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1. 发明授权

US08423117B2 System and method to process an acquired image of a subject anatomy to differentiate a portion of subject anatomy to protect relative to a portion to receive treatment 有权
标题翻译：用于处理受试者解剖结构的获得图像以区分受试者解剖结构的一部分以相对于接受治疗的部分进行保护的系统和方法
公开(公告)号：US08423117B2
公开(公告)日：2013-04-16
申请号：US12489138
申请日：2009-06-22
申请人： Eric Pichon , Stephen Solomon , George Getrajdman , Michel Grimaud , Yves Trousset
发明人： Eric Pichon , Stephen Solomon , George Getrajdman , Michel Grimaud , Yves Trousset
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B6/469 , A61B6/488 , A61B6/504 , A61B6/5235 , A61B6/5247 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61B2017/00243 , A61B2034/104 , A61B2034/105 , G06T7/12 , G06T2207/10121 , G06T2207/30101
摘要： A system and method to process an acquired image to differentiate a portion of subject anatomy to protect relative to a portion of anatomy to receive treatment is provided. The system includes a controller with program instructions to perform the steps of receiving an instruction to indicate a zone interest of the imaged anatomy to protect associated with treatment of the subject anatomy; calculating a first set of image elements associated with a first circulatory network in communication to supply a first zone of interest to treat and not in communication to supply a second zone of interest to protect; calculating a second set of image elements of the acquired image associated with a second circulatory network in communication to supply the second zone of interest to protect; and creating a display that differentiates the second set of image elements from a remainder of the acquired image.
摘要翻译：提供了一种用于处理所获取的图像以区分对象解剖结构的一部分以相对于解剖部分以接受治疗来保护的系统和方法。该系统包括具有程序指令的控制器，以执行以下步骤：接收指示所述成像解剖结构的区域兴趣以保护与所述对象解剖结构的治疗相关联的指令; 计算与通信中的第一循环网络相关联的第一组图像元素，以提供第一感兴趣区域来处理而不是通信以提供第二感兴趣区域以进行保护; 计算与通信中的第二循环网络相关联的所获取的图像的第二组图像元素，以提供所述第二感兴趣区域以进行保护; 以及创建将所述第二组图像元素与所获取的图像的其余部分区分开的显示器。

2. 发明申请

US20100324407A1 SYSTEM AND METHOD TO PROCESS AN ACQUIRED IMAGE OF A SUBJECT ANATOMY TO DIFFERENTIATE A PORTION OF SUBJECT ANATOMY TO PROTECT RELATIVE TO A PORTION TO RECEIVE TREATMENT 有权
标题翻译：用于处理主题解剖图的获得图像的系统和方法，以区分主题解剖部分相对于接受处理的部分的部分
公开(公告)号：US20100324407A1
公开(公告)日：2010-12-23
申请号：US12489138
申请日：2009-06-22
申请人： Eric Pichon , Stephen Solomon , George Getrajdman , Michel Grimaud , Yves Trousset
发明人： Eric Pichon , Stephen Solomon , George Getrajdman , Michel Grimaud , Yves Trousset
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B6/12 , A61B6/469 , A61B6/488 , A61B6/504 , A61B6/5235 , A61B6/5247 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61B2017/00243 , A61B2034/104 , A61B2034/105 , G06T7/12 , G06T2207/10121 , G06T2207/30101
摘要： A system and method to process an acquired image to differentiate a portion of subject anatomy to protect relative to a portion of anatomy to receive treatment is provided. The system includes a controller with program instructions to perform the steps of receiving an instruction to indicate a zone interest of the imaged anatomy to protect associated with treatment of the subject anatomy; calculating a first set of image elements associated with a first circulatory network in communication to supply a first zone of interest to treat and not in communication to supply a second zone of interest to protect; calculating a second set of image elements of the acquired image associated with a second circulatory network in communication to supply the second zone of interest to protect; and creating a display that differentiates the second set of image elements from a remainder of the acquired image.
摘要翻译：提供了一种用于处理所获取的图像以区分对象解剖结构的一部分以相对于解剖部分以接受治疗来保护的系统和方法。该系统包括具有程序指令的控制器，以执行以下步骤：接收指示所述成像解剖结构的区域兴趣以保护与所述对象解剖结构的治疗相关联的指令; 计算与通信中的第一循环网络相关联的第一组图像元素，以提供第一感兴趣区域来处理而不是通信以提供第二感兴趣区域以进行保护; 计算与通信中的第二循环网络相关联的所获取的图像的第二组图像元素，以提供所述第二感兴趣区域以进行保护; 以及创建将所述第二组图像元素与所获取的图像的其余部分区分开的显示器。

