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1. 发明申请

US20060269914A1 Quantitative test for bacterial pathogens 有权
标题翻译：细菌病原体的定量试验
公开(公告)号：US20060269914A1
公开(公告)日：2006-11-30
申请号：US10532319
申请日：2003-12-05
申请人： Ellen Baron , Wolf-Dieter Engel , Gerd Haberhausen , Peter Kaspar , Andreas Kogelnik
发明人： Ellen Baron , Wolf-Dieter Engel , Gerd Haberhausen , Peter Kaspar , Andreas Kogelnik
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6851
摘要： The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
摘要翻译：本发明涉及用于分析临床样品中细菌病原体的存在的方法，其包括以下步骤：（i）至少部分地从所述样品中分离核酸，其特征在于所述核酸选自：总核酸，总DNA或总RNA，（ii）定量包含对所述细菌病原体特异性的预选序列的核酸的量，和（iii）确定所述含有预定序列的核酸的量是否为特异性对于所述细菌病原体超过第一预定切断值。

2. 发明授权

US07718361B2 Quantitative test for bacterial pathogens 有权
标题翻译：细菌病原体的定量试验
公开(公告)号：US07718361B2
公开(公告)日：2010-05-18
申请号：US10532319
申请日：2003-12-05
申请人： Ellen J. Baron , Wolf-Dieter Engel , Gerd Haberhausen , Peter Kaspar , Andreas M. Kogelnik
发明人： Ellen J. Baron , Wolf-Dieter Engel , Gerd Haberhausen , Peter Kaspar , Andreas M. Kogelnik
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6851
摘要： The present invention is directed to a method for analyzing the presence of a bacterial pathogen in a clinical sample comprising the steps of (i) at least partially isolating nucleic acid from said sample, characterized in that said nucleic acid is selected from a group consisting of either total nucleic acid, total DNA or total RNA, (ii) quantifying the amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen, and (iii) determining whether said amount of nucleic acid comprising a preselected sequence which is specific for said bacterial pathogen exceeds a first predetermined cut off value.
摘要翻译：本发明涉及用于分析临床样品中细菌病原体的存在的方法，其包括以下步骤：（i）至少部分地从所述样品中分离核酸，其特征在于所述核酸选自：总核酸，总DNA或总RNA，（ii）定量包含对所述细菌病原体特异性的预选序列的核酸的量，和（iii）确定所述含有预定序列的核酸的量是否为特异性对于所述细菌病原体超过第一预定切断值。

3. 发明申请

US20060240427A1 Method for the detection of pathogenic gram positive bacteria from the genera staphylococcus, enterococcus and streptococcus 审中-公开
标题翻译：检测葡萄球菌属，肠球菌属和链球菌属病原性革兰氏阳性菌的方法
公开(公告)号：US20060240427A1
公开(公告)日：2006-10-26
申请号：US10534955
申请日：2003-12-02
申请人： Gerd Haberhausen , Thomas Emrich , Rudi Rossasu , Geert Jannes , Daniel Vos
发明人： Gerd Haberhausen , Thomas Emrich , Rudi Rossasu , Geert Jannes , Daniel Vos
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/14 , C12Q1/6851 , G01N2333/31 , G01N2333/315
摘要： The present invention is directed to a method for identification of a Gram positive pathogenic bacterium comprising an amplification step with at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from a first predetermined sub-group of pathogenic Gram positive bacteria, and a detection step with at least a first hybridization reagent capable of specifically detecting a preselected nucleic acid sequence region from the first predetermined sub-group of pathogenic Gram positive bacteria, said detection step comprising steps monitoring whether hybridization has occurred at a preselected temperature, said occurrence of hybridization being indicative for at least the genus of a pathogenic organism present in the sample, and monitoring temperature dependence of hybridization, said temperature dependence being indicative for at least the species of the pathogenic Gram positive bacterium.
摘要翻译：本发明涉及一种用于鉴定革兰氏阳性致病菌的方法，其包括扩增步骤，所述扩增步骤具有至少第一组扩增引物，所述第一组扩增引物能够从病原性革兰氏阳性细菌的第一预定亚组扩增预选的核酸序列区以及检测步骤，其具有至少能够特异性检测来自病原革兰氏阳性细菌的第一预定亚组的预选核酸序列区的第一杂交试剂，所述检测步骤包括监测在预选温度下是否发生杂交的步骤，所述杂交的发生指示至少存在于样品中的致病生物体的属，并且监测杂交的温度依赖性，所述温度依赖性指示致病性革兰氏阳性细菌的种类。

4. 发明申请

US20060115819A1 Detection, identification and differentiation of eubacterial taxa using a hybridization assay 审中-公开
标题翻译：使用杂交测定法检测，鉴定和分化真菌分类群
公开(公告)号：US20060115819A1
公开(公告)日：2006-06-01
申请号：US10537787
申请日：2003-12-08
申请人： Sofie Claeys , Geert Jannes , Gerd Haberhausen , Thomas Emrich , Lia Verdoodt
发明人： Sofie Claeys , Geert Jannes , Gerd Haberhausen , Thomas Emrich , Lia Verdoodt
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定葡萄球菌物种，特别是金黄色葡萄球菌的方法。本发明还涉及用于特异性检测和/或鉴定葡萄球菌物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的衍生自ITS区的新的核酸序列，特别是金黄色葡萄球菌，在生物样品中。它还涉及用于在样品中扩增葡萄球菌物种的所述间隔区的核酸引物。

