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1. 发明授权

US09615781B2 Systems and methods for monitoring depth of consciousness 有权
公开(公告)号：US09615781B2
公开(公告)日：2017-04-11
申请号：US13364766
申请日：2012-02-02
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison , James N. Watson
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison , James N. Watson
IPC分类号： A61B5/00 , G06F19/00 , A61B5/1455 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/14551 , A61B5/04001 , A61B5/0476 , A61B5/40 , A61B5/4821 , A61B5/7239 , A61B5/7264 , G06F19/00 , G16H50/20 , G16H50/30
摘要： During patient monitoring, a depth of consciousness (DOC) measure, such as a bispectral index, may be used in conjunction with additional information obtained from an awareness metric derived from one or more physiological signals, such as a photoplethysmograph signal. In an embodiment, a DOC measure may be combined with information from an awareness metric to produce a combined DOC measure. In an embodiment, information from an awareness metric derived from one or more physiological signals may be used to provide an indication of confidence in a DOC measure. In an embodiment, a DOC measure may be used to provide an indication of confidence in a depth of consciousness assessment based on an awareness metric. In an embodiment, one or the other of a DOC measure and an awareness metric may be used to provide an indication of a patient's depth of consciousness (e.g., by one “overriding” the other).

2. 发明申请

US20120203087A1 SYSTEMS AND METHODS FOR MONITORING DEPTH OF CONSCIOUSNESS 有权
标题翻译：监测深度深度的系统和方法
公开(公告)号：US20120203087A1
公开(公告)日：2012-08-09
申请号：US13364766
申请日：2012-02-02
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison , James N. Watson
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison , James N. Watson
IPC分类号： A61B5/00 , A61B6/00 , A61B5/04 , A61B5/1455 , A61B5/021
CPC分类号： A61B5/14551 , A61B5/04001 , A61B5/0476 , A61B5/40 , A61B5/4821 , A61B5/7239 , A61B5/7264 , G06F19/00 , G16H50/20 , G16H50/30
摘要： During patient monitoring, a depth of consciousness (DOC) measure, such as a bispectral index, may be used in conjunction with additional information obtained from an awareness metric derived from one or more physiological signals, such as a photoplethysmograph signal. In an embodiment, a DOC measure may be combined with information from an awareness metric to produce a combined DOC measure. In an embodiment, information from an awareness metric derived from one or more physiological signals may be used to provide an indication of confidence in a DOC measure. In an embodiment, a DOC measure may be used to provide an indication of confidence in a depth of consciousness assessment based on an awareness metric. In an embodiment, one or the other of a DOC measure and an awareness metric may be used to provide an indication of a patient's depth of consciousness (e.g., by one “overriding” the other).
摘要翻译：在患者监视期间，可以结合从源自一个或多个生理信号（诸如光电体积描记信号）的意识度量获得的附加信息结合使用意识深度（DOC）测量，例如双谱指数。在一个实施例中，DOC测量可以与来自感知度量的信息组合以产生组合的DOC测量。在一个实施例中，可以使用来自一个或多个生理信号的意识度量的信息来提供在DOC测量中的置信度。在一个实施例中，DOC测量可以用于基于意识度量提供意识深度评估深度的置信度。在一个实施例中，可以使用DOC测量和意识度量中的一个或另一个来提供患者的意识深度的指示（例如，通过一个“覆盖”另一个）。

3. 发明授权

US09138183B2 Combined physiological sensor systems and methods 有权
标题翻译：组合生理传感器系统和方法
公开(公告)号：US09138183B2
公开(公告)日：2015-09-22
申请号：US13020704
申请日：2011-02-03
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/01 , A61B5/0205 , A61B5/024 , A61B5/16
CPC分类号： A61B5/02055 , A61B5/01 , A61B5/0205 , A61B5/02433 , A61B5/14552 , A61B5/165 , A61B5/6814 , A61B5/6826 , A61B5/6838 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors. The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.
摘要翻译：提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。可以根据多个不同的几何形状有利地定位传感器。组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

