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1. 发明授权

US07919594B2 Human anti-CD100 antibodies 有权
标题翻译：人抗CD100抗体
公开(公告)号：US07919594B2
公开(公告)日：2011-04-05
申请号：US12030356
申请日：2008-02-13
申请人： Ernest S. Smith , Terrence Lee Fisher, Jr. , Maurice Zauderer
发明人： Ernest S. Smith , Terrence Lee Fisher, Jr. , Maurice Zauderer
IPC分类号： C12P21/08 , C07K16/00 , C07K17/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for treating diseases associated with CD100, including certain types of cancers, autoimmune diseases, inflammatory diseases including central nervous system (CNS) and peripheral nervous system (PNS) inflammatory diseases, transplant rejections, and invasive angiogenesis. Compositions include anti-CD100 antibodies capable of binding to a soluble human CD100 antigen or a CD100 antigen located on the surface of a human CD100-expressing cell, wherein the antibody has CD100 blocking activity that is achieved by having at least one optimized CDR or FWR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD100 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD100 antibodies.
摘要翻译：提供用于治疗与CD100相关的疾病的组合物和方法，包括某些类型的癌症，自身免疫疾病，包括中枢神经系统（CNS）和周围神经系统（PNS）炎性疾病，移植排斥和侵袭性血管发生的炎性疾病。组合物包括能够结合位于人CD100表达细胞表面的可溶性人CD100抗原或CD100抗原的抗CD100抗体，其中所述抗体具有CD100阻断活性，其通过具有至少一种优化的CDR或FWR 在抗体的可变区内工程化。组合物还包括单克隆抗体的抗原结合片段，变体和衍生物，产生这些抗体组合物的细胞系和编码抗体氨基酸序列的分离的核酸分子。本发明还包括药物组合物，其包含本发明的抗CD100抗体或其药学上可接受的载体中的抗原结合片段，变体或衍生物，以及这些抗CD100抗体的使用方法。

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