3. 发明申请

US20050222793A1 Method and system for calibrating deformed instruments 审中-公开
标题翻译：校准变形仪器的方法和系统
公开(公告)号：US20050222793A1
公开(公告)日：2005-10-06
申请号：US10817652
申请日：2004-04-02
申请人： Charles Lloyd , Michel Grimaud , Alex Li , Lewis Levine , Jon Lea
发明人： Charles Lloyd , Michel Grimaud , Alex Li , Lewis Levine , Jon Lea
IPC分类号： A61B5/05 , A61B19/00 , G01C19/00
CPC分类号： A61B90/36 , A61B34/20 , A61B2034/102 , A61B2034/2051 , A61B2034/2055 , A61B2034/207 , A61B2090/0813
摘要： Certain embodiments of the present invention provide a system and method for calibrating an instrument for an image-guided operation. The method includes placing a plurality of fiducials on an instrument, obtaining a plurality of measurements for the instrument using the plurality of fiducials, determining a representation of the instrument in a reference coordinate system using the plurality of measurements for use in tracking the instrument, and performing an image-guided operation using an image data set and representation of the instrument. The representation may be a closed form registration for the instrument. The measurements for the instrument may be obtained using a plurality of fiducials and a sensor. The fiducials may be indentations and/or grooves in the instrument. In an embodiment, the representation of the instrument is dynamically updated during an image-guided operation. In an embodiment, the representation of the instrument is compared to a computer-generated model of the instrument.
摘要翻译：本发明的某些实施例提供了一种校准用于图像引导操作的仪器的系统和方法。该方法包括将多个基准放置在仪器上，使用多个基准获得用于仪器的多个测量结果，使用多个用于跟踪仪器的测量值在参考坐标系中确定仪器的表示，以及使用图像数据集和仪器的表示执行图像引导操作。该表示可能是该仪器的封闭表格注册。仪器的测量可以使用多个基准和传感器来获得。基准可能是仪器中的凹陷和/或凹槽。在一个实施例中，在图像引导操作期间动态地更新仪器的表示。在一个实施例中，将仪器的表示与计算机生成的仪器模型进行比较。

