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1. 发明申请

US20080252769A1 Camera Arrangement, Mobile Phone Comprising a Camera Arrangement, Method of Manufacturing a Camera Arrangement 审中-公开
标题翻译：摄像机布置，包括摄像机布置的手机，制造摄像机布置的方法
公开(公告)号：US20080252769A1
公开(公告)日：2008-10-16
申请号：US10597608
申请日：2005-01-24
申请人： Emile Johannes Karel Verstegen , Arjen Gerben Van Der Sijde , Edwin Maria Wolterink , Hendrik Roelof Stapert
发明人： Emile Johannes Karel Verstegen , Arjen Gerben Van Der Sijde , Edwin Maria Wolterink , Hendrik Roelof Stapert
IPC分类号： H04N5/225
CPC分类号： H04N5/2254 , G02B3/14 , G02B13/006 , G02F1/1313 , G02F1/133305 , G02F1/29 , G02F2001/294 , G02F2203/28 , H04N5/2257 , H04N5/23212 , H04N5/23296
摘要： The present invention relates to a camera arrangement as for instance used in a mobile phone that utilizes a liquid crystal based lens for providing an adjustable depth of focus. The camera arrangement comprises a photo sensor (201) array and at least two lenses (202, 203, 204) that are arranged in a fixed and unitary arrangement. At least one of the lenses (202) comprises a liquid crystal layer (101) that provides for adjustable focal length in that lens. The additional lens(-es) (203, 204) might have fixed or adjustable focal length depending on the application. According to one embodiment, the camera arrangement comprises at least one additional adjustable lens ant the lenses are arranged so as to provide for adjustable depth′ of focus as well as for an adjustable depth of field.
摘要翻译：本发明涉及例如在移动电话中使用的相机装置，其利用基于液晶的透镜来提供可调节的焦深。相机装置包括光传感器（201）阵列和布置成固定和整体布置的至少两个透镜（202,203,204）。至少一个透镜（202）包括在该透镜中提供可调焦距的液晶层（101）。根据应用，附加镜头（-es）（203,204）可能具有固定或可调焦距。根据一个实施例，照相机装置包括至少一个附加的可调透镜，这些透镜被布置成提供可调焦深度以及可调节的景深。

2. 发明授权

US07935213B2 Non-leaching adhesive system and its use in a liquid immersion objective 有权
标题翻译：非浸出粘合剂系统及其在液体浸入物中的应用
公开(公告)号：US07935213B2
公开(公告)日：2011-05-03
申请号：US12629155
申请日：2009-12-02
申请人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar van Santen
发明人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar van Santen
IPC分类号： B29C65/00 , B32B37/12 , B32B7/12
CPC分类号： C09J135/02
摘要： A non-leaching adhesive system and its use in a liquid immersion objective for immersion-writing of masters for optical discs are disclosed. The adhesive system comprises at least one monomer, selected from among the group of acrylate and methacrylate monomers, allylic monomers, norbornene monomers, hybrid monomers thereof, containing chemically different polymerizable groups, and multifunctional thiol monomers, provided that said thiol is used in combination with at least one of said non-thiol monomers; and a polymerization initiator. At least one of said monomers, not being a thiol, is provided with at least two functional polymerizable groups to obtain a crosslinked polymer network. The polymerization initiator is preferably an initiator that can be activated both thermally and with UV radiation. The adhesive system may further contain a reactive diluent. Further the use of the present adhesive system in mounting a liquid immersion objective is disclosed.
摘要翻译：公开了一种非浸出粘合剂系统及其在用于浸入式写入光盘的液浸物镜中的用途。粘合剂体系包含至少一种选自丙烯酸酯和甲基丙烯酸酯单体的单体，烯丙基单体，降冰片烯单体，含有化学不同的可聚合基团的杂化单体和多官能硫醇单体，条件是所述硫醇与所述非硫醇单体中的至少一种; 和聚合引发剂。至少一种所述单体（不是硫醇）具有至少两个官能的可聚合基团以获得交联的聚合物网络。聚合引发剂优选是能够以热辐射和UV辐射活化的引发剂。粘合剂体系还可以含有反应性稀释剂。此外，公开了本发明的粘合剂系统在安装液浸物镜中的用途。

