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1. 发明申请

US20130183239A1 ISOTOPIC CARBON CHOLINE ANALOGS 审中-公开
标题翻译：同位素碳氢化合物模拟物
公开(公告)号：US20130183239A1
公开(公告)日：2013-07-18
申请号：US13824547
申请日：2011-09-20
申请人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Sajinder Luthra
发明人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Sajinder Luthra
IPC分类号： A61K51/04 , C07C215/08
CPC分类号： A61K51/04 , C07B59/001 , C07B2200/05 , C07C215/08 , C07C215/40
摘要： Novel choline-derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases).
摘要翻译：具有与用于正电子发射断层扫描（PET）的同位素碳的新型胆碱衍生的放射性示踪剂或与改变的胆碱代谢相关的疾病状态的单光子发射计算机断层摄影（SPECT）成像（例如，前列腺，乳腺，脑，食管的肿瘤成像，卵巢，子宫内膜，肺和前列腺癌原发性肿瘤，淋巴结转移或转移）。

2. 发明申请

US20130202530A1 NOVEL RADIOTRACER 审中-公开
标题翻译：新浪微博
公开(公告)号：US20130202530A1
公开(公告)日：2013-08-08
申请号：US13825347
申请日：2011-09-20
申请人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao , David Turton , Anthony Wilson , Rajiv Bhalla , Diana Brickute
发明人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao , David Turton , Anthony Wilson , Rajiv Bhalla , Diana Brickute
IPC分类号： A61K51/04
CPC分类号： A61K51/04 , C07B59/001 , C07B2200/05 , C07C213/08 , C07C215/08 , C07C215/40 , Y10T428/13
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
摘要翻译：用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）的新型放射性示踪剂与改变的胆碱代谢相关的疾病状态（例如，前列腺，乳腺，脑，食管，卵巢，子宫内膜，肺和前列腺癌原发性肿瘤，淋巴结转移或转移）。本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。

3. 发明申请

US20130178653A1 NOVEL PRECURSOR OF RADIOLABELLED CHOLINE ANALOG COMPOUNDS 审中-公开
标题翻译：放射性胆固醇模拟化合物的新型前体
公开(公告)号：US20130178653A1
公开(公告)日：2013-07-11
申请号：US13824438
申请日：2011-09-20
申请人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao
发明人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao
IPC分类号： C07C215/08 , C07C217/10
CPC分类号： C07C215/08 , C07B2200/05 , C07C217/10 , C07C309/73
摘要： The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases.
摘要翻译：本发明描述了用于制备用于正电子发射断层扫描（PET）或疾病的单光子发射计算机断层成像（SPECT）成像的放射性示踪剂的径向标记的胆碱类似物的中间体，前体。

4. 发明授权

US08961930B2 Isatin derivatives for use as in vivo imaging agents 有权
标题翻译：靛红衍生物用作体内成像剂
公开(公告)号：US08961930B2
公开(公告)日：2015-02-24
申请号：US13062064
申请日：2009-09-04
申请人： Eric Ofori Aboagye , Graham Smith , Quang-De Nguyen , Erik Arstad , Matthias Eberhard Glaser
发明人： Eric Ofori Aboagye , Graham Smith , Quang-De Nguyen , Erik Arstad , Matthias Eberhard Glaser
IPC分类号： A61K49/00 , C07D403/12 , C07D403/14 , C07D405/14 , A61K51/00 , A61M36/14
CPC分类号： C07D403/12 , C07D403/14 , C07D405/14
摘要： Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.
摘要翻译：靛红5-磺酰胺衍生物，包含衍生物的药物组合物，其作为分子显像剂的用途，其用于诊断或治疗与凋亡失调相关的疾病或病症的用途，合成衍生物的方法，半胱天冬酶活性的分子成像方法并且公开了细胞凋亡和评估测试物质对胱天蛋白酶活性的治疗效果的方法。

