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1. 发明授权

US4124533A Metal coordination complexes containing optically active phosphine or arsine ligands 失效
标题翻译：含有光学活性膦或胂配体的金属配位络合物
公开(公告)号：US4124533A
公开(公告)日：1978-11-07
申请号：US559200
申请日：1975-03-17
申请人： William S. Knowles , Milton J. Sabacky
发明人： William S. Knowles , Milton J. Sabacky
IPC分类号： B01J31/18 , B01J31/22 , B01J31/24 , C07F9/32 , C07F9/34 , C07F9/40 , C07F9/53 , C07F15/00
CPC分类号： C07F9/53 , B01J31/2291 , B01J31/2404 , C07F9/32 , C07F9/34 , C07F9/40 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/825 , B01J2531/827 , B01J2531/828
摘要： Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.
摘要翻译： β-取代-α-酰氨基 - 丙烯酸均相催化氢化的方法，其在氢化后产生光学活性混合物。该方法包括在光学活性配位金属络合物氢化催化剂存在下β-取代-α-酰氨基丙烯酸的氢化，其中金属选自铑，铱，钌，锇，钯和铂。

2. 发明授权

US5232708A Coated veterinary implants 失效
标题翻译：涂有兽用植入物
公开(公告)号：US5232708A
公开(公告)日：1993-08-03
申请号：US886220
申请日：1992-05-21
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/32 , A61K9/50 , A61K38/27
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering of from about 3 to 25 ug PVA/mm.sup.2 surface area of pellet.
摘要翻译：用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成约3至25ug PVA的连续均匀覆盖 / mm2颗粒表面积。

3. 发明授权

US5091185A Coated veterinary implants 失效
标题翻译：涂层兽医植入物
公开(公告)号：US5091185A
公开(公告)日：1992-02-25
申请号：US541114
申请日：1990-06-20
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/22 , A61K9/50 , A61K38/27 , A61K47/32 , A61P15/00
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering 3 to 25 .mu.m PVA/mm.sup.2.

4. 发明授权

US4119652A Catalytic asymmetric hydrogenation 失效
标题翻译：催化不对称氢化
公开(公告)号：US4119652A
公开(公告)日：1978-10-10
申请号：US700254
申请日：1976-06-25
申请人： William S. Knowles , Milton J. Sabacky
发明人： William S. Knowles , Milton J. Sabacky
IPC分类号： B01J31/18 , B01J31/24 , C07C5/03 , C07C45/62 , C07C51/36 , C07F15/00
CPC分类号： C07F15/008 , B01J31/1875 , B01J31/188 , B01J31/1895 , B01J31/24 , C07C45/62 , C07C5/03 , C07C51/36 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/825 , B01J2531/827 , B01J2531/828 , C07C2531/22 , C07C2531/24
摘要： Process for the homogeneous catalytic hydrogenation of olefins, capable of existing as enantiomorphs upon hydrogenation of the olefinic bond, which yields on hydrogenation an optically active mixture. The process comprises the hydrogenation of the olefin in the presence of an optically active coordinated metal hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.This process is a generalized process for any asymmetric hydrogenation of olefins in which one optical enantiomorph is desired. It is also a generalized process for the selective hydrogenation of olefins in the presence of other reactive groups which are easily hydrogenated. It is especially useful for the preparation of natural products which possess optical activity, such as amino acids, and for products such as flavors, fragrances which may require optical activity for their utilitization.This invention also relates to new optically active coordinated hydrogenation catalysts.
摘要翻译：用于烯烃均相催化氢化的方法，其能够在烯烃键氢化时作为对映体存在，其在氢化时产生光学活性混合物。该方法包括在光学活性配位金属氢化催化剂存在下对烯烃进行氢化，其中金属选自铑，铱，钌，锇，钯和铂。

5. 发明授权

US4294989A Methylcyclohexyl-O-anisylphosphine 失效
标题翻译：甲基环己基-O-茴香醚
公开(公告)号：US4294989A
公开(公告)日：1981-10-13
申请号：US939568
申请日：1978-09-05
申请人： William S. Knowles , Milton J. Sabacky
发明人： William S. Knowles , Milton J. Sabacky
IPC分类号： B01J31/18 , B01J31/24 , C07F9/32 , C07F9/34 , C07F9/40 , C07F9/50 , C07F9/53 , C07F9/70
CPC分类号： C07F9/70 , B01J31/1875 , B01J31/2404 , C07F9/32 , C07F9/34 , C07F9/40 , C07F9/50 , C07F9/53 , B01J2231/645 , B01J2531/822
摘要： Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.
摘要翻译： β-取代-α-酰氨基 - 丙烯酸均相催化氢化的方法，其在氢化后产生光学活性混合物。该方法包括在光学活性配位金属络合物氢化催化剂存在下β-取代-α-酰氨基丙烯酸的氢化，其中金属选自铑，铱，钌，锇，钯和铂。该方法是用于β-取代-α-酰氨基 - 丙烯酸的任何不对称氢化的通用方法，其中一个α-氨基酸对映体是所需的最终产物。特别适用于制备具有光学活性且具有附着于不对称中心的氢的自然界中发现的α-氨基酸。本发明还涉及新的光学活性配位金属络合物氢化催化剂。

