专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5091185A Coated veterinary implants 失效
标题翻译：涂层兽医植入物
公开(公告)号：US5091185A
公开(公告)日：1992-02-25
申请号：US541114
申请日：1990-06-20
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/22 , A61K9/50 , A61K38/27 , A61K47/32 , A61P15/00
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering 3 to 25 .mu.m PVA/mm.sup.2.

2. 发明授权

US5232708A Coated veterinary implants 失效
标题翻译：涂有兽用植入物
公开(公告)号：US5232708A
公开(公告)日：1993-08-03
申请号：US886220
申请日：1992-05-21
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/32 , A61K9/50 , A61K38/27
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering of from about 3 to 25 ug PVA/mm.sup.2 surface area of pellet.
摘要翻译：用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成约3至25ug PVA的连续均匀覆盖 / mm2颗粒表面积。

3. 发明授权

US5156851A Coated veterinary implants 失效
标题翻译：涂有兽用植入物
公开(公告)号：US5156851A
公开(公告)日：1992-10-20
申请号：US762202
申请日：1991-09-19
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/50 , A61K9/58 , A61K38/27
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering having a weight of from about 3 to 25 ug/mm.sup.2.
摘要翻译：用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成重量为约3至 25 ug / mm2。

4. 发明授权

US09107821B2 Stable bortezomib formulations 有权
标题翻译：稳定的硼替佐米制剂
公开(公告)号：US09107821B2
公开(公告)日：2015-08-18
申请号：US13592228
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69 , A61K31/4965 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/19 , C07B63/04
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译：硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。

5. 发明申请

US20120322763A1 Stable Bortezomib Formulations 有权
公开(公告)号：US20120322763A1
公开(公告)日：2012-12-20
申请号：US13592235
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.

6. 发明授权

US09180093B2 Stable bortezomib formulations 有权
公开(公告)号：US09180093B2
公开(公告)日：2015-11-10
申请号：US13592235
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69 , A61K31/4965 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/19 , C07B63/04
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.

7. 发明申请

US20110230441A1 STABLE BORTEZOMIB FORMULATIONS 有权
标题翻译：稳定的BORTEZOMIB配方
公开(公告)号：US20110230441A1
公开(公告)日：2011-09-22
申请号：US13051102
申请日：2011-03-18
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69 , C07F5/02 , C07K5/08 , A61P35/00
CPC分类号： A61K31/69 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4965 , A61K47/10
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译：硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。

8. 发明申请

US20100330158A1 PROTEIN-ASSISTED DRUG DELIVERY SYSTEM FOR THE TARGETED ADMINISTRATION OF ACTIVE AGENTS 审中-公开
标题翻译：蛋白质辅助药物输送系统，用于有针对性的药剂管理
公开(公告)号：US20100330158A1
公开(公告)日：2010-12-30
申请号：US12748221
申请日：2010-03-26
申请人： Vishal Soni , Kanaiyalal R. Patel , Dasaradhi Lakkaraju , Navneet Puri
发明人： Vishal Soni , Kanaiyalal R. Patel , Dasaradhi Lakkaraju , Navneet Puri
IPC分类号： A61K9/127 , A61K38/00 , A61P25/00
CPC分类号： A61K9/1271 , A61K38/164 , Y02A50/473
摘要： The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically acceptable active agent and at least one protein selected from the group consisting of a fimbrial adhesin protein, a membrane protein, and combinations thereof. The inventive compositions and prodrugs of the present invention selectively target the blood-brain barrier and deliver hydrophilic and lipophilic active agents of varying sizes to the central nervous system.
摘要翻译：本发明提供了用于靶向药物递送至患者的中枢神经系统的组合物和前药。本发明的组合物和前药包括药学上可接受的活性剂和至少一种选自纤毛粘连素蛋白，膜蛋白及其组合的蛋白质。本发明的本发明组合物和前药选择性地靶向血脑屏障，并将不同大小的亲水和亲脂性活性剂递送至中枢神经系统。

9. 发明授权

US07037516B2 Non-aqueous surfactant-containing formulations for extended release of somatotropin 有权
公开(公告)号：US07037516B2
公开(公告)日：2006-05-02
申请号：US10792992
申请日：2004-03-04
申请人： Yunhua N. Jeng , Kanaiyalal R. Patel
发明人： Yunhua N. Jeng , Kanaiyalal R. Patel
IPC分类号： C07K15/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/107 , A61K38/1709 , A61K47/10 , A61K47/26
摘要： The present invention provides compositions comprising biologically-active somatotropin formulated for extended release and methods of preparing and methods of using the same. These compositions comprise somatotropin, at least a first bioavailability-enhancing constituent (BEC), and a substantially non-aqueous, hydrophobic excipient, and optionally a second BEC. The first BEC is typically a surfactant (preferably a non-ionic surfactant) or a cyclodextrin compound. The optional second BEC may comprise (i) amino acids or amino acid derivatives; (ii) hydroxamate derivatives; (iii) non-reducing carbohydrates; (iv) oxo-acid salts; or (v) a mixture of two or more compounds from within the foregoing classes (i)–(iv).

10. 发明授权

US07048938B2 Non-aqueous injectable formulations for extended release of somatotropin 有权
标题翻译：用于延长生长激素释放的非水性注射用制剂
公开(公告)号：US07048938B2
公开(公告)日：2006-05-23
申请号：US10793232
申请日：2004-03-04
申请人： Kanaiyalal R. Patel , Yunhua N. Jeng
发明人： Kanaiyalal R. Patel , Yunhua N. Jeng
IPC分类号： C07K15/00
CPC分类号： A61K38/27 , A61K9/0019 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/44
摘要： The present invention provides compositions which allow for the extended release and enhanced bioavailability of biologically-active polypeptides following parenteral delivery to an animal. More particularly, it concerns compositions comprising biologically-active somatotropin formulated for extended release, methods of preparing these compositions, and methods of using the same. These compositions comprise somatotropin, a bioavailability-enhancing constituent (BEC), and a substantially non-aqueous, hydrophobic excipient. The BEC may comprise (i) amino acids or amino acid derivatives, such as histidine-HCl; (ii) hydroxamate derivatives, such as histidine hydroxamate or suberohydroxamic acid; (iii) non-reducing carbohydrates, such as trehalose or trehalose octaacetate; (iv) oxo-acid salts, such as a mixture of monobasic and dibasic sodium phosphate; or (v) a mixture of two or more compounds from within the foregoing classes (i)–(iv).
摘要翻译：本发明提供了允许在肠胃外输送到动物后的生物活性多肽的延长释放和增强的生物利用度的组合物。更具体地，涉及包含用于延长释放的生物活性生长激素配制剂，制备这些组合物的方法和使用该组合物的方法的组合物。这些组合物包含生长激素，生物利用度增加成分（BEC）和基本上非水性的疏水性赋形剂。 BEC可以包含（i）氨基酸或氨基酸衍生物，例如组氨酸-HCl; （ii）异羟肟酸衍生物，例如羟肟酸组氨酸或苏泊酸肟酸; （iii）非还原性碳水化合物，例如海藻糖或海藻糖八乙酸酯; （iv）含氧酸盐，例如一元和二元磷酸钠的混合物; 或（v）来自上述（i） - （iv）类的两种或更多种化合物的混合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式