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1. 发明申请

US20120165897A1 Rate Initialization and Overdrive Pacing for Capture Threshold Testing 有权
标题翻译：速率初始化和超速起搏用于捕获阈值测试
公开(公告)号：US20120165897A1
公开(公告)日：2012-06-28
申请号：US13306615
申请日：2011-11-29
申请人： Eric K. Enrooth , Sunipa Saha , Clayton Foster , Yanting Dong
发明人： Eric K. Enrooth , Sunipa Saha , Clayton Foster , Yanting Dong
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3714
摘要： Approaches for rate initialization and overdrive pacing used during capture threshold testing are described. Cardiac cycles are detected and the cardiac events of a cardiac chamber that occur during the cardiac cycles are monitored. The number of intrinsic beats in the cardiac events is counted. Initialization for a capture threshold test involves maintaining a pre-test pacing rate for the capture threshold test if the number of intrinsic beats in the cardiac events is less than a threshold. The pacing rate is increased for the capture threshold test if the number of intrinsic beats in the cardiac events is greater than the threshold.
摘要翻译：描述捕获阈值测试期间使用的速率初始化和超速起搏的方法。检测到心脏周期，并监测在心脏周期期间发生的心室的心脏事件。计数心脏事件中的固有搏动次数。捕获阈值测试的初始化涉及如果心脏事件中的固有搏动次数小于阈值，则保持捕获阈值测试的预先测试起搏速率。如果心脏事件中的固有搏动次数大于阈值，则针对捕获阈值测试，起搏速率将增加。

2. 发明授权

US08725261B2 Rate initialization and overdrive pacing for capture threshold testing 有权
标题翻译：速率初始化和超速起搏用于捕获阈值测试
公开(公告)号：US08725261B2
公开(公告)日：2014-05-13
申请号：US13306615
申请日：2011-11-29
申请人： Eric K. Enrooth , Sunipa Saha , Clayton S. Foster , Yanting Dong
发明人： Eric K. Enrooth , Sunipa Saha , Clayton S. Foster , Yanting Dong
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3714
摘要： Approaches for rate initialization and overdrive pacing used during capture threshold testing are described. Cardiac cycles are detected and the cardiac events of a cardiac chamber that occur during the cardiac cycles are monitored. The number of intrinsic beats in the cardiac events is counted. Initialization for a capture threshold test involves maintaining a pre-test pacing rate for the capture threshold test if the number of intrinsic beats in the cardiac events is less than a threshold. The pacing rate is increased for the capture threshold test if the number of intrinsic beats in the cardiac events is greater than the threshold.
摘要翻译：描述捕获阈值测试期间使用的速率初始化和超速起搏的方法。检测到心脏周期，并监测在心脏周期期间发生的心室的心脏事件。计数心脏事件中的固有搏动次数。捕获阈值测试的初始化涉及如果心脏事件中的固有搏动次数小于阈值，则保持捕获阈值测试的预先测试起搏速率。如果心脏事件中的固有搏动次数大于阈值，则针对捕获阈值测试，起搏速率将增加。

3. 发明授权

US08271086B2 Pacing output determination based on selected capture threshold values 有权
标题翻译：基于所选捕获阈值的起搏输出确定
公开(公告)号：US08271086B2
公开(公告)日：2012-09-18
申请号：US12341617
申请日：2008-12-22
申请人： John Voegele , Clayton Foster , David W. Yost , Scott Meyer , Yanting Dong , Kevin J. Stalsberg , Derek D. Bohn , Eric K. Enrooth
发明人： John Voegele , Clayton Foster , David W. Yost , Scott Meyer , Yanting Dong , Kevin J. Stalsberg , Derek D. Bohn , Eric K. Enrooth
IPC分类号： A61N1/365 , A61N1/08
CPC分类号： A61N1/3712
摘要： Approaches for adjusting the pacing energy delivered by a pacemaker are provided. Adjusting the pacing energy involves performing a plurality of capture threshold tests, each capture threshold test measuring a capture threshold of the heart. One or more measured captured thresholds are selected, including at least one capture threshold that is higher relative to other measured capture thresholds acquired by the plurality of capture threshold tests. The pacing energy is adjusted based on the one or more selected capture thresholds.
摘要翻译：提供了调节由起搏器提供的起搏能量的方法。调整起搏能量包括执行多个捕获阈值测试，每个捕获阈值测试测量心脏的捕获阈值。选择一个或多个测量的捕获阈值，包括相对于通过多个捕获阈值测试获取的其他测量的捕获阈值更高的捕获阈值。基于一个或多个选择的捕获阈值来调整起搏能量。

