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1. 发明申请

US20130034552A1 TEMPERATURE SENSITIVE CONJUGATE COMPOSITIONS, AND USES RELATED THERETO 有权
标题翻译：温度敏感的结合组合物及其相关用途
公开(公告)号：US20130034552A1
公开(公告)日：2013-02-07
申请号：US13583055
申请日：2011-03-08
申请人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
发明人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
IPC分类号： C07K19/00 , A61P7/02 , C12N15/63 , A61K39/395 , C07H21/04
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/78 , C07K16/2848 , C07K2317/622 , C07K2319/00
摘要： This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.
摘要翻译：本公开涉及温度敏感性缀合物，组合物和与其相关的用途。在某些实施方案中，本公开涉及包含a）温度敏感聚合物和b）抗体的缀合物聚合物。通常抗体具有血小板受体的表位。抗体可以是单链抗体，其中血小板受体是GPIIb / IIIa，例如抗GPIIb / IIIa抗体。在某些实施方案中，抗体特异性结合GPIIb / IIIa的活化构象，即活化特异性GPIIb / IIIa抗体。

2. 发明授权

US09035028B2 Temperature sensitive conjugate compositions 有权
标题翻译：温度敏感的共轭组合物
公开(公告)号：US09035028B2
公开(公告)日：2015-05-19
申请号：US13583055
申请日：2011-03-08
申请人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
发明人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
IPC分类号： C12P21/08 , A61K38/17 , A61K47/48 , C07K14/78 , C07K16/28
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/78 , C07K16/2848 , C07K2317/622 , C07K2319/00
摘要： This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.
摘要翻译：本公开涉及温度敏感性缀合物，组合物和与其相关的用途。在某些实施方案中，本公开涉及包含a）温度敏感聚合物和b）抗体的缀合物聚合物。通常抗体具有血小板受体的表位。抗体可以是单链抗体，其中血小板受体是GPIIb / IIIa，例如抗GPIIb / IIIa抗体。在某些实施方案中，抗体特异性结合GPIIb / IIIa的活化构象，即活化特异性GPIIb / IIIa抗体。

3. 发明授权

US09365650B2 Single chain antibodies that specifically bind to the activated state of the platelet integrin receptor GP IIb/IIIa 有权
标题翻译：单链抗体特异性结合血小板整合素受体GP IIb / IIIa的活化状态
公开(公告)号：US09365650B2
公开(公告)日：2016-06-14
申请号：US13986452
申请日：2008-01-02
申请人： Karlheinz Peter
发明人： Karlheinz Peter
IPC分类号： C07K16/28 , A61K39/395 , A61K47/48 , A61K49/16 , A61K49/18 , A61K51/10 , A61K49/04 , C07K14/81 , A61K39/00
CPC分类号： C07K16/2848 , A61K47/6849 , A61K49/04 , A61K49/16 , A61K49/1818 , A61K51/1027 , A61K2039/505 , C07K14/811 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.
摘要翻译：本发明提供了一种抗凝血剂，其包括能够抑制凝血的第一元件和能够靶向活化血小板的第二元件，其中当向受试者施用药剂时，第二元素将第一元素引导至活化血小板。还提供了一种用于检测血管异常的探针，包括（a）能够靶向活化血小板的结合元件和（b）标签。申请人已经表明，针对活化血小板的药剂和探针可用于诊断和治疗凝血障碍。

4. 发明申请

US20140147445A1 Selective Targeting of the CD40L/Mac-1 Interaction by Small Peptide Inhibitors and its Use for the Treatment of Inflammation and Atherogenesis 有权
标题翻译：小肽抑制剂CD40L / Mac-1相互作用的选择性靶向及其用于治疗炎症和动脉粥样硬化的用途
公开(公告)号：US20140147445A1
公开(公告)日：2014-05-29
申请号：US13880498
申请日：2011-08-17
申请人： Andreas Zirlik , Dennis Wolf , Karlheinz Peter
发明人： Andreas Zirlik , Dennis Wolf , Karlheinz Peter
IPC分类号： A61K39/395 , C07K16/24 , A61K38/12 , A61K38/08 , A61K38/10
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/1709 , C07K16/241 , C07K16/2845 , C07K2317/33 , C07K2317/34 , C07K2317/70 , C07K2317/76
摘要： The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.
摘要翻译： CD40L / Mac-1相互作用被小肽抑制剂和/或抗体选择性靶向，并且这样的肽用于特异性治疗炎症和动脉粥样化形成。特别地，公开了包含具有氨基酸序列EQLKKSKTL的多肽和与表位特异性结合的抗体的药物组合物。

