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1. 发明申请

US20060100304A1 Replacement or supplementation of a nucleus pulposus using a hydrogel 审中-公开
标题翻译：使用水凝胶替代或补充髓核
公开(公告)号：US20060100304A1
公开(公告)日：2006-05-11
申请号：US11134309
申请日：2005-05-23
申请人： Edward Vresilovic , Michael Keane , Alastair Clemow , Nigel Smith
发明人： Edward Vresilovic , Michael Keane , Alastair Clemow , Nigel Smith
IPC分类号： A61F2/44 , A61F2/46 , A61B17/90 , A61F2/00 , A61B17/00 , A61L27/00
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

2. 发明申请

US20110270286A1 METHOD OF FORMING AND THE RESULTING MEMBRANE COMPOSITION FOR SURGICAL SITE PRESERVATION 有权
标题翻译：形成和结构膜组合物的手术保存方法
公开(公告)号：US20110270286A1
公开(公告)日：2011-11-03
申请号：US13142294
申请日：2008-12-29
申请人： Michael Keane , William Miller , Nigel Smith
发明人： Michael Keane , William Miller , Nigel Smith
IPC分类号： A61B17/00
CPC分类号： A61L31/14 , A61L31/06 , A61L31/129 , A61L31/145 , A61L31/18 , C08L29/04 , C08L39/06
摘要： A method of forming and the resulting membrane composition for securement to a patient's bone or tissue to reduce the formation of tissue adhesions following a surgical procedure comprises a first component and a second component. The first component comprises a hydrogel including at least one crosslinked polymer. The second component comprises a textile component. The composition has a thickness between about two tenths of a millimeter (0.2 mm) to about six tenths of a millimeter (0.6 mm), a suture retention strength between about one Newton (1 N) to about thirteen Newtons (13 N), a static coefficient of friction between about one hundredth (0.01) and about one-half (0.5), a kinetic coefficient of friction between about one hundredth (0.01) and about one-half (0.5) and a flexibility of less than thirty millimeters (30 mm) bend length. A method of reducing the occurrence of tissue adhesions following surgery comprises applying the membrane composition to a surgical site.
摘要翻译：一种形成方法和所得的膜组合物用于固定到患者的骨骼或组织以减少外科手术后组织粘连的形成包括第一组分和第二组分。第一组分包含包含至少一种交联聚合物的水凝胶。第二部件包括纺织部件。该组合物具有约十分之二十毫米（0.2毫米）至约十六分之一毫米（0.6毫米）之间的厚度，约一牛顿（1N）至约十三牛顿（13N）之间的缝合线保持强度，一静态摩擦系数在约百分之一（0.01）至约一半（0.5）之间，摩擦系数约在百分之一（0.01）至约一半（0.5）之间，弹性小于三十毫米 mm）弯曲长度。减少手术后组织粘连发生的方法包括将膜组合物施用于手术部位。

3. 发明授权

US08748508B2 Method of forming and the resulting membrane composition for surgical site preservation 有权
标题翻译：成型方法和所得的外用部位保存膜组合物
公开(公告)号：US08748508B2
公开(公告)日：2014-06-10
申请号：US13142294
申请日：2008-12-29
申请人： Michael Keane , William Miller , Nigel Smith
发明人： Michael Keane , William Miller , Nigel Smith
IPC分类号： A61L27/16
CPC分类号： A61L31/14 , A61L31/06 , A61L31/129 , A61L31/145 , A61L31/18 , C08L29/04 , C08L39/06
摘要： A method of forming and the resulting membrane composition for securement to a patient's bone or tissue to reduce the formation of tissue adhesions following a surgical procedure comprises a first component and a second component. The first component comprises a hydrogel including at least one crosslinked polymer. The second component comprises a textile component. The composition has a thickness between about two tenths of a millimeter (0.2 mm) to about six tenths of a millimeter (0.6 mm), a suture retention strength between about one Newton (1 N) to about thirteen Newtons (13 N), a static coefficient of friction between about one hundredth (0.01) and about one-half (0.5), a kinetic coefficient of friction between about one hundredth (0.01) and about one-half (0.5) and a flexibility of less than thirty millimeters (30 mm) bend length. A method of reducing the occurrence of tissue adhesions following surgery comprises applying the membrane composition to a surgical site.
摘要翻译：一种形成方法和所得的膜组合物用于固定到患者的骨骼或组织以减少外科手术后组织粘连的形成包括第一组分和第二组分。第一组分包含包含至少一种交联聚合物的水凝胶。第二部件包括纺织部件。该组合物具有约十分之二十毫米（0.2毫米）至约十六分之一毫米（0.6毫米）之间的厚度，约一牛顿（1N）至约十三牛顿（13N）之间的缝合线保持强度，一静态摩擦系数在约百分之一（0.01）至约一半（0.5）之间，摩擦系数约在百分之一（0.01）至约一半（0.5）之间，弹性小于三十毫米 mm）弯曲长度。减少手术后组织粘连发生的方法包括将膜组合物施用于手术部位。