4. 发明申请

US20100318151A1 SYSTEMS AND METHODS FOR MANAGING NOISE IN IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于管理可植入医疗设备中的噪声的系统和方法
公开(公告)号：US20100318151A1
公开(公告)日：2010-12-16
申请号：US12815871
申请日：2010-06-15
申请人： Sunipa Saha , Eric K. Enrooth , Scot C. Boon
发明人： Sunipa Saha , Eric K. Enrooth , Scot C. Boon
IPC分类号： A61N1/37 , G01R29/26 , G06F19/00
CPC分类号： A61N1/371 , A61B5/0428 , A61B5/0432 , A61B5/7203 , A61B5/7217 , A61N1/3714 , A61N1/3718 , G06K9/0051
摘要： Embodiments of the invention are related to managing noise in sensed signals in implantable medical devices, amongst other things. In an embodiment the invention includes a method for processing electrical signals obtained from a patient including gathering a first set of electrical signals using an implantable medical device, filtering to provide a second set of electrical signals, the second set including frequencies above a threshold frequency, and estimating the amount of noise present in the first set of electrical signals based on the magnitude of the second set. In an embodiment, the invention includes a medical device configured to gather a first set of electrical signals, filter the first set to provide a second set of electrical signals including frequencies above a threshold frequency, and estimate the amount of noise present in the first set based on the magnitude of the second set. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及管理可植入医疗装置中的感测信号中的噪声等。在一个实施例中，本发明包括一种用于处理从患者获得的电信号的方法，包括使用可植入医疗装置收集第一组电信号，滤波以提供第二组电信号，所述第二组包括高于阈值频率的频率，以及基于第二组的大小来估计存在于第一组电信号中的噪声量。在一个实施例中，本发明包括被配置为收集第一组电信号的医疗设备，对第一组进行滤波以提供包括高于阈值频率的频率的第二组电信号，以及估计第一组中存在的噪声量基于第二组的大小。本文还包括其它实施例。

5. 发明授权

US09345890B2 Systems and methods for managing noise in implantable medical devices 有权
标题翻译：用于管理可植入医疗设备中的噪声的系统和方法
公开(公告)号：US09345890B2
公开(公告)日：2016-05-24
申请号：US12815871
申请日：2010-06-15
申请人： Sunipa Saha , Eric K. Enrooth , Scot C. Boon
发明人： Sunipa Saha , Eric K. Enrooth , Scot C. Boon
IPC分类号： A61N1/37 , A61B5/0428 , A61B5/0432 , A61B5/00 , G06K9/00
CPC分类号： A61N1/371 , A61B5/0428 , A61B5/0432 , A61B5/7203 , A61B5/7217 , A61N1/3714 , A61N1/3718 , G06K9/0051
摘要： Embodiments of the invention are related to managing noise in sensed signals in implantable medical devices, amongst other things. In an embodiment the invention includes a method for processing electrical signals obtained from a patient including gathering a first set of electrical signals using an implantable medical device, filtering to provide a second set of electrical signals, the second set including frequencies above a threshold frequency, and estimating the amount of noise present in the first set of electrical signals based on the magnitude of the second set. In an embodiment, the invention includes a medical device configured to gather a first set of electrical signals, filter the first set to provide a second set of electrical signals including frequencies above a threshold frequency, and estimate the amount of noise present in the first set based on the magnitude of the second set. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及管理可植入医疗装置中的感测信号中的噪声等。在一个实施例中，本发明包括一种用于处理从患者获得的电信号的方法，包括使用可植入医疗装置收集第一组电信号，滤波以提供第二组电信号，所述第二组包括高于阈值频率的频率，以及基于第二组的大小来估计存在于第一组电信号中的噪声量。在一个实施例中，本发明包括被配置为收集第一组电信号的医疗设备，对第一组进行滤波以提供包括高于阈值频率的频率的第二组电信号，以及估计第一组中存在的噪声量基于第二组的大小。本文还包括其它实施例。

