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1. 发明申请

US20070141563A1 Control for nucleic acid testing 有权
标题翻译：核酸测试控制
公开(公告)号：US20070141563A1
公开(公告)日：2007-06-21
申请号：US11638655
申请日：2006-12-12
申请人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
发明人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6844 , C12Q2600/166 , C12Q2545/101
摘要： The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
摘要翻译：本发明涉及通过向测试样品添加内部控制生物分子来检测测试样品中的靶生物分子的方法; 将阴性对照样品与阳性对照样品和试剂对照样品或者将测试样品的内部对照生物分子加入到阴性对照样品中，加入到包含目标生物分子的阳性对照样品中，并提供试剂对照样品，其包含目标生物分子，在每个样品中确定一个信号，并验证信号从而检测目标生物分子。本发明还涉及用于验证指示存在目标生物分子的信号的确定的方法。本发明还涉及用于检测样品中一组靶核酸成员的存在或不存在的方法以及用于验证指示靶核酸组成员的信号的确定的方法酸。

2. 发明授权

US07981606B2 Control for nucleic acid testing 有权
标题翻译：核酸测试控制
公开(公告)号：US07981606B2
公开(公告)日：2011-07-19
申请号：US11638655
申请日：2006-12-12
申请人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
发明人： Thomas Emrich , Gerd Haberhausen , Martin Moczko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2600/166 , C12Q2545/101
摘要： The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the test sample, to a negative control sample, to a positive control sample comprising the target biomolecule and providing a reagent control sample comprising the target biomolecule, determining in each sample a signal, and verifying the signal thereby detecting the target biomolecule. The invention is also related to a method for verifying the determination of a signal indicating the presence of a target biomolecule. The invention is further related to a method for detecting the presence or the absence of a member of a group of target nucleic acids in a sample and a method for verifying the determination of a signal indicating the presence of a member of a group of target nucleic acids.
摘要翻译：本发明涉及通过向测试样品添加内部控制生物分子来检测测试样品中的靶生物分子的方法; 将阴性对照样品与阳性对照样品和试剂对照样品或者将测试样品的内部对照生物分子加入到阴性对照样品中，加入到包含目标生物分子的阳性对照样品中，并提供试剂对照样品，其包含目标生物分子，在每个样品中确定一个信号，并验证信号从而检测目标生物分子。本发明还涉及用于验证指示存在目标生物分子的信号的确定的方法。本发明还涉及用于检测样品中一组靶核酸成员的存在或不存在的方法以及用于验证指示靶核酸组成员的信号的确定的方法酸。

3. 发明申请

US20060099596A1 Multiplex assay detection of pathogenic organisms 审中-公开
标题翻译：病原生物多重检测检测
公开(公告)号：US20060099596A1
公开(公告)日：2006-05-11
申请号：US10534915
申请日：2003-12-02
申请人： Gerd Haberhausen , Thomas Emrich , Gregor Sagner , Martin Moczko , Gudrun Schmitz-Agheguian
发明人： Gerd Haberhausen , Thomas Emrich , Gregor Sagner , Martin Moczko , Gudrun Schmitz-Agheguian
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/6851
摘要： The present invention is directed to a method for identification of a pathogenic organism from a predetermined group of pathogens, comprising (i) isolating a clinical sample containing at least partially purified nucleic acid, (ii) subjecting at least a first aliquot of said clinical specimen to at least one amplification and detection reaction in one reaction vessel comprising (iia) an amplification step using at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from several or all members of said predetermined group of pathogens, (iib) a detection step using at least 2, 3 or multiple hybridization reagents, said reagents together being capable of specifically detecting a pre-selected nucleic acid sequence region from all members of said group of pathogens, said detection step (iib) comprising steps monitoring hybridization of each of said hybridization reagents at a pre-selected temperature, said hybridization being indicative for at least the genus of said pathogen present in the sample, and monitoring temperature dependence of hybridization, said temperature dependence being indicative for at least the species of said pathogen, and (iii) determining whether said amplification and detection reaction is indicative for the presence of a specific member of said pre-selected group of pathogens.
摘要翻译：本发明涉及从预定病原体组中鉴定病原生物的方法，其包括（i）分离含有至少部分纯化的核酸的临床样品，（ii）对所述临床标本的至少第一等分试样至少在一个反应容器中进行扩增和检测反应，其包括（i）扩增步骤，使用至少第一组扩增引物，所述第一组扩增引物能够扩增来自所述预定病原体组的数个或全部成员的预选核酸序列区（ iib）使用至少2,3或多个杂交试剂的检测步骤，所述试剂一起能够特异性检测来自所述病原体组的所有成员的预先选择的核酸序列区，所述检测步骤（iib）包括监测步骤每个所述杂交试剂在预选温度下进行杂交，所述杂交是指示性的至少存在于样品中的所述病原体的属和监测杂交的温度依赖性，所述温度依赖性指示至少所述病原体的种类，和（iii）确定所述扩增和检测反应是否表明存在的所述预先选择的病原体组的特定成员。

4. 发明申请

US20060134618A1 Detection, identification and differentiation of eubacterial taxa using a hybridization assay 审中-公开
标题翻译：使用杂交测定法检测，鉴定和分化真菌分类群
公开(公告)号：US20060134618A1
公开(公告)日：2006-06-22
申请号：US10535629
申请日：2003-12-08
申请人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Thomas Emrich , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Thomas Emrich , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔物）区域的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

