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    • 2. 发明授权
    • Antibodies to cyclooxygenase variants
    • 环氧合酶变体的抗体
    • US07601816B2
    • 2009-10-13
    • US11601208
    • 2006-11-17
    • Daniel SimmonsN. Vishvanath Chandrasekharan
    • Daniel SimmonsN. Vishvanath Chandrasekharan
    • C07K16/00C07K16/40
    • C12N9/0083
    • The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring inton 1, or fragment thereof, of cyclooxygenase 1. The invention further relates to the diagnosis of aberrant cyclooxygenase type 1 variant gene or gene product; the identification, production, and use of compounds which modulate cyclooxygenase type 1 variant gene expression or the activity of the cyclooxygenase type 1 variant gene product including but not limited to nucleic acid encoding cyclooxygenase type 1 variants and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules; and pharmaceutical formulations and routes of administration for such compounds.
    • 本发明涉及新型环氧合酶1型(COX-1)变体酶的分离。 更具体地,本发明涉及鉴定环加氧酶1的内含子1或其片段的环氧合酶转录物。本发明还涉及异常环氧合酶1型变体基因或基因产物的诊断; 调节环氧合酶1型变体基因表达的化合物的鉴定,生产和使用或环加氧酶1型变体基因产物的活性,包括但不限于编码环氧合酶1型变体及其同系物,类似物和缺失的核酸,作为 以及反义,核酶,三螺旋,抗体和多肽分子以及小的无机分子; 以及这些化合物的药物制剂和给药途径。
    • 3. 发明申请
    • SYSTEM AND METHOD FOR REPLICATING OFFLINE SCHEDULING TRANSACTIONS FROM A CLIENT TO A SERVER
    • 从客户端到服务器的离线安排交易的系统和方法
    • US20120254282A1
    • 2012-10-04
    • US13477993
    • 2012-05-22
    • Daniel SimmonsJosh Lindquist
    • Daniel SimmonsJosh Lindquist
    • G06F15/16
    • G06Q10/109H04L67/14H04L67/327H04L69/329
    • A facility for replicating offline scheduling transactions directed to a server is provided. The facility is implemented as a client-side application that integrates with and utilizes components of a store-and-forward application, which is operable to execute on a client to guarantee that transactions submitted on the client are replicated and carried out on a service hosted on a remote server even in light of intermittent connectivity between the client, the server, and networks. Records describing transactions intended remote service are written to an outbox of the store-and-forward application on the client. If the item is intended for the scheduling application, the facility is invoked by the store-and-forward application to send the item to the scheduling application. Otherwise, the facility returns the item to the outbox for processing by other components of the store-and-forward application.
    • 提供用于复制定向到服务器的离线调度事务的设施。 该设施实施为与存储转发应用程序集成并利用存储转发应用程序的组件的客户端应用程序,该应用程序可操作以在客户机上执行以保证在客户机上提交的事务被复制并在托管服务上执行 即使在客户端,服务器和网络之间间歇连接的情况下也可以在远程服务器上进行。 描述预期远程服务的事务的记录将写入客户端上的存储转发应用程序的发件箱。 如果该项目旨在用于调度应用程序,则由存储转发应用程序调用该设施以将该项目发送到调度应用程序。 否则,设备将该项目返回到发件箱以供存储转发应用程序的其他组件处理。
    • 4. 发明授权
    • Cyclooxygenase variants and methods of use
    • 环氧合酶变体和使用方法
    • US07179627B2
    • 2007-02-20
    • US10260937
    • 2002-09-28
    • Daniel SimmonsN. Vishvanath Chandrasekharan
    • Daniel SimmonsN. Vishvanath Chandrasekharan
    • C12N9/02C12N1/20C12N15/00C12Q1/26C12P21/04A01N25/00C07H21/04C12Q1/00C12Q1/68
    • C12N9/0083
    • The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring inton 1, or fragment thereof, of cyclooxygenase 1. The invention further relates to the diagnosis of aberrant cyclooxygenase type 1 variant gene or gene product; the identification, production, and use of compounds which modulate cyclooxygenase type 1 variant gene expression or the activity of the cyclooxygenase type 1 variant gene product including but not limited to nucleic acid encoding cyclooxygenase type 1 variants and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules; and pharmaceutical formulations and routes of administration for such compounds.
