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1. 发明申请

US20080138296A1 Foam prepared from nanoemulsions and uses 审中-公开
标题翻译：泡沫由纳米乳液和用途制成
公开(公告)号：US20080138296A1
公开(公告)日：2008-06-12
申请号：US11975621
申请日：2007-10-19
申请人： Dov Tamarkin , Alex Besonov , Meir Eini , Jorge Danziger
发明人： Dov Tamarkin , Alex Besonov , Meir Eini , Jorge Danziger
IPC分类号： A61K9/107 , A61K8/06 , B82B1/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/068 , A61K8/342 , A61K8/375 , A61K8/39 , A61K8/498 , A61K8/4993 , A61K8/602 , A61K8/73 , A61K8/731 , A61K8/737 , A61K8/8141 , A61K8/8147 , A61K8/86 , A61K8/87 , A61K9/0014 , A61K9/1075 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/26 , A61K47/38 , A61K2800/21 , A61Q19/00
摘要： The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water nano emulsion composition includes: (a) a nano oil globule system, comprising substantially of sub-micron oil globules; (b) about 0.1% to about 5% by weight of at least one stabilizing agent, selected from the group consisting of (i) a non-ionic surfactant, (ii) an ionic surfactant, and (iii) a polymeric agent; and (c) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration. The present invention further provides methods of treating, alleviating or preventing a disorder of the skin, body cavity or mucosal surface using such foamable compositions; and to methods of producing such foams having an improved bubble size.
摘要翻译：本发明提供一种用于给予皮肤，体表，体腔或粘膜表面的发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。水可发泡油中的纳米乳液组合物包括：（a）纳米油球系统，其基本上包含亚微米级的微球; （b）约0.1重量％至约5重量％的至少一种稳定剂，选自（i）非离子表面活性剂，（ii）离子表面活性剂和（iii）聚合物剂; 和（c）浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂，加入水和任选的成分以使总质量达到100％。当从气溶胶容器释放时，可发泡组合物形成适合局部给药的膨胀泡沫。本发明还提供了使用这种可发泡组合物治疗，减轻或预防皮肤，体腔或粘膜表面疾病的方法; 以及制造具有改善的气泡尺寸的这种泡沫的方法。

2. 发明授权

US08486374B2 Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses 有权
标题翻译：亲水性，非水性药物载体和组合物和用途
公开(公告)号：US08486374B2
公开(公告)日：2013-07-16
申请号：US12014088
申请日：2008-01-14
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
IPC分类号： A61K33/00 , A61K47/34 , A61K31/375 , A61K31/355 , A61K31/351 , A61K31/4412 , A61K31/47 , A61K31/57 , A61K9/12 , A61K31/522 , A61K31/135 , A61K31/00
CPC分类号： A61K9/12 , A01N25/02 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/047 , A61K31/135 , A61K31/351 , A61K31/355 , A61K31/375 , A61K31/4412 , A61K31/522 , A61K47/10 , A61K47/14 , A61K47/38
摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
摘要翻译：适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i）两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。

3. 发明申请

US20080063607A1 Oleaginous pharmaceutical and cosmetic foam 审中-公开
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US20080063607A1
公开(公告)日：2008-03-13
申请号：US11894798
申请日：2007-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
IPC分类号： A61K9/12 , A61K47/00 , A61P17/00
CPC分类号： A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0046 , A61K9/122 , A61K2800/5422 , A61Q17/04 , A61Q19/007 , A61Q19/04 , A61Q19/08 , A61Q19/10
摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。

