专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4146603A Tumor specific glycoproteins and method for detecting tumorigenic cancers 失效
标题翻译：肿瘤特异性糖蛋白和检测肿瘤坏死因子的方法
公开(公告)号：US4146603A
公开(公告)日：1979-03-27
申请号：US770103
申请日：1977-02-18
申请人： Eugene A. Davidson , Sally D. Bolmer
发明人： Eugene A. Davidson , Sally D. Bolmer
IPC分类号： G01N33/50 , A61K38/16 , A61K39/00 , A61K39/395 , A61K45/00 , C07K1/22 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , G01N33/574 , G01N33/16 , A61K43/00
CPC分类号： C07K16/18 , C07K14/47 , G01N33/57469 , Y10S436/804 , Y10S436/825 , Y10S530/806 , Y10S530/828 , Y10S530/83
摘要： A new class of glycoproteins has been found to be produced by human cancer cells and is not produced by normal cells and said glycoprotein is present in the sera of cancer patients. This tumor specific glycoprotein can be characterized by its isoelectric point of from about 4.2 to 4.6 and by the perchloric acid soluble fraction thereof having a sialic acid content of above about 0.065 mg/ml of initial serum sample. The presence of a tumorigenic cancer in a patient can be determined by detecting the presence of the tumor specific glycoprotein in the blood sera of a patient.

2. 再颁专利

USRE36064E Disinfection method and composition therefor 失效
标题翻译：消毒方法及其组成
公开(公告)号：USRE36064E
公开(公告)日：1999-01-26
申请号：US052641
申请日：1993-04-23
申请人： Eugene A. Davidson , Robert D. Kross
发明人： Eugene A. Davidson , Robert D. Kross
IPC分类号： A01N59/00 , A61K33/14
CPC分类号： A01N59/00
摘要： There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
摘要翻译：在一方面，公开了可用于消毒底物的产生氯酸的组合物。组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐，例如亚氯酸钠。组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量％。在优选的实施方案中，组合物还含有邻位二羟基或多羟基化合物。在另一个优选的实施方案中，与亚氯酸盐离子的总浓度相比，组合物含有至少10倍摩尔过量的水溶性氯离子。另一方面，公开了一种消毒底物的方法。该方法包括将上述组合物施用于底物。在另一方面，公开了一种制备上述组合物的方法。该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。

3. 发明申请

US20110123980A1 SEQUENCE-SPECIFIC DETECTION OF NUCLEOTIDE SEQUENCES 有权
标题翻译：序列特异性检测核苷酸序列
公开(公告)号：US20110123980A1
公开(公告)日：2011-05-26
申请号：US11884366
申请日：2006-02-15
申请人： Mark Danielsen , Eugene A. Davidson , Kenneth L. Dretchen , Traci L. Pals
发明人： Mark Danielsen , Eugene A. Davidson , Kenneth L. Dretchen , Traci L. Pals
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/6818 , C12Q2565/1015 , C12Q2521/307
摘要： A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
摘要翻译：本文描述了用于检测DNA样品中目标核苷酸序列的存在的方法，其中包含单链DNA的测试样品在允许探针的序列特异性杂交的条件下暴露于DNA探针和切口内切核酸酶到补充靶序列。探针包含与要检测的靶序列互补的序列，该序列还包括切口内切核酸酶的识别序列。如果样品含有靶序列，则探针与靶标杂交，并由切口内切核酸酶切割，使得目标完好无损。观察由切口内切核酸酶切割的探针的存在表明DNA样品中靶核苷酸序列的存在。

4. 发明授权

US5808074A Benzoylecgonine conjugate diagnostic reagents 失效
标题翻译：苯并恶唑偶联物诊断试剂
公开(公告)号：US5808074A
公开(公告)日：1998-09-15
申请号：US792227
申请日：1997-01-31
申请人： D. Channe Gowda , Eugene A. Davidson
发明人： D. Channe Gowda , Eugene A. Davidson
IPC分类号： C07D451/06 , C07D451/10 , C07D451/12 , G01N33/53
CPC分类号： C07D451/06 , Y10S530/849
摘要： A benzoylecgonine conjugate represented by the following formula: ##STR1## wherein, R is H or CH.sub.3 ; R' is --NH--NH--, --(NH).sub.2 --CO--(CH.sub.2).sub.n --CO--NH--NH--, or related linear chains wherein at least one (CH.sub.2) is replaced with a substituent selected from the group consisting of an ether, an amide, a sulfide, a disulfide, an alkyl, an aryl, an alkoxy, an aryloxy or an alkylhalide; and T is a targeting substance selected from the group consisting of proteins, peptides, antigens, polypeptides, dyes, biotins, enzymes, antibodies, hormones, carbohydrates, polysaccharide supports, and filter paper.
摘要翻译：由下式表示的苯甲酰芽子碱缀合物：其中，R为H或CH 3; R'是-NH-NH-， - （NH）2 -CO-（CH 2）n -CO-NH-NH-或相关线性链，其中至少一个（CH 2）被选自以下的取代基取代：的醚，酰胺，硫化物，二硫化物，烷基，芳基，烷氧基，芳氧基或烷基卤; T是选自蛋白质，肽，抗原，多肽，染料，生物素，酶，抗体，激素，碳水化合物，多糖载体和滤纸的靶向物质。

