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1. 发明申请

US20080292560A1 SILICONE IN GLYCOL PHARMACEUTICAL AND COSMETIC COMPOSITIONS WITH ACCOMMODATING AGENT 审中-公开
标题翻译：糖果糖浆与化妆品的化学成分
公开(公告)号：US20080292560A1
公开(公告)日：2008-11-27
申请号：US12049203
申请日：2008-03-14
申请人： Dov TAMARKIN , Doron FRIEDMAN , Ella ZLATKIS , Tal BERMAN , David SCHUZ
发明人： Dov TAMARKIN , Doron FRIEDMAN , Ella ZLATKIS , Tal BERMAN , David SCHUZ
IPC分类号： A61K9/12 , A61K8/04
CPC分类号： A61K9/12 , A61K8/046 , A61K8/345 , A61K8/585 , A61K8/731 , A61K8/732 , A61K8/8147 , A61K8/86 , A61K8/891 , A61K31/00 , A61K47/10 , A61K47/24 , A61K2800/31 , A61Q19/00 , A61K2300/00
摘要： A carrier, composition or foam formulation comprising; a silicone; about 25% to about 98% of a solvent selected from the group consisting of (1) a propylene glycol or derivative and (2) a polyethylene glycol (PEG) or derivative or mixtures thereof; 0% to about 48% of at least one secondary solvent; and an Accommodating Agent or Complex; and methods of treatment. A hygroscopic silicone in glycol containing composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and a therapeutic agent.
摘要翻译：一种载体，组合物或泡沫体制剂，其包含：硅胶约25％至约98％的选自（1）丙二醇或衍生物的溶剂和（2）聚乙二醇（PEG）或其衍生物或其混合物; 0％至约48％的至少一种第二溶剂; 和住宿代理或综合体; 和治疗方法。含二醇的组合物中的吸湿硅酮包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和治疗剂。

2. 发明申请

US20080253973A1 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 审中-公开
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：US20080253973A1
公开(公告)日：2008-10-16
申请号：US11971197
申请日：2008-01-08
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。

3. 发明申请

US20120237453A1 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 有权
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：US20120237453A1
公开(公告)日：2012-09-20
申请号：US12350650
申请日：2009-01-08
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。

4. 发明申请

US20110097279A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20110097279A1
公开(公告)日：2011-04-28
申请号：US12974857
申请日：2010-12-21
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P17/00 , A61K8/06 , A61Q19/00
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

5. 发明申请

US20080206155A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20080206155A1
公开(公告)日：2008-08-28
申请号：US11940290
申请日：2007-11-14
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近所述油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

6. 发明申请

US20080260655A1 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途
公开(公告)号：US20080260655A1
公开(公告)日：2008-10-23
申请号：US12025547
申请日：2008-02-04
申请人： Dov TAMARKIN , Doron FRIEDMAN , Enbal ZIV , Meir EINI , Tal BERMAN , Jorge DANZIGER , Rita KEYNAN , David SCHUZ
发明人： Dov TAMARKIN , Doron FRIEDMAN , Enbal ZIV , Meir EINI , Tal BERMAN , Jorge DANZIGER , Rita KEYNAN , David SCHUZ
IPC分类号： A61K9/12 , A61K8/04 , A61P17/00 , A61Q19/00
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。

7. 发明申请

US20080206161A1 QUIESCENT FOAMABLE COMPOSITIONS, STEROIDS, KITS AND USES THEREOF 审中-公开
标题翻译：各种可泡沫组合物，STEROIDS，KITS及其用途
公开(公告)号：US20080206161A1
公开(公告)日：2008-08-28
申请号：US12020381
申请日：2008-01-25
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P29/00
CPC分类号： A61K9/122 , A01N25/16 , A61K9/0014 , A61K9/0034 , A01N53/00
摘要： The present invention relates to an emulsion steroid composition as a foamable vehicle in which the vehicle is stable or stabilized by the presence of at least one quiesence agent; therapeutical kit containing such composition; to methods of treatment using such composition; to methods of enhancing the stability of such composition.
摘要翻译：本发明涉及一种乳化类固醇组合物作为其中载体通过至少一种静止剂的存在而稳定或稳定的起泡载体; 含有该组合物的治疗试剂盒; 使用这种组合物的治疗方法; 涉及提高这种组合物的稳定性的方法。

8. 发明申请

US20090041680A1 Wax Foamable Vehicle and Pharmaceutical Compositions Thereof 有权
标题翻译：蜡可发泡车辆及其药物组合物
公开(公告)号：US20090041680A1
公开(公告)日：2009-02-12
申请号：US12187840
申请日：2008-08-07
申请人： Dov TAMARKIN , Rita KEYNAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Rita KEYNAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P43/00 , A61Q90/00
CPC分类号： A61K9/124 , A61K8/046 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/4993 , A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/1075 , A61K9/122 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
摘要翻译：提供了包含至少一种蜡，蜡质物质，对应物或衍生物，稳定剂，水和推进剂的独特的可发泡车辆或载体。在一些实施方案中，蜡是液体蜡。在一些实施方式中，蜡包括固体蜡和液体蜡。组合物基本上不含晶体。选择组分以提供基本上耐老化和相分离的组合物和/或可以基本上溶解和/或稳定活性成分。还提供了具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。

9. 发明申请

US20110281827A1 COMPOSITIONS, GELS AND FOAMS WITH RHEOLOGY MODULATORS AND USES THEREOF 有权
标题翻译：组成，凝胶和流变学调节剂及其用途
公开(公告)号：US20110281827A1
公开(公告)日：2011-11-17
申请号：US13100724
申请日：2011-05-04
申请人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
发明人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
IPC分类号： A61K31/65 , A61K31/575 , A61P17/10 , A61K31/58 , A61P31/04 , A61P29/00 , A61K31/60 , A61K31/327
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
摘要翻译：本公开一般涉及用于化妆品或药物应用的组合物。组合物包括载体和流变学调节剂。

10. 发明申请

US20090068118A1 DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION 有权
标题翻译：用于输送可发泡组合物的装置
公开(公告)号：US20090068118A1
公开(公告)日：2009-03-12
申请号：US12204771
申请日：2008-09-04
申请人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
发明人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
IPC分类号： A61K9/12 , A61M31/00
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译：用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送。泡沫输送装置可以具有多个孔。

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