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1. 发明授权

US6038630A Shared access control device for integrated system with multiple functional units accessing external structures over multiple data buses 失效
标题翻译：用于具有多个功能单元的集成系统的共享访问控制设备通过多个数据总线访问外部结构
公开(公告)号：US6038630A
公开(公告)日：2000-03-14
申请号：US47139
申请日：1998-03-24
申请人： Eric M. Foster , Dennis E. Franklin , Stefan P. Jackowski , David Wallach
发明人： Eric M. Foster , Dennis E. Franklin , Stefan P. Jackowski , David Wallach
IPC分类号： G06F13/16 , G06F13/40 , G06F13/00
CPC分类号： G06F13/4022 , G06F13/1684
摘要： A multi-path access control device for an integrated system is presented which allows simultaneous access to multiple external devices coupled thereto by multiple functional units. The multiple functional units are coupled to the shared access control device across two or more high speed, shared data buses. The control device includes multiple bus ports, each coupled to a different data bus, and a non-blocking crossbar switch coupled to the bus ports for controlling forwarding, with zero cycle latency, of requests from the functional units. Multiple external device ports are coupled to the non-blocking crossbar switch for receiving requests forwarded by the crossbar switch, and each external device is coupled to a different external device port. The crossbar switch allows multiple requests at the bus ports directed to different external devices to be forwarded to different external device ports for simultaneous accessing of different external devices coupled thereto pursuant to the multiple requests.
摘要翻译：提出了一种用于集成系统的多路径访问控制装置，其允许通过多个功能单元同时访问与其耦合的多个外部设备。多个功能单元通过两个或更多个高速共享数据总线耦合到共享访问控制设备。控制设备包括多个总线端口，每个总线端口耦合到不同的数据总线，以及耦合到总线端口的非阻塞交叉开关，用于控制来自功能单元的请求的零周期等待时间的转发。多个外部设备端口耦合到非阻塞交叉开关，用于接收由交叉开关转发的请求，并且每个外部设备耦合到不同的外部设备端口。交叉开关允许在指向不同外部设备的总线端口上的多个请求被转发到不同的外部设备端口，以便根据多个请求同时访问与其耦合的不同外部设备。

2. 发明申请

US20120144504A1 CASPASE-8 AND SKIN DISEASE 审中-公开
标题翻译： CASPASE-8和皮肤疾病
公开(公告)号：US20120144504A1
公开(公告)日：2012-06-07
申请号：US12090478
申请日：2006-10-16
申请人： David Wallach , Andrei Kovalenko , Tae-Bong Kang , Jin Chul Kim
发明人： David Wallach , Andrei Kovalenko , Tae-Bong Kang , Jin Chul Kim
IPC分类号： A61K31/713 , C07K14/435 , C07H21/02 , A61K38/48 , A61K31/711 , A61K38/17 , A61P17/00 , A61P17/06 , C12N9/50 , C12Q1/37 , C12Q1/68 , G01N33/573 , A01K67/027 , C40B30/00 , A61K49/00 , C12N15/57
CPC分类号： C12N15/1137 , A61K38/1761 , A61K38/177 , A61K38/4873 , C12N15/1135 , C12N2310/14 , C12N2310/531 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y304/22061 , G01N33/573 , G01N2333/96466
摘要： The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.
摘要翻译：本发明涉及治疗或预防炎性皮肤疾病，病症或病症，通过调节通常由皮肤中的胱天蛋白酶-8调节的蛋白质或通过增加皮肤中的半胱天冬酶-8活性或水平。本发明的另一方面涉及用于诊断炎症性皮肤疾病，病症或病症或倾向于在个体中发展所述疾病病症或病症的方法。本发明的其它方面涉及用于鉴定涉及炎性皮肤病，病症或病症的病程或病理学的靶蛋白的方法以及筛选候选化合物以治疗所述疾病，病症或病症的方法。特别地，本发明涉及炎性皮肤疾病如特应性皮炎和牛皮癣。

3. 发明授权

US08138323B2 Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA 有权
标题翻译：分离的cDNA编码肿瘤坏死因子结合蛋白II，其纯化和载体，宿主和使用这种cDNA的过程
公开(公告)号：US08138323B2
公开(公告)日：2012-03-20
申请号：US10319536
申请日：2002-12-16
申请人： David Wallach , Hartmut Engelmann , Dan Aderka , Daniela Novick , Menachem Rubinstein
发明人： David Wallach , Hartmut Engelmann , Dan Aderka , Daniela Novick , Menachem Rubinstein
IPC分类号： C12N15/28 , C12N15/79 , C12N15/74 , C12N5/10 , C12N1/21
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151
摘要： An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.
摘要翻译：分离的DNA分子具有编码肿瘤坏死因子（TNF）结合蛋白II的片段的序列。其长度足以用作用于产生针对作为TNF结合蛋白II的片段的多肽的抗体的免疫原。 DNA可用于产生可复制的表达载体和原核或真核表达宿主细胞。这样的宿主细胞可用于产生由这样的DNA分子编码的多肽。

4. 发明授权

US08034340B2 Method for treating an immune disorder by decreasing NIK-SIVA complex formation 有权
标题翻译：通过降低NIK-SIVA复合体形成来治疗免疫疾病的方法
公开(公告)号：US08034340B2
公开(公告)日：2011-10-11
申请号：US10580542
申请日：2004-11-30
申请人： David Wallach , Parameswaran Ramakrishnan , Wangxia Wang , Taisia Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Wangxia Wang , Taisia Shmushkovich
IPC分类号： A61K39/00 , C07K16/00 , C07K16/44
CPC分类号： C07K16/40 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N2333/70578 , G01N2333/912 , G01N2500/02
摘要： Methods and agents for immune modulation and methods for identifying putative immune modulators are provided.
摘要翻译：提供免疫调节的方法和试剂以及鉴定推定的免疫调节剂的方法。

