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1. 发明申请

US20110063607A1 Sample holder for dynamic light scattering 有权
标题翻译：用于动态光散射的样品架
公开(公告)号：US20110063607A1
公开(公告)日：2011-03-17
申请号：US12807208
申请日：2010-08-31
申请人： Elisabeth Maurer , Georg Maurer , Keddie Brown , Gyasi Bourne , Kenneth MacCallum , Paul Charlebois
发明人： Elisabeth Maurer , Georg Maurer , Keddie Brown , Gyasi Bourne , Kenneth MacCallum , Paul Charlebois
IPC分类号： G01N21/01
CPC分类号： G01N21/0332 , G01N15/0211 , G01N21/15 , G01N21/51 , G01N2015/0065 , G01N2015/0084 , G01N2015/0222 , G01N2021/513 , Y10T436/101666
摘要： There is described a sample holder and associated fluid container assembly for optical analysis of a fluid sample within a translucent container of the fluid container assembly. The sample holder includes clamping members rotatably mounted to a frame for rotation, about parallel axes spaced apart from each other, between a container accepting position in which the clamping members are spaced apart from the translucent container, and an analysis position in the clamping members abut the translucent container. The clamping members each define an optical waveguide slot extending therethrough that is substantially aligned with the translucent container when the clamping members are disposed in the analysis position, to thereby provide optical access to the translucent container for optical analysis of the fluid sample therein.
摘要翻译：描述了用于在流体容器组件的半透明容器内的流体样品的光学分析的样品保持器和相关联的流体容器组件。样品架包括夹紧构件，夹紧构件可旋转地安装到框架上，围绕彼此间隔开的平行轴线在夹持构件与半透明容器间隔开的容器接收位置之间旋转并且夹紧构件中的分析位置邻接半透明的容器。夹紧构件各自限定了延伸穿过其中的光波导槽，当将夹紧构件设置在分析位置时，其基本上与半透明容器对准，从而提供对半透明容器的光学接近以便在其中对流体样品进行光学分析。

2. 发明授权

US08663575B2 Sample holder for dynamic light scattering 有权
标题翻译：用于动态光散射的样品架
公开(公告)号：US08663575B2
公开(公告)日：2014-03-04
申请号：US12807208
申请日：2010-08-31
申请人： Elisabeth Maurer , Georg Maurer , Keddie Brown , Gyasi Bourne , Kenneth MacCallum , Paul Charlebois
发明人： Elisabeth Maurer , Georg Maurer , Keddie Brown , Gyasi Bourne , Kenneth MacCallum , Paul Charlebois
IPC分类号： C12Q1/68 , B01L3/00 , G01N31/00 , C12M1/34 , G01N21/01
CPC分类号： G01N21/0332 , G01N15/0211 , G01N21/15 , G01N21/51 , G01N2015/0065 , G01N2015/0084 , G01N2015/0222 , G01N2021/513 , Y10T436/101666
摘要： There is described a sample holder and associated fluid container assembly for optical analysis of a fluid sample within a translucent container of the fluid container assembly. The sample holder includes clamping members rotatably mounted to a frame for rotation, about parallel axes spaced apart from each other, between a container accepting position in which the clamping members are spaced apart from the translucent container, and an analysis position in the clamping members abut the translucent container. The clamping members each define an optical waveguide slot extending therethrough that is substantially aligned with the translucent container when the clamping members are disposed in the analysis position, to thereby provide optical access to the translucent container for optical analysis of the fluid sample therein.
摘要翻译：描述了用于在流体容器组件的半透明容器内的流体样品的光学分析的样品保持器和相关联的流体容器组件。样品架包括夹紧构件，夹紧构件可旋转地安装到框架上，围绕彼此间隔开的平行轴线在夹持构件与半透明容器间隔开的容器接收位置之间旋转并且夹紧构件中的分析位置邻接半透明的容器。夹紧构件各自限定了延伸穿过其中的光波导槽，当将夹紧构件设置在分析位置时，其基本上与半透明容器对准，从而提供对半透明容器的光学接近以便在其中对流体样品进行光学分析。