    • 本发明涉及新型环氧合酶1型(COX-1)变体酶的分离。 更具体地,本发明涉及鉴定环加氧酶1的内含子1或其片段的环氧合酶转录物。本发明还涉及异常环氧合酶1型变体基因或基因产物的诊断; 调节环氧合酶1型变体基因表达的化合物的鉴定,生产和使用或环加氧酶1型变体基因产物的活性,包括但不限于编码环氧合酶1型变体及其同系物,类似物和缺失的核酸,作为 以及反义,核酶,三螺旋,抗体和多肽分子以及小的无机分子; 以及这些化合物的药物制剂和给药途径。
    • 5. 发明申请
    • Novel cyclooxygenase variants and methods of use
    • 新型环加氧酶变体和使用方法
    • US20070065445A1
    • 2007-03-22
    • US11601208
    • 2006-11-17
    • Daniel SimmonsN. Chandrasekharan
    • Daniel SimmonsN. Chandrasekharan
    • A61K39/395A61K48/00G01N33/567C07H21/04C12P31/00C12P21/06C12N9/02
    • C12N9/0083
    • The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring inton 1, or fragment thereof, of cyclooxygenase 1. The invention further relates to the diagnosis of aberrant cyclooxygenase type 1 variant gene or gene product; the identification, production, and use of compounds which modulate cyclooxygenase type 1 variant gene expression or the activity of the cyclooxygenase type 1 variant gene product including but not limited to nucleic acid encoding cyclooxygenase type 1 variants and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules; and pharmaceutical formulations and routes of administration for such compounds.
    • 本发明涉及新型环氧合酶1型(COX-1)变体酶的分离。 更具体地,本发明涉及鉴定环加氧酶1的内含子1或其片段的环氧合酶转录物。本发明还涉及异常环氧合酶1型变体基因或基因产物的诊断; 调节环氧合酶1型变体基因表达的化合物的鉴定,生产和使用或环加氧酶1型变体基因产物的活性,包括但不限于编码环氧合酶1型变体及其同系物,类似物和缺失的核酸,作为 以及反义,核酶,三螺旋,抗体和多肽分子以及小的无机分子; 以及这些化合物的药物制剂和给药途径。
    • 7. 发明授权
    • System and method for replicating offline scheduling transactions from a client to a server
    • 从客户机到服务器复制离线调度事务的系统和方法
    • US09183547B2
    • 2015-11-10
    • US13477993
    • 2012-05-22
    • Daniel SimmonsJosh Lindquist
    • Daniel SimmonsJosh Lindquist
    • G06F15/16G06F15/173G06Q10/10H04L29/08
    • G06Q10/109H04L67/14H04L67/327H04L69/329
    • A facility for replicating offline scheduling transactions directed to a server is provided. The facility is implemented as a client-side application that integrates with and utilizes components of a store-and-forward application, which is operable to execute on a client to guarantee that transactions submitted on the client are replicated and carried out on a service hosted on a remote server even in light of intermittent connectivity between the client, the server, and networks. Records describing transactions intended remote service are written to an outbox of the store-and-forward application on the client. If the item is intended for the scheduling application, the facility is invoked by the store-and-forward application to send the item to the scheduling application. Otherwise, the facility returns the item to the outbox for processing by other components of the store-and-forward application.