6. 发明授权

US08145296B2 Adaptive windowing for cardiac waveform discrimination 有权
标题翻译：心脏波形鉴别的自适应窗口
公开(公告)号：US08145296B2
公开(公告)日：2012-03-27
申请号：US12538297
申请日：2009-08-10
申请人： Kevin J. Stalsberg , Yanting Dong , Scott Meyer , Eric K. Enrooth , Derek D. Bohn
发明人： Kevin J. Stalsberg , Yanting Dong , Scott Meyer , Eric K. Enrooth , Derek D. Bohn
IPC分类号： A61B5/042
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/0472 , A61B5/7217
摘要： Cardiac devices and methods provide adaptation of detection windows used to determine a cardiac response to pacing. Adapting a detection window involves sensing a cardiac signal indicative of a particular type of cardiac pacing response, and detecting a feature of the sensed cardiac signal. The cardiac response detection window associated with the type of cardiac pacing response is preferentially adjusted based on the location of the detected cardiac feature. Preferential adjustment of the detection window may involve determining a direction of change between the detection window and the detected feature. The detection window may be adapted more aggressively in a more preferred direction and less aggressively in a less preferred direction.
摘要翻译：心脏装置和方法提供用于确定对起搏的心脏反应的检测窗口的适应。适应检测窗口包括感测指示特定类型的心脏起搏反应的心脏信号，以及检测感测到的心脏信号的特征。基于检测到的心脏特征的位置优先调整与心脏起搏响应类型相关联的心脏响应检测窗口。检测窗口的优先调整可以包括确定检测窗口和检测到的特征之间的变化方向。检测窗口可以在更优选的方向上更积极地改变，并且在较不优选的方向上较不积极地适配。

7. 发明申请

US20100286743A1 Methods and Systems for Mitigating the Occurrence of Arrhythmia During Atrial Pacing 有权
标题翻译：心房起搏减轻心律失常发生的方法和系统
公开(公告)号：US20100286743A1
公开(公告)日：2010-11-11
申请号：US12772725
申请日：2010-05-03
申请人： Eric K. Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
发明人： Eric K. Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.
摘要翻译：非心房颤动可导致心律失常的心律失常的长时间心脏周期。描述了旨在避免心律失常长时间短周期的方法。对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

8. 发明申请

US20130013019A1 Dynamic Morphology Based Atrial Automatic Threshold 审中-公开
标题翻译：基于动态形态的心房自动阈值
公开(公告)号：US20130013019A1
公开(公告)日：2013-01-10
申请号：US13612077
申请日：2012-09-12
申请人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
发明人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3712
摘要： Methods and systems for performing capture threshold tests are described. During an initialization procedure a capture detection interval and capture detection threshold are determined based on peak values of cardiac signals sensed following the supracapture threshold initialization pulses. Following initialization, a plurality of pacing pulses to the atrium are delivered and the peak values of the cardiac signals sensed following each of the plurality of pacing pulses are determined. The peak values are compared to the pacing artifact threshold and the capture detection threshold. A timing of each of the peak values is compared to the capture detection interval. For each pacing pulse, discrimination between a captured response, a noncaptured response, and a fusion response is based on the peak value and timing comparisons.
摘要翻译：描述用于执行捕获阈值测试的方法和系统。在初始化过程期间，捕获检测间隔和捕获检测阈值是基于超标准阈值初始化脉冲之后感测的心脏信号的峰值来确定的。在初始化之后，传送到心房的多个起搏脉冲，并且确定在多个起搏脉冲之后检测到的心脏信号的峰值。将峰值与起搏伪像阈值和捕获检测阈值进行比较。将每个峰值的定时与捕获检测间隔进行比较。对于每个起搏脉冲，捕获的响应，非捕获响应和融合响应之间的区别基于峰值和时序比较。