3. 发明申请

US20070041877A1 Sample holder for dynamic light scattering 有权
标题翻译：用于动态光散射的样品架
公开(公告)号：US20070041877A1
公开(公告)日：2007-02-22
申请号：US11208080
申请日：2005-08-19
申请人： Elisabeth Maurer , Georg Maurer , Keddie Brown
发明人： Elisabeth Maurer , Georg Maurer , Keddie Brown
IPC分类号： B01L3/00
CPC分类号： G01N21/51 , G01N21/0332 , Y10T436/101666
摘要： A sample holder holds various sizes of capillaries or cuvettes for use in dynamic light scattering (DLS) or quasi-elastic light scattering (QELS), such as in DLS of fluid samples such as platelet solutions, whole blood, colloids or the like. The sample holder has a base with a stationary backing member and a sliding, rail-mounted clamping member that is magnetically biased toward the backing member. The sample holder has Peltier-type thermoelectric heating/cooling elements that extend the full height of the clamping and backing members to optimize heat transfer efficiency. The sample holder further includes horizontal slots that enable collection of scattered light from various angles around the device. Finned heat sinks are mounted above and below the horizontal slots on the outwardly facing surfaces of the backing and clamping members to stabilize the temperature of the fluid sample in the sample holder without interfering with incident or scattered light.
摘要翻译：样品架具有用于动态光散射（DLS）或准弹性光散射（QELS）的各种尺寸的毛细管或比色皿，例如液体样品如血小板溶液，全血，胶体等的DLS。样品保持器具有带有固定背衬构件的底座和滑动的轨道安装的夹紧构件，其被朝向背衬构件磁偏置。样品架具有Peltier型热电加热/冷却元件，其延伸夹紧和背衬构件的全部高度，以优化传热效率。样品架还包括能够收集来自设备周围的各种角度的散射光的水平槽。鳍状散热器安装在背衬和夹紧构件的向外的表面上的水平狭槽的上方和下方，以稳定样品架中的流体样品的温度，而不干扰入射或散射的光。

4. 发明授权

US09134336B2 Dual analyzer system for biological fluid 有权
标题翻译：生物流体双分析仪系统
公开(公告)号：US09134336B2
公开(公告)日：2015-09-15
申请号：US13501282
申请日：2010-08-31
申请人： Elisabeth Maurer , Long Hin Fong
发明人： Elisabeth Maurer , Long Hin Fong
IPC分类号： G01N33/48 , G01N35/10
CPC分类号： G01N35/1097 , G01N35/08
摘要： The described apparatus for analyzing a biological sample includes a first analysis instrument fluidly connected to a reservoir for receiving a first flow of the biological fluid and adapted for performing a measurement of a property of the biological sample. A second analysis instrument is fluidly connected to the reservoir for receiving a second flow of the biological fluid and adapted for performing a thermally controlled analysis of the biological sample. The second analysis instrument includes a thermally controlled chamber. A flow stopping device stops the second flow within the thermally controlled chamber in order to allow the second analysis instrument to perform the thermally controlled analysis of the biological sample. The first analysis instrument may include, for example, a hematology analyzer or a flow cytometer, and the second analysis instrument may include, for example, a dynamic light scattering instrument.
摘要翻译：所描述的用于分析生物样品的装置包括流体连接到储存器的第一分析仪器，用于接收生物流体的第一流并且适于执行生物样品的性质的测量。第二分析仪器流体地连接到储存器，用于接收生物流体的第二流，并适于对生物样品进行热控制分析。第二分析仪器包括一个热控室。流动停止装置停止热控制室内的第二流动，以便允许第二分析仪器对生物样品进行热控分析。第一分析仪器可以包括例如血液分析仪或流式细胞仪，并且第二分析仪器可以包括例如动态光散射仪器。

5. 发明申请

US20120198922A1 Dual Analyzer System for Biological fluid 有权
标题翻译：生物流体双分析仪系统
公开(公告)号：US20120198922A1
公开(公告)日：2012-08-09
申请号：US13501282
申请日：2010-08-31
申请人： Elisabeth Maurer , Long Hin Fong
发明人： Elisabeth Maurer , Long Hin Fong
IPC分类号： G01N21/49 , G01N33/487 , G01N1/28
CPC分类号： G01N35/1097 , G01N35/08
摘要： The described apparatus for analyzing a biological sample includes a first analysis instrument fluidly connected to a reservoir for receiving a first flow of the biological fluid and adapted for performing a measurement of a property of the biological sample. A second analysis instrument is fluidly connected to the reservoir for receiving a second flow of the biological fluid and adapted for performing a thermally controlled analysis of the biological sample. The second analysis instrument includes a thermally controlled chamber. A flow stopping device stops the second flow within the thermally controlled chamber in order to allow the second analysis instrument to perform the thermally controlled analysis of the biological sample. The first analysis instrument may include, for example, a hematology analyzer or a flow cytometer, and the second analysis instrument may include, for example, a dynamic light scattering instrument.
摘要翻译：所描述的用于分析生物样品的装置包括流体连接到储存器的第一分析仪器，用于接收生物流体的第一流并且适于执行生物样品的性质的测量。第二分析仪器流体地连接到储存器，用于接收生物流体的第二流，并适于对生物样品进行热控制分析。第二分析仪器包括一个热控室。流动停止装置停止热控制室内的第二流动，以便允许第二分析仪器对生物样品进行热控分析。第一分析仪器可以包括例如血液分析仪或流式细胞仪，并且第二分析仪器可以包括例如动态光散射仪器。

