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1. 发明授权

US06640149B1 System and method of developing a can bottom profile and a can with a domed bottom structure 失效
标题翻译：开发罐底型材的系统和方法以及具有圆顶底部结构的罐体
公开(公告)号：US06640149B1
公开(公告)日：2003-10-28
申请号：US09532167
申请日：2000-03-21
申请人： Dubravko Nardini , Yi Gao , Stuart MacEwen
发明人： Dubravko Nardini , Yi Gao , Stuart MacEwen
IPC分类号： G06F1750
CPC分类号： B21D51/26 , G06F17/50
摘要： A method of developing a can (e.g. beverage) bottom profile is presented. More specifically, finite element analysis on a parametric representation of a beverage can is used for developing an improved beverage can design. By specifying performance parameters that the beverage can must meet and providing specific geometric limitations on the design an improved beverage can design is obtained. The resulting improved beverage can design is independent of the gauge of the material used in construction thereof. The improved beverage can provides a concave dome on the bottom of the can connected to a bottom stand which in turn is connected to a cylindrical side wall of the can via a slanted connecting wall.
摘要翻译：提出了一种开发罐（例如饮料）底部轮廓的方法。更具体地说，使用饮料罐参数表示的有限元分析来开发改进的饮料罐设计。通过指定饮料必须满足的性能参数并在设计上提供具体的几何限制，可以获得改进的饮料罐设计。所得到的改进的饮料罐设计与其在构造中使用的材料的规格无关。改进的饮料可以在连接到底架上的罐的底部上提供凹入的圆顶，底座又通过倾斜的连接壁连接到罐的圆柱形侧壁。

3. 发明申请

US20130085181A1 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：US20130085181A1
公开(公告)日：2013-04-04
申请号：US13485032
申请日：2012-05-31
申请人： Yi Gao , Tzuchi R. Ju , Dennis Y. Lee , Nicole Nguyen , Huailiang Wu
发明人： Yi Gao , Tzuchi R. Ju , Dennis Y. Lee , Nicole Nguyen , Huailiang Wu
IPC分类号： A61K31/192
CPC分类号： A61K31/192 , A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K31/194 , A61K47/38
摘要： The present invention provides a modified release formulation comprising an active agent in a hydrophilic polymer matrix wherein the active agent is a salt of fenofibric acid wherein the release rate of the formulation in an in vitro dissolution is substantially independent of the ionic strength of the dissolution media.
摘要翻译：本发明提供一种在亲水性聚合物基质中包含活性剂的改性释放制剂，其中活性剂是非诺贝酸盐，其中制剂在体外溶出中的释放速率基本上与溶出介质的离子强度无关。

4. 发明申请

US20120264780A1 SOLID COMPOSITIONS 有权
标题翻译：固体组合物
公开(公告)号：US20120264780A1
公开(公告)日：2012-10-18
申请号：US13156793
申请日：2011-06-09
申请人： Simon Kullmann , Ulrich Westedt , Mirko Pauli , Rudolf Schroeder , Gerd Woehrle , Tanja Heitermann , Renato Koenig , Madlen Thiel , Yi Gao , Jianwei Wu , Bryan K. Erickson
发明人： Simon Kullmann , Ulrich Westedt , Mirko Pauli , Rudolf Schroeder , Gerd Woehrle , Tanja Heitermann , Renato Koenig , Madlen Thiel , Yi Gao , Jianwei Wu , Bryan K. Erickson
IPC分类号： A61K31/4545 , A61P31/14 , A61K31/4184
CPC分类号： C07D401/14 , C07D403/14 , C07D417/14
摘要： The present invention features solid compositions comprising Compound IA, IB or IC, or a pharmaceutically acceptable salt thereof, in an amorphous form. In one embodiment, Compound IA, IB or IC, or a pharmaceutically acceptable salt thereof, is formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant.
摘要翻译：本发明的特征在于包含无定形形式的化合物1A，IB或IC或其药学上可接受的盐的固体组合物。在一个实施方案中，将化合物1A，IB或IC或其药学上可接受的盐配制在包含药学上可接受的亲水性聚合物，优选药学上可接受的表面活性剂的无定形固体分散体中。

5. 发明申请

US20120220562A1 Anti-Viral Compounds 审中-公开
公开(公告)号：US20120220562A1
公开(公告)日：2012-08-30
申请号：US13404429
申请日：2012-02-24
申请人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
发明人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
IPC分类号： A61K31/496 , A61K31/506 , A61K31/4545 , A61P31/14 , C07D403/14 , C07D401/14 , C07D405/14 , A61K31/4178 , A61K31/454
CPC分类号： C07D403/14 , C07D207/16
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