4. 发明授权

US09561960B2 Biomedical materials 有权
标题翻译：生物医学材料
公开(公告)号：US09561960B2
公开(公告)日：2017-02-07
申请号：US12303951
申请日：2007-06-07
申请人： Iain Ronald Gibson , Janet Mabel Scott Skakle , Nigel Smith , Thomas Buckland
发明人： Iain Ronald Gibson , Janet Mabel Scott Skakle , Nigel Smith , Thomas Buckland
IPC分类号： C01B25/32 , A61K49/00 , A61K49/08
CPC分类号： A61K49/08 , A61K49/00 , A61K49/1803 , A61L27/025 , A61L27/425 , A61L2430/02 , C01B25/32
摘要： A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprise a compound having the general chemical formula: Ca10−yGdy(PO4)6−x(SiO4)x(OH)2−x+y where 0
摘要翻译：一种包含钆的合成的基于磷酸钙的生物医学材料。该材料可以包含具有以下通式的化合物：Ca10-yGy（PO4）6-x（SiO4）x（OH）2-x + y，其中0

5. 发明授权

US08439949B2 Facet joint augmentation with hydrogels 有权
标题翻译：与水凝胶共面增厚
公开(公告)号：US08439949B2
公开(公告)日：2013-05-14
申请号：US13055833
申请日：2009-07-24
申请人： Beat Lechmann , Robert Frigg , Nigel Smith
发明人： Beat Lechmann , Robert Frigg , Nigel Smith
IPC分类号： A61B17/70
CPC分类号： A61F2/28 , A61B17/562 , A61B2017/00526 , A61B2017/00862 , A61B2017/00898 , A61F2/4405 , A61F2002/2839 , A61F2002/30065 , A61F2002/30069 , A61F2002/30075 , A61F2002/30224 , A61F2002/30583 , A61F2002/3085 , A61F2210/0061 , A61F2210/0071 , A61F2210/0085 , A61F2230/0069
摘要： A method for augmenting a facet joint. The method includes exposing the posterior aspects of a spinal motion segment in a first incision, preparing an access path through a separate postero-lateral percutaneous incision using a drilling instrument that traverses through at least a portion of the lamina and an inferior facet articulation surface, and terminates within the facet joint gap, and injecting augmentation filler into the facet joint gap.
摘要翻译：一种增加小关节的方法。该方法包括在第一切口中暴露脊柱运动段的后方，通过穿过穿过至少一部分层的钻孔仪器和下小面关节表面来准备穿过单独的后外侧经皮切口的进入路径，并在小关节间隙内终止，并将增量填充物注入到小关节间隙中。