5. 发明申请

US20090317329A2 ANTICOAGULATION AGENT AND USES THEREOF 审中-公开
标题翻译：抗凝剂及其用途
公开(公告)号：US20090317329A2
公开(公告)日：2009-12-24
申请号：US11988196
申请日：2008-12-18
申请人： Karlheinz Peter
发明人： Karlheinz Peter
IPC分类号： A61K49/00 , C07K16/18 , A61K39/395 , C12N15/11 , G01N33/53
CPC分类号： C07K16/2848 , A61K47/6849 , A61K49/04 , A61K49/16 , A61K49/1818 , A61K51/1027 , A61K2039/505 , C07K14/811 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.
摘要翻译：本发明提供了一种抗凝血剂，其包括能够抑制凝血的第一元件和能够靶向活化血小板的第二元件，其中当向受试者施用药剂时，第二元素将第一元素引导至活化血小板。还提供了一种用于检测血管异常的探针，包括（a）能够靶向活化血小板的结合元件和（b）标签。申请人已经表明，针对活化血小板的药剂和探针可用于诊断和治疗凝血障碍。

6. 发明授权

US06521905B1 Method and device for detecting the position of a transparent moving conveyor belt 失效
标题翻译：用于检测透明移动输送带位置的方法和装置
公开(公告)号：US06521905B1
公开(公告)日：2003-02-18
申请号：US09657896
申请日：2000-09-08
申请人： Wolfgang Luxem , Karlheinz Peter , Rolf Spitz
发明人： Wolfgang Luxem , Karlheinz Peter , Rolf Spitz
IPC分类号： G01N2186
CPC分类号： G01D5/342
摘要： A method and device for detecting the position of a transparent conveyor belt including directing light beams (2) onto the region of an edge (3) of the conveyor belt, detecting a jump in intensity of the light beam (2, 2′) as a consequence of the partial insertion of the conveyor belt into the beam path (2) and evaluating the detected jump in intensity in order to determine the position of the conveyor belt, wherein the light beams (2) are linear polarized light and the beam path (2) is directed at an angle or irradiation (&agr;) between 40° and 80° of the light (2) onto the bounding surface (7) in such a way that a high degree of reflection is achieved and reflected light and non-reflected light is detected.
摘要翻译：一种用于检测透明传送带的位置的方法和装置，包括将光束（2）引导到传送带的边缘（3）的区域上，检测光束（2,2'）的强度跳跃为传输带部分地插入到光束路径（2）中并且评估检测到的强度跳跃的结果，以便确定传送带的位置，其中光束（2）是线性偏振光，并且光束路径（2）以光（2）的40°和80°之间的角度或照射（α）被引导到边界表面（7）上，使得实现高度的反射并且反射光和非反射光检测到反射光。

7. 发明申请

US20150328879A1 PRECISION REGISTRATION IN PRINTING CYLINDER SYSTEMS 审中-公开
标题翻译：印刷机系统精密注册
公开(公告)号：US20150328879A1
公开(公告)日：2015-11-19
申请号：US14280707
申请日：2014-05-19
申请人： Matthias Hermann Regelsberger , Karlheinz Peter
发明人： Matthias Hermann Regelsberger , Karlheinz Peter
IPC分类号： B41F13/08
CPC分类号： B41F13/025 , B41F5/24 , B41F7/02 , B41P2213/20 , B41P2213/90 , Y10T428/24802
摘要： A printing system for printing on a web of media traveling along a web transport path including a plurality of print stations located along the web transport path, each print station including a printing cylinder having a printing cylinder circumference for printing on the web of media at a corresponding print location. A plurality of web-transport rollers are used to guide the web of media along the web transport path, each having a roller circumference that is substantially equal to an integer fraction of the printing cylinder circumference.
摘要翻译：一种打印系统，用于在沿着纸幅传送路径行进的介质纸幅上进行打印，所述纸张传送路径包括沿着纸幅传送路径定位的多个打印站，每个打印站包括印刷滚筒，所述印刷滚筒具有用于在相应的打印位置。使用多个卷筒纸传送辊来沿纸幅输送路径引导纸幅，每个纸幅具有基本上等于印刷滚筒圆周的整数分数的辊圆周。