    • 提供用于复制定向到服务器的离线调度事务的设施。 该设施实施为与存储转发应用程序集成并利用存储转发应用程序的组件的客户端应用程序,该应用程序可操作以在客户机上执行以保证在客户端上提交的事务被复制并在托管的服务上执行 即使在客户端,服务器和网络之间间歇连接的情况下也可以在远程服务器上进行。 描述预期远程服务的事务的记录将写入客户端上的存储转发应用程序的发件箱。 如果该项目旨在用于调度应用程序,则由存储转发应用程序调用该设施以将该项目发送到调度应用程序。 否则,设备将该项目返回到发件箱以供存储转发应用程序的其他组件处理。
    • 8. 发明授权
    • System and method for replicating offline scheduling transactions from a client to a server
    • 从客户机到服务器复制离线调度事务的系统和方法
    • US08185590B2
    • 2012-05-22
    • US11004315
    • 2004-12-02
    • Daniel SimmonsJosh Lindquist
    • Daniel SimmonsJosh Lindquist
    • G06F15/16
    • G06Q10/109H04L67/14H04L67/327H04L69/329
    • A facility for replicating offline scheduling transactions directed to a server is provided. The facility is implemented as a client-side application that integrates with and utilizes components of a store-and-forward application, which is operable to execute on a client to guarantee that transactions submitted on the client are replicated and carried out on a service hosted on a remote server even in light of intermittent connectivity between the client, the server, and networks. Records describing transactions intended remote service are written to an outbox of the store-and-forward application on the client. When online, the store-and-forward application first invokes the facility, which processes the items in the outbox by iteratively retrieving the items from the outbox and, for each item, determining whether the item is a transaction intended for the scheduling application. If the item is intended for the scheduling application, the facility sends the item to the scheduling application. Otherwise, if the item is not intended for the scheduling application, the facility returns the item to the outbox for processing by other components of the store-and-forward application.
    • 提供用于复制定向到服务器的离线调度事务的设施。 该设施实施为与存储转发应用程序集成并利用存储转发应用程序的组件的客户端应用程序,该应用程序可操作以在客户机上执行以保证在客户端上提交的事务被复制并在托管的服务上执行 即使在客户端,服务器和网络之间间歇连接的情况下也可以在远程服务器上进行。 描述预期远程服务的事务的记录将写入客户端上的存储转发应用程序的发件箱。 在线时,存储转发应用程序首先调用该设施,该设施通过从发件箱迭代地检索项目来处理发件箱中的项目,并且对于每个项目,确定该项目是否是用于调度应用程序的事务。 如果该项目用于调度应用程序,则该设施将该项目发送到调度应用程序。 否则,如果项目不适用于调度应用程序,则设施将该项目返回到发件箱,以便由存储转发应用程序的其他组件进行处理。
    • 9. 发明申请
    • DETECTION OF GRADUAL TRANSITIONS IN VIDEO SEQUENCES
    • 检视视频序列中的梯度过渡
    • US20100302453A1
    • 2010-12-02
    • US12445875
    • 2007-10-05
    • Stavros PaschalakisDaniel Simmons
    • Stavros PaschalakisDaniel Simmons
    • H04N9/64H04N5/14
    • H04N5/147H04N19/14H04N19/87
    • A technique is disclosed for detecting gradual transitions between frames of a video sequence such as fade and dissolve transitions. For each frame, the intensity values of pixels at corresponding positions within a window of frames including the subject frame are compared, and signs are allocated to the calculated differences. The number of each type of sign is determined for each pixel position and the larger number of matching signs is assigned as a measure of the monotonicity of the direction of intensity variations at the pixel position between the frame and the surrounding frames. A global monotonicity measure is then calculated for the frame as a whole using the monotonicity values for each pixel position. This is repeated for each frame to generate a temporal sequence of frame intensity change monotonicity measures. Slopes within this temporal sequence representative of gradual Transitions between video frames are detected. Alternatively, the values in the temporal sequence are compared with a threshold to identify values representative of gradual transitions between video frames.
    • 公开了一种用于检测视频序列的帧之间的逐渐转变的技术,例如渐变和解码转换。 对于每个帧,比较包括对象帧在内的帧的窗口内的对应位置处的像素的强度值,并将符号分配给所计算的差。 针对每个像素位置确定每种类型的符号的数量,并且将较大数量的匹配符号分配为帧和周围帧之间的像素位置处的强度变化方向的单调性的度量。 然后,使用每个像素位置的单调性值,为整个帧计算全局单调性度量。 这对于每个帧重复以产生帧强度变化单调性度量的时间序列。 在该时间序列之间的斜率表示视频帧之间的逐渐转换。 或者,将时间序列中的值与阈值进行比较,以识别表示视频帧之间的逐渐转换的值。