5. 发明申请

US20120065088A1 SEQUENCE-SPECIFIC DETECTION OF NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：序列特异性检测核苷酸序列
公开(公告)号：US20120065088A1
公开(公告)日：2012-03-15
申请号：US13202887
申请日：2010-02-23
申请人： Mark Danielsen , Joel Credle , Eugene A. Davidson , Kenneth L. Dretchen
发明人： Mark Danielsen , Joel Credle , Eugene A. Davidson , Kenneth L. Dretchen
IPC分类号： C40B30/04 , C12Q1/70 , C12Q1/68 , C07H1/00 , C07H21/04 , C40B40/06
CPC分类号： C12Q1/6823 , C12Q1/6837 , C12Q1/6888 , C12Q1/689 , C12Q1/701 , Y02A50/53
摘要： A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
摘要翻译：本文描述了用于检测DNA样品中目标核苷酸序列的存在的方法，其中包含单链DNA的测试样品在允许探针的序列特异性杂交的条件下暴露于DNA探针和切口内切核酸酶到补充靶序列。探针包含与要检测的靶序列互补的序列，该序列还包括切口内切核酸酶的识别序列。如果样品含有靶序列，则探针与靶标杂交，并由切口内切核酸酶切割，使得目标完好无损。观察由切口内切核酸酶切割的探针的存在表明DNA样品中靶核苷酸序列的存在。

6. 发明授权

US08062895B2 Misfolded protein sensor method 有权
标题翻译：误差蛋白传感器方法
公开(公告)号：US08062895B2
公开(公告)日：2011-11-22
申请号：US12726941
申请日：2010-03-18
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
IPC分类号： G01N33/52 , G01N33/50 , G01N33/00 , G01N33/48
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译：用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。这反过来又催化与测试样品结合探针相关联的信号的传播。因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。

7. 发明授权

US07691639B2 Misfolded protein sensor method 有权
标题翻译：误差蛋白传感器方法
公开(公告)号：US07691639B2
公开(公告)日：2010-04-06
申请号：US10494906
申请日：2002-05-30
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
IPC分类号： G01N33/52 , G01N33/50 , G01N33/00 , G01N33/48
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译：用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。这反过来，催化与测试样品结合探针相关联的信号的传播。因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。

8. 发明授权

US4986990A Disinfection method and composition therefor 失效
标题翻译：消毒方法及其组成
公开(公告)号：US4986990A
公开(公告)日：1991-01-22
申请号：US420651
申请日：1989-10-11
申请人： Eugene A. Davidson , Robert D. Kross
发明人： Eugene A. Davidson , Robert D. Kross
IPC分类号： A01N59/00
CPC分类号： A01N59/00
摘要： There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above. This process comprises contacting the protic acid with the metal chlorite to form the disinfecting composition.
摘要翻译：在一方面，公开了可用于消毒底物的产生氯酸的组合物。组合物包含含有适量的质子酸如柠檬酸或苹果酸的水溶液和适量的金属亚氯酸盐，例如亚氯酸钠。组合物中亚氯酸形式的亚氯酸根离子浓度不超过亚氯酸根离子浓度总量的约15重量％。在优选的实施方案中，组合物还含有邻位二羟基或多羟基化合物。在另一个优选的实施方案中，与亚氯酸盐离子的总浓度相比，组合物含有至少10倍摩尔过量的水溶性氯离子。另一方面，公开了一种消毒底物的方法。该方法包括将上述组合物施用于底物。在另一方面，公开了一种制备上述组合物的方法。该方法包括使质子酸与亚氯酸金属接触以形成消毒组合物。

9. 发明授权

US09012142B2 Sequence-specific detection of nucleotide sequences 有权
标题翻译：序列特异性检测核苷酸序列
公开(公告)号：US09012142B2
公开(公告)日：2015-04-21
申请号：US11884366
申请日：2006-02-15
申请人： Mark Danielsen , Eugene A. Davidson , Kenneth L. Dretchen , Traci K. Pals
发明人： Mark Danielsen , Eugene A. Davidson , Kenneth L. Dretchen , Traci K. Pals
IPC分类号： C12Q1/68 , C12P19/34 , C12N9/00 , C12M1/34
CPC分类号： C12Q1/6823 , C12Q1/6818 , C12Q2565/1015 , C12Q2521/307
摘要： A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
摘要翻译：本文描述了用于检测DNA样品中目标核苷酸序列的存在的方法，其中包含单链DNA的测试样品在允许探针的序列特异性杂交的条件下暴露于DNA探针和切口内切核酸酶到补充靶序列。探针包含与要检测的靶序列互补的序列，该序列还包括切口内切核酸酶的识别序列。如果样品含有靶序列，则探针与靶标杂交，并由切口内切核酸酶切割，使得目标完好无损。观察由切口内切核酸酶切割的探针的存在表明DNA样品中靶核苷酸序列的存在。

10. 发明申请

US20100267151A1 MISFOLDED PROTEIN SENSOR METHOD 有权
标题翻译： MISFOLDED蛋白传感器方法
公开(公告)号：US20100267151A1
公开(公告)日：2010-10-21
申请号：US12726941
申请日：2010-03-18
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
IPC分类号： G01N33/68
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译：用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。这反过来又催化与测试样品结合探针相关联的信号的传播。因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式