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1. 发明授权

US5753302A Acoustic dispenser 失效
标题翻译：声音分配器
公开(公告)号：US5753302A
公开(公告)日：1998-05-19
申请号：US661211
申请日：1996-06-10
申请人： Hoi Cheong Steve Sun , Pabitra Datta , William Yat Chung Chiang , Howard Christopher Rivenburg , Bawa Singh , Dominic S. Rosati , James Regis Matey
发明人： Hoi Cheong Steve Sun , Pabitra Datta , William Yat Chung Chiang , Howard Christopher Rivenburg , Bawa Singh , Dominic S. Rosati , James Regis Matey
IPC分类号： A61K41/00 , B05B5/047 , B05B17/06 , B05D1/06 , B05B7/00 , B05C3/05 , B05D1/12
CPC分类号： A61K41/00 , A61K41/0014 , B05B17/06 , B05B5/047 , B01J2219/00468
摘要： The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.
摘要翻译：本发明提供一种用于将物体推向基板的声学分配器，以及分配器的使用方法。声学分配器使用声振动源和用于施加声振动的膜，其中物体从膜推进到基底。声音分配器和本发明的方法可以与许多类型的物体一起使用。在一些实施方案中，物体是干粉末中的颗粒，其可以包括例如药物活性成分。在其它实施方案中，物体是珠，其优选具有约100至约300微米的平均直径。此外，声音分配器可以与多于一种类型的物体一起使用，例如两种类型的物体，例如珠粒和干粉。在一些情况下，声音分配器还包括用于基于尺寸将一种类型的物体与另一种物体分离的膜，由此在沉积之前一种类型的物体与另一种物体分离。

2. 发明授权

US5857456A Inhaler apparatus with an electronic means for enhanced release of dry powders 失效
标题翻译：具有电子装置的吸入装置，用于增强干粉的释放
公开(公告)号：US5857456A
公开(公告)日：1999-01-12
申请号：US661212
申请日：1996-06-10
申请人： Hoi Cheong Steve Sun , Bawa Singh , Howard Christopher Rivenburg , Pabitra Datta , Nitin Vithabhi Desai
发明人： Hoi Cheong Steve Sun , Bawa Singh , Howard Christopher Rivenburg , Pabitra Datta , Nitin Vithabhi Desai
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0051 , A61M15/0055 , A61M2205/0233
摘要： The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrateIn another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.
摘要翻译：本发明部分地涉及具有沉积有药剂的基底的吸入器装置，该基底被配置为电子释放药物。在优选实施例中，吸入器在其上包括导电层和介电层。在优选实施例中，吸入器还包括位于衬底上方的第二导电层，而不与衬底接触。在某些优选实施例中，电压源连接到衬底中的导电层和衬底上方的第二导电层。在其它优选实施例中，吸入器装置还包括位于衬底下方的第三导电层，并且电压源优选地连接到衬底上方的第二导电层和衬底下方的第三导电层。在另一方面，本发明提供一种从吸入器分配药物的方法，包括：（a）为吸入器提供具有沉积在其上的药物的基底，所述基底包括导电层和电介质层以及连接到所述导电层的电压源; 和（b）致动电压源。

3. 发明授权

US06591833B2 Inhaler apparatus with modified surfaces for enhanced release of dry powders 失效
标题翻译：具有改性表面的吸入器装置，用于增强干粉的释放
公开(公告)号：US06591833B2
公开(公告)日：2003-07-15
申请号：US09782419
申请日：2001-02-13
申请人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
发明人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0051 , A61M2205/0233
摘要： In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.
摘要翻译：在一个方面，本发明提供了一种吸入器装置，其包括与用于吸入的药物接触的内表面，所述内表面包括接口管的内表面和其上沉积有药物的基底，所述内表面中的至少一个包括凹陷或凸起区域在其中，凸起区域之间具有谷部。在某些优选实施例中，内表面是在其上沉积有药物的基底上的表面，在其它优选实施例中，内表面是吸入器的接口的内表面。除了提供表面拓扑以最小化药物和吸入器表面之间的接触面积之外，表面优选地由具有低表面能的材料制成，并且更优选地，当不带电时也不具有实质范围与药物的离子或静电相互作用。此外，材料优选基本上与药物无化学反应。