6. 发明申请

US20120190113A1 Macroporous Microcarrier Specific to Liver Cell, Preparation Method and Use Thereof 审中-公开
标题翻译：特异于肝细胞的大孔微载体，其制备方法和用途
公开(公告)号：US20120190113A1
公开(公告)日：2012-07-26
申请号：US13389595
申请日：2010-04-17
申请人： Yi Gao , Mingxin Pan , Duhui Gong , Zhi Zhang , Huancheng Zhou , Zhiwei Hu
发明人： Yi Gao , Mingxin Pan , Duhui Gong , Zhi Zhang , Huancheng Zhou , Zhiwei Hu
IPC分类号： C12N5/071
CPC分类号： C08B37/003 , C08H1/00 , C08J3/12 , C08J9/0061 , C08J9/286 , C08J2389/00 , C08J2405/00 , C08L5/08 , C08L89/00 , C12N5/0075 , C12N5/067 , C12N2531/00 , C12N2533/50 , C12N2533/72 , C08L2666/26
摘要： The present invention provides a macroporous microcarrier specific to hepatocytes using silk fibroin and galactosylated chitosan as main raw material, a preparation method thereof, and application for hepatocyte culture under the culture condition of microgravity rotation. The macroporous microcarrier s a sphere prepared from silk fibroin and galactosylated chitosan under the effect of crosslinker, wherein based on the total weight of the sphere, the content of silk fibroin is 50-80 wt % and the content of galactosylated chitosan is 15-40 wt %. The diameter of the microcarrier is 200-500 μm, and the aperture of the microcarrier is 40-80 μm. Compared with normal solid scaffold material, the microcarrier provided by the present invention has larger surface area/volume ratio and, a sinus gap structure extremely similar with in-vivo liver sinus structure, therefore it is more conducive to adhering of the hepatocytes on the scaffold material, contacting between cells, transporting oxygen and nutrient components and excreting metabolic products.
摘要翻译：本发明提供使用丝素蛋白和半乳糖基化壳聚糖作为主要原料的肝细胞特异性的大孔微载体，其制备方法，以及微重力旋转培养条件下肝细胞培养的应用。由丝素蛋白和半乳糖基化壳聚糖制备的大孔微球体在交联剂的作用下，其中以球体总重为基准，丝素蛋白含量为50-80重量％，半乳糖基化壳聚糖含量为15-40重量％％。微载体的直径为200-500μm，微载体的孔径为40-80μm。与正常的固体支架材料相比，本发明提供的微载体具有较大的表面积/体积比，以及与体内肝窦结构非常相似的窦间隙结构，因此更有利于肝细胞在支架上的粘附材料，细胞之间的接触，运输氧气和营养成分并排出代谢产物。

7. 发明申请

US20060280791A1 Pharmaceutical formulations 审中-公开
标题翻译：药物制剂
公开(公告)号：US20060280791A1
公开(公告)日：2006-12-14
申请号：US11399983
申请日：2006-04-07
申请人： Tzuchi Ju , Claudia Davila , Kevin Engh , Yi Gao , Linda Gustavson , Shyamala Jayaraman , David LeBlond , Dennis Lee , Tong Zhu
发明人： Tzuchi Ju , Claudia Davila , Kevin Engh , Yi Gao , Linda Gustavson , Shyamala Jayaraman , David LeBlond , Dennis Lee , Tong Zhu
IPC分类号： A61K31/192 , A61K9/20
CPC分类号： A61K9/5026 , A61K9/0004 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K31/192
摘要： The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.
摘要翻译：本发明涉及包含含有2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸中的至少一种的活性剂，2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸或缓冲的2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸。

8. 外观设计

USD981214S1 Limiter of tension tube 有权
公开(公告)号：USD981214S1
公开(公告)日：2023-03-21
申请号：US29859378
申请日：2022-11-09
申请人： Yi Gao
设计人： Yi Gao

9. 发明授权

US08691938B2 Anti-viral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US08691938B2
公开(公告)日：2014-04-08
申请号：US12813301
申请日：2010-06-10
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
IPC分类号： C07K16/00 , A61K31/66
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译：描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

10. 发明授权

US08216725B2 Electrolyte for batteries and battery packs 有权
标题翻译：电池用电池和电池组
公开(公告)号：US08216725B2
公开(公告)日：2012-07-10
申请号：US12352981
申请日：2009-01-13
申请人： Yi Gao , JiangMin Zhu
发明人： Yi Gao , JiangMin Zhu
IPC分类号： H01M6/16
CPC分类号： H01M10/0567 , H01M10/0525 , H01M10/0568 , H01M10/4235
摘要： Electrolyte for lithium secondary batteries and battery packs includes a lithium salt, a non-aqueous solvent, and an additive. The additive includes two or more members selected from the group consisting of substances A, B and C, wherein A includes one or more fused ring compounds and fused heterocyclic compounds, B includes an alkoxy aromatic compound, and C includes halogenated borane-based salt.
摘要翻译：锂二次电池和电池组的电解液包括锂盐，非水溶剂和添加剂。添加剂包括选自物质A，B和C中的两种或多种，其中A包括一个或多个稠环化合物和稠合杂环化合物，B包括烷氧基芳族化合物，C包括卤代硼烷基盐。

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