3. 发明授权

US07642297B2 Non-leaching adhesive system and its use in a liquid immersion objective 有权
标题翻译：非浸出粘合剂系统及其在液体浸入物中的应用
公开(公告)号：US07642297B2
公开(公告)日：2010-01-05
申请号：US10568837
申请日：2004-08-05
申请人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar Van Santen
发明人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar Van Santen
IPC分类号： C08F2/46 , C09J4/02
CPC分类号： C09J135/02
摘要： A non-leaching adhesive system and its use in a liquid immersion objective for immersion-writing of masters for optical discs are disclosed. The adhesive system comprises at least one monomer, selected from among the group of acrylate and methacrylate monomers, allylic monomers, norbornene monomers, hybrid monomers thereof, containing chemically different polymeriazble groups, and multifunctional thiol monomers, provided that said thiol is used in combination with at least one of said non-thiol monomers; and a polymerization initiator. At least one of said monomers, not being a thiol, is provided with at least two functional polymerizable groups to obtain a crosslinked polymer network. The polymerization initiator is preferably an initiator that can be activated both thermally and with UV radiation. The adhesive system may further contain a reactive diluent. Further the use of the present adhesive system in mounting a liquid immersion objective is disclosed.
摘要翻译：公开了一种非浸出粘合剂系统及其在用于浸入式写入光盘的液浸物镜中的用途。粘合剂体系包含至少一种选自丙烯酸酯和甲基丙烯酸酯单体的单体，烯丙基单体，降冰片烯单体，含有化学上不同的聚合物基团的杂化单体和多官能硫醇单体，条件是所述硫醇与所述非硫醇单体中的至少一种; 和聚合引发剂。至少一种所述单体（不是硫醇）具有至少两个官能的可聚合基团以获得交联的聚合物网络。聚合引发剂优选是能够以热辐射和UV辐射活化的引发剂。粘合剂体系还可以含有反应性稀释剂。此外，公开了本发明的粘合剂系统在安装液浸物镜中的用途。

4. 发明申请

US20100071848A1 NON-LEACHING ADHESIVE SYSTEM AND ITS USE IN A LIQUID IMMERSION OBJECTIVE 有权
标题翻译：非浸出粘合剂体系及其在液体渗透中的应用目的
公开(公告)号：US20100071848A1
公开(公告)日：2010-03-25
申请号：US12629155
申请日：2009-12-02
申请人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar van Santen
发明人： Emile Johannes Karel Verstegen , Johan George Kloosterboer , Hendrik Roelof Stapert , Jacobus Hermanus Maria Neijzen , Helmar van Santen
IPC分类号： C09J5/02 , G03F7/004 , C09J5/04
CPC分类号： C09J135/02
摘要： A non-leaching adhesive system and its use in a liquid immersion objective for immersion-writing of masters for optical discs are disclosed. The adhesive system comprises at least one monomer, selected from among the group of acrylate and methacrylate monomers, allylic monomers, norbornene monomers, hybrid monomers thereof, containing chemically different polymerizable groups, and multifunctional thiol monomers, provided that said thiol is used in combination with at least one of said non-thiol monomers; and a polymerization initiator. At least one of said monomers, not being a thiol, is provided with at least two functional polymerizable groups to obtain a crosslinked polymer network. The polymerization initiator is preferably an initiator that can be activated both thermally and with UV radiation. The adhesive system may further contain a reactive diluent. Further the use of the present adhesive system in mounting a liquid immersion objective is disclosed.
摘要翻译：公开了一种非浸出粘合剂系统及其在用于浸入式写入光盘的液浸物镜中的用途。粘合剂体系包含至少一种选自丙烯酸酯和甲基丙烯酸酯单体的单体，烯丙基单体，降冰片烯单体，含有化学不同的可聚合基团的杂化单体和多官能硫醇单体，条件是所述硫醇与所述非硫醇单体中的至少一种; 和聚合引发剂。至少一种所述单体（不是硫醇）具有至少两个官能的可聚合基团以获得交联的聚合物网络。聚合引发剂优选是能够以热辐射和UV辐射活化的引发剂。粘合剂体系还可以含有反应性稀释剂。此外，公开了本发明的粘合剂系统在安装液浸物镜中的用途。