6. 发明申请

US20070222088A1 Overlay Metrology Mark 审中-公开
标题翻译：叠加计量标记
公开(公告)号：US20070222088A1
公开(公告)日：2007-09-27
申请号：US10549860
申请日：2004-04-08
申请人： Nigel Smith , Michael Hammond
发明人： Nigel Smith , Michael Hammond
IPC分类号： H01L23/544 , H01L21/66
CPC分类号： G03F9/7076
摘要： An overlay metrology mark for determining the relative position between two or more layers of an integrated circuit structure comprising a first mark portion associated with and in particular developed on a first layer and a second mark portion associated with and in particular developed on a second layer, wherein the first and second mark portions together constitute, when the mark is properly aligned, at least one pair of test zones, each test zone comprising a first mark section formed as part of the first mark portion and a second mark section formed as part of the second mark portion each comprising a plurality of elongate rectangular mark structures in parallel array adjacently disposed to form the said test zone such that the mark structures in each test zone are in alignment in a first direction within the test zone but are substantially at 90° with respect to the mark structures of at least one other test zone in alignment in a second direction, and wherein the test zones making up the or each pair are laterally displaced relative to each other along one of the said directions. A method of marking and a method of determining overlay error are also described.
摘要翻译：用于确定集成电路结构的两层或更多层之间的相对位置的覆盖计量标记，其包括与第一层相关联并且特别地在第一层上开发的第一标记部分和与第二层相关联并且特别地在第二层上开发的第二标记部分，其中当所述标记被适当对准时，所述第一和第二标记部分一起构成至少一对测试区域，每个测试区域包括形成为所述第一标记部分的一部分的第一标记部分和形成为所述第一标记部分的一部分的第二标记部分所述第二标记部分每个包括多个平行排列的细长矩形标记结构，以相邻设置以形成所述测试区域，使得每个测试区域中的标记结构在测试区域内沿第一方向对齐，但基本上为90° 相对于在第二方向上对准的至少另一个测试区的标记结构，并且其中测试区mak 所述一对或每对中的一对沿着所述方向中的一个相对于彼此横向移位。还描述了一种标记方法和确定重叠误差的方法。

7. 发明申请

US20050247725A1 Dispenser 审中-公开
标题翻译：分配器
公开(公告)号：US20050247725A1
公开(公告)日：2005-11-10
申请号：US10507187
申请日：2003-03-12
申请人： Nigel Smith
发明人： Nigel Smith
IPC分类号： E03D9/02 , E03D9/03 , B67B7/00 , G01F11/00
CPC分类号： E03D9/032 , E03D2009/024
摘要： The invention provides an adaptation to a rimstick dispenser of the type having a reservoir of active liquid and a flow controller to control the rate at which liquid is dispensed from the reservoir. In accordance with the invention a source of further active substance is provided so as to improve the efficacy of the dispenser, without otherwise affecting the assembly or operation of the dispenser. In one embodiment this source of further active is retained about the outlet neck of the reservoir so as to be sandwiched between the reservoir and the flow controller when the two components are assembled together.
摘要翻译：本发明提供对具有活性液体储存器和流量控制器的类型的边框分配器的适应性，以控制从储存器分配液体的速率。根据本发明，提供进一步活性物质的来源以提高分配器的功效，而不会影响分配器的组装或操作。在一个实施例中，这种进一步活动的源保持在储存器的出口颈部周围，以便当两个部件组装在一起时被夹在储存器和流量控制器之间。

8. 发明授权

US08788284B2 Method and system using combined healthcare-payment device and web portal for receiving patient medical information 有权
标题翻译：使用组合医疗支付设备和门户网站接收患者医疗信息的方法和系统
公开(公告)号：US08788284B2
公开(公告)日：2014-07-22
申请号：US11796185
申请日：2007-04-27
申请人： Nigel Smith
发明人： Nigel Smith
IPC分类号： G06F19/00
CPC分类号： G06F19/328 , G06F19/00 , G06Q20/102 , G06Q40/02 , G06Q40/08 , G06Q50/24 , G16H10/60
摘要： Embodiments of systems and methods in accordance with the present invention relate to a centralized portal for making healthcare information of a patient accessible to a plurality of entities, including but not limited to the patient himself/herself, healthcare providers authorized by the patient, and healthcare payers (insurance carriers) authorized by the patient. In one embodiment, the portal comprises a website associated with a portable consumer device (such as a HSA magnetic stripe credit/debit card) of the patient, and hosted on a server accessible over the world wide web or another computer network. The patient sets a privacy level associated with his or her medical record on the host site, the privacy level granting certain entities (for example healthcare providers or insurance carriers) access to particular medical records of the patient. Upon presenting the portable consumer device to an authorized healthcare provider, medical information previously transmitted through a payment processing network may be received at the authorized healthcare provider.
摘要翻译：根据本发明的系统和方法的实施例涉及用于使多个实体可访问的患者的医疗保健信息的集中门户，所述多个实体包括但不限于患者本人，由患者授权的医疗服务提供者以及医疗保健由病人授权的付款人（保险人）。在一个实施例中，门户包括与患者的便携式消费者设备（例如HSA磁条信用/借记卡）相关联的网站，并且托管在可通过万维网或另一计算机网络访问的服务器上。患者设置与他/她在宿主站点上的病历相关联的隐私级别，授予某些实体（例如医疗服务提供者或保险公司）访问患者的特定医疗记录的隐私级别。在将便携式消费者设备呈现给授权的医疗保健提供者时，先前通过支付处理网络发送的医疗信息可以在授权的医疗保健提供者处接收。