4. 发明授权

US5544219A Procedure for automatic position-finding of points of interest during a mammography examination using stereotactic technique 失效
标题翻译：使用立体定位技术在乳房X线照相检查期间自动定位感兴趣的程序
公开(公告)号：US5544219A
公开(公告)日：1996-08-06
申请号：US332743
申请日：1994-11-01
申请人： Serge Muller , Michel Grimaud , Robert Heidsieck
发明人： Serge Muller , Michel Grimaud , Robert Heidsieck
IPC分类号： A61B19/00 , G06T5/20 , G06T5/30 , G06T7/00 , H04N13/00 , A61B6/12
CPC分类号： G06T5/30 , A61B90/10 , G06T7/0042 , G06T2207/10012 , G06T2207/30068 , H04N2013/0074
摘要： A process is disclosed which involves automatic position-finding for a point of interest of an object that exhibits high contrast as compared with surrounding tissues, the process being carried out by means of a stereotactic photographic device that includes a digital image acquisition system. The process includes a number of steps for each image belonging to the pair of stereotactic images. An initial analysis of a histogram of the image pixels are made, and a subsequent determination is made of a threshold corresponding to the difference between the high contrast objects and the surrounding tissues. A subsequent determination is made of the threshold of the image, in order to obtain a binary image incorporating two gray levels. This is followed by the filtering of the threshold determined image in the preceding step, based on morphological criteria of the object in which the point of interest is located. This operation is designed to obtain a segmented projection of the object of interest. This is followed by the localization of the point of interest in the image reference mark. Utilization of the process is for stereotactic examinations performed during mammography.
摘要翻译：公开了一种涉及与周围组织相比显示高对比度的物体的感兴趣点的自动位置查找的过程，该过程通过包括数字图像采集系统的立体定向照相装置进行。该过程包括属于一对立体定向图像的每个图像的多个步骤。进行图像像素的直方图的初始分析，并且随后确定对应于高对比度对象与周围组织之间的差的阈值。随后确定图像的阈值，以便获得并入两个灰度级的二进制图像。接下来是基于目标位置的对象的形态标准对前一步骤中的阈值确定图像的过滤。该操作被设计为获得感兴趣对象的分段投影。接下来是图像参考标记中的兴趣点的本地化。该过程的利用是在乳房X线照相术期间进行的立体定向检查。

5. 发明授权

US5347594A Method of image analysis 失效
标题翻译：图像分析方法
公开(公告)号：US5347594A
公开(公告)日：1994-09-13
申请号：US988099
申请日：1992-12-10
申请人： Michel Grimaud
发明人： Michel Grimaud
IPC分类号： H04N1/407 , G06K9/00
CPC分类号： H04N1/4072
摘要： In order to analyze an image, a search is made, for all the minima of the image, for the dynamic of these minima. When the dynamic of these minima is small it corresponds finally to noise. If this measured dynamic is large, the minimum is regarded as being representative of a sufficiently significant irregularity in the image signal.
摘要翻译：为了分析图像，对于图像的所有最小值，搜索这些最小值的动态。当这些最小值的动态很小时，它最终对应于噪声。如果该测量动态较大，则将该最小值视为代表图像信号中足够显着的不规则性。

6. 发明授权

US07035450B1 Method for locating an element of interest contained in a three-dimensional object, in particular during a stereotactic investigation in the X-ray examination of the breast 失效
标题翻译：用于定位包含在三维物体中的感兴趣元素的方法，特别是在乳房X线检查中的立体定向调查期间
公开(公告)号：US07035450B1
公开(公告)日：2006-04-25
申请号：US09214822
申请日：1999-01-11
申请人： Serge Muller , Michel Grimaud , Robert Heidsieck , Thierry Salmon Legagneur , Sylvie Bothorel
发明人： Serge Muller , Michel Grimaud , Robert Heidsieck , Thierry Salmon Legagneur , Sylvie Bothorel
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G06K2209/053 , G06T7/32 , G06T7/593 , G06T2207/30068
摘要： The stereotaxic images being digitized, a target pixel in a target region of interest is selected, a target window of chosen dimensional characteristics and containing the said target region of interest is generated around the selected target pixel, a set of pixels is determined in a second image, according to a predetermined selection criterion, a second window, of the same dimensional characteristics as the said target window, is generated around each selected pixel, a correlation processing between the grey-scale levels of the pixels of each second window and the grey-scale levels of the pixels of the target window is carried out so as to obtain a correlation value for each second window, and the region of interest homologous to the target region of interest is identified on the basis of the analysis of the set of correlation values thus obtained, so as to minimize the risks of matching error between the homologous regions of interest. The element of interest is then located on the basis of the positions of the two homologous regions.
摘要翻译：数字化的立体定位图像，目标感兴趣区域中的目标像素被选择，选择的维度特征的目标窗口并且包含所述目标感兴趣区域的周围围绕所选择的目标像素生成，在一秒钟内确定一组像素根据预定的选择标准，在每个所选择的像素周围生成与所述目标窗口相同的尺寸特性的第二窗口，每个第二窗口的像素的灰度级与灰度之间的相关处理执行目标窗口的像素的级别以便获得每个第二窗口的相关值，并且基于相关集合的分析来识别与目标感兴趣区域同源的兴趣区域从而最小化感兴趣的同源区域之间匹配误差的风险。感兴趣的元素然后基于两个同源区域的位置。