5. 发明申请

US20110236312A1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS 审中-公开
标题翻译：核素类似物可用作POSITRON排放成像（PET）成像剂
公开(公告)号：US20110236312A1
公开(公告)日：2011-09-29
申请号：US13061701
申请日：2009-08-28
申请人： Eric Ofori Aboagye , Graham Smith
发明人： Eric Ofori Aboagye , Graham Smith
IPC分类号： A61K51/04 , C07F13/00 , C07D409/14 , C07F5/00 , C07F1/08 , A61P35/00 , A61P29/00 , A61P9/00 , C08F8/30 , C08G63/00 , C09D123/36
CPC分类号： C07H19/073 , C07H5/10 , C07H23/00
摘要： The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided.
摘要翻译：本发明提供了包含4'-硫代胸苷或4'-硫代-2'-脱氧尿苷衍生物的4'-硫代核苷的化合物，其包含通过三唑连接物连接的正电子或单光子发射放射性同位素或相应的非放射性同位素到N-3位置。还提供了制备这些化合物的方法和该化合物在医药中的用途。

6. 发明授权

US08963602B2 Fast pulse generator 有权
标题翻译：快速脉冲发生器
公开(公告)号：US08963602B2
公开(公告)日：2015-02-24
申请号：US11575696
申请日：2005-09-21
申请人： David Robert Bolton , Graham Smith
发明人： David Robert Bolton , Graham Smith
IPC分类号： H03K3/00 , H03B19/00
CPC分类号： H03B19/00
摘要： A pulse generator is disclosed. The pulse generator can include an ac source for providing an ac signal. A pulsed switch can be connected to an ac output of the ac source that is adapted or configured to generate a pulsed output from the ac signal and a non-linear frequency multiplier adapted or configured to shorten the pulses of the pulsed output. The pulsed switch can include a mixer.
摘要翻译：公开了一种脉冲发生器。脉冲发生器可以包括用于提供交流信号的交流电源。脉冲开关可以连接到交流电源的交流输出，适配或配置为产生来自交流信号的脉冲输出，以及适用于或配置为缩短脉冲输出脉冲的非线性倍频器。脉冲开关可以包括混合器。

7. 发明申请

US20130129447A1 Modified Fastener and Insertion Tool 审中-公开
标题翻译：修改紧固件和插入工具
公开(公告)号：US20130129447A1
公开(公告)日：2013-05-23
申请号：US13743545
申请日：2013-01-17
申请人： Eduardo Antonio Canizares, JR. , Graham Smith
发明人： Eduardo Antonio Canizares, JR. , Graham Smith
IPC分类号： F16B23/00 , B25B23/10 , B21K1/56
CPC分类号： F16B23/0007 , A61B17/8615 , A61B17/862 , A61B17/888 , A61B17/8891 , B21K1/56 , B25B15/005 , B25B23/101 , F16B23/003 , F16B23/0061 , Y10T29/49826
摘要： According to example configurations, a modified screw head includes one or more slots or grooved channels. A screwdriver device includes a tip that can be inserted into a cavity in the head of the screw to torque the modified screw into an object. The screwdriver device includes a sleeve. The sleeve slides along a shaft of the screwdriver. The sleeve includes inward protruding posts (e.g., pins, fingers, etc.). Sliding of the sleeve over the screw's head requires that inward protruding posts in the sleeve be aligned with the grooves on the sidewall of the screw's head. Subsequent to aligning and sliding the sleeve into the grooved channels of the screw's head, the user twists the sleeve to secure the screw head to the screwdriver's tip. The sleeve can be spring-loaded to pull the head of the screw toward a handle end of the screwdriver after a user releases the sleeve.
摘要翻译：根据示例性构造，改进的螺钉头包括一个或多个槽或槽形通道。螺丝刀装置包括能够插入到螺钉的头部中的空腔中的尖端，以将改进的螺钉扭转成物体。螺丝刀装置包括套筒。套筒沿螺丝刀的轴滑动。套筒包括向内突出的柱（例如，针，手指等）。将套筒滑过螺钉头部需要使套筒内的向内突出的柱与螺钉头部侧壁上的凹槽对准。在将套筒对准和滑动到螺钉头部的槽形通道中之后，用户扭转套筒以将螺钉头固定到螺丝刀的尖端。在使用者释放套筒之后，套筒可以被弹簧加载以将螺钉的头部拉向螺丝刀的手柄端。

