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    • 3. 发明申请
    • Scanning Laser Projector
    • 扫描激光投影机
    • US20120105812A1
    • 2012-05-03
    • US13289422
    • 2011-11-04
    • Ronald DekkerEdwin Jan Klein
    • Ronald DekkerEdwin Jan Klein
    • G03B21/14
    • H04N9/3129A61B5/0062A61B5/0064A61B5/0068A61B5/4887A61B5/489G02B6/12004G02B6/12007G02B6/29388G02B2006/12035G03B21/2033G03B33/06G03B33/12
    • A scanning projector for projecting an image comprising multiple wavelength signals is disclosed. Embodiments of the present invention include a beam combiner comprising a planar lightwave circuit having a plurality of surface waveguides arranged to define a plurality of input ports, a mixing region, and an output port. Each input port receives a different wavelength signal and provides it to the mixing region. The mixing region combines the plurality of wavelength signals into a single composite output beam that is scanned over a region to create an image in a region.In some embodiments, the projector (1) interrogates image points in the region using a first wavelength signal to determine a measurand and (2) projects an image over the image points of the region using a second wavelength signal, wherein each image point is illuminated with the second wavelength signal based on a measurand at that image point.
    • 公开了一种用于投影包括多个波长信号的图像的扫描投影仪。 本发明的实施例包括一种光束组合器,其包括具有布置成限定多个输入端口的多个表面波导的平面光波电路,混合区域和输出端口。 每个输入端口接收不同的波长信号并将其提供给混合区域。 混合区域将多个波长信号组合成单个复合输出光束,该单个复合输出光束在区域上扫描以在区域中产生图像。 在一些实施例中,投影仪(1)使用第一波长信号询问该区域中的图像点以确定被测量,并且(2)使用第二波长信号在图像点上投影图像,其中每个图像点被照亮 基于在该图像点处的被测量的第二波长信号。
    • 10. 发明申请
    • CARDIOMYOCYTES-CONTAINING DEVICE AND METHOD FOR MANUFACTURING AND USING THE SAME
    • 含有血小板活性的装置及其制造和使用方法
    • US20120094323A1
    • 2012-04-19
    • US13147607
    • 2010-02-02
    • Ronald DekkerAnja Van De Stolpe
    • Ronald DekkerAnja Van De Stolpe
    • C12Q1/18H01B13/00B05D5/00C12M1/34B05D1/36
    • G01N1/30C12N5/0657C12N2503/02C12N2535/10G01N33/5061
    • Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.
    • 公开了一种用于确定化合物的心脏毒性的装置,包括承载可变形叠层(34)的基底(10),所述叠层通过空腔(32)部分地与基底分离,允许外部变形 所述堆叠包括夹在所述第一和第二可变形层之间的第一可变形层(16),第二可变形层(20)和多电极结构(18),所述第二可变形层承载心肌细胞图案(28 ) 和安装在基板上的用于将心肌细胞暴露于化合物的液体容器(26)。 还公开了制造这种装置的方法。 本发明还涉及该装置用于药物靶发现和/或药物开发的用途,以及用于开发由细胞拉伸,特别是心脏疾病模型引起或改变的疾病的疾病模型的方法。