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1. 发明申请

US20130312868A1 Method and Device for Fast Dissolution of Solid Protein Composition 审中-公开
标题翻译：用于快速溶解固体蛋白质组合物的方法和装置
公开(公告)号：US20130312868A1
公开(公告)日：2013-11-28
申请号：US13722348
申请日：2012-12-20
申请人： Erez Ilan , Kfir Regev , Dana Leitman , Israel Nur , Moti Meron , John Goodman
发明人： Erez Ilan , Kfir Regev , Dana Leitman , Israel Nur , Moti Meron , John Goodman
IPC分类号： C07K14/75
CPC分类号： C07K14/75 , A61M5/19 , A61M5/284 , B01F3/12 , B01F5/0685 , B01F13/0023 , B01F13/0052 , B01F15/0225 , B01F15/0258
摘要： Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.
摘要翻译：提供了用于将固体蛋白质组合物（例如包含纤维蛋白原的固体组合物）溶解在水性溶剂中的方法和装置。所述方法包括使用含有一定体积的固体纤维蛋白原组合物的封闭容器和顶部空间，其中顶部空间内的压力低于大气压。将水溶剂引入容器中同时保持低于大气压的压力，然后加入溶剂后，顶部空间的尺寸减小，使压力达到大气压。这些装置适用于所公开的方法。

2. 发明申请

US20100217231A1 Device for administering an at least two-component substance 审中-公开
标题翻译：用于施用至少两种组分物质的装置
公开(公告)号：US20100217231A1
公开(公告)日：2010-08-26
申请号：US12708453
申请日：2010-02-18
申请人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
发明人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
IPC分类号： A61M5/31 , A61B17/03 , A61M35/00
CPC分类号： A61M5/1582 , A61B17/00491 , A61B2017/00495 , A61M5/3297 , A61M2025/0039
摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.
摘要翻译：用于施用至少两种组分物质的装置包括同心的腔排列，其包括（i）具有在第一端具有入口开口的内腔和在其第一端相对的第二端处具有出口开口的末端的内套管，和（ii）外护套，其具有相对的第一和第二端面向所述内套管的相应的第一和第二端，并且沿着所述内套管的第一和第二端之间的轴向长度包围所述内套管，其中，其第二端密封地和固定地连接到内套管并且围绕内插管限定外腔，并且其中内插管设置有至少一个开口，用于提供围绕内插管的外腔与内套管之间的流体连通内套管。

3. 发明申请

US20110182991A1 METHOD FOR IMPROVED FIBRIN SEALING 有权
标题翻译：改进纤维素密封方法
公开(公告)号：US20110182991A1
公开(公告)日：2011-07-28
申请号：US13015999
申请日：2011-01-28
申请人： Erez Ilan , Kfir Regev , Israel Nur
发明人： Erez Ilan , Kfir Regev , Israel Nur
IPC分类号： A61K9/14 , A61K38/48 , A61P17/02 , A61P17/00
CPC分类号： A61L24/043 , A61L24/0015 , A61L24/0042 , A61L24/10 , A61L24/106 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/45 , A61L2300/61 , A61L2400/04 , B65D81/32
摘要： The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.
摘要翻译：本发明涉及一种纤维蛋白基质，其制备和用途，用于有效地密封粘膜或其它潮湿组织中的缺陷。

4. 发明授权

US08962033B2 Method for improved fibrin sealing 有权
标题翻译：改善纤维蛋白封闭的方法
公开(公告)号：US08962033B2
公开(公告)日：2015-02-24
申请号：US13015999
申请日：2011-01-28
申请人： Erez Ilan , Kfir Regev , Israel Nur
发明人： Erez Ilan , Kfir Regev , Israel Nur
IPC分类号： A61K9/50 , A61L24/10
CPC分类号： A61L24/043 , A61L24/0015 , A61L24/0042 , A61L24/10 , A61L24/106 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/45 , A61L2300/61 , A61L2400/04 , B65D81/32
摘要： The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.
摘要翻译：本发明涉及一种纤维蛋白基质，其制备和用途，用于有效地密封粘膜或其它潮湿组织中的缺陷。

5. 发明授权

US08640921B2 Device, system and method for dispensing a fixed dose of fluid 有权
标题翻译：用于分配固定剂量流体的装置，系统和方法
公开(公告)号：US08640921B2
公开(公告)日：2014-02-04
申请号：US13209650
申请日：2011-08-15
申请人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
发明人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
IPC分类号： B67D7/70
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/19 , A61M5/204 , A61M5/31586 , A61M35/003
摘要： The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel.
摘要翻译：本发明涉及一种用于分配固定剂量的流体的装置，该装置包括至少一个桶; 至少一个柱塞至少部分地封闭在所述筒体内; 运动转换机构，用于将施加到所述筒外部的致动压力传递到所述至少一个柱塞在分配方向上的运动，其中所述运动转换机构包括至少一个旋转齿轮; 以及用于将活塞与运动转换机构分离的释放机构，其中在释放位置，所述至少一个柱塞可以在与所述分配方向相反的方向上移动，而与所述至少一个齿轮的旋转运动无关，并且其中柱塞在与分配相反的方向上的运动使得能够将流体装载到筒中。