4. 发明授权

US08588878B2 Simultaneous measurement of pulse and regional blood oxygen saturation 有权
标题翻译：同时测量脉搏和局部血氧饱和度
公开(公告)号：US08588878B2
公开(公告)日：2013-11-19
申请号：US12944945
申请日：2010-11-12
申请人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
发明人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/7203 , A61B5/726
摘要： Methods and systems are provided that allow for the simultaneous calculation of pulse and regional blood oxygen saturation. An oximeter system that includes a sensor with a plurality of emitters and detectors may be used to calculate a pulse and/or regional blood oxygen saturation. A plurality of light signals may be emitted from light emitters. A first light signal may be received at a first light detector and a second light signal may be received at a second light detector. A pulse and/or regional blood oxygen saturation value may be calculated based on the received first and/or second light signals. The pulse and regional blood oxygen saturation values may be calculated substantially simultaneously. The calculated pulse and regional blood oxygen saturation values as well as other blood oxygen saturation values may be displayed simultaneously in a preconfigured portion of a display.
摘要翻译：提供了允许同时计算脉搏和局部血氧饱和度的方法和系统。包括具有多个发射器和检测器的传感器的血氧计系统可用于计算脉搏和/或区域血氧饱和度。可以从发光体发射多个光信号。可以在第一光检测器处接收第一光信号，并且可以在第二光检测器处接收第二光信号。可以基于接收的第一和/或第二光信号计算脉搏和/或区域血氧饱和度值。可以基本上同时计算脉搏和区域血氧饱和度值。计算出的脉冲和区域血氧饱和度值以及其他血氧饱和度值可以同时显示在显示器的预配置部分中。

5. 发明申请

US20110112379A1 SYSTEMS AND METHODS FOR PROVIDING SENSOR ARRAYS FOR DETECTING PHYSIOLOGICAL CHARACTERISTICS 有权
标题翻译：用于提供传感器阵列以检测生理特性的系统和方法
公开(公告)号：US20110112379A1
公开(公告)日：2011-05-12
申请号：US12944955
申请日：2010-11-12
申请人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
发明人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0205 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/6804 , A61B5/72 , A61B5/7221 , A61B5/726 , A61B5/7264 , A61B2562/0233 , A61B2562/046 , G06F19/34 , G16H15/00 , G16H40/63 , G16H50/20 , Y10S128/92 , Y10S128/925 , G06F19/345
摘要： Systems and methods for determining physiological parameters of a subject using a sensor array. In an embodiment, a sensor array may contain sensor elements for determining multiple physiological parameters. A combination of sensor elements and the physiological parameters determined may be selected based on signals obtained from the sensor elements of the sensor array. A sensor array may be connected to a monitoring device that may select an optimal sensor element or combination of sensor elements and one or more physiological parameters to be determined. The monitoring device may then determine physiological parameters using the selected combination of sensor elements and display information associated with the parameters on a monitor for use, for example, in monitoring a medical patient.
摘要翻译：用于使用传感器阵列确定对象的生理参数的系统和方法。在一个实施例中，传感器阵列可以包含用于确定多个生理参数的传感器元件。可以基于从传感器阵列的传感器元件获得的信号来选择传感器元件和确定的生理参数的组合。传感器阵列可以连接到可以选择最佳传感器元件或传感器元件的组合和要确定的一个或多个生理参数的监视设备。监测装置然后可以使用所选择的传感器元件的组合和与监视器上的参数相关联的显示信息来确定生理参数，以便例如用于监测医疗患者。

