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1. 发明申请

US20140356316A1 AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS 有权
标题翻译：用作纯化酸序列的胺聚合物
公开(公告)号：US20140356316A1
公开(公告)日：2014-12-04
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

2. 发明授权

US09655920B2 Amine polymers for use as bile acid sequestrants 有权
公开(公告)号：US09655920B2
公开(公告)日：2017-05-23
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02 , A61K45/06
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

3. 发明授权

US09181364B2 Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants 有权
标题翻译：交联聚乙烯胺，聚烯丙胺和聚乙烯亚胺，用作胆汁酸螯合剂
公开(公告)号：US09181364B2
公开(公告)日：2015-11-10
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785 , C08F20/52 , C08F22/38 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

4. 发明申请

US20130022570A1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权
标题翻译：交联的聚乙烯胺，聚甲基丙烯酸和聚乙烯亚胺作为双酸序列使用
公开(公告)号：US20130022570A1
公开(公告)日：2013-01-24
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

5. 发明申请

US20130189215A1 POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：用作单酯酸序列的聚霉素
公开(公告)号：US20130189215A1
公开(公告)日：2013-07-25
申请号：US13581102
申请日：2011-02-24
申请人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： C08F226/06 , A61K45/06 , C08G73/06 , A61K31/787
CPC分类号： C08F226/06 , A61K31/155 , A61K31/397 , A61K31/785 , A61K31/787 , A61K45/06 , C08G73/0273 , C08G73/0616 , C08G73/0627 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

6. 发明授权

US07608674B2 Pharmaceutical compositions comprising cross-linked small molecule amine polymers 失效
标题翻译：包含交联的小分子胺聚合物的药物组合物
公开(公告)号：US07608674B2
公开(公告)日：2009-10-27
申请号：US10980991
申请日：2004-11-03
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C11D1/00 , C08F26/06
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译：描述了阴离子结合聚合物。阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。还描述了药物组合物，使用方法和试剂盒。

7. 发明申请

US20100029897A1 ANION-BINDING POLYMERS AND USES THEREOF 有权
标题翻译： ANION-BINDING聚合物及其用途
公开(公告)号：US20100029897A1
公开(公告)日：2010-02-04
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08G73/00
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译：描述了阴离子结合聚合物。阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。还描述了药物组合物，使用方法和试剂盒。

8. 发明授权

US07589238B2 Treatment of hyperphosphatemia using crosslinked small molecule amine polymers 失效
标题翻译：使用交联的小分子胺聚合物治疗高磷酸盐血症
公开(公告)号：US07589238B2
公开(公告)日：2009-09-15
申请号：US11465444
申请日：2006-08-17
申请人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klaemer , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han Ting Chang , Florence Roger , Gerrit Klaemer , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C07C211/11 , C08G2/00
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译：描述了阴离子结合聚合物。阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。还描述了药物组合物，使用方法和试剂盒。

9. 发明授权

US07718746B2 Anion-binding polymers and uses thereof 有权
标题翻译：阴离子结合聚合物及其用途
公开(公告)号：US07718746B2
公开(公告)日：2010-05-18
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08F26/06 , C07C211/11
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译：描述了阴离子结合聚合物。阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不能用于高于聚合物的目标离子的一定百分比MW的非相互作用溶质。在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。还描述了药物组合物，使用方法和试剂盒。

10. 发明申请

US20060267805A1 Method and system for data input 审中-公开
标题翻译：数据输入方法和系统
公开(公告)号：US20060267805A1
公开(公告)日：2006-11-30
申请号：US11441716
申请日：2006-05-26
申请人： Leila Glazkova , Angela Lee
发明人： Leila Glazkova , Angela Lee
IPC分类号： H03M11/00
CPC分类号： G06F3/0233 , G06F3/0235
摘要： Provided is a method and system for correcting key input when a key button which a user intends to input and its neighbor buttons are simultaneously pressed on a small-size keyboard. For information input, simultaneous activation by the operator of a combination of keys of a keyboard is performed, wherein each of possibility for simultaneous activation of the combination of keys is associated with an individual code generated at simultaneous activation of this combination of keys. The generated code is loaded into the adaptive code conversion unit converting this individual input code into the most probable output code, which is visualized on a display after processing by the device processor for selection of the required symbol and confirmation of the selection.
摘要翻译：提供了一种用于在用户想要输入的键按钮及其相邻按钮在小尺寸键盘上同时按下时校正键输入的方法和系统。对于信息输入，执行操作者键盘的键的组合的同时激活，其中用于同时激活键组合的每个可能性与在同时激活该键组合时生成的单独代码相关联。将生成的代码加载到自适应代码转换单元中，将该单独的输入代码转换为最可能的输出代码，其在由设备处理器处理以选择所需符号并选择确认之后在显示器上可视化。

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