6. 发明申请

US20120043347A1 DEVICE, SYSTEM AND METHOD FOR DISPENSING A FIXED DOSE OF FLUID 有权
标题翻译：用于分配流体固定剂量的装置，系统和方法
公开(公告)号：US20120043347A1
公开(公告)日：2012-02-23
申请号：US13209650
申请日：2011-08-15
申请人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
发明人： Moti Meron , Aner Tsuk , Roee Atlas , Israel Nur
IPC分类号： B67D7/70 , G01F11/00 , B65D88/54
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/19 , A61M5/204 , A61M5/31586 , A61M35/003
摘要： The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel.
摘要翻译：本发明涉及一种用于分配固定剂量的流体的装置，该装置包括至少一个桶; 至少一个柱塞至少部分地封闭在所述筒体内; 运动转换机构，用于将施加到所述筒外部的致动压力传递到所述至少一个柱塞在分配方向上的运动，其中所述运动转换机构包括至少一个旋转齿轮; 以及用于将活塞与运动转换机构分离的释放机构，其中在释放位置，所述至少一个柱塞可以在与所述分配方向相反的方向上移动，而与所述至少一个齿轮的旋转运动无关，并且其中柱塞在与分配相反的方向上的运动使得能够将流体装载到筒中。

7. 发明申请

US20110238009A1 DEVICES FOR INJECTING A SUBSTANCE AND METHODS THEREFOR 有权
标题翻译：用于注射物质的装置及其方法
公开(公告)号：US20110238009A1
公开(公告)日：2011-09-29
申请号：US13053448
申请日：2011-03-22
申请人： Moti Meron , Israel Nur , Roee Atlas
发明人： Moti Meron , Israel Nur , Roee Atlas
IPC分类号： A61M5/31 , A61M5/315 , A61M5/32
CPC分类号： A61M5/3294 , A61B17/00491 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31578 , A61M5/31581 , A61M5/31596 , A61M5/322 , A61M5/3257 , A61M5/326 , A61M5/3287 , A61M5/3293 , A61M5/46 , A61M2005/3128 , A61M2005/3206
摘要： A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.
摘要翻译：用于注射的装置包括具有上端的壳体，包括具有注射针开口的底表面的下端以及在所述上端和下端之间延伸的轴线。该装置包括设置在壳体内用于在缩回位置和延伸位置之间移动的注射针。

8. 发明授权

US09278181B2 Devices for injecting a substance and methods therefor 有权
标题翻译：用于注射物质的装置及其方法
公开(公告)号：US09278181B2
公开(公告)日：2016-03-08
申请号：US13053448
申请日：2011-03-22
申请人： Moti Meron , Israel Nur , Roee Atlas
发明人： Moti Meron , Israel Nur , Roee Atlas
IPC分类号： A61M5/31 , A61M5/32 , A61M5/24 , A61B17/00 , A61M5/19 , A61M5/315 , A61M5/20 , A61M5/46
CPC分类号： A61M5/3294 , A61B17/00491 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31578 , A61M5/31581 , A61M5/31596 , A61M5/322 , A61M5/3257 , A61M5/326 , A61M5/3287 , A61M5/3293 , A61M5/46 , A61M2005/3128 , A61M2005/3206
摘要： A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position.
摘要翻译：用于注射的装置包括具有上端的壳体，包括具有注射针开口的底表面的下端以及在所述上端和下端之间延伸的轴线。该装置包括设置在壳体内用于在缩回位置和延伸位置之间移动的注射针。

9. 发明授权

US08981058B2 Gelatin sponge comprising an active ingredient, its preparation and use 有权
标题翻译：明胶海绵含有活性成分，其制备及用途
公开(公告)号：US08981058B2
公开(公告)日：2015-03-17
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
IPC分类号： A61K38/00 , A61K9/00 , A61K9/70 , A61L15/32 , A61L15/42 , A61L15/44 , A61K38/48
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译：本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中足够量的液体即使在干燥后也保持海绵的柔韧性。然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。

10. 发明授权

US08968724B2 Compositions suitable for treatment of spinal disease, disorder or condition 有权
标题翻译：适合治疗脊髓疾病，病症或病症的组合物
公开(公告)号：US08968724B2
公开(公告)日：2015-03-03
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
IPC分类号： A01N63/00 , A61L27/38 , A61L27/36 , C12N5/077 , A61K35/16
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译：本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。

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