4. 发明申请

US20080299220A1 HYDROPHILIC, NON-AQUEOUS PHARMACEUTICAL CARRIERS AND COMPOSITIONS AND USES 有权
标题翻译：非水性药用植物及其组合物和用途
公开(公告)号：US20080299220A1
公开(公告)日：2008-12-04
申请号：US12014088
申请日：2008-01-14
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
IPC分类号： A61K33/00 , A61K47/34 , A61K31/375 , A61K31/355 , A61K31/351 , A61K31/4412 , A61K31/047 , A61K31/57 , A61K9/12 , A61K31/522 , A61K31/135
CPC分类号： A61K9/12 , A01N25/02 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/047 , A61K31/135 , A61K31/351 , A61K31/355 , A61K31/375 , A61K31/4412 , A61K31/522 , A61K47/10 , A61K47/14 , A61K47/38
摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
摘要翻译：适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i）两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。

5. 发明申请

US20070292461A1 Oleaginous pharmaceutical and cosmetic foam 审中-公开
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US20070292461A1
公开(公告)日：2007-12-20
申请号：US11653205
申请日：2007-01-12
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
IPC分类号： A61K8/02 , A61P17/12 , A61P23/02 , A61P3/02 , A61P31/00 , A61P31/12 , A61P35/00 , A61Q19/02 , A61Q19/04 , A61Q19/08
CPC分类号： A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0046 , A61K9/122 , A61K2800/5422 , A61Q17/04 , A61Q19/007 , A61Q19/04 , A61Q19/08 , A61Q19/10
摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。

6. 发明授权

US10117812B2 Foamable composition combining a polar solvent and a hydrophobic carrier 有权
公开(公告)号：US10117812B2
公开(公告)日：2018-11-06
申请号：US11488989
申请日：2006-07-19
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/04 , A61K47/14 , A61K47/22 , A61K8/49 , A61K8/06 , A61K8/31 , A61K8/37 , A61K9/00 , A61K9/107 , A61K9/12 , A61Q19/00 , A01N25/16 , A61K8/96 , A61K35/04 , A61K47/06 , A61K47/10 , A61K8/73 , A61K8/81 , A61K47/32 , A61K47/38 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

7. 发明授权

US09622947B2 Foamable composition combining a polar solvent and a hydrophobic carrier 有权
公开(公告)号：US09622947B2
公开(公告)日：2017-04-18
申请号：US12350854
申请日：2009-01-08
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/04 , A61K8/96 , A61K47/14 , A61K47/06 , A61K47/10 , A61K9/00 , A61K35/04 , A61K9/12 , A61K8/37 , A61K8/31 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A01N25/16
CPC分类号： A61K8/046 , A01N25/16 , A61K8/062 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/731 , A61K8/8176 , A61K8/965 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K35/04 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/38 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

8. 发明授权

US08362091B2 Foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：可发泡车辆及其药物组合物
公开(公告)号：US08362091B2
公开(公告)日：2013-01-29
申请号：US12767511
申请日：2010-04-26
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A01N25/16 , A61K47/00 , A61K47/30 , A61K47/32
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

9. 发明授权

US07820145B2 Oleaginous pharmaceutical and cosmetic foam 有权
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US07820145B2
公开(公告)日：2010-10-26
申请号：US10835505
申请日：2004-04-28
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，共溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

10. 发明申请

US20070020213A1 Foamable composition combining a polar solvent and a hydrophobic carrier 审中-公开
标题翻译：组合极性溶剂和疏水性载体的可发泡组合物
公开(公告)号：US20070020213A1
公开(公告)日：2007-01-25
申请号：US11488989
申请日：2006-07-19
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K8/00
CPC分类号： A61K8/046 , A01N25/16 , A61K8/062 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/731 , A61K8/8176 , A61K8/965 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K35/04 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/38 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.
摘要翻译：本发明涉及可发泡载体或化妆品或药物组合物，其包含：（1）浓度为10重量％至70重量％的有机载体，其中所述有机载体同时包含：（i）至少一种疏水性有机物载体，和（ii）至少一种极性溶剂; （2）至少一种表面活性剂; （3）水; 和（4）至少一种浓度为总组合物重量的3％至25％的液化或压缩气体推进剂。本发明还提供了治疗，减轻或预防哺乳动物受试者病症的方法，包括将上述组合物施用于受影响的靶位点。

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