5. 发明授权

US07169828B2 Method of manufacturing a replica as well as a replica obtained by carrying out an UV light-initiated cationic polymerization 失效
标题翻译：制造复制品的方法以及通过进行UV光引发的阳离子聚合获得的复制品
公开(公告)号：US07169828B2
公开(公告)日：2007-01-30
申请号：US10500767
申请日：2002-12-16
申请人： Johan George Kloosterboer , Fredericus Johannes Touwslager , Emile Johannes Karel Verstegen , Hendrik Roelof Stapert
发明人： Johan George Kloosterboer , Fredericus Johannes Touwslager , Emile Johannes Karel Verstegen , Hendrik Roelof Stapert
IPC分类号： C08F2/46 , B29D11/00 , G02B1/00 , G02B1/04
CPC分类号： B44C3/042 , B29C35/0888 , B29C2035/0827 , B29D11/00134 , B29D11/00442 , B29K2105/0002 , C08G59/68 , C08G65/18 , C08G2650/16
摘要： The invention relates to a method of manufacturing a replica, which method comprises the provision of a polymerizable resin composition between a front mold having a pre-shaped surface and a back mold having a pre-shaped surface, carrying out a curing treatment and removing the replica thus manufactured from the molds. The invention further relates to a replica obtained by carrying out a UV light-initiated cationic polymerization.
摘要翻译：本发明涉及一种制造复制品的方法，该方法包括在具有预成形表面的前模具和具有预成形表面的后模之间提供可聚合树脂组合物，进行固化处理并除去这样由模具制造的复制品。本发明还涉及通过进行UV光引发的阳离子聚合而获得的复制品。

6. 发明授权

US08815162B2 Microelectronic sensor device for DNA detection 有权
标题翻译：用于DNA检测的微电子传感器装置
公开(公告)号：US08815162B2
公开(公告)日：2014-08-26
申请号：US12303448
申请日：2007-05-24
申请人： Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
发明人： Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
IPC分类号： G05D23/00
CPC分类号： G01N21/6454 , B01L3/5027 , B01L3/50851 , B01L7/525 , B01L7/54 , B01L2200/147 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , C12Q1/6825 , G01N21/0332 , G01N21/6428 , G01N2021/6439 , C12Q2565/1015 , C12Q2527/101 , C12Q2527/107
摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.
摘要翻译：本发明涉及一种微电子传感器装置和一种用于研究生物靶物质（20）的方法，例如DNA片段等寡核苷酸。在一个实施方案中，所述装置包括反应表面（RS），目标特异性反应物（10）附着到所述反应表面（RS），并且位于样品室（SC）和选择性可控制的加热元件（HE）阵列之间。样品室（SC）中的温度曲线可以根据需要进行控制，以提供例如PCR和/或受控熔化杂交的条件。反应物（10）和/或目标物质（20）包含具有可观察性质（如荧光）的标记物（12），如果目标物质（20）与反应物（10）结合，则其变化，所述性质被检测通过传感器元件阵列，例如光电传感器（SE）。标记物（12）的荧光优选通过FRET转移到不同的荧光标记物（22），或者如果靶物质（20）被结合则被淬灭。

7. 发明申请

US20120040853A1 REAL TIME MULTIPLEX PCR DETECTION ON SOLID SURFACES USING DOUBLE STRANDED NUCLEIC ACID SPECIFIC DYES 审中-公开
标题翻译：使用双重棒状核酸特异性染料对固体表面进行实时多重PCR检测
公开(公告)号：US20120040853A1
公开(公告)日：2012-02-16
申请号：US13131333
申请日：2009-11-17
申请人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
发明人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
IPC分类号： C40B30/04
CPC分类号： C12Q1/6851 , C12Q2565/519 , C12Q2565/101 , C12Q2561/113
摘要： The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids.
摘要翻译：本发明提供允许使用对双链核酸特异性的染料的一次反应（多重）中实时检测大量目标核酸的方法。

8. 发明申请

US20110319275A1 METHOD FOR IMMOBILIZING NUCLEIC ACIDS ON A SUPPORT 有权
标题翻译：用于在支持物上固定核酸的方法
公开(公告)号：US20110319275A1
公开(公告)日：2011-12-29
申请号：US13121206
申请日：2009-09-22
申请人： Anke Pierik , Hendrik Roelof Stapert
发明人： Anke Pierik , Hendrik Roelof Stapert
IPC分类号： C40B20/08 , C40B50/18 , C40B40/06
CPC分类号： C12Q1/6837 , C12Q2525/173
摘要： The present invention relates to a method for immobilizing nucleic acids on a support, comprising the provision of a nucleic acid with a stretch of nucleotides of only one basetype and the immobilization of said nucleic acid on a support by crosslinking by light, wherein said crosslinking by light is performed at a wavelength of about 300-500 nm, preferably at a wavelength of 365 nm. The present invention further relates to a method for the analysis of nucleic acids immobilized according to the invention, which comprises the hybridization of the immobilized nucleic acid with complementary and mismatch segments. Furthermore, the present invention relates to immobilized nucleic acids obtainable by the method of the invention, the use of accordingly immobilized nucleic acids for the production of nucleic acid arrays and a diagnostic kit, comprising an array of nucleic acids which are immobilized according to the present invention.
摘要翻译：本发明涉及用于将核酸固定在载体上的方法，其包括提供具有仅一种碱基类型的核苷酸序列的核酸和通过光交联将所述核酸固定在载体上，其中所述交联通过光在约300-500nm的波长处进行，优选在365nm的波长下进行。本发明还涉及用于分析根据本发明固定的核酸的方法，其包括将固定的核酸与互补和错配片段杂交。此外，本发明涉及通过本发明的方法可获得的固定化核酸，使用相应地固定的核酸来生产核酸阵列和诊断试剂盒，其包含根据本发明固定的核酸阵列发明。

