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1. 发明授权

US08021056B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US08021056B2
公开(公告)日：2011-09-20
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

2. 发明申请

US20110018259A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20110018259A1
公开(公告)日：2011-01-27
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： F16L25/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

3. 发明授权

US07802923B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US07802923B2
公开(公告)日：2010-09-28
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

4. 发明申请

US20090129728A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20090129728A1
公开(公告)日：2009-05-21
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/00 , F16J15/02
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

5. 发明授权

US07175810B2 Processing of particles 有权
标题翻译：颗粒加工
公开(公告)号：US07175810B2
公开(公告)日：2007-02-13
申请号：US10849715
申请日：2004-05-19
申请人： Don W. Arnold , David J. Rakestraw , Phillip H. Paul , Patrick Pak-Ho Leung
发明人： Don W. Arnold , David J. Rakestraw , Phillip H. Paul , Patrick Pak-Ho Leung
IPC分类号： G01N33/48
CPC分类号： G01N21/05 , G01N15/1404 , G01N15/1459 , G01N21/64 , G01N27/447 , G01N33/54313 , G01N2015/1497 , G01N2021/0346 , G01N2035/00564 , Y10T436/2575
摘要： Particles dispersed in a liquid are assembled in a configuration in which all the particles lie in the same plane, and the assembled particles are processed while in that configuration. The assembled particles can for example be simultaneously exposed to electromagnetic radiation which elicits from the particles a response which provides information about the particles. The particles can for example be cells, cell fragments, or analyte-bearing beads of the type conventionally analyzed in a cytometer.
摘要翻译：分散在液体中的颗粒以其中所有颗粒位于相同平面中的构型组装，并且组装的颗粒在该构造中被处理。组装的颗粒可以例如同时暴露于从颗粒引起的电磁辐射，该响应提供关于颗粒的信息。颗粒可以例如是在细胞计数器中常规分析的类型的细胞，细胞碎片或分析物携带珠。

6. 发明授权

US06572749B1 Electrokinetic high pressure hydraulic system 有权
标题翻译：电动高压液压系统
公开(公告)号：US06572749B1
公开(公告)日：2003-06-03
申请号：US09912154
申请日：2001-07-23
申请人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号： B05B500
CPC分类号： G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based system. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译：一种电动高压液压泵，用于在毛细管系统中操纵流体。泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体特别是在毛细管系统（微系统）中流动。本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及现场可携带性。通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。

7. 发明授权

US06277257B1 Electrokinetic high pressure hydraulic system 有权
标题翻译：电动高压液压系统
公开(公告)号：US06277257B1
公开(公告)日：2001-08-21
申请号：US09271687
申请日：1999-03-18
申请人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号： B01D6144
CPC分类号： G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译：一种电动高压液压泵，用于在毛细管系统中操纵流体。泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体特别是在毛细管系统（Microsystems）中通常流动。本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及现场可携带性。通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。

8. 发明授权

US07927477B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US07927477B2
公开(公告)日：2011-04-19
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

9. 发明申请

US20090090174A1 Precision Flow Control System 有权
标题翻译：精密流量控制系统
公开(公告)号：US20090090174A1
公开(公告)日：2009-04-09
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G01N30/32 , B01D35/14 , G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

10. 发明授权

US08685218B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US08685218B2
公开(公告)日：2014-04-01
申请号：US13046496
申请日：2011-03-11
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

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