9. 发明申请

US20110130764A1 FACET JOINT AUGMENTATION WITH HYDROGELS 有权
标题翻译： FACET与HYDROGEL的接合
公开(公告)号：US20110130764A1
公开(公告)日：2011-06-02
申请号：US13055833
申请日：2009-07-24
申请人： Beat Lechmann , Robert Frigg , Nigel Smith
发明人： Beat Lechmann , Robert Frigg , Nigel Smith
IPC分类号： A61B17/58
CPC分类号： A61F2/28 , A61B17/562 , A61B2017/00526 , A61B2017/00862 , A61B2017/00898 , A61F2/4405 , A61F2002/2839 , A61F2002/30065 , A61F2002/30069 , A61F2002/30075 , A61F2002/30224 , A61F2002/30583 , A61F2002/3085 , A61F2210/0061 , A61F2210/0071 , A61F2210/0085 , A61F2230/0069
摘要： The present invention provides a system and method for the augmentation of a degenerated facet joint. A low modulus filler material is injected into the joint capsule in a minimally invasive way through the lamina and the superior facet articulation surface, while leaving the facet capsule and the inferior facet articulation surface completely intact, to thereby alleviate pressure on the articulating bone surfaces.
摘要翻译：本发明提供了一种用于增加退化小关节的系统和方法。将低模量填充材料以微创的方式通过薄层和上面的关节表面注入关节囊，同时使小面胶囊和下面的关节表面完全完整，从而减轻关节骨表面的压力。

10. 发明授权

US07800824B2 Method for designing gratings 有权
标题翻译：光栅设计方法
公开(公告)号：US07800824B2
公开(公告)日：2010-09-21
申请号：US11774402
申请日：2007-07-06
申请人： Shih Chun Wang , Yi Sha Ku , Chun Hung Ko , Deh Ming Shyu , Nigel Smith
发明人： Shih Chun Wang , Yi Sha Ku , Chun Hung Ko , Deh Ming Shyu , Nigel Smith
IPC分类号： G02B5/18 , G02B27/44
CPC分类号： G02B5/18 , G02B27/0012 , Y10S359/90
摘要： A method for designing a grating comprises steps of (a1) generating a first diffraction spectrum based on calculation values of a plurality of structural parameters, (a2) calculating a first difference value between the first diffraction spectrum and a first nominal spectrum, (a3) setting a default difference value with the first difference value and default structural parameter values with the structural parameter values, (b1) changing one of the structural parameter values to generate a second diffraction spectrum, (b2) calculating a second difference value between the second diffraction spectrum and a second nominal spectrum, and (c) comparing the default difference value and the second difference value, updating a default difference value with the smaller one, and updating the default structural parameter values with the structural parameter values corresponding to the smaller one.
摘要翻译：一种光栅设计方法，包括以下步骤：（a1）基于多个结构参数的计算值产生第一衍射光谱，（a2）计算第一衍射光谱和第一标称光谱之间的第一差值，（a3）设置具有所述结构参数值的所述第一差值和默认结构参数值的默认差值，（b1）改变所述结构参数值之一以产生第二衍射谱，（b2）计算所述第二衍射频谱和第二标称频谱，以及（c）比较默认差值和第二差值，更新较小值的默认差值，并用对应于较小值的结构参数值更新默认结构参数值。

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