6. 发明授权

US08986207B2 Systems and methods for providing sensor arrays for detecting physiological characteristics 有权
标题翻译：用于提供用于检测生理特征的传感器阵列的系统和方法
公开(公告)号：US08986207B2
公开(公告)日：2015-03-24
申请号：US12944955
申请日：2010-11-12
申请人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
发明人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/0205 , G06F19/00 , A61B5/024 , A61B5/08
CPC分类号： A61B5/14552 , A61B5/0205 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/6804 , A61B5/72 , A61B5/7221 , A61B5/726 , A61B5/7264 , A61B2562/0233 , A61B2562/046 , G06F19/34 , G16H15/00 , G16H40/63 , G16H50/20 , Y10S128/92 , Y10S128/925 , G06F19/345
摘要： Systems and methods for determining physiological parameters of a subject using a sensor array. In an embodiment, a sensor array may contain sensor elements for determining multiple physiological parameters. A combination of sensor elements and the physiological parameters determined may be selected based on signals obtained from the sensor elements of the sensor array. A sensor array may be connected to a monitoring device that may select an optimal sensor element or combination of sensor elements and one or more physiological parameters to be determined. The monitoring device may then determine physiological parameters using the selected combination of sensor elements and display information associated with the parameters on a monitor for use, for example, in monitoring a medical patient.
摘要翻译：用于使用传感器阵列确定受试者的生理参数的系统和方法。在一个实施例中，传感器阵列可以包含用于确定多个生理参数的传感器元件。可以基于从传感器阵列的传感器元件获得的信号来选择传感器元件和确定的生理参数的组合。传感器阵列可以连接到可以选择最佳传感器元件或传感器元件的组合和要确定的一个或多个生理参数的监视设备。监测装置然后可以使用所选择的传感器元件的组合和与监视器上的参数相关联的显示信息来确定生理参数，以便例如用于监测医疗患者。

7. 发明申请

US20110190600A1 COMBINED PHYSIOLOGICAL SENSOR SYSTEMS AND METHODS 有权
标题翻译：组合生理传感器系统和方法
公开(公告)号：US20110190600A1
公开(公告)日：2011-08-04
申请号：US13020704
申请日：2011-02-03
申请人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
发明人： Edward M. McKenna , Bo Chen , Youzhi Li , Paul Stanley Addison
IPC分类号： A61B5/00
CPC分类号： A61B5/02055 , A61B5/01 , A61B5/0205 , A61B5/02433 , A61B5/14552 , A61B5/165 , A61B5/6814 , A61B5/6826 , A61B5/6838 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors. The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.
摘要翻译：提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。可以根据多个不同的几何形状有利地定位传感器。组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

8. 发明申请

US20110112382A1 SYSTEMS AND METHODS FOR COMBINED PHYSIOLOGICAL SENSORS 审中-公开
标题翻译：用于组合生理传感器的系统和方法
公开(公告)号：US20110112382A1
公开(公告)日：2011-05-12
申请号：US12944950
申请日：2010-11-12
申请人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
发明人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
IPC分类号： A61B5/00
CPC分类号： A61B5/0478 , A61B5/02427 , A61B5/14551 , A61B2562/182
摘要： Systems and methods are provided for monitoring the physiological state of a subject. One or more physiological parameters of a subject may be determined from a photoplethysmograph (PPG) signal or signals obtained using at least one PPG sensor. In some embodiments, an electrical physiological signal (EPS) sensor may be located in or near a PPG sensor. A sensor configuration including both PPG sensors and EPS sensors may be advantageously used to detect a PPG signal or signals in combination with one or more EPS signal or signals. To reduce potential interference between an EPS sensor and a PPG sensor, fiber-optic input and output lines may be used to transmit optical signals from light generating circuitry and light detecting circuitry. In some embodiments, the generating and detecting circuitry may be located remotely from one another and may further be located remotely from the EPS sensor, PPG sensor, or both.
摘要翻译：提供了用于监测受试者的生理状态的系统和方法。受试者的一个或多个生理参数可以从光电容积描记器（PPG）信号或使用至少一个PPG传感器获得的信号来确定。在一些实施例中，电生理信号（EPS）传感器可以位于PPG传感器中或附近。包括PPG传感器和EPS传感器的传感器配置可以有利地用于检测与一个或多个EPS信号或信号相结合的PPG信号或信号。为了减少EPS传感器和PPG传感器之间的潜在干扰，光纤输入和输出线路可用于从光生成电路和光检测电路传输光信号。在一些实施例中，生成和检测电路可以彼此远离地定位，并且可以进一步远离EPS传感器，PPG传感器或两者。