9. 发明申请

US20090116125A1 LENS SYSTEM 审中-公开
标题翻译：镜头系统
公开(公告)号：US20090116125A1
公开(公告)日：2009-05-07
申请号：US12302049
申请日：2007-05-25
申请人： Aleksey Kolesnychenko , Sjoerd Stallinga , Hendrik Roelof Stapert
发明人： Aleksey Kolesnychenko , Sjoerd Stallinga , Hendrik Roelof Stapert
IPC分类号： G02B9/00 , G02B17/00 , G01J5/08
CPC分类号： G01J5/08 , G01J5/0037 , G01J5/0806 , G01J5/0809 , G01J5/0846 , G01J5/0862 , G01J5/089 , G01J5/602 , G01J2005/0077 , G01N2021/6478 , G02B27/42 , G02B27/4233
摘要： The present invention concerns a lens system. More specifically, it concerns a lens system comprising a first lens (3), a deflection element (5) and a second lens (6), wherein the deflection element (5) is arranged between the first lens (3) and the second lens (6). The deflection element comprises at least a first annular zone and a second annular zone, the annular zones being arranged in a concentric fashion and wherein the deflection angle of each annular zone is different from the deflection angle of every other annular zone. Furthermore, the present invention concerns a temperature analysis system comprising a lens system and the use of a temperature analysis system.
摘要翻译：本发明涉及一种透镜系统。更具体地，涉及一种包括第一透镜（3），偏转元件（5）和第二透镜（6）的透镜系统，其中偏转元件（5）布置在第一透镜（3）和第二透镜（6）。偏转元件至少包括第一环形区域和第二环形区域，环形区域以同心方式布置，并且其中每个环形区域的偏转角度与每隔一个环形区域的偏转角度不同。此外，本发明涉及包括透镜系统和使用温度分析系统的温度分析系统。

10. 发明申请

US20100230610A1 INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES 审中-公开
标题翻译：具有照相机阵列和样品库阵列的集成设备
公开(公告)号：US20100230610A1
公开(公告)日：2010-09-16
申请号：US12294469
申请日：2007-03-20
申请人： Pieter Jan Van Der Zaag , Nigel David Young , Hendrik Roelof Stapert
发明人： Pieter Jan Van Der Zaag , Nigel David Young , Hendrik Roelof Stapert
IPC分类号： G01J1/58 , B23P17/04
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/76 , Y10T29/49826
摘要： An integrated device for detecting emissions from a sample (70) involves forming an array of photo detectors (20) for detecting the emissions and forming an array of sites for receiving the sample such that edges of the sites are defined by edges of the photo detectors. A side wall of a site using a diode can provide a side wall suitable for ink-jet printing samples such as biomolecules with no extra mask steps. This helps enable the sample and the photo detector to be mutually aligned more easily or more cost effectively than conventional devices where the site for receiving the sample is formed separately from the photo detector. The detection can be in any direction, such as lateral or vertical detection. Lateral optical detection with a shielded photodiode means only light emanating from one pixel/spot is detected. A light source (200) to stimulate emissions can be integrated.
摘要翻译：用于检测来自样品（70）的发射的集成装置涉及形成用于检测发射的光电检测器（20）的阵列，并形成用于接收样品的位置阵列，使得位置的边缘由光电检测器的边缘限定。使用二极管的位点的侧壁可以提供适合于喷墨打印样品的侧壁，例如没有额外掩模步骤的生物分子。这有助于样品和光电检测器与传统的接收样品的部位与光电检测器分开形成的装置更容易或更经济地相互对准。检测可以在任何方向，例如横向或垂直检测。使用屏蔽光电二极管的横向光学检测意味着仅检测到从一个像素/点发出的光。可以集成用于刺激排放物的光源（200）。

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