9. 发明授权

US08290590B2 Dynamic morphology based atrial automatic threshold 有权
标题翻译：动态形态基于心房自动阈值
公开(公告)号：US08290590B2
公开(公告)日：2012-10-16
申请号：US11601217
申请日：2006-11-17
申请人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
发明人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3712
摘要： Methods and systems for performing capture threshold tests are described. During an initialization procedure a capture detection interval and capture detection threshold are determined based on peak values of cardiac signals sensed following the supracapture threshold initialization pulses. Following initialization, a plurality of pacing pulses to the atrium are delivered and the peak values of the cardiac signals sensed following each of the plurality of pacing pulses are determined. The peak values are compared to the pacing artifact threshold and the capture detection threshold. A timing of each of the peak values is compared to the capture detection interval. For each pacing pulse, discrimination between a captured response, a noncaptured response, and a fusion response is based on the peak value and timing comparisons.
摘要翻译：描述用于执行捕获阈值测试的方法和系统。在初始化过程期间，捕获检测间隔和捕获检测阈值是基于超标准阈值初始化脉冲之后感测的心脏信号的峰值来确定的。在初始化之后，传送到心房的多个起搏脉冲，并且确定在多个起搏脉冲之后检测到的心脏信号的峰值。将峰值与起搏伪像阈值和捕获检测阈值进行比较。将每个峰值的定时与捕获检测间隔进行比较。对于每个起搏脉冲，捕获的响应，非捕获响应和融合响应之间的区别基于峰值和时序比较。

10. 发明授权

US07801610B2 Methods and systems for management of atrial retrograde conduction and pacemaker mediated tachyarrhythmia 有权
标题翻译：用于管理心房逆行传导和起搏器介导的快速性心律失常的方法和系统
公开(公告)号：US07801610B2
公开(公告)日：2010-09-21
申请号：US11601092
申请日：2006-11-17
申请人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
发明人： Derek D. Bohn , Ankur Garg , Eric K. Enrooth
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3621 , A61N1/3712 , A61N1/3714
摘要： Methods and systems for classifying cardiac responses to pacing stimulation and managing retrograde conduction and pacemaker mediated tachyarrhythmia are described. An atrial pacing pulse and a ventricular pacing pulse are delivered during a paced cardiac cycle. A post ventricular atrial refractory period (PVARP) is timed following the ventricular pacing pulse. The system determines if the atrial pacing pulse captures the atrium. An atrial depolarization occurring after the paced cardiac cycle is sensed. Retrograde management is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization occurred during the PVARP. Pacemaker mediated tachyarrhythmia (PMT) is initiated if the atrial pacing pulse did not capture the atrium and the atrial depolarization did not occur during the PVARP.
摘要翻译：描述了用于分类心脏起搏刺激响应和管理逆行传导和起搏器介导的快速性心律失常的方法和系统。心律起搏脉搏和心室起搏脉搏在心跳期间进行。心室起搏脉搏后定时心室心房不应期（PVARP）。该系统确定心房起搏脉冲是否捕获心房。感觉到起搏心动周期后出现心房去极化。如果心房起搏脉搏没有捕获心房并且在PVARP期间发生心房去极化，则开始逆行管理。如果心房起搏脉搏没有捕获心房并且在PVARP期间没有发生心房去极化，起搏器介导的快速性心律失常（PMT）开始。

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