6. 发明申请

US20110104743A1 Dynamic Light Scattering for in vitro Testing of Bodily Fluids 有权
标题翻译：动态光散射用于体液检测体液
公开(公告)号：US20110104743A1
公开(公告)日：2011-05-05
申请号：US13001654
申请日：2008-07-04
申请人： Elisabeth Maurer , Cheryl Pittendreigh
发明人： Elisabeth Maurer , Cheryl Pittendreigh
IPC分类号： C12Q1/04 , G01N15/02
CPC分类号： G01N21/49 , G01N15/0211 , G01N15/05 , G01N21/51 , G01N2015/0084
摘要： A method of diagnosing a pathological condition by detecting microparticles in a sample of bodily fluid using dynamic light scattering (DLS) is disclosed. The detection of microparticles in the bodily fluid by DLS may be used as an indicator of existing disease, to evaluate a risk of disease, as well as to monitor the efficacy of a treatment for disease.
摘要翻译：公开了通过使用动态光散射（DLS）检测体液样品中的微粒来诊断病理状况的方法。通过DLS检测体液中的微粒可以用作现有疾病的指标，以评估疾病的风险，以及监测疾病治疗的功效。

7. 发明申请

US20100136611A1 METHOD OF DETECTING BACTERIAL CONTAMINATION USING DYNAMIC LIGHT SCATTERING 有权
标题翻译：使用动态光散射检测细菌污染的方法
公开(公告)号：US20100136611A1
公开(公告)日：2010-06-03
申请号：US12525467
申请日：2008-02-01
申请人： Elisabeth Maurer
发明人： Elisabeth Maurer
IPC分类号： C12Q1/06 , C12M1/34
CPC分类号： C12Q1/04 , G01N15/0211 , G01N15/1429 , G01N15/1456 , G01N2015/0084 , G01N2015/0088 , G01N2015/0092 , G01N2015/0222 , G01N2015/03 , G01N2015/1402
摘要： Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically translucent window can be held within another variant of the sample holder. Still alternatively, platelet storage bags having one or more tubes detachably appended to the bag can be used. A sample is drawn off into an appended tube for placement directly into the sample holder. This method provides a number of related, non-invasive techniques for detecting whether bacteria has contaminated a platelet concentrate. Contamination indicators include a population of particles different from platelets, microparticles or proteins, bad-quality platelets, i.e. low DLS score, and very high or very low scattering intensity.
摘要翻译：使用动态光散射（DLS）仪器和样品架进行血小板浓缩物中细菌污染检测的方法。血小板浓缩物的样品可以垂直或水平地保持在样品架中的毛细管中。或者，修改为包括光学半透明窗口的新颖血小板储存袋可以保持在样品保持器的另一个变体中。或者，可以使用具有可拆卸地附接到袋的一个或多个管的血小板储存袋。将样品抽出到附加的管中以直接放置在样品架中。该方法提供了许多相关的非侵入性技术来检测细菌是否已经污染了血小板浓缩物。污染指标包括与血小板，微粒或蛋白质不同的颗粒群，不良质量的血小板，即低DLS评分，以及非常高或非常低的散射强度。

