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1. 发明授权

US06994826B1 Method and apparatus for controlling cross contamination of microfluid channels 有权
标题翻译：用于控制微流体通道交叉污染的方法和装置
公开(公告)号：US06994826B1
公开(公告)日：2006-02-07
申请号：US09669862
申请日：2000-09-26
申请人： Ernest F. Hasselbrink, Jr. , Jason E. Rehm , Phillip H. Paul , Don W. Arnold
发明人： Ernest F. Hasselbrink, Jr. , Jason E. Rehm , Phillip H. Paul , Don W. Arnold
IPC分类号： B01L3/02 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502746 , B01L2200/0605 , B01L2300/0861 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/086
摘要： A method for controlling fluid flow at junctions in microchannel systems. Control of fluid flow is accomplished generally by providing increased resistance to electric-field and pressure-driven flow in the form of regions of reduced effective cross-sectional area within the microchannels and proximate a channel junction. By controlling these flows in the region of a microchannel junction it is possible to eliminate sample dispersion and cross contamination and inject well-defined volumes of fluid from one channel to another.
摘要翻译：一种用于控制微通道系统中接合处流体流动的方法。流体流动的控制通常通过以微通道内和接近通道连接处的有效截面积减小的区域形式的电场和压力驱动流提供增加的阻力来实现。通过控制这些在微通道连接区域中的这些流动，可以消除样品分散和交叉污染，并将明确定义的体积从一个通道注入另一个通道。

2. 发明授权

US07927477B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US07927477B2
公开(公告)日：2011-04-19
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

3. 发明申请

US20090090174A1 Precision Flow Control System 有权
标题翻译：精密流量控制系统
公开(公告)号：US20090090174A1
公开(公告)日：2009-04-09
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G01N30/32 , B01D35/14 , G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

4. 发明授权

US08685218B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US08685218B2
公开(公告)日：2014-04-01
申请号：US13046496
申请日：2011-03-11
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

5. 发明申请

US20110186157A1 Precision Flow Control System 有权
标题翻译：精密流量控制系统
公开(公告)号：US20110186157A1
公开(公告)日：2011-08-04
申请号：US13046496
申请日：2011-03-11
申请人： Phillip H. PAUL , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. PAUL , Jason E. Rehm , Don W. Arnold
IPC分类号： F15D1/00
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

6. 发明授权

US07465382B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US07465382B2
公开(公告)日：2008-12-16
申请号：US10246284
申请日：2002-09-17
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04 , B01L11/00
CPC分类号： G05D7/0682 , G01N30/32 , G01N30/34 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

7. 发明授权

US08021056B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US08021056B2
公开(公告)日：2011-09-20
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

8. 发明申请

US20110018259A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20110018259A1
公开(公告)日：2011-01-27
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： F16L25/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

9. 发明授权

US07802923B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US07802923B2
公开(公告)日：2010-09-28
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

10. 发明申请

US20090129728A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20090129728A1
公开(公告)日：2009-05-21
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/00 , F16J15/02
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

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