5. 发明申请

US20070141563A1 Control for nucleic acid testing 有权
标题翻译：核酸测试控制
公开(公告)号：US20070141563A1
公开(公告)日：2007-06-21
申请号：US11638655
申请日：2006-12-12
申请人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
发明人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6844 , C12Q2600/166 , C12Q2545/101
摘要： The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
摘要翻译：本发明涉及通过向测试样品添加内部控制生物分子来检测测试样品中的靶生物分子的方法; 将阴性对照样品与阳性对照样品和试剂对照样品或者将测试样品的内部对照生物分子加入到阴性对照样品中，加入到包含目标生物分子的阳性对照样品中，并提供试剂对照样品，其包含目标生物分子，在每个样品中确定一个信号，并验证信号从而检测目标生物分子。本发明还涉及用于验证指示存在目标生物分子的信号的确定的方法。本发明还涉及用于检测样品中一组靶核酸成员的存在或不存在的方法以及用于验证指示靶核酸组成员的信号的确定的方法酸。

6. 发明申请

US20090017456A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY 审中-公开
标题翻译：使用杂交测定法检测，鉴定和鉴定非特异性毒素
公开(公告)号：US20090017456A1
公开(公告)日：2009-01-15
申请号：US12045183
申请日：2008-03-10
申请人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04 , C07H21/02
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

7. 发明申请

US20060134618A1 Detection, identification and differentiation of eubacterial taxa using a hybridization assay 审中-公开
标题翻译：使用杂交测定法检测，鉴定和分化真菌分类群
公开(公告)号：US20060134618A1
公开(公告)日：2006-06-22
申请号：US10535629
申请日：2003-12-08
申请人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Thomas Emrich , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Thomas Emrich , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔物）区域的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

8. 发明授权

US06248522B1 Reduction of cross-contaminations in nucleic acid amplifications 有权
标题翻译：减少核酸扩增中的交叉污染
公开(公告)号：US06248522B1
公开(公告)日：2001-06-19
申请号：US09136959
申请日：1998-08-20
申请人： Gerd Haberhausen , Stephan Jäger , Harald Sobek
发明人： Gerd Haberhausen , Stephan Jäger , Harald Sobek
IPC分类号： C12Q168
CPC分类号： C12Q1/6848 , C12Q2527/125 , C12Q2525/125 , C12Q2521/531
摘要： The invention concerns a method for the amplification of nucleic acids using a reagent which prevents reactivation of degradation enzymes. This enables a simpler prevention of contaminations.
摘要翻译：本发明涉及使用防止降解酶再活化的试剂来扩增核酸的方法。这使得能够更简单地防止污染。

9. 发明授权

US07981606B2 Control for nucleic acid testing 有权
标题翻译：核酸测试控制
公开(公告)号：US07981606B2
公开(公告)日：2011-07-19
申请号：US11638655
申请日：2006-12-12
申请人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
发明人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2600/166 , C12Q2545/101
摘要： The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
摘要翻译：本发明涉及通过向测试样品添加内部控制生物分子来检测测试样品中的靶生物分子的方法; 将阴性对照样品与阳性对照样品和试剂对照样品或者将测试样品的内部对照生物分子加入到阴性对照样品中，加入到包含目标生物分子的阳性对照样品中，并提供试剂对照样品，其包含目标生物分子，在每个样品中确定一个信号，并验证信号从而检测目标生物分子。本发明还涉及用于验证指示存在目标生物分子的信号的确定的方法。本发明还涉及用于检测样品中一组靶核酸成员的存在或不存在的方法以及用于验证指示靶核酸组成员的信号的确定的方法酸。

10. 发明申请

US20090098558A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF PROTEUS SPECIES USING THE SPACER REGION 审中-公开
标题翻译：使用间隔区域的物种的检测，鉴定和鉴定
公开(公告)号：US20090098558A1
公开(公告)日：2009-04-16
申请号：US12252561
申请日：2008-10-16
申请人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
发明人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/68 , C12Q1/689
摘要： The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribionucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample.The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region.It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
摘要翻译：本发明涉及用于特异性检测和/或鉴定变形菌属物种的16S和23S核糖体核糖核酸（rRNA）或rRNA基因之间的ITS区域的新核酸序列，特别是变形杆菌，普通变形杆菌和/或变形杆菌在生物样品中。本发明还涉及使用衍生自ITS（内部转录间隔物）区的所述新的核酸序列来特异性检测和/或鉴定变形杆菌物种，特别是奇异变形杆菌，普通变形杆菌和/或变形杆菌的方法。它还涉及用于扩增样品中变形杆菌物种的所述间隔区的核酸引物。

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