4. 发明授权

US06298847B1 Inhaler apparatus with modified surfaces for enhanced release of dry powders 失效
标题翻译：具有改进表面的吸入器装置，用于增强干粉的释放
公开(公告)号：US06298847B1
公开(公告)日：2001-10-09
申请号：US09210214
申请日：1998-12-11
申请人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
发明人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0051 , A61M2205/0233
摘要： In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.
摘要翻译：在一个方面，本发明提供了一种吸入器装置，其包括与用于吸入的药物接触的内表面，所述内表面包括接口管的内表面和其上沉积有药物的基底，所述内表面中的至少一个包括凹陷或凸起区域在其中，凸起区域之间具有谷部。在某些优选实施例中，内表面是在其上沉积有药物的基底上的表面，在其它优选实施例中，内表面是吸入器的接口的内表面。除了提供用于使药物和吸入器的表面之间的接触面积最小化的表面拓扑之外，表面优选地由具有低表面能的材料制成，并且更优选地，当不带电时也不具有实质的范德与药物的离子或静电相互作用。此外，材料优选基本上与药物无化学反应。

5. 发明授权

US5871010A Inhaler apparatus with modified surfaces for enhanced release of dry powders 失效
标题翻译：具有改进表面的吸入器装置，用于增强干粉的释放
公开(公告)号：US5871010A
公开(公告)日：1999-02-16
申请号：US661213
申请日：1996-06-10
申请人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
发明人： Pabitra Datta , Howard Christopher Rivenburg , Nitin Desai
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0051 , A61M2205/0233
摘要： In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.
摘要翻译：一方面，本发明提供一种吸入器装置，其包括与用于吸入的药物接触的内表面，所述内表面包括接口管的内表面和基底，其上沉积有至少一个所述内表面的药物，所述内表面包括凹陷或凸起其中的凸起区域之间具有谷部。在某些优选实施例中，内表面是在其上沉积有药物的基底上的表面，在其它优选实施例中，内表面是吸入器的接口的内表面。除了提供用于使药物和吸入器的表面之间的接触面积最小化的表面拓扑之外，表面优选地由具有低表面能的材料制成，并且更优选地，当不带电时也不具有实质的范德与药物的离子或静电相互作用。此外，材料优选基本上与药物无化学反应。

6. 发明授权

US5012155A Surface treatment of phosphor particles and method for a CRT screen 失效
标题翻译：荧光体颗粒的表面处理和CRT屏幕的方法
公开(公告)号：US5012155A
公开(公告)日：1991-04-30
申请号：US455069
申请日：1989-12-22
申请人： Pabitra Datta , Ronald N. Friel , Robert P. Thompson
发明人： Pabitra Datta , Ronald N. Friel , Robert P. Thompson
IPC分类号： C09K11/02 , H01J9/22 , H01J29/20
CPC分类号： H01J9/225 , C09K11/025 , H01J29/20
摘要： The method of surface-treating dry-powdered phosphor particles for use in manufacturing a viewing screen for a CRT to control the triboelectric charge characteristics of the phosphor particles includes the steps of dissolving a suitable quantity of a polymeric coupling agent in a suitable solvent to form a mixture, surface-treating the phosphor particles by adding them to the mixture to provide a coating of the coupling agent thereon, and then drying the surface-treated phosphor particles. The resultant dry-powdered surface-treated phosphor particles are used to make a luminescent viewing screen for a CRT. The coupling agent controls the triboelectric charge characteristics of the phosphor particles during the electrophotographic manufacturing of the screen.
摘要翻译：用于制造用于CRT的观察屏以控制荧光体颗粒的摩擦带电特性的干粉状磷光体颗粒的表面处理方法包括以下步骤：将合适数量的聚合偶联剂溶解在合适的溶剂中以形成混合物，通过将其添加到混合物中来对荧光体颗粒进行表面处理以在其上提供偶联剂的涂层，然后干燥表面处理的荧光体颗粒。所得干粉末表面处理荧光体颗粒用于制造用于CRT的发光观察屏。耦合剂在屏幕的电子照相制造期间控制荧光体颗粒的摩擦电荷特性。

