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1. 发明申请

US20060177437A1 Binding peptides: methods for their generation and use 审中-公开
标题翻译：结合肽：其生成和使用的方法
公开(公告)号：US20060177437A1
公开(公告)日：2006-08-10
申请号：US11299288
申请日：2005-12-09
申请人： Erwin Houtzager , Wietse Willebrands , Guy de Roo , KeesJan Francoijs , Irma Vijn
发明人： Erwin Houtzager , Wietse Willebrands , Guy de Roo , KeesJan Francoijs , Irma Vijn
IPC分类号： A61K39/395 , C07K16/10 , C07K16/12 , C07K16/40
CPC分类号： C07K1/107 , G01N33/5375
摘要： Described are means and methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use, such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
摘要翻译：描述了产生与合适核心区域相关的结合肽，所得蛋白质分子及其用途的方法和方法。本发明提供了在整个使用范围内与使用结合分子相关的问题的解决方案。结合分子可以设计成适应极端的使用条件，如极端温度或pH值。或者，可以设计结合分子以响应环境中非常微妙的变化。

2. 发明申请

US20060292634A1 Structure for presenting desired peptide sequences 审中-公开
公开(公告)号：US20060292634A1
公开(公告)日：2006-12-28
申请号：US11437858
申请日：2006-05-19
申请人： Erwin Houtzager , Irma Vijn , Peter Sijmons
发明人： Erwin Houtzager , Irma Vijn , Peter Sijmons
IPC分类号： C40B30/06 , C40B40/08 , C40B40/10 , C40B50/06
CPC分类号： C12N15/1044 , C07K14/705 , C07K14/70503 , C07K2319/00
摘要： Means and methods for generating binding peptide associated with a suitable core region are disclosed, the resulting proteinaceous molecule and uses thereof. A solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.

3. 发明申请

US20050037427A1 Structure for presenting desired peptide sequences 审中-公开
标题翻译：用于呈现所需肽序列的结构
公开(公告)号：US20050037427A1
公开(公告)日：2005-02-17
申请号：US10732180
申请日：2003-12-10
申请人： Erwin Houtzager , Irma Vijn , Cornelis Francoijs , Peter Sijmons
发明人： Erwin Houtzager , Irma Vijn , Cornelis Francoijs , Peter Sijmons
IPC分类号： C07K14/705 , C12N15/10 , G01N33/53
CPC分类号： C07K14/70503 , C07K2319/00 , C12N15/1044
摘要： Provided are means and methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
摘要翻译：提供了用于产生与合适核心区域相关联的结合肽，所得蛋白质分子及其用途的方法和方法。本发明提供了在整个使用范围内与使用结合分子相关的问题的解决方案。结合分子可以设计成适应极端的使用条件，如极端的温度或pH值。或者，可以设计结合分子以响应环境中非常微妙的变化。

4. 发明申请

US20060140889A1 Affinity proteins for controlled application of cosmetic substances 审中-公开
标题翻译：用于受控应用化妆品物质的亲和蛋白质
公开(公告)号：US20060140889A1
公开(公告)日：2006-06-29
申请号：US11150871
申请日：2005-06-10
申请人： Erwin Houtzager , Irma Vijn , Peter Sijmons , Grant Mudge , Addi Fadel
发明人： Erwin Houtzager , Irma Vijn , Peter Sijmons , Grant Mudge , Addi Fadel
IPC分类号： A61K8/64 , A61K8/65 , C11D3/386
CPC分类号： A61Q19/00 , A61K8/64 , A61K8/65 , A61K47/6435 , A61K47/6803 , A61K2800/57 , A61Q1/02 , A61Q1/06 , A61Q5/10 , A61Q11/00 , A61Q13/00 , A61Q15/00
摘要： Provided are means and methods for applying a cosmetic substance to a desired target. The method comprises providing a conjugate of a proteinaceous substance having a specific affinity for the target molecule linked to a cosmetic substance, whereby the resulting connection between the cosmetic substance and the target molecule can be disrupted upon the presence of a chemical and/or physical signal.
摘要翻译：提供了将化妆品应用于期望的靶标的方法和方法。该方法包括提供与化妆品物质连接的靶分子具有特异性亲和性的蛋白质物质的缀合物，由此化妆品物质和靶分子之间的连接可以在存在化学和/或物理信号时被破坏。

