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1. 发明申请

US20060155316A1 METHODS AND APPARATUS FOR EXPRESSING BODY FLUID FROM AN INCISION 审中-公开
标题翻译：用于从体内表达体液的方法和装置
公开(公告)号：US20060155316A1
公开(公告)日：2006-07-13
申请号：US11276237
申请日：2006-02-20
申请人： Edward Perez , Jeffrey Roe , Charles Raney
发明人： Edward Perez , Jeffrey Roe , Charles Raney
IPC分类号： A61B17/32 , A61B5/00
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B10/0045 , A61B2010/008
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
摘要翻译：体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。在针从切口移除之后，施加力以形成与切口周围关系的凹陷的身体组织环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此体液通过切口的开口被迫出来。刺激构件安装到用于施加力的刺血针承载壳体的端部。刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。

2. 发明授权

US07758518B2 Devices and methods for expression of bodily fluids from an incision 有权
标题翻译：用于从切口表达体液的装置和方法
公开(公告)号：US07758518B2
公开(公告)日：2010-07-20
申请号：US12353666
申请日：2009-01-14
申请人： Edward Perez , Charles C. Raney , Paul Patel
发明人： Edward Perez , Charles C. Raney , Paul Patel
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194
摘要： Systems and methods for the expression of bodily fluid from an incision in the skin include devices which bear against the skin in a manner to retain the fluid adjacent the incision site and urge the fluid inwardly toward the incision. Systems utilize a constricting member, a bi-stable expression member, or a pressing member. The present invention further encompasses combinations of the foregoing expression systems with each other, as well as with other expression devices known in the art. Moreover, the invention includes the combination of the expression systems with incising, sampling and/or testing systems, particularly in a single, integrated device. The present invention also contemplates the associated methods for expressing bodily fluid from an incision, including in combination with methods for incising, sampling and/or testing of the bodily fluid.
摘要翻译：用于从皮肤切口表达体液的系统和方法包括以保持与切口部位相邻的流体并将流体向内朝向切口推动的方式抵靠皮肤的装置。系统利用收缩构件，双稳态表达构件或按压构件。本发明还包括上述表达系统彼此的组合，以及本领域已知的其它表达装置。此外，本发明包括表达系统与切割，采样和/或测试系统的组合，特别是在单个集成设备中。本发明还考虑了用于从切口表达体液的相关方法，包括结合用于切开，取样和/或测试体液的方法。

3. 发明授权

US07497866B2 Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses 失效
标题翻译：用于在角膜上产生上皮瓣和用于在上皮瓣或膜下面放置眼睛装置和透镜的方法，上皮分层装置以及上皮和眼睛装置和透镜的结构
公开(公告)号：US07497866B2
公开(公告)日：2009-03-03
申请号：US10346664
申请日：2003-01-17
申请人： Edward Perez
发明人： Edward Perez
IPC分类号： A61F9/00
CPC分类号： A61F9/013 , A61B17/32 , A61B2017/320052 , A61F2/142 , A61F2/147 , A61F9/0133
摘要： These methods, devices, and structures are useful in the field of ophthalmology; the devices and methods relate variously to separating or lifting corneal epithelium from the eye preferably in a substantially continuous layer, placing a lens or other suitable ocular or medical device beneath the epithelial membrane, and to the resulting structures formed by those procedures. The de-epilthelialization devices generally utilize a non-cutting separator or dissector that is configured to separate the epithelium at a naturally occurring cleavage surface in the eye between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida. The separator or dissector may have a structure that rolls or vibrates (or both) at that cleavage surface or interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or a pocket. The epithelium may then be replaced on the cornea after a refractive procedure or after placement of an ocular lens (or other subepithelial device) on the eye. The subepithelial device may comprise a wide variety of synthetic, natural, or composite polymeric materials. The step of replacing epithelial tissue upon the subepithelial device or upon the anterior corneal surface promotes epithelial healing.
摘要翻译：这些方法，装置和结构在眼科领域是有用的; 所述装置和方法涉及各种不同方式将角膜上皮细胞从眼睛中分离或提升，优选在基本上连续的层中，将透镜或其它合适的眼部或医疗装置放置在上皮膜下方，以及由这些程序形成的所得结构。去皮上皮化装置通常使用非切割分离器或解剖器，其被配置为在上皮和角膜基质（鲍曼氏膜）之间的眼睛中天然存在的切割表面分离上皮，特别是在层的区域中分离 lucida 分离器或解剖器可以具有在解剖步骤期间在该切割表面或界面处滚动或振动（或两者）的结构。分离的上皮可以从眼睛的表面抬起或剥离以形成上皮瓣或口袋。然后可以在屈光手术之后或在将眼部透镜（或其他上皮下装置）放置在眼睛上之后在角膜上替换上皮。上皮下装置可以包括多种合成，天然或复合聚合物材料。在上皮下装置或前角膜表面上取代上皮组织的步骤促进上皮愈合。