8. 发明申请

US20130116206A1 QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS 审中-公开
标题翻译：用作PET成像剂的喹啉衍生物
公开(公告)号：US20130116206A1
公开(公告)日：2013-05-09
申请号：US13518000
申请日：2010-12-22
申请人： Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
发明人： Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
IPC分类号： C07D215/54 , C07H19/056 , A61K31/706 , A61K31/4706 , A61K31/4709 , C07D401/12 , A61K45/06
CPC分类号： C07D215/54 , A61K31/4706 , A61K31/4709 , A61K31/706 , A61K45/06 , C07D401/12 , C07H19/056
摘要： There is provided compounds of formula (I), wherein R1, R2, X1, X2, and X3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as positron emission tomography (PET) imaging agents, useful in the treatment of diseases in which inhibition of epidermal growth factor receptor tyrosine kinase activity or the inhibition of HER2 activity is desired and/or required, and useful in the treatment of cancer.
摘要翻译：提供式（I）化合物，其中R1，R2，X1，X2和X3具有说明书中给出的含义及其药学上可接受的盐，该化合物可用作正电子发射断层摄影（PET）成像剂，有用在治疗其中期望和/或需要抑制表皮生长因子受体酪氨酸激酶活性或抑制HER2活性的疾病，并且可用于治疗癌症。

9. 发明申请

US20130066371A1 BONE GRAFT PLACEMENT DEVICE 有权
标题翻译：骨格栅放置装置
公开(公告)号：US20130066371A1
公开(公告)日：2013-03-14
申请号：US13606886
申请日：2012-09-07
申请人： Jon-Paul Rogers , Timothy P. Callahan , Jeffrey Wyman , Graham Smith , Daniel B. Ellls
发明人： Jon-Paul Rogers , Timothy P. Callahan , Jeffrey Wyman , Graham Smith , Daniel B. Ellls
IPC分类号： A61B17/04
CPC分类号： A61B17/8872 , A61B17/0401 , A61B17/0485 , A61B17/0487 , A61B17/1684 , A61B17/1697 , A61B17/1778 , A61B17/82 , A61B17/864 , A61B17/8897 , A61B2017/00407 , A61B2017/0404 , A61B2017/0488 , A61B2017/0496 , A61B2017/06176 , A61F2/4081 , A61F2/4601
摘要： A surgical assembly includes a first guidewire and a second guidewire, in which each of the first guidewire and the second guidewire are configured to be received by a bone block, a first suture loop, a second suture loop, a first locking component, and a second locking component, in which the first locking component is coupled to the first suture loop and the second locking component is coupled to the second suture loop. The locking component has a hole formed therethrough, in which the hole of the locking component is configured to receive the suture, and may be tethered to a suture by knots engaging a counterbore at opposed ends of a bore defined by the hole.
摘要翻译：外科组件包括第一导丝和第二导丝，其中第一导丝和第二导丝中的每一个被构造成由骨块，第一缝线环，第二缝合线环，第一锁定部件和第二锁定部件，其中第一锁定部件联接到第一缝合线环，并且第二锁定部件联接到第二缝合线环。锁定部件具有穿过其中形成的孔，其中锁定部件的孔构造成容纳缝合线，并且可以通过在由孔限定的孔的相对端处与沉孔接合的节点结合到缝合线。

10. 发明申请

US20080047080A1 GrillClean, a barbeque grill cleaning system 审中-公开
标题翻译： GrillClean烧烤烤架清洁系统
公开(公告)号：US20080047080A1
公开(公告)日：2008-02-28
申请号：US11895165
申请日：2007-08-24
申请人： Graham Smith
发明人： Graham Smith
IPC分类号： A46B13/00
CPC分类号： A47L13/34 , A46B2200/3033 , A46B2200/3073 , A47L17/02
摘要： GrillClean is a new method of cleaning the cooking grid of an outdoor barbeque grill. Rather than the usual method of scraping the debris from the grid while it is on the cooking unit, causing the debris to fall into the unit, this device involves removing the cooking grid from the grill and immersing it in a water bath with scrub brushes and scrub pads along with spray nozzles of water, resulting in a more complete cleaning in a much shorter period of time. This is because both sides of the grid are being cleaned at the same time with brushes and scrub pads the full width of the cooking grid and at the same time the grid is being immersed in a water bath and then rinsed by a spray as it is removed.
摘要翻译： GrillClean是一种清洁户外烧烤架的烹饪网格的新方法。而不是通常的方法，当它在烹饪单元上时从栅格上刮除碎屑，导致碎屑落入该单元中，该装置包括从烤架中移除烹饪栅格并将其浸入带有刷子的水浴中，擦洗垫以及水的喷嘴，从而在更短的时间内进行更完整的清洁。这是因为网格的两面正在用刷子和擦洗垫同时清洁烹饪格栅的整个宽度，同时网格被浸入水浴中，然后用喷雾器冲洗，因为它是删除。

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