5. 发明申请

US20090291888A1 MODULATORS OF TNF RECEPTOR ASSOCIATED FACTOR (TRAF), THEIR PREPARATION AND USE 有权
标题翻译： TNF受体相关因子（TRAF）的调节剂，其制备和使用
公开(公告)号：US20090291888A1
公开(公告)日：2009-11-26
申请号：US12365136
申请日：2009-02-03
申请人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
发明人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/00 , C12N1/00 , C12P21/00 , C07K16/00 , C12Q1/68 , A61K31/7052 , G01N33/53 , C07H21/00 , A61P43/00
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K2319/00 , C12N2799/021
摘要： A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要翻译：编码能够结合肿瘤坏死因子受体相关因子（TRAF）分子的蛋白质的DNA序列，由所述DNA序列编码的TRAF结合蛋白，其同工型，类似物，片段和衍生物，其生产DNA的方法序列和蛋白质，以及DNA序列和蛋白质的用途。

6. 发明申请

US20090269331A1 CASPASE-8 AND INFLAMMATION, INFECTION AND WOUND HEALING 失效
标题翻译： CASPASE-8和炎症，感染和创伤治疗
公开(公告)号：US20090269331A1
公开(公告)日：2009-10-29
申请号：US12306929
申请日：2007-06-27
申请人： David Wallach , Rinai Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
发明人： David Wallach , Rinai Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
IPC分类号： A61K39/395 , A61K38/16 , A61K31/7088 , A61K38/07
CPC分类号： A61K38/4873 , A61K38/55 , C12N15/113 , C12N15/1135 , C12N2310/11 , C12Y304/22061 , Y02A50/409 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing
摘要翻译：本发明涉及胱天蛋白酶-8在细胞内病原体感染，炎症和伤口愈合中的调节作用

7. 发明申请

US20090098106A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH NF-kB ACTIVITY 有权
标题翻译：用于治疗与NF-kB活性相关的疾病的药物组合物
公开(公告)号：US20090098106A1
公开(公告)日：2009-04-16
申请号：US11722898
申请日：2005-12-11
申请人： David Wallach , Parameswaran Ramakrishnan , Taisa Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Taisa Shmushkovich
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , C07K16/00 , C07K14/00
CPC分类号： C07K16/18 , C07K14/47 , C12N9/1205 , G01N2500/02
摘要： A method of treating a disease associated with NF-κB activity. The method is effected by providing to a subject in need thereof a therapeutically effective amount of an agent capable of modulating NIK-HC8 binding.
摘要翻译：治疗与NF-κB活性相关的疾病的方法。该方法通过向有需要的受试者提供治疗有效量的能够调节NIK-HC8结合的试剂来实现。

8. 发明授权

US07485456B1 Modulators of TNF receptor associated factor (TRAF), their preparation and use 失效
标题翻译： TNF受体相关因子（TRAF）的调节剂，其制备和用途
公开(公告)号：US07485456B1
公开(公告)日：2009-02-03
申请号：US09155676
申请日：1997-04-01
申请人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
发明人： David Wallach , Nikolai Malinin , Mark Boldin , Andrei Kovalenko , Igor Mett
IPC分类号： C07K1/00 , C12Q1/68 , C12P21/06 , C12N15/00 , A61K39/395 , C07H21/00 , C07H21/02
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K2319/00 , C12N2799/021
摘要： A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要翻译：编码能够结合肿瘤坏死因子受体相关因子（TRAF）分子的蛋白质的DNA序列，由所述DNA序列编码的TRAF结合蛋白，其同工型，类似物，片段和衍生物，其生产DNA的方法序列和蛋白质，以及DNA序列和蛋白质的用途。

9. 发明授权

US07416730B2 Derivatives of the IL-2 receptor gamma chain, their production and use 有权
标题翻译： IL-2受体γ链的衍生物，其生产和使用
公开(公告)号：US07416730B2
公开(公告)日：2008-08-26
申请号：US10511722
申请日：2003-04-15
申请人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
发明人： David Wallach , Parameswaran Ramakrishnan , Taisia Shmushkovich
IPC分类号： C07K14/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/7155 , C12N2799/022
摘要： This invention relates to the use of the IL-2 common gamma chain (cγc) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules.
摘要翻译：本发明涉及IL-2常见γ链（cgammac）和相关分子用于调节由NIK控制的信号活性的用途，以及一些新的这样的分子。

10. 发明授权

US07354736B2 Caspase-8 binding protein, its preparation and use 失效
标题翻译：胱天蛋白酶-8结合蛋白，其制备及应用
公开(公告)号：US07354736B2
公开(公告)日：2008-04-08
申请号：US10488614
申请日：2002-09-04
申请人： David Wallach , Tania Goncharov , Ganesh Kolumam , Akhil Rajput
发明人： David Wallach , Tania Goncharov , Ganesh Kolumam , Akhil Rajput
IPC分类号： C12P21/06 , C12N15/00 , C12N5/00 , C07H21/04 , C07K14/00
CPC分类号： C07K14/47 , A01K2217/05
摘要： The present invention relates to a caspase-8 interacting polypeptide (Cari), methods for its preparation, and its use.
摘要翻译：本发明涉及半胱天冬酶-8相互作用多肽（Cari），其制备方法及其应用。

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