专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20210340572A1 HIGH-CONTENT IMAGING OF MICROFLUIDIC DEVICES 有权
公开(公告)号：US20210340572A1
公开(公告)日：2021-11-04
申请号：US17375324
申请日：2021-07-14
申请人： EMULATE, Inc.
发明人： Kyung-Jin Jang , Daniel Levner , Konstantia-Roumvini Kodella , Jonathan Rubins , Debora Barreiros Petropolis , matt Boeckeler , Geraldine Hamilton
IPC分类号： C12N15/88 , C12N15/86 , C12Q1/02
摘要： The present invention is related to high-content microscopy imaging of microfluidic cell culture systems. A method of high-content microfluidic device microscopy is contemplated, along with related statistical analysis and microfluidic device adaptors.

2. 发明申请

US20210003559A1 Method for Assessing a Compound Interacting with a Target on Epithelial Cells 有权
公开(公告)号：US20210003559A1
公开(公告)日：2021-01-07
申请号：US16912391
申请日：2020-06-25
申请人： Hoffmann-La Roche Inc. , F. Hoffmann-La Roche AG , Emulate, Inc.
发明人： Cristina Bertinetti-Lapatki , Lauriane Cabon , Adrian B. Roth , Annie Moisan , Nikolche Gjorevski , Jordan S. Kerns , Geraldine A. Hamilton , Catherine Karalis , Heather Grant , Riccardo Barrile , Debora Barreiros Petropolis , Chaitra Belgur
IPC分类号： G01N33/50
摘要： Disclosed herein is a method for assessing a compound interacting with a target on polarized epithelial cells. The method comprising the steps of providing an organ chip comprising a main channel and polarized epithelial cells, wherein the main channel is divided into an apical channel and a basal channel separated by the polarized epithelial cells, wherein the apical side of the polarized epithelial cells is directed towards the apical channel and the basolateral side of the polarized epithelial cells is directed towards the basal channel. Determining the localization and optionally the expression level of the target on the polarized epithelial cells. Administering the compound and optionally immune cells, preferably peripheral blood mononuclear cells (PBMC) to the basal channel, when the target is localized on the basolateral side of the epithelial cells or administering the compound and optionally immune cells, preferably peripheral blood mononuclear cells (PBMC) to the apical channel, when the target is localized on the apical side of the epithelial cells. Measuring a parameter of the administration of the compound and the peripheral blood mononuclear cells.

3. 发明申请

US20210341378A1 HIGH-CONTENT IMAGING OF MICROFLUIDIC DEVICES 有权
公开(公告)号：US20210341378A1
公开(公告)日：2021-11-04
申请号：US17375237
申请日：2021-07-14
申请人： EMULATE, Inc.
发明人： Kyung-Jin Jang , Daniel Levner , Konstantia-Roumvini Kodella , Jonathan Rubins , Debora Barreiros Petropolis , Samatha Peel , Adam M. Corrigan , Beate Ehrardt , Pedro Pinto , Dominic Williams , Matt Boeckeler , Alison J. Foster , Geraldine Hamilton , Lorna Ewart Ewart
IPC分类号： G01N15/14 , G01N33/50 , G02B21/00
摘要： The present invention is related to high-content microscopy imaging of microfluidic cell culture systems. A method of high-content microfluidic device microscopy is contemplated. along with related statistical analysis and microfluidic device adaptors.

4. 发明公开

US20230159899A1 DEVICES AND METHODS FOR SIMULATING A FUNCTION OF LIVER TISSUE 审中-公开
公开(公告)号：US20230159899A1
公开(公告)日：2023-05-25
申请号：US17992168
申请日：2022-11-22
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner , Monicah Otieno
IPC分类号： C12N5/071 , A61K35/407 , C12M3/06 , C12M1/12 , B01L3/00 , C12M3/00
CPC分类号： C12N5/067 , A61K35/407 , C12M23/16 , C12M25/02 , B01L3/5027 , C12M21/08 , C12N2502/28 , C12N2533/52 , C12N2533/90 , C12M25/14 , C12N5/0068
摘要： Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.

5. 发明申请

US20220106547A1 COMPOSITIONS AND METHODS OF USING PARTIAL GEL LAYERS IN A MICROFLUIDIC DEVICE 有权
公开(公告)号：US20220106547A1
公开(公告)日：2022-04-07
申请号：US17514659
申请日：2021-10-29
申请人： Emulate, Inc.
发明人： Debora Barreiros Petropolis , Remi Villenave , Janna Nawroth , Tanvi Shroff , S. Jordan Kerns , Antonio Varone
IPC分类号： C12M3/06 , C12M1/12 , C12N5/071
摘要： The present invention relates to the use of gels for cell cultures, including but not limited to microfluidic devices and transwell devices, for culturing cells, such as organ cells, e.g. airway cells, intestinal cells, etc., and co-culturing cells, (e.g. parenchymal cells and endothelial cells, etc). As one example, the use of gels results in improved lung cell cultures, such as when using transwells and microfluidic devices, (e.g. for culturing healthy airway epithelial cells, culturing diseased airway epithelial cells, e.g., CF epithelial cells that are ciliated). The present invention relates to fluidic devices, methods and systems for use with gel layers within a microfluidic device. In particular, a partial gel layer is disposed within a microchannel of a microfluidic device. For example, a partial gel layer has a thickness ranging between approximately 20-100 μm. A dilute partial gel layer of less than 100 μm may be formed from a polymer solution of 0.5 mg/ml. A cell-permeable partial gel layer having a thickness ranging between approximately 20-50 μm may be formed from a polymer solution of 1-3 mg/ml. A partial gel layer may be formed by a hydrodynamic shearing technique. Such thin gel layers can support a variety of cell cultures, including but not limited to single cells, cell populations, cell layers, differentiated cell layers, and/or primary tissues. The present invention is related to the field of imaging and image processing. In particular, the invention is related to imaging that supports the determination of cell membrane cilia beating frequency. For example, methods described herein encompass cilia beat frequency in the context of membrane region and/or distances between regions. Alternatively, the methods described here encompass cilia beat synchrony and correlation of beat frequency between cell membrane regions.

6. 发明申请

US20190093077A1 DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A LIVER TISSUE 审中-公开
公开(公告)号：US20190093077A1
公开(公告)日：2019-03-28
申请号：US15781423
申请日：2016-12-02
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner
IPC分类号： C12N5/071 , C12M3/00
摘要： Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式