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1. 发明申请

US20090292234A1 SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE 失效
标题翻译：具有微流控无菌交换装置的血液系统和方法
公开(公告)号：US20090292234A1
公开(公告)日：2009-11-26
申请号：US12509395
申请日：2009-07-24
申请人： Edward F. Leonard , Alan C. West , Nina C. Siiapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Siiapley , Zhongliang Tang
IPC分类号： A61M1/16
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

2. 发明申请

US20100004578A1 APPARATUS AND SYSTEMS FOR MEMBRANELESS SEPARATION OF FLUIDS 失效
标题翻译：用于液体无菌分离的装置和系统
公开(公告)号：US20100004578A1
公开(公告)日：2010-01-07
申请号：US12499038
申请日：2009-07-07
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/14
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

3. 发明授权

US08083706B2 Apparatus and systems for membraneless separation of fluids 失效
标题翻译：用于液体无膜分离的装置和系统
公开(公告)号：US08083706B2
公开(公告)日：2011-12-27
申请号：US12499038
申请日：2009-07-07
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M37/00 , A61M29/00 , G10N21/00 , G01N31/00 , G01N33/00 , B01D21/24 , B01D25/30 , B01D33/70 , B01D11/00 , B01D12/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

4. 发明授权

US07850633B2 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device 失效
标题翻译：具有微流体无膜交换装置的血液疗法的系统和方法
公开(公告)号：US07850633B2
公开(公告)日：2010-12-14
申请号：US12509395
申请日：2009-07-24
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/34 , B01D61/24 , B01D61/14 , B01D61/38
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

5. 发明授权

US08021318B2 Methods of blood-based therapies having a microfluidic membraneless exchange device 有权
标题翻译：具有微流体无膜交换装置的血液疗法的方法
公开(公告)号：US08021318B2
公开(公告)日：2011-09-20
申请号：US12942519
申请日：2010-11-09
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/34 , B01D61/24 , B01D61/14 , B01D61/38
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M1/3482 , A61M1/3621 , A61M2206/11 , B01D11/04 , B01D11/0496 , B01D61/243 , B01D61/28 , B01L3/5027 , G01N2001/4016 , Y10T436/255
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

6. 发明授权

US07588550B2 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device 失效
标题翻译：具有微流体无膜交换装置的血液疗法的系统和方法
公开(公告)号：US07588550B2
公开(公告)日：2009-09-15
申请号：US11776360
申请日：2007-07-11
申请人： Edward F. Leonard , Alan C. West , Nina C. Shaplely , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shaplely , Zhongliang Tang
IPC分类号： A61M37/00 , B32B27/04 , B32B27/12
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。当血液是样品液体时，例如，这可能包括从血液样品到提取液中去除“小”分子，“中”分子，大分子，大分子聚集体和细胞。

7. 发明授权

US08491516B2 Systems and methods for membraneless dialysis 失效
标题翻译：无膜透析的系统和方法
公开(公告)号：US08491516B2
公开(公告)日：2013-07-23
申请号：US13298344
申请日：2011-11-17
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/00 , A61M1/14 , A61M1/34 , A61M1/36 , B01D63/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：公开了用于通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。这些实施例可用于从尺寸变化的样品流体中去除组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

8. 发明申请

US20120061304A1 SYSTEMS AND METHODS FOR MEMBRANELESS DIALYSIS 失效
标题翻译：用于无膜透析的系统和方法
公开(公告)号：US20120061304A1
公开(公告)日：2012-03-15
申请号：US13298344
申请日：2011-11-17
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/16 , B01D36/02 , B81B1/00
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：公开了用于通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。这些实施例可用于从尺寸变化的样品流体中去除组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

9. 发明申请

US20120292253A1 SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS 失效
公开(公告)号：US20120292253A1
公开(公告)日：2012-11-22
申请号：US13566592
申请日：2012-08-03
申请人： Edward F. Leonard , Alan C. West , Christian P. Aucoin , Edgar E. Nanne
发明人： Edward F. Leonard , Alan C. West , Christian P. Aucoin , Edgar E. Nanne
IPC分类号： B01D61/14 , B81B1/00
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M2205/7563 , A61M2206/11 , B01D11/0492 , B01D11/0496 , G01N2030/0045
摘要： A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

10. 发明授权

US08097162B2 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams 失效
公开(公告)号：US08097162B2
公开(公告)日：2012-01-17
申请号：US12948284
申请日：2010-11-17
申请人： Edward F. Leonard , Alan C. West , Christian Paul Aucoin , Edgar E. Nanne
发明人： Edward F. Leonard , Alan C. West , Christian Paul Aucoin , Edgar E. Nanne
IPC分类号： B01D61/38 , B01D61/24 , B01D61/14 , B01D11/00 , A61M1/34 , A61M37/00
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/32 , A61M2205/7563 , A61M2206/11 , B01D11/0492 , B01D11/0496 , G01N2030/0045
摘要： A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

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