6. 发明授权

US4142992A Asymmetric catalysis 失效
标题翻译：不对称催化
公开(公告)号：US4142992A
公开(公告)日：1979-03-06
申请号：US724049
申请日：1976-09-16
申请人： William S. Knowles , Milton J. Sabacky , Billy D. Vineyard
发明人： William S. Knowles , Milton J. Sabacky , Billy D. Vineyard
IPC分类号： C07C233/47 , B01J27/14 , B01J31/24 , C07C231/16 , C07F9/02 , C07F9/50 , B01J31/12
CPC分类号： B01J31/2409 , B01J31/24 , B01J31/2414 , C07F9/02 , C07F9/5027 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827
摘要： New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.

7. 发明授权

US4130410A Herbicidal use of substituted phenyl phosphinic acids 失效
标题翻译：除草剂使用取代苯基次膦酸
公开(公告)号：US4130410A
公开(公告)日：1978-12-19
申请号：US773625
申请日：1977-03-02
申请人： Milton J. Sabacky
发明人： Milton J. Sabacky
IPC分类号： A01N57/22 , A01N9/36
CPC分类号： A01N57/22
摘要： Substituted phenyl phosphinic acids and derivatives thereof exhibit herbicidal activity, especially when used to control broadleaf weeds.
摘要翻译：取代的苯基次膦酸及其衍生物表现出除草活性，特别是当用于控制阔叶杂草时。

8. 发明授权

US4008281A Asymmetric catalysis 失效
标题翻译：不对称催化
公开(公告)号：US4008281A
公开(公告)日：1977-02-15
申请号：US514987
申请日：1974-10-15
申请人： William S. Knowles , Milton J. Sabacky , Billy D. Vineyard
发明人： William S. Knowles , Milton J. Sabacky , Billy D. Vineyard
IPC分类号： C07B31/00 , B01J20060101 , B01J27/18 , B01J31/00 , B01J31/18 , B01J31/24 , B01J31/28 , C07B53/00 , C07B61/00 , C07C20060101 , C07C51/36 , C07C57/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07C231/18 , C07C233/47 , C07D209/10 , C07D233/64 , C07D307/38 , C07D317/48 , C07D333/24 , C07F20060101 , C07F9/02 , C07F9/48 , C07F9/50 , C07F15/00 , C07F9/53
CPC分类号： B01J31/24 , B01J31/2409 , B01J31/2414 , C07F15/0073 , C07F15/008 , C07F9/02 , C07F9/5027 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , B01J31/1875
摘要： New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.
摘要翻译：可用于光学活性催化剂的新的光学活性双膦化合物。这种催化剂特别适用于催化不对称氢化。

9. 发明授权

US5156851A Coated veterinary implants 失效
标题翻译：涂有兽用植入物
公开(公告)号：US5156851A
公开(公告)日：1992-10-20
申请号：US762202
申请日：1991-09-19
申请人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
发明人： Ernesto J. Castillo , Kenneth E. Eigenberg , Kanaiyalal R. Patel , Milton J. Sabacky
IPC分类号： A61K9/00 , A61K9/50 , A61K9/58 , A61K38/27
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering having a weight of from about 3 to 25 ug/mm.sup.2.
摘要翻译：用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成重量为约3至 25 ug / mm2。

10. 发明授权

US4265827A Catalytic asymmetric hydrogenation 失效
标题翻译：催化不对称氢化
公开(公告)号：US4265827A
公开(公告)日：1981-05-05
申请号：US939569
申请日：1978-09-05
申请人： William S. Knowles , Milton J. Sabacky
发明人： William S. Knowles , Milton J. Sabacky
IPC分类号： B01J31/18 , B01J31/24 , C07F9/32 , C07F9/34 , C07F9/40 , C07F9/50 , C07F9/53 , C07F9/70 , C07F9/68
CPC分类号： C07F9/70 , B01J31/1875 , B01J31/1895 , B01J31/2404 , C07F9/32 , C07F9/34 , C07F9/40 , C07F9/50 , C07F9/53 , B01J2231/645 , B01J2531/822
摘要： Process for the homogeneous catalytic hydrogenation of .alpha.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.beta.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.
摘要翻译： α-取代-α-酰氨基丙烯酸的均相催化氢化的方法，其在氢化后产生光学活性混合物。该方法包括在光学活性配位金属络合物氢化催化剂存在下，β-取代-β-酰氨基丙烯酸的氢化，其中金属选自铑，铱，钌，锇，钯和铂。该方法是用于β-取代-α-酰氨基 - 丙烯酸的任何不对称氢化的通用方法，其中一个α-氨基酸对映体是所需的最终产物。特别适用于制备具有光学活性且具有附着于不对称中心的氢的自然界中发现的α-氨基酸。本发明还涉及新的光学活性配位金属络合物氢化催化剂。

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