5. 发明申请

US20060240427A1 Method for the detection of pathogenic gram positive bacteria from the genera staphylococcus, enterococcus and streptococcus 审中-公开
标题翻译：检测葡萄球菌属，肠球菌属和链球菌属病原性革兰氏阳性菌的方法
公开(公告)号：US20060240427A1
公开(公告)日：2006-10-26
申请号：US10534955
申请日：2003-12-02
申请人： Gerd Haberhausen , Thomas Emrich , Rudi Rossasu , Geert Jannes , Daniel Vos
发明人： Gerd Haberhausen , Thomas Emrich , Rudi Rossasu , Geert Jannes , Daniel Vos
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/14 , C12Q1/6851 , G01N2333/31 , G01N2333/315
摘要： The present invention is directed to a method for identification of a Gram positive pathogenic bacterium comprising an amplification step with at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from a first predetermined sub-group of pathogenic Gram positive bacteria, and a detection step with at least a first hybridization reagent capable of specifically detecting a preselected nucleic acid sequence region from the first predetermined sub-group of pathogenic Gram positive bacteria, said detection step comprising steps monitoring whether hybridization has occurred at a preselected temperature, said occurrence of hybridization being indicative for at least the genus of a pathogenic organism present in the sample, and monitoring temperature dependence of hybridization, said temperature dependence being indicative for at least the species of the pathogenic Gram positive bacterium.
摘要翻译：本发明涉及一种用于鉴定革兰氏阳性致病菌的方法，其包括扩增步骤，所述扩增步骤具有至少第一组扩增引物，所述第一组扩增引物能够从病原性革兰氏阳性细菌的第一预定亚组扩增预选的核酸序列区以及检测步骤，其具有至少能够特异性检测来自病原革兰氏阳性细菌的第一预定亚组的预选核酸序列区的第一杂交试剂，所述检测步骤包括监测在预选温度下是否发生杂交的步骤，所述杂交的发生指示至少存在于样品中的致病生物体的属，并且监测杂交的温度依赖性，所述温度依赖性指示致病性革兰氏阳性细菌的种类。

6. 发明申请

US20060115819A1 Detection, identification and differentiation of eubacterial taxa using a hybridization assay 审中-公开
标题翻译：使用杂交测定法检测，鉴定和分化真菌分类群
公开(公告)号：US20060115819A1
公开(公告)日：2006-06-01
申请号：US10537787
申请日：2003-12-08
申请人： Sofie Claeys , Geert Jannes , Gerd Haberhausen , Thomas Emrich , Lia Verdoodt
发明人： Sofie Claeys , Geert Jannes , Gerd Haberhausen , Thomas Emrich , Lia Verdoodt
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定葡萄球菌物种，特别是金黄色葡萄球菌的方法。本发明还涉及用于特异性检测和/或鉴定葡萄球菌物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的衍生自ITS区的新的核酸序列，特别是金黄色葡萄球菌，在生物样品中。它还涉及用于在样品中扩增葡萄球菌物种的所述间隔区的核酸引物。

7. 发明申请

US20090017456A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY 审中-公开
标题翻译：使用杂交测定法检测，鉴定和鉴定非特异性毒素
公开(公告)号：US20090017456A1
公开(公告)日：2009-01-15
申请号：US12045183
申请日：2008-03-10
申请人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04 , C07H21/02
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

8. 发明申请

US20090098558A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF PROTEUS SPECIES USING THE SPACER REGION 审中-公开
标题翻译：使用间隔区域的物种的检测，鉴定和鉴定
公开(公告)号：US20090098558A1
公开(公告)日：2009-04-16
申请号：US12252561
申请日：2008-10-16
申请人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
发明人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/68 , C12Q1/689
摘要： The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribionucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample.The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region.It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
摘要翻译：本发明涉及用于特异性检测和/或鉴定变形菌属物种的16S和23S核糖体核糖核酸（rRNA）或rRNA基因之间的ITS区域的新核酸序列，特别是变形杆菌，普通变形杆菌和/或变形杆菌在生物样品中。本发明还涉及使用衍生自ITS（内部转录间隔物）区的所述新的核酸序列来特异性检测和/或鉴定变形杆菌物种，特别是奇异变形杆菌，普通变形杆菌和/或变形杆菌的方法。它还涉及用于扩增样品中变形杆菌物种的所述间隔区的核酸引物。

9. 发明申请

US20050176048A1 Detection, identification and differentiation of Proteus species using the spacer region 审中-公开
标题翻译：使用间隔区域的变形杆菌物种的检测，鉴定和分化
公开(公告)号：US20050176048A1
公开(公告)日：2005-08-11
申请号：US11050445
申请日：2005-02-04
申请人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
发明人： Geert Jannes , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/68 , C12Q1/689
摘要： The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
摘要翻译：本发明涉及用于特异性检测和/或鉴定变形菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的ITS区域的新核酸序列，特别是变形杆菌，普通变形杆菌和/或变形杆菌在生物样品中。本发明还涉及使用衍生自ITS（内部转录间隔物）区的所述新的核酸序列来特异性检测和/或鉴定变形杆菌物种，特别是奇异变形杆菌，普通变形杆菌和/或变形杆菌的方法。它还涉及用于扩增样品中变形杆菌物种的所述间隔区的核酸引物。

10. 发明授权

US09273361B2 Detection, identification and differentiation of eubacterial taxa using a hybridization assay 有权
标题翻译：使用杂交测定法检测，鉴定和分化真菌分类群
公开(公告)号：US09273361B2
公开(公告)日：2016-03-01
申请号：US13748380
申请日：2013-01-23
申请人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde De Henau , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

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