8. 发明授权

US09134206B2 Container for non-invasive fluid sample access 有权
标题翻译：用于非侵入性流体样品进入的容器
公开(公告)号：US09134206B2
公开(公告)日：2015-09-15
申请号：US13817877
申请日：2011-08-31
申请人： Elisabeth Maurer
发明人： Elisabeth Maurer
IPC分类号： G01N1/00 , G01N1/28 , B01L3/00 , G01N21/03 , G01N21/51
CPC分类号： G01N1/28 , B01L3/505 , B01L2200/141 , B01L2200/143 , B01L2300/044 , B01L2300/047 , B01L2400/0481 , B01L2400/0638 , G01N21/03 , G01N2021/0346 , G01N2021/0364 , G01N2021/513
摘要： A deformable container (5) containing a fluid product to be tested includes a flexible outer wall (10) enclosing a main cavity (9) therein for holding the fluid product and at least one appendix (14) for containing a sample volume to be tested. The appendix is displaceable from a first position, wherein the appendix is invaginated within a periphery of the deformable container, and a second position, wherein the appendix protrudes outwardly from the outer wall and defines a second cavity (7) therein for a sample fluid volume, such as to permit testing of the sample volume within the appendix (14). The appendix is displaced into the second position by the fluid product within the deformable container when pressure is applied to the outer wall to force the sample volume of the fluid product from the main cavity of the deformable container into the second cavity of the appendix.
摘要翻译：包含待测试的流体产品的可变形容器（5）包括在其中包围其中的主腔（9）的柔性外壁（10），用于保持流体产品和至少一个用于容纳要测试的样品体积的附件（14）。阑尾可以从第一位置移位，其中附件在可变形容器的周边内陷入第二位置，第二位置，其中附件从外壁向外突出并且在其中限定了用于样品流体体积的第二腔（7），例如允许在附录（14）内测试样品量。当压力施加到外壁上时，附件被可变形容器内的流体产品移动到第二位置，以迫使流体产品的样品体积从可变形容器的主腔进入阑尾的第二腔。

9. 发明授权

US08877458B2 Method of detecting bacterial contamination using dynamic light scattering 有权
标题翻译：使用动态光散射检测细菌污染的方法
公开(公告)号：US08877458B2
公开(公告)日：2014-11-04
申请号：US12525467
申请日：2008-02-01
申请人： Elisabeth Maurer
发明人： Elisabeth Maurer
IPC分类号： C12Q1/04 , G01N15/02 , G01N15/00
CPC分类号： C12Q1/04 , G01N15/0211 , G01N15/1429 , G01N15/1456 , G01N2015/0084 , G01N2015/0088 , G01N2015/0092 , G01N2015/0222 , G01N2015/03 , G01N2015/1402
摘要： Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically translucent window can be held within another variant of the sample holder. Still alternatively, platelet storage bags having one or more tubes detachably appended to the bag can be used. A sample is drawn off into an appended tube for placement directly into the sample holder. This method provides a number of related, non-invasive techniques for detecting whether bacteria has contaminated a platelet concentrate. Contamination indicators include a population of particles different from platelets, microparticles or proteins, bad-quality platelets, i.e. low DLS score, and very high or very low scattering intensity.
摘要翻译：使用动态光散射（DLS）仪器和样品架进行血小板浓缩物中细菌污染检测的方法。血小板浓缩物的样品可以垂直或水平地保持在样品架中的毛细管中。或者，修改为包括光学半透明窗口的新颖血小板储存袋可以保持在样品保持器的另一个变体中。或者，可以使用具有可拆卸地附接到袋的一个或多个管的血小板储存袋。将样品抽出到附加的管中以直接放置在样品架中。该方法提供了许多相关的非侵入性技术来检测细菌是否已经污染了血小板浓缩物。污染指标包括与血小板，微粒或蛋白质不同的颗粒群，不良质量的血小板，即低DLS评分，以及非常高或非常低的散射强度。

10. 发明授权

US08323922B2 Dynamic light scattering for in vitro testing of bodily fluids 有权
标题翻译：动态光散射用于体液检测体液
公开(公告)号：US08323922B2
公开(公告)日：2012-12-04
申请号：US13001654
申请日：2008-07-04
申请人： Elisabeth Maurer , Cheryl Pittendreigh
发明人： Elisabeth Maurer , Cheryl Pittendreigh
IPC分类号： C12Q1/04 , A01N1/02
CPC分类号： G01N21/49 , G01N15/0211 , G01N15/05 , G01N21/51 , G01N2015/0084
摘要： A method of diagnosing a pathological condition by detecting microparticles in a sample of bodily fluid using dynamic light scattering (DLS) is disclosed. The detection of microparticles in the bodily fluid by DLS may be used as an indicator of existing disease, to evaluate a risk of disease, as well as to monitor the efficacy of a treatment for disease.
摘要翻译：公开了通过使用动态光散射（DLS）检测体液样品中的微粒来诊断病理状况的方法。通过DLS检测体液中的微粒可以用作现有疾病的指标，以评估疾病的风险，以及监测疾病治疗的功效。

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