4. 发明申请

US20070060845A1 Method and apparatus for sampling bodily fluid 失效
标题翻译：用于取样体液的方法和装置
公开(公告)号：US20070060845A1
公开(公告)日：2007-03-15
申请号：US11353849
申请日：2006-02-14
申请人： Edward Perez
发明人： Edward Perez
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150236 , A61B5/150244 , A61B5/150396 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/008
摘要： Bodily fluid is sampled by causing a lancet mounted in a housing to be displaced toward a skin surface. A vacuum mechanism disposed on the housing is utilized to create a suction in the area to be incised causing bodily fluid to pool. The vacuum mechanism may then be deactivated thereby releasing the vacuum force on the skin, or repeatedly activated and deactivated. After the vacuum device has been utilized, the lancet is advanced to form an incision. The vacuum device may be activated, activated and deactivated, or repeatedly activated and deactivated after forming the incision. The sample may be withdrawn from the incision through a capillary tube.
摘要翻译：通过使安装在壳体中的刺血针向皮肤表面移位来对体液进行取样。设置在壳体上的真空机构用于在要切割的区域中产生吸力，从而引起体液流入。然后可以使真空机构失效，从而释放皮肤上的真空力，或反复激活和去激活。在使用真空装置之后，先将刺血针形成切口。真空装置可以被激活，激活和停用，或者在形成切口之后反复激活和去激活。样品可以通过毛细管从切口中取出。

5. 发明申请

US20060064112A1 Ocular device applicator 审中-公开
标题翻译：眼部装置施放器
公开(公告)号：US20060064112A1
公开(公告)日：2006-03-23
申请号：US10937206
申请日：2004-09-08
申请人： Edward Perez
发明人： Edward Perez
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： An ocular device applicator for inserting an ocular device beneath a corneal epithelium. The ocular device applicator places an ocular device onto a cornea that has been at least partially delaminated. The ocular device applicator comprises an ocular device holder and a manipulator. In some versions an ocular device may be secured in and/or released from the device by force applied in the holder, or by a releasable adhesive.
摘要翻译：一种用于将眼睛装置插入角膜上皮下的眼部装置施用器。眼睛装置施用器将眼睛装置放置在至少部分分层的角膜上。眼部装置施用器包括眼部装置保持器和操纵器。在一些版本中，眼睛装置可以通过施加在保持器中的力或通过可释放的粘合剂固定在装置中和/或从装置释放。

6. 发明申请

US20090041106A1 Variable equalizer apparatus 有权
标题翻译：可变均衡器装置
公开(公告)号：US20090041106A1
公开(公告)日：2009-02-12
申请号：US12213214
申请日：2008-06-16
申请人： Edward Perez , David Wallis
发明人： Edward Perez , David Wallis
IPC分类号： H03H7/30
CPC分类号： H04L25/03885 , H03F3/62 , H03F2200/63
摘要： A variable equalizer apparatus for forward and/or reverse equalizers in an amplifier. The system can include a structure to allow continuous contact of the signal flow as an equalizer is removed; jumpers with fixed resistors and associated capacitors and inductors to produce a variable range over many different values; and/or variable resistance potentiometers with fixed resistors and associated capacitors and inductors to produce a variable range over separate value equalizers.
摘要翻译：用于放大器中的正向和/或反向均衡器的可变均衡器装置。该系统可以包括当均衡器被去除时允许信号流的连续接触的结构; 具有固定电阻器和相关电容器和电感器的跳线器可产生许多不同值的可变范围; 和/或具有固定电阻器和相关电容器和电感器的可变电阻电位器，以在单独的值均衡器上产生可变范围。

7. 发明申请

US20070265649A1 Epithelial delaminating device 审中-公开
标题翻译：上皮分层装置
公开(公告)号：US20070265649A1
公开(公告)日：2007-11-15
申请号：US11640630
申请日：2006-12-18
申请人： Edward Perez
发明人： Edward Perez
IPC分类号： A61F9/00
CPC分类号： A61F9/013
摘要： The described device is useful in the field of opthalmology. The devices and methods for using it involve separating or lifting corneal epithelium from the eye in a substantially continuous layer to form a flap or pocket. In particular, the devices generally utilize a non-cutting, oscillating separator or dissector that is configured to separate the epithelium at naturally occurring cleavage surfaces in the eye, particularly between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida, the separator or dissector having a structure that oscillates at that cleavage surface interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or pocket. The epithelium may then be replaced on the cornea after a refractive procedure or placement of an ocular lens on the eye.
摘要翻译：所描述的装置在眼科学领域是有用的。用于其的装置和方法涉及在基本上连续的层中将角膜上皮分离或提升眼睛以形成瓣或口袋。特别地，这些装置通常使用非切割振荡分离器或解剖器，其被配置为在眼睛中的天然存在的切割表面，特别是在上皮和角膜基质（鲍曼膜）之间分离上皮，特别是在该区域中分离的分离器或解剖器，其具有在解剖步骤期间在该切割面界面处振荡的结构。分离的上皮可以从眼表面抬起或剥离，形成上皮瓣或口袋。然后可以在屈光手术或眼睛透镜放置在眼睛上之后，在角膜上替换上皮。