9. 发明申请

US20110112387A1 SIMULTANEOUS MEASUREMENT OF PULSE AND REGIONAL BLOOD OXYGEN SATURATION 有权
标题翻译：脉搏和区域血氧饱和度的同时测量
公开(公告)号：US20110112387A1
公开(公告)日：2011-05-12
申请号：US12944945
申请日：2010-11-12
申请人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
发明人： Youzhi Li , Bo Chen , Edward M. McKenna , Paul Stanley Addison
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/7203 , A61B5/726
摘要： Methods and systems are provided that allow for the simultaneous calculation of pulse and regional blood oxygen saturation. An oximeter system that includes a sensor with a plurality of emitters and detectors may be used to calculate a pulse and/or regional blood oxygen saturation. A plurality of light signals may be emitted from light emitters. A first light signal may be received at a first light detector and a second light signal may be received at a second light detector. A pulse and/or regional blood oxygen saturation value may be calculated based on the received first and/or second light signals. The pulse and regional blood oxygen saturation values may be calculated substantially simultaneously. The calculated pulse and regional blood oxygen saturation values as well as other blood oxygen saturation values may be displayed simultaneously in a preconfigured portion of a display.
摘要翻译：提供了允许同时计算脉搏和局部血氧饱和度的方法和系统。包括具有多个发射器和检测器的传感器的血氧计系统可用于计算脉搏和/或区域血氧饱和度。可以从发光体发射多个光信号。可以在第一光检测器处接收第一光信号，并且可以在第二光检测器处接收第二光信号。可以基于接收的第一和/或第二光信号计算脉搏和/或区域血氧饱和度值。可以基本上同时计算脉搏和区域血氧饱和度值。计算出的脉冲和区域血氧饱和度值以及其他血氧饱和度值可以同时显示在显示器的预配置部分中。

10. 发明申请

US20120136261A1 Systems and methods for calibrating physiological signals with multiple techniques 审中-公开
标题翻译：用多种技术校准生理信号的系统和方法
公开(公告)号：US20120136261A1
公开(公告)日：2012-05-31
申请号：US12956932
申请日：2010-11-30
申请人： Rakesh Sethi , Robert Stoughton , James N. Watson , Paul Stanley Addison , Shannon E. Campbell , Daniel Lisogurski , Edward M. McKenna
发明人： Rakesh Sethi , Robert Stoughton , James N. Watson , Paul Stanley Addison , Shannon E. Campbell , Daniel Lisogurski , Edward M. McKenna
IPC分类号： A61B5/021
CPC分类号： A61B5/02125 , A61B5/14551 , A61B5/1495 , A61B2560/0223
摘要： Systems and methods are disclosed herein for calibrating the calculation of physiological parameters. Two or more calibration techniques may be used to determine a relationship between physiological measurements and a desired physiological parameter, such as a relationship between differential pulse transit time (DPTT) and blood pressure. Different calibration techniques may be used in a serial fashion, one after the other, or in a parallel fashion, with different weights accorded to each calibration technique. When physiological or other changes occur, the calibration data may be stored for later use and new calibration data may be generated.
摘要翻译：本文公开了用于校准生理参数的计算的系统和方法。可以使用两种或更多种校准技术来确定生理测量与所需生理参数之间的关系，例如差异脉冲传播时间（DPTT）与血压之间的关系。不同的校准技术可以一个接一个地以串行的方式使用，或者以平行的方式使用，具有与每个校准技术相符的不同重量。当发生生理或其他变化时，校准数据可以被存储以供以后使用，并且可以生成新的校准数据。

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