5. 发明授权

US07070926B2 Chimaeric phages 失效
公开(公告)号：US07070926B2
公开(公告)日：2006-07-04
申请号：US09882621
申请日：2001-06-15
申请人： Erwin Houtzager , Ton Logtenberg , Cornelis A. de Kruif
发明人： Erwin Houtzager , Ton Logtenberg , Cornelis A. de Kruif
IPC分类号： C12Q1/68
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/14121 , C12N2795/14122
摘要： A chimeric phage having a coat comprising a mixture of proteins. The mixture of proteins includes a fusion protein wherein a protein is fused to a functional form of a phage coat protein, and a mutant form of the phage coat protein characterized in that a phage having no wild type phage coat protein from which the mutant form is derived but having a coat comprising the mutant form and no copies of the functional form is less infectious than a phage comprising no wild type phage coat protein from which the mutant form is derived and having a coat comprising the mutant form and at least one copy of the functional form. Also, the associated phage collection comprising the chimaeric phage or an infectious phage containing at least one copy of a mutant form of a phage coat protein wherein the mutant form has lost the ability to mediate infection of a natural host by the infectious phage. Also a method for producing a phage particle. Also, a helper phage having a nucleic acid encoding phage proteins or functional equivalents for the assembly of the helper phage.

6. 发明申请

US20090017521A1 Chimaeric phages 有权
标题翻译：杂种噬菌体
公开(公告)号：US20090017521A1
公开(公告)日：2009-01-15
申请号：US11977954
申请日：2007-10-26
申请人： Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
发明人： Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
IPC分类号： C12N7/00
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/10021 , C12N2795/10022
摘要： The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.
摘要翻译：本发明涉及产生辅助噬菌体和用于鉴定结合分子的噬菌体展示文库的领域。本发明提供具有包含蛋白质混合物的衣服的嵌合噬菌体。蛋白质混合物包含具有融合到噬菌体外壳蛋白的功能形式的蛋白质分子和噬菌体外壳蛋白的突变形式的融合蛋白，其中所述突变形式在与宿主细胞受体结合中受损。本发明还提供了新的噬菌体集合，新颖的辅助噬菌体以及用于产生嵌合噬菌体，感染性噬菌体和辅助噬菌体的方法和手段。

7. 发明申请

US20070269888A1 Bioreactor Assembly Comprising at Least One Tray-Like Rocking Platform 失效
标题翻译：生物反应器组装包括最少一个类似托盘的摇摆平台
公开(公告)号：US20070269888A1
公开(公告)日：2007-11-22
申请号：US11663532
申请日：2005-07-01
申请人： Erwin Houtzager , Sander Huurman
发明人： Erwin Houtzager , Sander Huurman
IPC分类号： C12N7/00 , C12N1/20 , C12N5/06
CPC分类号： B01F11/0017 , C12M23/14 , C12M23/28 , C12M23/48 , C12M27/16
摘要： The present invention relates to a bioreactor assembly comprising a reactor frame that permits linear upscaling under identical conditions of culture volumes from two liters to thousands of liters. The bioreactor comprises at least one rocking platforms being capable of holding at least one disposable bag adapted for receiving a total volume of at least 2 liters. Said at least one platforms have a tray-like shape, that induces the fluid in the bag to move and form a wave-like motion. Said at least one platforms are attached to the reactor frame and are positioned on top of each other along a vertical axis. In particular, the weight distribution of the rocking platforms is approximately in balance during rocking. The present invention further relates to methods using the bioreactor assembly.
摘要翻译：本发明涉及一种生物反应器组件，其包括反应器框架，该反应器框架允许在从两升到几千升的相同培养体积条件下进行线性升高。生物反应器包括至少一个摆动平台，其能够容纳至少一个适于接收至少2升的总体积的一次性袋。所述至少一个平台具有托盘状形状，其引导袋中的流体移动并形成波状运动。所述至少一个平台连接到反应器框架并且沿垂直轴线彼此定位在顶部。特别地，在摇摆过程中摇摆平台的重量分布近似平衡。本发明还涉及使用生物反应器组件的方法。