7. 发明授权

US4560601A High-density information disc lubricants 失效
标题翻译：高密度信息盘润滑油
公开(公告)号：US4560601A
公开(公告)日：1985-12-24
申请号：US636310
申请日：1984-07-31
申请人： Pabitra Datta
发明人： Pabitra Datta
IPC分类号： C10M169/04 , G11B3/70 , B32B3/02
CPC分类号： C10M169/04 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2209/103 , C10M2215/16 , C10M2215/202 , C10M2215/204 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/30 , C10M2229/025 , C10M2229/0405 , C10M2229/0415 , C10M2229/0425 , C10M2229/0435 , C10M2229/0445 , C10M2229/0455 , C10M2229/0465 , C10M2229/0475 , C10M2229/0485 , C10M2229/0505 , C10M2229/0515 , C10M2229/0525 , C10M2229/0535 , C10M2229/0545 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66 , C10N2250/121 , Y10T428/31663 , Y10T428/31667
摘要： High-density information records are lubricated with a methyl alkyl siloxane lubricant containing an effective amount of a donor-acceptor complex to reduce moisture sensitivity.
摘要翻译：使用含有有效量的供体 - 受体复合物的甲基烷基硅氧烷润滑剂润滑高密度信息记录以降低湿度敏感性。

8. 发明授权

US4390579A Doped polyphenylene ether lubricant for high density information discs 失效
标题翻译：掺杂聚苯醚润滑剂用于高密度信息盘
公开(公告)号：US4390579A
公开(公告)日：1983-06-28
申请号：US389431
申请日：1982-06-17
申请人： Pabitra Datta , Eugene S. Poliniak
发明人： Pabitra Datta , Eugene S. Poliniak
IPC分类号： G11B9/06 , G11B23/50 , B32B3/02 , G11B3/70 , G11B5/72
CPC分类号： G11B9/065 , G11B23/505 , Y10T428/25 , Y10T428/30 , Y10T428/31504 , Y10T428/31935
摘要： High density information discs comprising a conductive carbon-loaded polyvinylchloride disc are lubricated with a polyphenylene ether containing a polar dopant substituted with a long chain alkyl group in amounts sufficient to reduce surface tension of the polyphenylene ether to enable adequate wetting of the disc surface. The successful application of this doped lubricant provides the discs with excellent lubrication, highly resistant to oxidation, moisture and shear stress.
摘要翻译：包含导电碳负载的聚氯乙烯盘的高密度信息盘由含有用长链烷基取代的极性掺杂剂的聚苯醚润滑，其量足以降低聚苯醚的表面张力，以使盘表面能够充分润湿。这种掺杂润滑剂的成功应用为圆盘提供了优异的润滑，高度抗氧化，抗水分和剪切应力。

9. 发明授权

US4241120A Video discs and molding compositions therefor 失效
标题翻译：视频光盘及其成型组合物
公开(公告)号：US4241120A
公开(公告)日：1980-12-23
申请号：US959846
申请日：1978-11-13
申请人： Pabitra Datta , Ronald N. Friel
发明人： Pabitra Datta , Ronald N. Friel
IPC分类号： C08L27/06 , G11B9/06 , H04N1/30 , B32B3/02
CPC分类号： G11B9/063 , C08L27/06 , Y10T428/2991 , Y10T428/2998 , Y10T428/31663
摘要： A polyvinyl chloride based molding composition containing polymer grafted conductive carbon particles has good processability, low heat distortion temperature and good dispersion of the conductive particles and can be molded to form video discs of improved electrical properties.
摘要翻译：含有聚合物接枝的导电碳颗粒的聚氯乙烯基成型组合物具有良好的加工性能，低热变形温度和良好的导电颗粒分散性，并且可以模塑成具有改进的电性能的视盘。

10. 发明授权

US4097617A Phosphonitrile fluoroelastomer coated carrier particles for use in electrophotographic process 失效
标题翻译：用于电子照相工艺的磷腈含氟弹性体涂层载体颗粒
公开(公告)号：US4097617A
公开(公告)日：1978-06-27
申请号：US831147
申请日：1977-09-07
申请人： Pabitra Datta
发明人： Pabitra Datta
IPC分类号： G03G9/113 , G03G9/10 , G03G9/14
CPC分类号： G03G9/1138 , G03G9/1134 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/2998
摘要： Coated carrier particles for use in an electrophotographic process are prepared by applying a thin coating of a phosphonitrile fluoroelastomer to the surface of the carrier particles. The coated carriers are long lived and capable of imparting a negative triboelectric charge to electroscopic powders mixed therewith.
摘要翻译：通过在载体颗粒的表面施加薄的磷腈氟弹性体涂层来制备用于电子照相方法的涂覆载体颗粒。涂覆的载体是长寿命的并且能够对与其混合的电磁粉末赋予负的摩擦电荷。

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