8. 发明授权

US09145014B1 Drive gears providing improved registration in digital printing systems 有权
标题翻译：驱动齿轮提供数字打印系统的改进注册
公开(公告)号：US09145014B1
公开(公告)日：2015-09-29
申请号：US14280724
申请日：2014-05-19
申请人： Matthias Hermann Regelsberger , Karlheinz Peter , Gary Alan Kneezel
发明人： Matthias Hermann Regelsberger , Karlheinz Peter , Gary Alan Kneezel
IPC分类号： B41J11/00 , B41J2/01 , B41J15/02
CPC分类号： B41J15/04 , B41J3/543
摘要： A printing system for printing on a web of media traveling along a web transport path, including a plurality of printheads for printing on the web of media, each of the printheads being configured to print at one or more corresponding print locations along the web transport path. A plurality of web transport rollers guide the web of media along the web transport path. A drive roller causes the web of media to move along the web transport path. The drive roller has an affixed driven gear driven by a motor using a gear train including one or more drive gears which transfer torque from the motor to the driven gear. The driven gear and the drive gears are constrained to rotate substantially an integer number of times as the web of media is advanced along the web transport path between two successive print locations.
摘要翻译：一种打印系统，用于在沿着纸幅传送路径行进的介质纸幅上打印，包括用于在纸幅上打印的多个打印头，每个打印头被配置为沿着纸幅传送路径在一个或多个对应的打印位置打印。多个卷材输送辊沿纸幅输送路径引导纸幅。驱动辊使介质网沿着纸幅传送路径移动。驱动辊具有由马达驱动的固定的从动齿轮，所述从动齿轮使用包括一个或多个驱动齿轮的齿轮系，齿轮系将扭矩从马达传递到从动齿轮。从动齿轮和驱动齿轮被限制为当介质幅材沿两个连续打印位置之间的纸幅输送路径前进时，基本上旋转一整数倍。

9. 发明授权

US08678687B2 Method and device for automatically adapting a write cycle in a digital printing machine 有权
标题翻译：用于在数字印刷机中自动适应写周期的方法和装置
公开(公告)号：US08678687B2
公开(公告)日：2014-03-25
申请号：US13406832
申请日：2012-02-28
申请人： Karlheinz Peter
发明人： Karlheinz Peter
IPC分类号： B41J13/00 , B41J15/00 , G03G15/00 , B65H23/04
CPC分类号： B41J11/42 , B41J11/0035 , B41J15/165
摘要： A method for automatically adapting a write cycle to a movement of a web-shaped medium in a digital printing machine, as a function of the thickness of the web-shaped medium guided around first and second transport or guide rollers, includes providing the first and second transport or guide rollers having a known diameters, the diameter of the second being different from the diameter of the first. A rotational speed ratio N(T) between the first and second transport or guide rollers (9, 11) is determined while the printing material (6) is guided around the transport or guide rollers (9, 11). The write cycle is determined at least with the use of the previously determined rotational speed ratio N(T).
摘要翻译：根据围绕第一和第二传送或引导辊引导的腹板状介质的厚度的函数，自动地将写周期适应于数字印刷机中的网状介质的移动的方法包括提供第一和第具有已知直径的第二输送或导辊，第二输送或导辊的直径不同于第一输送管的直径。当打印材料（6）围绕输送辊或引导辊（9,11）被引导时，确定第一和第二输送或导辊（9,11）之间的转速比N（T）。至少使用先前确定的转速比N（T）来确定写入周期。

10. 发明授权

US08455627B2 Human antibody specific for activated state of platelet integrin receptor GPIIb/IIIa 有权
标题翻译：血小板整合素受体GPIIb / IIIa活化状态的人抗体
公开(公告)号：US08455627B2
公开(公告)日：2013-06-04
申请号：US12877003
申请日：2010-09-07
申请人： Claudia Linhard , Stefan Knackmuss , Melvyn Little , Karlheinz Peter , Peter Roettgen , Meike Schwarz
发明人： Claudia Linhard , Stefan Knackmuss , Melvyn Little , Karlheinz Peter , Peter Roettgen , Meike Schwarz
IPC分类号： C07K16/28
CPC分类号： C07K16/2848 , C07K2317/21 , C07K2317/76
摘要： The present invention is directed to an antibody or derivative thereof of human origin for inhibiting platelet aggregation, characterized in that it is effective by substantially exclusive binding to the activated state of platelet integrin receptor GPIIb/IIIa.
摘要翻译：本发明涉及一种用于抑制血小板聚集的人来源的抗体或其衍生物，其特征在于，通过基本上独特地结合血小板整联蛋白受体GPIIb / IIIa的活化状态是有效的。

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