8. 发明申请

US20060247660A1 Corneal retention or stabilizing tool 审中-公开
标题翻译：角膜保留或稳定工具
公开(公告)号：US20060247660A1
公开(公告)日：2006-11-02
申请号：US11386231
申请日：2006-03-21
申请人： Edward Perez
发明人： Edward Perez
IPC分类号： A61F9/00
CPC分类号： A61F9/007 , A61B2017/306 , A61F9/013
摘要： Described here is a surgical device that typically is used to releasably hold the cornea of a human eye (and hence that eye) in such a way as to modestly deform the cornea and the eye, to maintain the eye's position for procedures upon the epithilial layer of the cornea, and to allow ease of replacement of an epithilial flap should one be produced. It may be used in combination with an epithilial delaminating tool, or an ocular device inserting tool. The stabilization device permits ready access to and creation of flaps or pockets of epithelium for later introduction of correcting lenses (e.g. using an ocular device insertion tool) or subtractive procedures such as LASIK or LASEK, prior to replacement of epithelium over the corrective lens or over the site of laser induced or surgically-induced corrective procedure.
摘要翻译：这里描述的是一种手术装置，其通常用于可释放地保持人眼（和因此眼睛）的角膜，以使角膜和眼睛适度变形，以保持眼睛在外耳层上的手术位置的角膜，并且允许容易地更换上皮瓣，如果可以产生。它可以与外耳分层工具或眼睛装置插入工具结合使用。稳定装置允许准备进入和产生上皮的襟翼或口袋，以便稍后在校正透镜上更换上皮或更换矫正透镜之前（例如使用眼部装置插入工具）或减数程序（例如LASIK或LASEK）激光诱导或手术诱导的矫正程序的部位。

9. 发明申请

US20060052796A1 Combined epithelial delaminator and inserter 审中-公开
标题翻译：组合上皮分层和插入
公开(公告)号：US20060052796A1
公开(公告)日：2006-03-09
申请号：US10937135
申请日：2004-09-08
申请人： Edward Perez , Jay Daulton , Paul Hsei
发明人： Edward Perez , Jay Daulton , Paul Hsei
IPC分类号： A61F9/00
CPC分类号： A61F9/013 , A61F2/147 , A61F9/0017 , A61F9/007
摘要： An ocular device applicator that is a combined delaminating and inserting device configured to partially delaminate the corneal epithelium and to place a corrective ocular device onto the delaminated cornea under the partially delaminated epithelium. The ocular device applicator leaves at least a portion of the delaminated corneal epithelium attached to the cornea. The ocular device applicator comprises an edge and an ocular device holder. In some versions an ocular device may be secured in and/or released from the device by force applied in the holder, or by a releasable adhesive. The ocular device applicator may be oscillated to facilitate delamination of the corneal epithelium and placement of an ocular device.
摘要翻译：一种眼部装置施用器，其是组合的分层和插入装置，其被配置为部分地分层角膜上皮并将矫正的眼睛装置放置在部分分层的上皮下的分层角膜上。眼部装置施用器离开附着在角膜上的分层的角膜上皮的至少一部分。眼部装置施用器包括边缘和眼睛装置保持器。在一些版本中，眼睛装置可以通过施加在保持器中的力或通过可释放的粘合剂固定在装置中和/或从装置释放。眼部装置施用器可以摆动以促进角膜上皮的分层和眼睛装置的放置。

10. 发明授权

US10439310B2 Circuit assembly pin 有权
公开(公告)号：US10439310B2
公开(公告)日：2019-10-08
申请号：US14668961
申请日：2015-03-25
申请人： Edward Perez , Thomas Michael Borkes
发明人： Edward Perez , Thomas Michael Borkes
IPC分类号： H01R9/05 , H01R12/70 , H01R13/02 , H01R13/04 , H01R13/62 , H01R4/48 , G01R1/04 , G01R1/06 , G01R31/02 , G01R31/28 , G01R31/27 , H01R12/73 , H01R13/03
摘要： A circuit assembly pin includes a barrel, and the barrel has a substantially cylindrical profile. The barrel is be received by socket on a first circuit board. The pin also includes a body connected to the barrel, and the body has a substantially rectangular cuboid profile. The body also includes a set of protrusions. The set of protrusions includes a set of legs to be inserted to a second circuit board. The set of protrusions comprises a substantially rectangular cuboid profile generally free of projections or depressions. The set of protrusions is substantially perpendicular to the barrel such that the first circuit board is substantially perpendicular to the second circuit board.

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