底上方的第二导电层，而不与衬底接触。在某些优选实施例中，电压源连接到衬底中的导电层和衬底上方的第二导电层。在其它优选实施例中，吸入器装置还包括位于衬底下方的第三导电层，并且电压源优选地连接到衬底上方的第二导电层和衬底下方的第三导电层。在另一方面，本发明提供一种从吸入器分配药物的方法，包括：（a）为吸入器提供具有沉积在其上的药物的基底，所述基底包括导电层和电介质层以及连接到所述导电层的电压源; 和（b）致动电压源。

7. 发明授权

US5846595A Method of making pharmaceutical using electrostatic chuck 失效
标题翻译：使用静电吸盘制造药物的方法
公开(公告)号：US5846595A
公开(公告)日：1998-12-08
申请号：US630050
申请日：1996-04-09
申请人： Hoi Cheong Steve Sun , Timothy Allen Pletcher
发明人： Hoi Cheong Steve Sun , Timothy Allen Pletcher
IPC分类号： A61K9/20 , A61K9/28 , B05B5/08 , H02N13/00 , B05D1/04 , A61J3/02 , B05D1/06
CPC分类号： H02N13/00 , A61K9/2086 , A61K9/2893 , B05B5/084 , B05B5/087 , B01J2219/00468
摘要： The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of particles on an objects, and the objects themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing, and optionally wherein the object is less than or equal to one millimeter in average width or diameter. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides an electrostatic chuck comprising a sensing electrode for sensing the number of particles attracted to the chuck, thereby providing for deposition of an accurate amount of particles. Furthermore, the present invention provides objects having selected areas in which particles are applied to the object via electrostatic means.
摘要翻译：本发明涉及静电卡盘，其使用方法，物体上的颗粒的静电沉积以及已经经受静电沉积的物体本身。一方面，本发明提供一种用于静电吸引物体的静电吸盘，其中所述物体用于化学或药物测定或制造，并且任选地其中所述物体的平均宽度或直径小于或等于1毫米。物体可以是药物底物，例如药物片剂。本发明的另外的实施方案提供了卡盘及其用于静电吸引诸如药物活性成分的颗粒到底物例如片剂。一方面，静电卡盘包括浮动电极，并且用于选择性地将颗粒吸引到浮动电极上方的衬底上，从而为选定图像中的颗粒沉积提供电荷成像。此外，本发明提供了一种静电卡盘，其包括感测电极，用于感测吸引到卡盘的颗粒数量，从而提供精确量的颗粒的沉积。此外，本发明提供了具有通过静电装置将颗粒施加到物体的选择区域的物体。

8. 发明授权

US06592671B2 Apparatus for clamping a planar substrate 失效
标题翻译：用于夹紧平面基板的装置
公开(公告)号：US06592671B2
公开(公告)日：2003-07-15
申请号：US09769227
申请日：2001-01-25
申请人： Hoi Cheong Steve Sun , Bogdan Brycki
发明人： Hoi Cheong Steve Sun , Bogdan Brycki
IPC分类号： B05B500
CPC分类号： A61K9/2072 , A61K9/2095 , B01J19/0046 , B01J2219/00459 , B01J2219/00468 , B01J2219/005 , B01J2219/00648 , B01J2219/00659 , B05B5/032 , B05B5/08 , B05B5/084 , B05B5/087 , H01L21/6831 , H01L21/6838 , H02N13/00
摘要： The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.
摘要翻译：本发明涉及一种用于将晶粒静电粘附到平面基板上的装置，包括：a。具有收集表面的静电卡盘，所述收集表面具有至少一个颗粒收集区，用于当所述平面基板层叠在所述收集表面上时，将带电粒子静电导向所述平面基板上的相应表面; 安布穿过静电卡盘的孔的图案允许低压源通过静电卡盘作用以粘附平面基板。

9. 发明授权

US06294024B1 Electrostatic chucks and a particle deposition apparatus therefor 失效
标题翻译：静电吸盘及其颗粒沉积设备
公开(公告)号：US06294024B1
公开(公告)日：2001-09-25
申请号：US09175287
申请日：1998-10-20
申请人： Hoi Cheong Steve Sun , Timothy Allen Pletcher
发明人： Hoi Cheong Steve Sun , Timothy Allen Pletcher
IPC分类号： B05C1904
CPC分类号： B05B5/087 , A61K9/2086 , A61K9/2893 , B01J2219/00468 , B05B5/08 , B05B5/082 , H02N13/00 , Y10T428/2991
摘要： The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides comprising a sensing electrode, optionally for use with an electrostatic chuck, for sensing the number of particles attracted to the objects on the chuck or other substrate, thereby providing for deposition of an accurate amount of particles. Furthermore, the present invention provides objects having selected areas in which particles are applied to the object via electrostatic means.
摘要翻译：本发明涉及静电卡盘，它们的使用方法，诸如干粉末中的物体的静电沉积到受体基底上，以及已经经过静电沉积的受体底物本身。一方面，本发明提供一种用于静电吸引物体的静电吸盘，其中该物体用于化学或药物测定或制造。物体可以是药物底物，例如药物片剂。本发明的另外的实施方案提供了卡盘及其用于静电吸引诸如药物活性成分的颗粒到底物例如片剂。一方面，静电卡盘包括浮动电极，并且用于选择性地将颗粒吸引到浮动电极上方的衬底上，从而为选定图像中的颗粒沉积提供电荷成像。另外，本发明提供了包括感测电极，可选地与静电卡盘一起使用，用于感测吸附到卡盘或其它基底上的物体的颗粒的数量，从而提供精确量的颗粒的沉积。此外，本发明提供了具有通过静电装置将颗粒施加到物体的选择区域的物体。

10. 发明授权

US06399143B1 Method for clamping and electrostatically coating a substrate 失效
标题翻译：夹持和静电涂覆基板的方法
公开(公告)号：US06399143B1
公开(公告)日：2002-06-04
申请号：US09095321
申请日：1998-06-10
申请人： Hoi Cheong Steve Sun , Bogdan Brycki
发明人： Hoi Cheong Steve Sun , Bogdan Brycki
IPC分类号： A61J300
CPC分类号： A61K9/2072 , A61K9/2095 , B01J19/0046 , B01J2219/00459 , B01J2219/00468 , B01J2219/005 , B01J2219/00648 , B01J2219/00659 , B05B5/032 , B05B5/08 , B05B5/084 , B05B5/087 , H01L21/6831 , H01L21/6838 , H02N13/00
摘要： The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.
摘要翻译：本发明涉及一种用于将晶粒静电粘附到平面基板上的装置，包括：a。具有收集表面的静电卡盘，所述收集表面具有至少一个颗粒收集区，用于当所述平面基板层叠在所述收集表面上时，将带电粒子静电导向所述平面基板上的相应表面; 安布穿过静电卡盘的孔的图案允许低压源通过静电卡盘作用以粘附平面基板。

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