8. 发明授权

US07901919B2 Chimaeric phages 有权
标题翻译：杂种噬菌体
公开(公告)号：US07901919B2
公开(公告)日：2011-03-08
申请号：US11977954
申请日：2007-10-26
申请人： Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
发明人： Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
IPC分类号： C12N7/00 , C12N7/01 , C12P21/06
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/10021 , C12N2795/10022
摘要： The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.
摘要翻译：本发明涉及产生辅助噬菌体和用于鉴定结合分子的噬菌体展示文库的领域。本发明提供具有包含蛋白质混合物的衣服的嵌合噬菌体。蛋白质混合物包含具有融合到噬菌体外壳蛋白的功能形式的蛋白质分子和噬菌体外壳蛋白的突变形式的融合蛋白，其中所述突变形式在与宿主细胞受体结合中受损。本发明还提供了新的噬菌体集合，新颖的辅助噬菌体以及用于产生嵌合噬菌体，感染性噬菌体和辅助噬菌体的方法和手段。

9. 发明申请

US20100146647A1 Antibody producing non-human mammals 审中-公开
标题翻译：产生非人类哺乳动物的抗体
公开(公告)号：US20100146647A1
公开(公告)日：2010-06-10
申请号：US12589181
申请日：2009-10-19
申请人： Ton Logtenberg , Mark Throsby , Robert A. Kramer , Rui Daniel Pinto , Cornelis A. de Kruif , Erwin Houtzager
发明人： Ton Logtenberg , Mark Throsby , Robert A. Kramer , Rui Daniel Pinto , Cornelis A. de Kruif , Erwin Houtzager
IPC分类号： C12P21/00 , A01K67/027 , C12N5/10
CPC分类号： C07K16/1282 , A01K67/027 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K16/248 , C07K2317/24 , C12N15/8509 , C12P21/00
摘要： Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
摘要翻译：描述了包含编码免疫球蛋白轻链的核酸的转基因非人动物，其中免疫球蛋白轻链是人类，人类样或人源化的。为核酸提供了使其对DNA重排和/或体细胞超突变有抗性的手段。在一个实施方案中，所述核酸包含用于在发育成熟B细胞的细胞的某一发育阶段期间在细胞中表达所需分子的表达盒。还提供了从转基因非人动物制备免疫球蛋白的方法。

10. 发明申请

US20050014261A1 Chimaeric phages 有权
标题翻译：杂种噬菌体
公开(公告)号：US20050014261A1
公开(公告)日：2005-01-20
申请号：US10480978
申请日：2002-06-14
申请人： Erwin Houtzager , Ton Logtenberg , Cornelis De Kruif
发明人： Erwin Houtzager , Ton Logtenberg , Cornelis De Kruif
IPC分类号： C07K14/005 , C12N7/00 , C12N15/10 , C12N15/74 , C12N15/86 , C40B40/02 , G01N33/68
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/10021 , C12N2795/10022
摘要： The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.
摘要翻译：本发明涉及产生辅助噬菌体和用于鉴定结合分子的噬菌体展示文库的领域。本发明提供具有包含蛋白质混合物的衣服的嵌合噬菌体。蛋白质混合物包含具有融合到噬菌体外壳蛋白的功能形式的蛋白质分子和噬菌体外壳蛋白的突变形式的融合蛋白，其中所述突变形式在与宿主细胞受体结合中受损。本发明还提供了新的噬菌体集合，新颖的辅助噬菌体以及用于产生嵌合噬菌体，感染性噬菌体和辅助噬菌体的方法和手段。

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