7. 发明申请

US20050228270A1 Method and system for geometric distortion free tracking of 3-dimensional objects from 2-dimensional measurements 审中-公开
标题翻译：用于二维测量的三维物体的几何失真自由跟踪的方法和系统
公开(公告)号：US20050228270A1
公开(公告)日：2005-10-13
申请号：US10962019
申请日：2004-10-08
申请人： Charles Lloyd , Michel Grimaud , Alex Li , Lewis Levine , Jon Lea
发明人： Charles Lloyd , Michel Grimaud , Alex Li , Lewis Levine , Jon Lea
IPC分类号： A61B5/05 , A61B19/00 , G01C19/00
CPC分类号： A61B90/36 , A61B34/20 , A61B2034/102 , A61B2034/2051 , A61B2034/2055 , A61B2034/207 , A61B2090/0813
摘要： Certain embodiments of the present invention provide a method and system for improved tracking of an internal object, such as an implant or part of the anatomy, during an image-guided operation. In an embodiment, the method may include obtaining a plurality of fiducials for an internal object from a plurality of projection views, obtaining a plurality of measurements for the internal object using the plurality of fiducials, forming a three-dimensional model of the internal object using the plurality of measurements from a plurality of projection views for use in tracking the internal object, and performing an image-guided operation using an image data set and a three-dimensional representation of the internal object. The fiducials may be indentations, curves, grooves and/or identifying features in the internal object. In an embodiment, the representation of the internal object is compared to a computer-generated model of the internal object.
摘要翻译：本发明的某些实施例提供了一种用于在图像引导操作期间改进跟踪内部对象（例如植入物或解剖结构的一部分）的方法和系统。在一个实施例中，该方法可以包括从多个投影视图中获得用于内部对象的多个基准，使用多个基准获得内部对象的多个测量，使用多个基准来形成内部对象的三维模型来自用于跟踪内部对象的多个投影视图的多个测量，以及使用图像数据集和内部对象的三维表示来执行图像引导操作。基准可以是内部物体中的凹痕，曲线，凹槽和/或识别特征。在一个实施例中，将内部对象的表示与内部对象的计算机生成的模型进行比较。

8. 发明授权

US5297036A Method for the correction of the measurements of optical density made on a radiographic film 失效
标题翻译：用于校正在放射线照相胶片上进行的光密度测量的方法
公开(公告)号：US5297036A
公开(公告)日：1994-03-22
申请号：US748813
申请日：1991-08-22
申请人： Michel Grimaud
发明人： Michel Grimaud
IPC分类号： A61B6/00 , G03B42/02 , G06T1/00 , G06T5/00 , G06T5/50 , G06F15/42
CPC分类号： G06T5/002 , A61B6/583 , G06T5/20 , G06T5/50 , G06T2207/20032 , G06T2207/30068
摘要： To carry out an automatic processing operation on radiographic images in mammography, it is shown that it is possible to correct the harmful effects of the linearity defect of the characteristic curve of sensitivity of the radiographic film used for this radiograph by making a statistical study of the noise in this image. It is shown that this statistical study enables the correction elements to be deduced directly using a top hat transformation. The processing is then independent of any prior knowledge that might be had of the sensitivity of the film or of the conditions in which the examined radiographs were acquired as well as subsequently developed.
摘要翻译：为了对乳房X线照相术中的放射摄影图像进行自动处理操作，可以通过对该X射线照相的统计学研究来校正用于该X射线照片的放射线照相胶片的特性曲线的线性缺陷的有害影响这个图像中的噪音。结果表明，该统计学研究使得可以使用顶帽变换直接推导校正元件。然后，该处理独立于可能具有电影敏感性的任何先前知识或获得检查的影像以及随后开发的条件。

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